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The map label for this gene is pat [H]

Identifier: 41410309

GI number: 41410309

Start: 4681199

End: 4682257

Strand: Direct

Name: pat [H]

Synonym: MAP4211

Alternate gene names: 41410309

Gene position: 4681199-4682257 (Clockwise)

Preceding gene: 41410308

Following gene: 41410310

Centisome position: 96.92

GC content: 73.37

Gene sequence:

>1059_bases
ATGCTGACCGTCCCGCGCCCGGCCGCCGGCGGCATCGGCGAGGCGCTGCCCGACGCGGTCGACCCGTTTGCCTTGTCGCT
CAACGAGAATCCCTTCCCGCCGCTGCCGGCGGTGCGCGCGGCGCTGATCCGTTCGGTGTGCACCGCCAACCGGTATCCGG
AGTTCCTGCCCGAGCGGCTGCGCGGGGTGATCGCCGAGCACATCGGTGTGCCGGCCGAGCTCGTGGTGCTGGGCGCCGGA
GCCACCGGCGTGATGCTGCAGGTGCTGCAGGCGTTGACCGCGCCGGGGGACGCCATCGCGATGGCCACCCCCACCTTCGA
CGGGTATCCGATCGTGGCGCGGATGGCCCGGCTGAACACCATCGCCGTCGCGCTGGACGAGCACGGGCAGCACGACCTGG
ACGGGCTCGCCGACGCGGCCGCGCGCGCCCGCGTGGTGGTGCTGTGCCGGCCGCACAACCCGACCGGAACCGTGGAGCCC
GCGGCCGCAGTCTTCCGGTTCCTGCGCCGGGTGCCGCGCGACACCGTCGTGCTGCTCGACGAGGCCTATGTCGAATTCAC
CGCGCCCGAGCACCGGATCGACGTCGCGGCGCTGGTGGCGTGCTTCCCCAATGTGGTGGTGGTGCGCACCTTCTCCAAGG
CGTACGGCCTGGCCGGGCTGCGGATCGGCTACGGGGTGGCGTCGCCGCGGCTGGCGCGGCCGCTGTGGGACCAGCAGCTG
CCGTTCGGCATCGCGATCACCAGCCTGCTCGCCGTCACGGCGTCGTATCGGGCCGAAGACGAACTGTCCCGGCGCATCCG
GTCGATCACCGCCGAACGCCGCCGGCTGCGGATGCGGCTGAGCGCGCTGGGCGTCTACACCACCAACGCGCACGCGAACT
TCGTTTACCTGCCGCCCGATCCGCAGGGGCGCGCGTGGCAGCGGGTCTTCGCCCGCGGCGGCGTCCGGGCGCGCTACTAC
CCGGACGGCGCGGCCCGGCTGACGGTGGGCAGTCGCGCCTCCACGGTGGCGGTGCTGTCGGCGGTGGGAAAGGCCACGCT
GGAGCGGCAAGTGCGGTAA

Upstream 100 bases:

>100_bases
AGCAGCGGATCAAGGCCGGAGACGTGGTCATGATGGCGGCGTTCGCGCACGCCGGCGATTTCGCCGGCGCCGCCGCGGTG
CGCTGGGGCGGGCGGGGCGG

Downstream 100 bases:

>100_bases
GAAAGGGCGTGGCCGACTCACGTCCTCACGAACGCGATCCGATCGCCGCCGCCCGGGCCAACTGGGAGCGCGCCGGGTGG
GGCGACGTGGCGCCGGGCAT

Product: hypothetical protein

Products: 2-Oxoglutarate; L-Histidinol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MLTVPRPAAGGIGEALPDAVDPFALSLNENPFPPLPAVRAALIRSVCTANRYPEFLPERLRGVIAEHIGVPAELVVLGAG
ATGVMLQVLQALTAPGDAIAMATPTFDGYPIVARMARLNTIAVALDEHGQHDLDGLADAAARARVVVLCRPHNPTGTVEP
AAAVFRFLRRVPRDTVVLLDEAYVEFTAPEHRIDVAALVACFPNVVVVRTFSKAYGLAGLRIGYGVASPRLARPLWDQQL
PFGIAITSLLAVTASYRAEDELSRRIRSITAERRRLRMRLSALGVYTTNAHANFVYLPPDPQGRAWQRVFARGGVRARYY
PDGAARLTVGSRASTVAVLSAVGKATLERQVR

Sequences:

>Translated_352_residues
MLTVPRPAAGGIGEALPDAVDPFALSLNENPFPPLPAVRAALIRSVCTANRYPEFLPERLRGVIAEHIGVPAELVVLGAG
ATGVMLQVLQALTAPGDAIAMATPTFDGYPIVARMARLNTIAVALDEHGQHDLDGLADAAARARVVVLCRPHNPTGTVEP
AAAVFRFLRRVPRDTVVLLDEAYVEFTAPEHRIDVAALVACFPNVVVVRTFSKAYGLAGLRIGYGVASPRLARPLWDQQL
PFGIAITSLLAVTASYRAEDELSRRIRSITAERRRLRMRLSALGVYTTNAHANFVYLPPDPQGRAWQRVFARGGVRARYY
PDGAARLTVGSRASTVAVLSAVGKATLERQVR
>Mature_352_residues
MLTVPRPAAGGIGEALPDAVDPFALSLNENPFPPLPAVRAALIRSVCTANRYPEFLPERLRGVIAEHIGVPAELVVLGAG
ATGVMLQVLQALTAPGDAIAMATPTFDGYPIVARMARLNTIAVALDEHGQHDLDGLADAAARARVVVLCRPHNPTGTVEP
AAAVFRFLRRVPRDTVVLLDEAYVEFTAPEHRIDVAALVACFPNVVVVRTFSKAYGLAGLRIGYGVASPRLARPLWDQQL
PFGIAITSLLAVTASYRAEDELSRRIRSITAERRRLRMRLSALGVYTTNAHANFVYLPPDPQGRAWQRVFARGGVRARYY
PDGAARLTVGSRASTVAVLSAVGKATLERQVR

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=327, Percent_Identity=28.4403669724771, Blast_Score=111, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6322075, Length=372, Percent_Identity=25.2688172043011, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9 [C]

Molecular weight: Translated: 37890; Mature: 37890

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVPRPAAGGIGEALPDAVDPFALSLNENPFPPLPAVRAALIRSVCTANRYPEFLPERL
CCCCCCCCCCCCCHHCHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
RGVIAEHIGVPAELVVLGAGATGVMLQVLQALTAPGDAIAMATPTFDGYPIVARMARLNT
HHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHE
IAVALDEHGQHDLDGLADAAARARVVVLCRPHNPTGTVEPAAAVFRFLRRVPRDTVVLLD
EEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEE
EAYVEFTAPEHRIDVAALVACFPNVVVVRTFSKAYGLAGLRIGYGVASPRLARPLWDQQL
HHHEEECCCCHHHHHHHHHHHCCCCEEEEEHHHHHCCCCEEECCCCCCCHHHCCHHHCCC
PFGIAITSLLAVTASYRAEDELSRRIRSITAERRRLRMRLSALGVYTTNAHANFVYLPPD
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCC
PQGRAWQRVFARGGVRARYYPDGAARLTVGSRASTVAVLSAVGKATLERQVR
CCCHHHHHHHHCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTVPRPAAGGIGEALPDAVDPFALSLNENPFPPLPAVRAALIRSVCTANRYPEFLPERL
CCCCCCCCCCCCCHHCHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
RGVIAEHIGVPAELVVLGAGATGVMLQVLQALTAPGDAIAMATPTFDGYPIVARMARLNT
HHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHE
IAVALDEHGQHDLDGLADAAARARVVVLCRPHNPTGTVEPAAAVFRFLRRVPRDTVVLLD
EEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEE
EAYVEFTAPEHRIDVAALVACFPNVVVVRTFSKAYGLAGLRIGYGVASPRLARPLWDQQL
HHHEEECCCCHHHHHHHHHHHCCCCEEEEEHHHHHCCCCEEECCCCCCCHHHCCHHHCCC
PFGIAITSLLAVTASYRAEDELSRRIRSITAERRRLRMRLSALGVYTTNAHANFVYLPPD
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCC
PQGRAWQRVFARGGVRARYYPDGAARLTVGSRASTVAVLSAVGKATLERQVR
CCCHHHHHHHHCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Glutamate; 3-(Imidazol-4-yl)-2-oxopropyl phosphate [C]

Specific reaction: L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate --> 2-Oxoglutarate + L-Histidinol phosphate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA