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The map label for this gene is hemL

Identifier: 41410118

GI number: 41410118

Start: 4481344

End: 4482681

Strand: Direct

Name: hemL

Synonym: MAP4020

Alternate gene names: 41410118

Gene position: 4481344-4482681 (Clockwise)

Preceding gene: 41410117

Following gene: 41410119

Centisome position: 92.79

GC content: 73.62

Gene sequence:

>1338_bases
ATGGGAAGCAGTGATCAGGCGACCGCGCACGCCAGGGCCCAGGCTGCCTCGGCGCGGTTGTTCGACGACGCCTGCGCCGT
CATCCCCGGCGGGGTGAACTCGCCCGTGCGGGCGTTCACCGCGGTGGGCGGGACGCCGCCGTTCATCACCGCCGCGCGCG
GCTGCCGGCTGACCGACGCCGACGGCAACCACTACGTGGACCTGGTGTGCTCGTGGGGGCCGATGATCCTGGGGCACGCG
CACCCGGCCGTCGTCGAGGCCGTCGCCAAGGCCGCCGCGTCCGGGCTGTCCTTCGGGGCGCCCACCCCGGCGGAAAGCGA
GCTGGCCGCCGAGATGATCGCCCGGGTGGCGCCGGTCGAGCGGATCCGGCTGGTCAACTCCGGCACCGAGGCCACCATGA
GCGCGGTGCGGTTGGCCCGCGGCTTCACCGGGCGCGCCAAGATCGTCAAGTTCTCCGGCTGCTACCACGGCCACGTGGAC
GCGCTGCTCGCCGACGCCGGCTCCGGGGTGGCCACCCTGGGGCTGCCGTCCTCGCCGGGCGTCACCGGCGCGACGGCCGC
CGACACGATCGTGTTGCCCTACAACGACATCGACGCCGTGCGGCAGGCGTTCACGGAGTTCGGCGACCAGATCGCGGCGG
TGATCACCGAGGCCAGCCCCGGCAACATGGGGGTGGTGCCGCCGGCGCCCGGCTTCAACGCGGCGCTGCGCGCGCTCACC
GCCGACCACGGCGCGCTGCTGATCGTCGACGAGGTGATGACGGGCTTCCGGGTCAGCCGAAGTGGTTGGTACGGAATCGA
TCCGGTGGACGCCGACCTGTTCACCTTCGGCAAGGTGATGAGCGGCGGCCTGCCGGCAGCCGCGTTCGGCGGCCGGGCCG
AGGTGATGGAACGGCTGGCGCCGCTGGGCCCGGTGTATCAGGCCGGCACCCTGTCGGGAAACCCGGTCGCGATGGCCGCC
GGGCTGGCCACGCTGCGCCACGCCGACGCCGCCGCCTACGCCGCGCTGGACGCCAACGCCGATCGGCTGGCCCGGCTGCT
GTCCGACGCGTTGACCAATGCCGGTGTGCCGCACCAGATTCCGCGGGCCGGCAACATGCTCAGCGTGTTCTTCACCGACA
CCCCGGTGACCGACTTCGCCTCCGCGCGGGCCACCCAGACCTGGCGCTATCCGCCGTTCTTCCACGCGCTGCTGGACGCC
GGCGTCTACCCGCCGTGCAGCGCCTTCGAGACGTGGTTCGTCTCCACCGCGCTGGACGACGACGCCTTCGACCGGATCGC
GGCGGCCCTGCCCGCCGCGGCCCGCGCCGCCGCGGGCGCCGACGAGGGGAATTCCTGA

Upstream 100 bases:

>100_bases
TTCATGGCGGCCCAGCAAGCCAACTCCTACGACGCCGACTAGCACCCTTCTGCTACACCCTGTAGTTGGAGGGGTGGCGA
AGGCTGGGACACTGGTCGTC

Downstream 100 bases:

>100_bases
TGGGCGAGCAGACCCGGGTGCACGTGGTGCGGCACGGCGAGGTGCACAACCCCGACGGCGTGCTGTACGGGCGGCTGCCC
GGGTTTCACCTGTCCGAGGC

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MGSSDQATAHARAQAASARLFDDACAVIPGGVNSPVRAFTAVGGTPPFITAARGCRLTDADGNHYVDLVCSWGPMILGHA
HPAVVEAVAKAAASGLSFGAPTPAESELAAEMIARVAPVERIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHVD
ALLADAGSGVATLGLPSSPGVTGATAADTIVLPYNDIDAVRQAFTEFGDQIAAVITEASPGNMGVVPPAPGFNAALRALT
ADHGALLIVDEVMTGFRVSRSGWYGIDPVDADLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVYQAGTLSGNPVAMAA
GLATLRHADAAAYAALDANADRLARLLSDALTNAGVPHQIPRAGNMLSVFFTDTPVTDFASARATQTWRYPPFFHALLDA
GVYPPCSAFETWFVSTALDDDAFDRIAAALPAAARAAAGADEGNS

Sequences:

>Translated_445_residues
MGSSDQATAHARAQAASARLFDDACAVIPGGVNSPVRAFTAVGGTPPFITAARGCRLTDADGNHYVDLVCSWGPMILGHA
HPAVVEAVAKAAASGLSFGAPTPAESELAAEMIARVAPVERIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHVD
ALLADAGSGVATLGLPSSPGVTGATAADTIVLPYNDIDAVRQAFTEFGDQIAAVITEASPGNMGVVPPAPGFNAALRALT
ADHGALLIVDEVMTGFRVSRSGWYGIDPVDADLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVYQAGTLSGNPVAMAA
GLATLRHADAAAYAALDANADRLARLLSDALTNAGVPHQIPRAGNMLSVFFTDTPVTDFASARATQTWRYPPFFHALLDA
GVYPPCSAFETWFVSTALDDDAFDRIAAALPAAARAAAGADEGNS
>Mature_444_residues
GSSDQATAHARAQAASARLFDDACAVIPGGVNSPVRAFTAVGGTPPFITAARGCRLTDADGNHYVDLVCSWGPMILGHAH
PAVVEAVAKAAASGLSFGAPTPAESELAAEMIARVAPVERIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHVDA
LLADAGSGVATLGLPSSPGVTGATAADTIVLPYNDIDAVRQAFTEFGDQIAAVITEASPGNMGVVPPAPGFNAALRALTA
DHGALLIVDEVMTGFRVSRSGWYGIDPVDADLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVYQAGTLSGNPVAMAAG
LATLRHADAAAYAALDANADRLARLLSDALTNAGVPHQIPRAGNMLSVFFTDTPVTDFASARATQTWRYPPFFHALLDAG
VYPPCSAFETWFVSTALDDDAFDRIAAALPAAARAAAGADEGNS

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=325, Percent_Identity=29.2307692307692, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI37574042, Length=337, Percent_Identity=28.486646884273, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI226442709, Length=306, Percent_Identity=28.7581699346405, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI24119277, Length=366, Percent_Identity=27.5956284153005, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI226442705, Length=254, Percent_Identity=29.9212598425197, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI13994255, Length=306, Percent_Identity=28.7581699346405, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI284507298, Length=242, Percent_Identity=30.5785123966942, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1786349, Length=430, Percent_Identity=52.3255813953488, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1789016, Length=339, Percent_Identity=32.4483775811209, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI145693181, Length=355, Percent_Identity=29.8591549295775, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1789759, Length=280, Percent_Identity=31.4285714285714, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787560, Length=377, Percent_Identity=31.0344827586207, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788044, Length=287, Percent_Identity=33.1010452961672, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=314, Percent_Identity=27.7070063694268, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=295, Percent_Identity=28.135593220339, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=360, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=300, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357415, Length=322, Percent_Identity=24.223602484472, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356575, Length=302, Percent_Identity=28.8079470198675, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 45520; Mature: 45388

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSDQATAHARAQAASARLFDDACAVIPGGVNSPVRAFTAVGGTPPFITAARGCRLTDA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHCCCCEEECC
DGNHYVDLVCSWGPMILGHAHPAVVEAVAKAAASGLSFGAPTPAESELAAEMIARVAPVE
CCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHH
RIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHVDALLADAGSGVATLGLPSSPG
HHEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCCCEEEECCCCCCC
VTGATAADTIVLPYNDIDAVRQAFTEFGDQIAAVITEASPGNMGVVPPAPGFNAALRALT
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
ADHGALLIVDEVMTGFRVSRSGWYGIDPVDADLFTFGKVMSGGLPAAAFGGRAEVMERLA
CCCCCEEEHHHHHHCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCHHHHHHHHC
PLGPVYQAGTLSGNPVAMAAGLATLRHADAAAYAALDANADRLARLLSDALTNAGVPHQI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCCCCC
PRAGNMLSVFFTDTPVTDFASARATQTWRYPPFFHALLDAGVYPPCSAFETWFVSTALDD
CCCCCEEEEEEECCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCH
DAFDRIAAALPAAARAAAGADEGNS
HHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GSSDQATAHARAQAASARLFDDACAVIPGGVNSPVRAFTAVGGTPPFITAARGCRLTDA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHCCCCEEECC
DGNHYVDLVCSWGPMILGHAHPAVVEAVAKAAASGLSFGAPTPAESELAAEMIARVAPVE
CCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHH
RIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHVDALLADAGSGVATLGLPSSPG
HHEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCCCEEEECCCCCCC
VTGATAADTIVLPYNDIDAVRQAFTEFGDQIAAVITEASPGNMGVVPPAPGFNAALRALT
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
ADHGALLIVDEVMTGFRVSRSGWYGIDPVDADLFTFGKVMSGGLPAAAFGGRAEVMERLA
CCCCCEEEHHHHHHCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCHHHHHHHHC
PLGPVYQAGTLSGNPVAMAAGLATLRHADAAAYAALDANADRLARLLSDALTNAGVPHQI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCCCCC
PRAGNMLSVFFTDTPVTDFASARATQTWRYPPFFHALLDAGVYPPCSAFETWFVSTALDD
CCCCCEEEEEEECCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCH
DAFDRIAAALPAAARAAAGADEGNS
HHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA