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The map label for this gene is betA [C]

Identifier: 41410256

GI number: 41410256

Start: 4635354

End: 4636793

Strand: Direct

Name: betA [C]

Synonym: MAP4158

Alternate gene names: 41410256

Gene position: 4635354-4636793 (Clockwise)

Preceding gene: 41410255

Following gene: 41410257

Centisome position: 95.97

GC content: 73.06

Gene sequence:

>1440_bases
TTGAAGAACGCCGTCTCGCACAGCGATGTGCTGATAGTCGGCGTCGGCAGCGCCGGATCGGTTGTCGCCGAACGTCTTTC
CGCTGATCCAGGGTGCACGGTGACCGTGGTCGAGGCGGGCCCGGCCCTCGACGACCCGGCGCTGCTCGCCCGGACCGCCA
ACGGGCTGCAATTGCCGATCGGCGTCGGCAGCCCGCTGGTGCGCCGATACCAGACCCAGCTCACCGAGCGGCCCGCCCGC
CGACACCCGCTGGTGCGCGGCGCCACCATCGGCGGCTCGGGCGCGATCAACGGCGGCTACTTCTGCCGCGGGCTGCCCCG
CGATTTCGACCGCCTCGGCCTGCCGGGCTGGGCATGGTCGGACGTGCTGGACAGCTTCCGCGCCATCGAGACCGACCTGG
ACTTCGACGGACCCGCGCACGGCCGCAGCGGCCCCATCCTGGTCCGCCGCACCCGCGAAATGACCGGAACCACAGAGCGT
TTCATCGACGCCGCGCGGCGCGCCGGATTCGGCTGGATCGACGACCTCAATGATGCTGCGGCCCAACCGGTTTCGGGGAT
CGGCGCGGTCCCGCTGAACATCGTCGACGGCGTCCGCAAGGGCTCGGGTGCGGGGTATCTGATCCCCGCGCTGAGCCGGC
CCAACCTGCGCGTGCAGGCGCACAGCCGGGTGGCGCGGCTGCGTTTGGCCGGCACCGTCGCCCGGGGCGCCGACGTGGTC
GGCCCGCACGGCCGGGCTACGCTGACCGCCGACCGAATCGTGTTGTGCGCCGGCGCCATTGAAACGGCGCACCTGCTGAT
GCTGTCCGGCATCGGCGAGCCGGGCATGCTGCGCGCCGCCGGGGTGCCGGTGCGCGTGGCGCTGCCGGTGGGGACGTCGT
TCAGCGATCACGCCGAATGGGTGCTGCCCACCGATTGGCCGGTGGCTCCCGGACGGCCGGTGCTCGAGGTGGTGCTCAGC
ACCGCCGACCATCTCGAGATCAGGCCGTACACCGGCGGGTTCGTGGCGATGACCGGCGACGGCACCGCCGGGCACGCCGA
CTGGCCGCACCTCGGGGTGGCGCTGATGCAACCCCGCGCGCGGGGTTGCCTGACGCTGGTGTCGGCCGATCCCGCCGTGC
CGCCCCGCATCGAGCACCGCTACGACAGCGAGCCCGGCGACGTCGCCGCGCTGGCCCGCGGCGCCGAGTTGGCCCGCGAA
TTGGCCGGCGGCACAACCGATGCCGCGGCGGTCATCTGGTCGACCTCCCAACACCTTTGCGGCACGGCGCCGATGGGGGT
CGACGGCGACCCGCGGGCGGTCGTCGACCCGCGGTGCCGGGTCCGCGGCATCGACAACCTGTGGGTGATCGACGGCTCGG
TGCTGCCCGCCATCACCAGCCGCGGCCCGCACGCCACCATCGTGATGATCGGGCACCGGGCCGCGGAATTCGTGCGGTGA

Upstream 100 bases:

>100_bases
GGTGGACGACCTGGCGTACGGGCTCGGGTTGTGGTGGGGTGTGCTACGGGAGCGCAACGCGCGCGCCCTCAAACCCCAGA
TCCGGAGTTAGCCCCCGCCC

Downstream 100 bases:

>100_bases
CGCCCCACCCGGGAGCTATCGCCGGGCCCATCCAGACCGATAGTCTCGTAGCTCGACCGATGTTCTCGTTGGCAATACGG
TTCGCAATACGGGAGGTGGC

Product: hypothetical protein

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MKNAVSHSDVLIVGVGSAGSVVAERLSADPGCTVTVVEAGPALDDPALLARTANGLQLPIGVGSPLVRRYQTQLTERPAR
RHPLVRGATIGGSGAINGGYFCRGLPRDFDRLGLPGWAWSDVLDSFRAIETDLDFDGPAHGRSGPILVRRTREMTGTTER
FIDAARRAGFGWIDDLNDAAAQPVSGIGAVPLNIVDGVRKGSGAGYLIPALSRPNLRVQAHSRVARLRLAGTVARGADVV
GPHGRATLTADRIVLCAGAIETAHLLMLSGIGEPGMLRAAGVPVRVALPVGTSFSDHAEWVLPTDWPVAPGRPVLEVVLS
TADHLEIRPYTGGFVAMTGDGTAGHADWPHLGVALMQPRARGCLTLVSADPAVPPRIEHRYDSEPGDVAALARGAELARE
LAGGTTDAAAVIWSTSQHLCGTAPMGVDGDPRAVVDPRCRVRGIDNLWVIDGSVLPAITSRGPHATIVMIGHRAAEFVR

Sequences:

>Translated_479_residues
MKNAVSHSDVLIVGVGSAGSVVAERLSADPGCTVTVVEAGPALDDPALLARTANGLQLPIGVGSPLVRRYQTQLTERPAR
RHPLVRGATIGGSGAINGGYFCRGLPRDFDRLGLPGWAWSDVLDSFRAIETDLDFDGPAHGRSGPILVRRTREMTGTTER
FIDAARRAGFGWIDDLNDAAAQPVSGIGAVPLNIVDGVRKGSGAGYLIPALSRPNLRVQAHSRVARLRLAGTVARGADVV
GPHGRATLTADRIVLCAGAIETAHLLMLSGIGEPGMLRAAGVPVRVALPVGTSFSDHAEWVLPTDWPVAPGRPVLEVVLS
TADHLEIRPYTGGFVAMTGDGTAGHADWPHLGVALMQPRARGCLTLVSADPAVPPRIEHRYDSEPGDVAALARGAELARE
LAGGTTDAAAVIWSTSQHLCGTAPMGVDGDPRAVVDPRCRVRGIDNLWVIDGSVLPAITSRGPHATIVMIGHRAAEFVR
>Mature_479_residues
MKNAVSHSDVLIVGVGSAGSVVAERLSADPGCTVTVVEAGPALDDPALLARTANGLQLPIGVGSPLVRRYQTQLTERPAR
RHPLVRGATIGGSGAINGGYFCRGLPRDFDRLGLPGWAWSDVLDSFRAIETDLDFDGPAHGRSGPILVRRTREMTGTTER
FIDAARRAGFGWIDDLNDAAAQPVSGIGAVPLNIVDGVRKGSGAGYLIPALSRPNLRVQAHSRVARLRLAGTVARGADVV
GPHGRATLTADRIVLCAGAIETAHLLMLSGIGEPGMLRAAGVPVRVALPVGTSFSDHAEWVLPTDWPVAPGRPVLEVVLS
TADHLEIRPYTGGFVAMTGDGTAGHADWPHLGVALMQPRARGCLTLVSADPAVPPRIEHRYDSEPGDVAALARGAELARE
LAGGTTDAAAVIWSTSQHLCGTAPMGVDGDPRAVVDPRCRVRGIDNLWVIDGSVLPAITSRGPHATIVMIGHRAAEFVR

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=539, Percent_Identity=29.1280148423006, Blast_Score=165, Evalue=7e-41,
Organism=Escherichia coli, GI1786503, Length=549, Percent_Identity=29.3260473588342, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17532301, Length=551, Percent_Identity=25.7713248638838, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24642048, Length=574, Percent_Identity=28.9198606271777, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI17137792, Length=553, Percent_Identity=28.3905967450271, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24642037, Length=568, Percent_Identity=27.4647887323944, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI45551458, Length=570, Percent_Identity=24.9122807017544, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45549471, Length=568, Percent_Identity=25, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI18859993, Length=572, Percent_Identity=24.8251748251748, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24642055, Length=305, Percent_Identity=32.4590163934426, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24642035, Length=310, Percent_Identity=30.3225806451613, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24642039, Length=310, Percent_Identity=31.2903225806452, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24642042, Length=309, Percent_Identity=30.7443365695793, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24642051, Length=306, Percent_Identity=32.6797385620915, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI18859995, Length=314, Percent_Identity=32.1656050955414, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24650267, Length=309, Percent_Identity=28.8025889967638, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24642059, Length=310, Percent_Identity=28.3870967741935, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24645930, Length=232, Percent_Identity=28.0172413793103, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 50130; Mature: 50130

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNAVSHSDVLIVGVGSAGSVVAERLSADPGCTVTVVEAGPALDDPALLARTANGLQLPI
CCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHCCCCCCEEEE
GVGSPLVRRYQTQLTERPARRHPLVRGATIGGSGAINGGYFCRGLPRDFDRLGLPGWAWS
CCCCHHHHHHHHHHHHCHHHHCCCEEEEEECCCCCCCCCEEECCCCCCHHHCCCCCCCHH
DVLDSFRAIETDLDFDGPAHGRSGPILVRRTREMTGTTERFIDAARRAGFGWIDDLNDAA
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHHCCCCCHHCCCHHH
AQPVSGIGAVPLNIVDGVRKGSGAGYLIPALSRPNLRVQAHSRVARLRLAGTVARGADVV
CCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCC
GPHGRATLTADRIVLCAGAIETAHLLMLSGIGEPGMLRAAGVPVRVALPVGTSFSDHAEW
CCCCCEEEECCEEEEEECCHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCCCE
VLPTDWPVAPGRPVLEVVLSTADHLEIRPYTGGFVAMTGDGTAGHADWPHLGVALMQPRA
EECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCEEECCCC
RGCLTLVSADPAVPPRIEHRYDSEPGDVAALARGAELARELAGGTTDAAAVIWSTSQHLC
CCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
GTAPMGVDGDPRAVVDPRCRVRGIDNLWVIDGSVLPAITSRGPHATIVMIGHRAAEFVR
CCCCCCCCCCCCEEECCCCEEECCCEEEEECCCCHHHHCCCCCCEEEEEEECCHHHHCC
>Mature Secondary Structure
MKNAVSHSDVLIVGVGSAGSVVAERLSADPGCTVTVVEAGPALDDPALLARTANGLQLPI
CCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHCCCCCCEEEE
GVGSPLVRRYQTQLTERPARRHPLVRGATIGGSGAINGGYFCRGLPRDFDRLGLPGWAWS
CCCCHHHHHHHHHHHHCHHHHCCCEEEEEECCCCCCCCCEEECCCCCCHHHCCCCCCCHH
DVLDSFRAIETDLDFDGPAHGRSGPILVRRTREMTGTTERFIDAARRAGFGWIDDLNDAA
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHHCCCCCHHCCCHHH
AQPVSGIGAVPLNIVDGVRKGSGAGYLIPALSRPNLRVQAHSRVARLRLAGTVARGADVV
CCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCC
GPHGRATLTADRIVLCAGAIETAHLLMLSGIGEPGMLRAAGVPVRVALPVGTSFSDHAEW
CCCCCEEEECCEEEEEECCHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCCCE
VLPTDWPVAPGRPVLEVVLSTADHLEIRPYTGGFVAMTGDGTAGHADWPHLGVALMQPRA
EECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCEEECCCC
RGCLTLVSADPAVPPRIEHRYDSEPGDVAALARGAELARELAGGTTDAAAVIWSTSQHLC
CCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
GTAPMGVDGDPRAVVDPRCRVRGIDNLWVIDGSVLPAITSRGPHATIVMIGHRAAEFVR
CCCCCCCCCCCCEEECCCCEEECCCEEEEECCCCHHHHCCCCCCEEEEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7836301 [H]