| Definition | Mycobacterium avium subsp. paratuberculosis K-10, complete genome. |
|---|---|
| Accession | NC_002944 |
| Length | 4,829,781 |
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The map label for this gene is glmS
Identifier: 41410351
GI number: 41410351
Start: 4721192
End: 4723066
Strand: Direct
Name: glmS
Synonym: MAP4253
Alternate gene names: 41410351
Gene position: 4721192-4723066 (Clockwise)
Preceding gene: 41410347
Following gene: 41410352
Centisome position: 97.75
GC content: 69.81
Gene sequence:
>1875_bases ATGTGCGGAATCGTCGGCTACGTCGGGCAGCAGCCCGCCTGCGCGGTCGTCATGGCCGCGCTGCGCCGCATGGAGTACCG CGGTTACGACTCCTCGGGAGTCGCGTTGGTCAACGGCGACGGCACCCTGACGGTGAGCCGCCGCGCCGGCCGGCTGGCCA ACCTCGAGGAGGCGGTGGCGCAGCTGCCGCCGTCGGCGCTGACCGGCACCACCGGCCTGGGCCACACCCGGTGGGCCACC CACGGCCGGCCCACCGACCGCAACGCGCACCCGCACCGCGACGCCGCCGGCAAGATCGCCGTGGTGCACAACGGCATCAT CGAGAACTACGCCGGCCTGCGCCACGAGCTGGAGGCCGACGGCGTGGAGTTCGCCAGCGACACCGACACCGAGGTCGCCG TGCACCTGGTGGCGCAGGCCTACCGGCACGGCCCGACGGCCGGCGACTTCGCCGCCTCGGTGCTCGCCGTGCTGCGCCGC CTCGACGGCCACTTCACCCTGGTGTTCGCCAACGCCGACGAACCCGGCACCATCGTCGCCGCCCGCCGCTCCACCCCGCT GGTGATCGGCATCGGCGACGGCGAGATGTTCGTCGGCTCCGACGTGGCGGCGTTCATCCCGCACACCCGCAACGCCATCG AGCTCGGCCAGGACCAGGCCGTGGTGCTCACCGCGGACGGCTACCGCATCACCGACTTCGACGGCAACGACGACCTGGGG CCCGGGGCGTACCGCGAATTCCACATCGACTGGGATCTGGCCGCCGCCGAGAAGGGCGGCTACGAGTACTTCATGCTCAA GGAGATCGCCGAGCAGCCCGCCGCGGTGGCCGACACGCTGCTCGGCCATTTCGTCGACGGCCGCATCGTGCTCGACGAGC AACGGCTGTCCGATCAGGAACTGCGCGAGGTCGACAAGGTGTTCGTGGTGGCCTGCGGCACCGCCTACCACTCCGGGCTG CTGGCCAAATACGCGATCGAGCACTGGACGCGGCTGCCGGTGGAAGTGGAGCTGGCCAGCGAATTCCGTTACCGCGACCC GGTTTTGGACCGCAGCACCCTGGTGGTCGCCATCTCGCAGTCCGGCGAGACCGCCGACACCCTGGAGGCGGTGCGGCACG CCAAGGAGCAGAAGGCCAAGGTGCTGGCGATCTGCAACACCAACGGCAGCCAGATCCCGCGCGAATGCGACGCCGTGCTC TACACCCGCGCCGGCCCGGAGATCGGCGTCGCCTCCACGAAGACGTTCCTGGCCCAGATCACCGCCAACTACCTGGTCGG CCTGGCGCTGGCGCAGGCCCGCGGCACCAAATACCCCGACGAGGTCGAGCGGGAATACCACGAGCTAGAAGCCATGCCGG ACCTGGTGGCGCGGGTGCTGGCGACGATCAAGCCGGTGGCCGCGCTGGCTCAGCGGTTCGCCCAGTCGCCGACCGTGCTG TTCCTGGGCCGCCACGTCGGCTACCCGGTGGCGCTGGAAGGCGCGCTTAAACTCAAGGAACTGGCCTACATGCACGCCGA GGGATTCGCCGCCGGCGAGCTCAAGCACGGGCCCATCGCGCTGATCGAGGACGACCTGCCGGTCATCGTCATCATGCCGT CGCCCAAAGGGTCGGCCGTGCTGCACGCCAAGCTGCTGTCCAACATCCGCGAAATCCAGGCCCGCGGCGCGATCACCATC GTCATCGCCGAGGAGGGCGACGACACGGTGCGGCCGTACGCCGATCACCTGATCGAAATCCCCTCGGTATCAACGCTTCT GCAGCCGCTGCTGTCGACCATCCCGCTGCAGGTGTTCGCCGCGTCGGTGGCCCAGGCCCGCGGCTACGACGTGGACAAGC CGCGAAACCTGGCCAAGTCCGTCACGGTGGAATAG
Upstream 100 bases:
>100_bases CATTTTCCCGGGGGCAGCGACGGTCATGACGGCCGCGGCGGCGCCGGCGGGCACCCGCGGACTGGCGGCTCGGCCCTGCG CCTGCACTACCCTGAGCAGA
Downstream 100 bases:
>100_bases CCGGGCAACGGCTTCACCCGGATAAGCCGCGCATCCGCGGTCGATCGATTACATTGCCCTGGGACAGCATTTCGGCGCCA GTGAGCAAGGCGCCCATGCC
Product: glucosamine--fructose-6-phosphate aminotransferase
Products: NA
Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]
Number of amino acids: Translated: 624; Mature: 624
Protein sequence:
>624_residues MCGIVGYVGQQPACAVVMAALRRMEYRGYDSSGVALVNGDGTLTVSRRAGRLANLEEAVAQLPPSALTGTTGLGHTRWAT HGRPTDRNAHPHRDAAGKIAVVHNGIIENYAGLRHELEADGVEFASDTDTEVAVHLVAQAYRHGPTAGDFAASVLAVLRR LDGHFTLVFANADEPGTIVAARRSTPLVIGIGDGEMFVGSDVAAFIPHTRNAIELGQDQAVVLTADGYRITDFDGNDDLG PGAYREFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVDGRIVLDEQRLSDQELREVDKVFVVACGTAYHSGL LAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVL YTRAGPEIGVASTKTFLAQITANYLVGLALAQARGTKYPDEVEREYHELEAMPDLVARVLATIKPVAALAQRFAQSPTVL FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDDLPVIVIMPSPKGSAVLHAKLLSNIREIQARGAITI VIAEEGDDTVRPYADHLIEIPSVSTLLQPLLSTIPLQVFAASVAQARGYDVDKPRNLAKSVTVE
Sequences:
>Translated_624_residues MCGIVGYVGQQPACAVVMAALRRMEYRGYDSSGVALVNGDGTLTVSRRAGRLANLEEAVAQLPPSALTGTTGLGHTRWAT HGRPTDRNAHPHRDAAGKIAVVHNGIIENYAGLRHELEADGVEFASDTDTEVAVHLVAQAYRHGPTAGDFAASVLAVLRR LDGHFTLVFANADEPGTIVAARRSTPLVIGIGDGEMFVGSDVAAFIPHTRNAIELGQDQAVVLTADGYRITDFDGNDDLG PGAYREFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVDGRIVLDEQRLSDQELREVDKVFVVACGTAYHSGL LAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVL YTRAGPEIGVASTKTFLAQITANYLVGLALAQARGTKYPDEVEREYHELEAMPDLVARVLATIKPVAALAQRFAQSPTVL FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDDLPVIVIMPSPKGSAVLHAKLLSNIREIQARGAITI VIAEEGDDTVRPYADHLIEIPSVSTLLQPLLSTIPLQVFAASVAQARGYDVDKPRNLAKSVTVE >Mature_624_residues MCGIVGYVGQQPACAVVMAALRRMEYRGYDSSGVALVNGDGTLTVSRRAGRLANLEEAVAQLPPSALTGTTGLGHTRWAT HGRPTDRNAHPHRDAAGKIAVVHNGIIENYAGLRHELEADGVEFASDTDTEVAVHLVAQAYRHGPTAGDFAASVLAVLRR LDGHFTLVFANADEPGTIVAARRSTPLVIGIGDGEMFVGSDVAAFIPHTRNAIELGQDQAVVLTADGYRITDFDGNDDLG PGAYREFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVDGRIVLDEQRLSDQELREVDKVFVVACGTAYHSGL LAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVL YTRAGPEIGVASTKTFLAQITANYLVGLALAQARGTKYPDEVEREYHELEAMPDLVARVLATIKPVAALAQRFAQSPTVL FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDDLPVIVIMPSPKGSAVLHAKLLSNIREIQARGAITI VIAEEGDDTVRPYADHLIEIPSVSTLLQPLLSTIPLQVFAASVAQARGYDVDKPRNLAKSVTVE
Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]
COG id: COG0449
COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 SIS domains [H]
Homologues:
Organism=Homo sapiens, GI4826742, Length=694, Percent_Identity=36.0230547550432, Blast_Score=394, Evalue=1e-109, Organism=Homo sapiens, GI205277386, Length=692, Percent_Identity=35.9826589595376, Blast_Score=383, Evalue=1e-106, Organism=Escherichia coli, GI1790167, Length=630, Percent_Identity=44.6031746031746, Blast_Score=494, Evalue=1e-141, Organism=Escherichia coli, GI1788651, Length=166, Percent_Identity=27.710843373494, Blast_Score=71, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17539970, Length=722, Percent_Identity=32.409972299169, Blast_Score=358, Evalue=4e-99, Organism=Caenorhabditis elegans, GI17532899, Length=726, Percent_Identity=31.6804407713499, Blast_Score=334, Evalue=7e-92, Organism=Caenorhabditis elegans, GI17532897, Length=441, Percent_Identity=36.5079365079365, Blast_Score=268, Evalue=5e-72, Organism=Saccharomyces cerevisiae, GI6322745, Length=723, Percent_Identity=33.0567081604426, Blast_Score=344, Evalue=3e-95, Organism=Saccharomyces cerevisiae, GI6323731, Length=438, Percent_Identity=28.5388127853881, Blast_Score=172, Evalue=1e-43, Organism=Saccharomyces cerevisiae, GI6323730, Length=209, Percent_Identity=35.4066985645933, Blast_Score=120, Evalue=9e-28, Organism=Drosophila melanogaster, GI21357745, Length=691, Percent_Identity=35.6005788712012, Blast_Score=401, Evalue=1e-112,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000583 - InterPro: IPR017932 - InterPro: IPR005855 - InterPro: IPR001347 [H]
Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]
EC number: =2.6.1.16 [H]
Molecular weight: Translated: 67200; Mature: 67200
Theoretical pI: Translated: 5.28; Mature: 5.28
Prosite motif: PS00443 GATASE_TYPE_II
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.3 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.3 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MCGIVGYVGQQPACAVVMAALRRMEYRGYDSSGVALVNGDGTLTVSRRAGRLANLEEAVA CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHH QLPPSALTGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNGIIENYAGLRHELEAD HCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCC GVEFASDTDTEVAVHLVAQAYRHGPTAGDFAASVLAVLRRLDGHFTLVFANADEPGTIVA CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEE ARRSTPLVIGIGDGEMFVGSDVAAFIPHTRNAIELGQDQAVVLTADGYRITDFDGNDDLG EECCCCEEEEECCCCEEECCCHHEECCCCCCHHHCCCCCEEEEEECCEEEEECCCCCCCC PGAYREFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVDGRIVLDEQRLSDQE CCCCEEEEEEEEEEECCCCCCEEEHHHHHHHCCHHHHHHHHHHHCCCEEEEEHHHCCHHH LREVDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQ HHHHHHEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCCEEEEEEEC SGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQI CCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHCEEEEECCCCCCCCCHHHHHHHHH TANYLVGLALAQARGTKYPDEVEREYHELEAMPDLVARVLATIKPVAALAQRFAQSPTVL HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDDLPVIVIMPSPKGSAV EEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCE LHAKLLSNIREIQARGAITIVIAEEGDDTVRPYADHLIEIPSVSTLLQPLLSTIPLQVFA EHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHEECCCHHHHHHHHHHHHHHHHHH ASVAQARGYDVDKPRNLAKSVTVE HHHHHHCCCCCCCCHHHHHHCCCC >Mature Secondary Structure MCGIVGYVGQQPACAVVMAALRRMEYRGYDSSGVALVNGDGTLTVSRRAGRLANLEEAVA CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHH QLPPSALTGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNGIIENYAGLRHELEAD HCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCC GVEFASDTDTEVAVHLVAQAYRHGPTAGDFAASVLAVLRRLDGHFTLVFANADEPGTIVA CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEE ARRSTPLVIGIGDGEMFVGSDVAAFIPHTRNAIELGQDQAVVLTADGYRITDFDGNDDLG EECCCCEEEEECCCCEEECCCHHEECCCCCCHHHCCCCCEEEEEECCEEEEECCCCCCCC PGAYREFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVDGRIVLDEQRLSDQE CCCCEEEEEEEEEEECCCCCCEEEHHHHHHHCCHHHHHHHHHHHCCCEEEEEHHHCCHHH LREVDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQ HHHHHHEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCCEEEEEEEC SGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQI CCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHCEEEEECCCCCCCCCHHHHHHHHH TANYLVGLALAQARGTKYPDEVEREYHELEAMPDLVARVLATIKPVAALAQRFAQSPTVL HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE FLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDDLPVIVIMPSPKGSAV EEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCE LHAKLLSNIREIQARGAITIVIAEEGDDTVRPYADHLIEIPSVSTLLQPLLSTIPLQVFA EHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHEECCCHHHHHHHHHHHHHHHHHH ASVAQARGYDVDKPRNLAKSVTVE HHHHHHCCCCCCCCHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]