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The map label for this gene is atsA

Identifier: 41410269

GI number: 41410269

Start: 4643469

End: 4645838

Strand: Direct

Name: atsA

Synonym: MAP4171

Alternate gene names: 41410269

Gene position: 4643469-4645838 (Clockwise)

Preceding gene: 41410268

Following gene: 41410271

Centisome position: 96.14

GC content: 66.58

Gene sequence:

>2370_bases
ATGGTGGCTGGTTCGGGGCAATCCGCGGAATTTTCCGGCCGGGTCGAGCTCGACATCCGGGATTCCGAACCGGACTGGGG
TCCCTACGCCGCGCCGACCGCCCCGCCGAACGCGCCCAACATCCTGTATCTGGTCTGGGACGACACCGGGATCGCGACGT
GGGACTGCTTCGGCGGTCTGGTGGAGATGCCGGCCATGTCGCGCATCGCCGAACGCGGCGTCCGGCTCTCGCAGTTCCAC
ACCACCGCGCTGTGCTCGCCGACCCGGGCGGCGTTGCTCACCGGTCGCAACGCCACGACCGTCGGGATGGCCACCATCGA
GGAGTTCACCGAGGGCTTCCCCAACGCCAACGGCCGCATCCCGTTCGACACCGCGCTGCTGTCCGAGGCGCTCGCCGAAC
ACGGTTACAACACTTACTGTGTCGGCAAGTGGCACCTGACGCCGCTGGAAGAATCCAACATGGCCTCGACCAAGCGGCAC
TGGCCGACCTCGCGCGGCTTCGAGCGGTTCTACGGCTTCCTGGGCGGCGAGACCGATCAGTGGTACCCCGACCTGGTCTA
CGACAACCATCCGGTGAGCCCGCCGGCCACCCCGGAGGACGGCTACCACCTCTCCAAGGACCTCGCCGACAAGACGATCG
AGTTCATCCGCGACGCCAAAGTGATTGCGCCGGAAAAGCCTTGGTTCTCCTATGTGTGTCCGGGCGCCGGGCACGCGCCG
CATCACGTGTTCAAGGAATGGGCCGACCGTTACGCCGGCCGCTTCGACATGGGTTATGAGCGCTACCGCGAGGTGGTGCT
GGAGCGGCAGAAGGCGATGGGGATCGTGCCGTCCGACACCGAATTGTCCCCGGTGAACCCGTATCTGGACGTGACGGGGC
CGCGCGGCGAGCCCTGGCCGTTGCAGGACACGGTGCGGCCGTGGGACTCGCTGAACGACGAGGAGAAGAAGCTGTTCGCC
CGGATGGCCGAGGTGTTCGCCGGCTTCCTGAGCTACACCGACGCCCAGATCGGCCGGATCCTGGACTATCTCGAGGAATC
GGGCCAGTTGGACGACACCATCATCGTGGTGATCTCCGACAACGGCGCCAGCGGTGAGGGTGGCCCGAACGGATCGGTCA
ACGAGGGCAAGTTCTTCAACGGCTACATCGACACCGTCGAGGAAAGCATGAAGCTGTTCGATCAGCTCGGCGGGCCGCAG
ACCTACAACCATTACCCGATCGGCTGGGCGATGGCGTTCAACACCCCCTACAAGCTGTACAAGCGGTACGCCTCGCATGA
GGGCGGCATCGCCGACACGGCGATCATCTCCTGGCCCAACGGAATCGCCGCGCACGGCGAGATCCGCGACAACTATGTCA
ACGTCTGCGACATCACCCCGACCGTGTACGACCTGCTGGGCATGTCCCCGCCGGAAACCGTCAAGGGGATCGCCCAGAAG
CCGCTGGACGGCGTGAGTTTCAAAGCGGCCCTTGACGATCCGAACGCCGACACCGGAAAGACCACCCAGTTCTACACCAT
GCTGGGCACCCGCGGCATCTGGCATGAGGGCTGGTTCGCCAACACCGTGCACGCGGCCACCCCGGCCGGCTGGTCGCACT
TCGACGCCGACCGCTGGGAGCTGTTCCACATCGAGGCCGACCGCAGCCAATGCCACGACCTAGCCGCTGAAAACCCGGAC
AAACTCGAAGAACTCAAGGCGTTGTGGTTCGCGGAGGCGGCCAGGTACAACGGGCTGCCGCTGTCGGACCTGAACATCCT
GGAGACCATGACCCGGTCCCGGCCGTACCTGGTCGGCGAACGGGACAGCTATGTCTACTACCCCGACTGCGCCGACGTCG
GCATCGGCGCCGCCGCCGAGATCCGCGGCCGATCGTTCTCGGTGCTGGCCGAGGCAACCGTCGACACCACCGGCGCCGAG
GGGGTGCTGTTCAAGCAGGGCGGGGCGCACGGCGGGCACGTGCTGTTCATCCAGGACGGGCGGCTGCACTACGTCTACAA
CTTCCTCGGCGAACGCCAGCAGGAGGTCTCCTCGTCGGTGCCCGTGCCGCTGGGCAGGCATCTGTTCGGCGCCAGCTATG
CACGGACGGGGACGGTCCCCGACAGCCACACCCCGCTCGGTGACCTGACGCTGTTCATCGACGACGAGGTCGTCGGCACC
CTGGCCGGGGTGAGCACCCACCCGGGGACTTTCGGGCTGGCGGGTGCCGGAATCACCGTGGGCCGCAACGGCGGATCGGG
GGTGTCCAGCCGGTTCAAGGCGCCGTTCGTGTTCACCGGCGGCACCATCGCCCGGGTCACCCTCGACCTGTCCGGCCGGC
CCTATCGCGACGTGGAAACCGAGATCGCCCTTGCCTTTTCGCGGGACTGA

Upstream 100 bases:

>100_bases
GGCGAAGTAACCCCTCCCCGCAAGAGGCACCGAAACGCCCGGCCCCGGGTGTAGTCTGCACGCGACGCGCGGCGAGTCCG
CGACGAGAGTGAGGCTGACG

Downstream 100 bases:

>100_bases
AGCCGCGACGGTCAGTCCGGGTTGGGCGCCTGCGGTGAGCTGATCGCGTCGACGGCGCCGGACACCTTGGCTTGAAAGTC
CGCCGACAGCGGGATGTAGC

Product: AtsA

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 789; Mature: 789

Protein sequence:

>789_residues
MVAGSGQSAEFSGRVELDIRDSEPDWGPYAAPTAPPNAPNILYLVWDDTGIATWDCFGGLVEMPAMSRIAERGVRLSQFH
TTALCSPTRAALLTGRNATTVGMATIEEFTEGFPNANGRIPFDTALLSEALAEHGYNTYCVGKWHLTPLEESNMASTKRH
WPTSRGFERFYGFLGGETDQWYPDLVYDNHPVSPPATPEDGYHLSKDLADKTIEFIRDAKVIAPEKPWFSYVCPGAGHAP
HHVFKEWADRYAGRFDMGYERYREVVLERQKAMGIVPSDTELSPVNPYLDVTGPRGEPWPLQDTVRPWDSLNDEEKKLFA
RMAEVFAGFLSYTDAQIGRILDYLEESGQLDDTIIVVISDNGASGEGGPNGSVNEGKFFNGYIDTVEESMKLFDQLGGPQ
TYNHYPIGWAMAFNTPYKLYKRYASHEGGIADTAIISWPNGIAAHGEIRDNYVNVCDITPTVYDLLGMSPPETVKGIAQK
PLDGVSFKAALDDPNADTGKTTQFYTMLGTRGIWHEGWFANTVHAATPAGWSHFDADRWELFHIEADRSQCHDLAAENPD
KLEELKALWFAEAARYNGLPLSDLNILETMTRSRPYLVGERDSYVYYPDCADVGIGAAAEIRGRSFSVLAEATVDTTGAE
GVLFKQGGAHGGHVLFIQDGRLHYVYNFLGERQQEVSSSVPVPLGRHLFGASYARTGTVPDSHTPLGDLTLFIDDEVVGT
LAGVSTHPGTFGLAGAGITVGRNGGSGVSSRFKAPFVFTGGTIARVTLDLSGRPYRDVETEIALAFSRD

Sequences:

>Translated_789_residues
MVAGSGQSAEFSGRVELDIRDSEPDWGPYAAPTAPPNAPNILYLVWDDTGIATWDCFGGLVEMPAMSRIAERGVRLSQFH
TTALCSPTRAALLTGRNATTVGMATIEEFTEGFPNANGRIPFDTALLSEALAEHGYNTYCVGKWHLTPLEESNMASTKRH
WPTSRGFERFYGFLGGETDQWYPDLVYDNHPVSPPATPEDGYHLSKDLADKTIEFIRDAKVIAPEKPWFSYVCPGAGHAP
HHVFKEWADRYAGRFDMGYERYREVVLERQKAMGIVPSDTELSPVNPYLDVTGPRGEPWPLQDTVRPWDSLNDEEKKLFA
RMAEVFAGFLSYTDAQIGRILDYLEESGQLDDTIIVVISDNGASGEGGPNGSVNEGKFFNGYIDTVEESMKLFDQLGGPQ
TYNHYPIGWAMAFNTPYKLYKRYASHEGGIADTAIISWPNGIAAHGEIRDNYVNVCDITPTVYDLLGMSPPETVKGIAQK
PLDGVSFKAALDDPNADTGKTTQFYTMLGTRGIWHEGWFANTVHAATPAGWSHFDADRWELFHIEADRSQCHDLAAENPD
KLEELKALWFAEAARYNGLPLSDLNILETMTRSRPYLVGERDSYVYYPDCADVGIGAAAEIRGRSFSVLAEATVDTTGAE
GVLFKQGGAHGGHVLFIQDGRLHYVYNFLGERQQEVSSSVPVPLGRHLFGASYARTGTVPDSHTPLGDLTLFIDDEVVGT
LAGVSTHPGTFGLAGAGITVGRNGGSGVSSRFKAPFVFTGGTIARVTLDLSGRPYRDVETEIALAFSRD
>Mature_789_residues
MVAGSGQSAEFSGRVELDIRDSEPDWGPYAAPTAPPNAPNILYLVWDDTGIATWDCFGGLVEMPAMSRIAERGVRLSQFH
TTALCSPTRAALLTGRNATTVGMATIEEFTEGFPNANGRIPFDTALLSEALAEHGYNTYCVGKWHLTPLEESNMASTKRH
WPTSRGFERFYGFLGGETDQWYPDLVYDNHPVSPPATPEDGYHLSKDLADKTIEFIRDAKVIAPEKPWFSYVCPGAGHAP
HHVFKEWADRYAGRFDMGYERYREVVLERQKAMGIVPSDTELSPVNPYLDVTGPRGEPWPLQDTVRPWDSLNDEEKKLFA
RMAEVFAGFLSYTDAQIGRILDYLEESGQLDDTIIVVISDNGASGEGGPNGSVNEGKFFNGYIDTVEESMKLFDQLGGPQ
TYNHYPIGWAMAFNTPYKLYKRYASHEGGIADTAIISWPNGIAAHGEIRDNYVNVCDITPTVYDLLGMSPPETVKGIAQK
PLDGVSFKAALDDPNADTGKTTQFYTMLGTRGIWHEGWFANTVHAATPAGWSHFDADRWELFHIEADRSQCHDLAAENPD
KLEELKALWFAEAARYNGLPLSDLNILETMTRSRPYLVGERDSYVYYPDCADVGIGAAAEIRGRSFSVLAEATVDTTGAE
GVLFKQGGAHGGHVLFIQDGRLHYVYNFLGERQQEVSSSVPVPLGRHLFGASYARTGTVPDSHTPLGDLTLFIDDEVVGT
LAGVSTHPGTFGLAGAGITVGRNGGSGVSSRFKAPFVFTGGTIARVTLDLSGRPYRDVETEIALAFSRD

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI59797060, Length=244, Percent_Identity=28.2786885245902, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI38569407, Length=247, Percent_Identity=29.5546558704453, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI157266309, Length=161, Percent_Identity=38.5093167701863, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI38569405, Length=247, Percent_Identity=29.5546558704453, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI109389362, Length=252, Percent_Identity=26.5873015873016, Blast_Score=90, Evalue=1e-17,
Organism=Homo sapiens, GI71852584, Length=146, Percent_Identity=37.6712328767123, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI58743319, Length=344, Percent_Identity=27.0348837209302, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI71852586, Length=146, Percent_Identity=37.6712328767123, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI31742482, Length=152, Percent_Identity=33.5526315789474, Blast_Score=81, Evalue=5e-15,
Organism=Homo sapiens, GI53831991, Length=137, Percent_Identity=35.036496350365, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI146229331, Length=193, Percent_Identity=32.1243523316062, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI146229329, Length=193, Percent_Identity=32.1243523316062, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI6005990, Length=193, Percent_Identity=32.1243523316062, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI146229324, Length=193, Percent_Identity=32.1243523316062, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI4503899, Length=255, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI87081924, Length=211, Percent_Identity=26.5402843601896, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533416, Length=339, Percent_Identity=25.9587020648968, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559078, Length=135, Percent_Identity=35.5555555555556, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363223, Length=355, Percent_Identity=24.2253521126761, Blast_Score=88, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24666109, Length=434, Percent_Identity=23.2718894009217, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24666175, Length=454, Percent_Identity=22.9074889867841, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281366397, Length=261, Percent_Identity=26.8199233716475, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI281366395, Length=261, Percent_Identity=26.8199233716475, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24666163, Length=261, Percent_Identity=26.8199233716475, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 86561; Mature: 86561

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2 ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAGSGQSAEFSGRVELDIRDSEPDWGPYAAPTAPPNAPNILYLVWDDTGIATWDCFGGL
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEHHHHHHH
VEMPAMSRIAERGVRLSQFHTTALCSPTRAALLTGRNATTVGMATIEEFTEGFPNANGRI
HHHHHHHHHHHCCCEEHHHHHHHHCCCCHHHEEECCCCCEEHHHHHHHHHHCCCCCCCCC
PFDTALLSEALAEHGYNTYCVGKWHLTPLEESNMASTKRHWPTSRGFERFYGFLGGETDQ
CHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHCCCCCC
WYPDLVYDNHPVSPPATPEDGYHLSKDLADKTIEFIRDAKVIAPEKPWFSYVCPGAGHAP
CCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEECCCCCCCH
HHVFKEWADRYAGRFDMGYERYREVVLERQKAMGIVPSDTELSPVNPYLDVTGPRGEPWP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCC
LQDTVRPWDSLNDEEKKLFARMAEVFAGFLSYTDAQIGRILDYLEESGQLDDTIIVVISD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
NGASGEGGPNGSVNEGKFFNGYIDTVEESMKLFDQLGGPQTYNHYPIGWAMAFNTPYKLY
CCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHH
KRYASHEGGIADTAIISWPNGIAAHGEIRDNYVNVCDITPTVYDLLGMSPPETVKGIAQK
HHHHCCCCCCCCEEEEECCCCCEECCCCCCCEEEEEECCHHHHHHHCCCCCHHHHHHHHC
PLDGVSFKAALDDPNADTGKTTQFYTMLGTRGIWHEGWFANTVHAATPAGWSHFDADRWE
CCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
LFHIEADRSQCHDLAAENPDKLEELKALWFAEAARYNGLPLSDLNILETMTRSRPYLVGE
EEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEC
RDSYVYYPDCADVGIGAAAEIRGRSFSVLAEATVDTTGAEGVLFKQGGAHGGHVLFIQDG
CCCEEECCCHHCCCCCCCCEECCCEEEEEEEEEECCCCCCEEEEECCCCCCCEEEEEECC
RLHYVYNFLGERQQEVSSSVPVPLGRHLFGASYARTGTVPDSHTPLGDLTLFIDDEVVGT
CEEEHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEECCHHHHH
LAGVSTHPGTFGLAGAGITVGRNGGSGVSSRFKAPFVFTGGTIARVTLDLSGRPYRDVET
HHCCCCCCCCCEECCCCEEEECCCCCCCHHHCCCCEEEECCEEEEEEEECCCCCCCCCCC
EIALAFSRD
EEEEEEECC
>Mature Secondary Structure
MVAGSGQSAEFSGRVELDIRDSEPDWGPYAAPTAPPNAPNILYLVWDDTGIATWDCFGGL
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEHHHHHHH
VEMPAMSRIAERGVRLSQFHTTALCSPTRAALLTGRNATTVGMATIEEFTEGFPNANGRI
HHHHHHHHHHHCCCEEHHHHHHHHCCCCHHHEEECCCCCEEHHHHHHHHHHCCCCCCCCC
PFDTALLSEALAEHGYNTYCVGKWHLTPLEESNMASTKRHWPTSRGFERFYGFLGGETDQ
CHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHCCCCCC
WYPDLVYDNHPVSPPATPEDGYHLSKDLADKTIEFIRDAKVIAPEKPWFSYVCPGAGHAP
CCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEECCCCCCCH
HHVFKEWADRYAGRFDMGYERYREVVLERQKAMGIVPSDTELSPVNPYLDVTGPRGEPWP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCC
LQDTVRPWDSLNDEEKKLFARMAEVFAGFLSYTDAQIGRILDYLEESGQLDDTIIVVISD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
NGASGEGGPNGSVNEGKFFNGYIDTVEESMKLFDQLGGPQTYNHYPIGWAMAFNTPYKLY
CCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHH
KRYASHEGGIADTAIISWPNGIAAHGEIRDNYVNVCDITPTVYDLLGMSPPETVKGIAQK
HHHHCCCCCCCCEEEEECCCCCEECCCCCCCEEEEEECCHHHHHHHCCCCCHHHHHHHHC
PLDGVSFKAALDDPNADTGKTTQFYTMLGTRGIWHEGWFANTVHAATPAGWSHFDADRWE
CCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
LFHIEADRSQCHDLAAENPDKLEELKALWFAEAARYNGLPLSDLNILETMTRSRPYLVGE
EEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEC
RDSYVYYPDCADVGIGAAAEIRGRSFSVLAEATVDTTGAEGVLFKQGGAHGGHVLFIQDG
CCCEEECCCHHCCCCCCCCEECCCEEEEEEEEEECCCCCCEEEEECCCCCCCEEEEEECC
RLHYVYNFLGERQQEVSSSVPVPLGRHLFGASYARTGTVPDSHTPLGDLTLFIDDEVVGT
CEEEHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEECCHHHHH
LAGVSTHPGTFGLAGAGITVGRNGGSGVSSRFKAPFVFTGGTIARVTLDLSGRPYRDVET
HHCCCCCCCCCEECCCCEEEECCCCCCCHHHCCCCEEEECCEEEEEEEECCCCCCCCCCC
EIALAFSRD
EEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]