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The map label for this gene is proC

Identifier: 41410089

GI number: 41410089

Start: 4448783

End: 4449679

Strand: Direct

Name: proC

Synonym: MAP3991

Alternate gene names: 41410089

Gene position: 4448783-4449679 (Clockwise)

Preceding gene: 41410088

Following gene: 41410090

Centisome position: 92.11

GC content: 72.46

Gene sequence:

>897_bases
GTGTCTGCGATGCTGTCCGGCATGGCAAGAATCGCAATCATCGGTGGCGGCAGCATCGGGGAGGCCCTGCTGTCGGGTCT
GCTGCGGGCGGGCCGGCAGGTCAAGGACCTGGTGGTGGTCGAGCGGGTTCCCGAGCGCGCCAAATATCTGGCCGACACCT
ACTCGGTGCTGATCACCTCGGTGGCCGACGCGGTGGAAAACGCGTCGTTCGTCGTGGTCGCGGTGAAACCGGCCGACGTC
GAGTCGGTGATGTCCGAGATCGCCCGCGCCGCCGGCCAGGCCGAGAGCGACACCGCCGAGCAGGTGTTCGTCACGGTCGC
CGCCGGGGTCACCATCGGCTACTTCGAATCCCGGCTGCCGGCCGGGACACCGGTGGTGCGGGCCATGCCGAACGCGGCCG
TGCTGGTCGGCGCCGGGGTCACCGCCCTGGCCAAGGGCCGCTTCGTCACCGCCCCGCAGCTCGAGGGCGTCTCGGCGCTG
TTCGACTCGGTCGGGGGCGTGCTGAGCGTGCCGGAGAGCCAGATGGACGCCGTCACCGCCCTCTCCGGCTCCGGGCCGGC
GTATTTCTTCCTGCTGGTGGAGGCCCTGGTGGACGCCGGGGTGGCCGCGGGCCTGAGCCGCGAGGTGGCCGCCGACCTGA
CCGCCCAGACCATGGCCGGCTCGGCGGCGATGCTGCTGGAGCGGATGGACGCCGATCGGCGACTGGGCGAGGCGGAGACG
CCCGGGCTGCGGGTGGACGCCACCGCCACCCAGCTGCGGGCCACGGTGACCTCCCCGGGCGGCACCACCGCGGCCGGCCT
GCGCGAGCTGGAGCGGGGGGGCCTGCGGGCCGCCGTCGACGCCGCCGTCCAGGCCGCCAAAATGCGCTCTGAGCAGCTAA
GAATTACATCGGAGTAA

Upstream 100 bases:

>100_bases
CGACTGGTTCGACGAGGACCACACCGTCGTCGACAGCCTGGGCCGCCTGGTGGTGCAGGCCCGCCAGCTGGCCCTGGTCC
CTGCCGCTCCTTAGCCGGCG

Downstream 100 bases:

>100_bases
TCCAAGAATTTTGAACTGATTGTCCCCCACCAGTACCAGTAACCCCATTAGTCCCGCTATTCTCCTTGTGTAAGCGCGTG
TCGGTGCCAGCGGAGGGGAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSAMLSGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVVERVPERAKYLADTYSVLITSVADAVENASFVVVAVKPADV
ESVMSEIARAAGQAESDTAEQVFVTVAAGVTIGYFESRLPAGTPVVRAMPNAAVLVGAGVTALAKGRFVTAPQLEGVSAL
FDSVGGVLSVPESQMDAVTALSGSGPAYFFLLVEALVDAGVAAGLSREVAADLTAQTMAGSAAMLLERMDADRRLGEAET
PGLRVDATATQLRATVTSPGGTTAAGLRELERGGLRAAVDAAVQAAKMRSEQLRITSE

Sequences:

>Translated_298_residues
MSAMLSGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVVERVPERAKYLADTYSVLITSVADAVENASFVVVAVKPADV
ESVMSEIARAAGQAESDTAEQVFVTVAAGVTIGYFESRLPAGTPVVRAMPNAAVLVGAGVTALAKGRFVTAPQLEGVSAL
FDSVGGVLSVPESQMDAVTALSGSGPAYFFLLVEALVDAGVAAGLSREVAADLTAQTMAGSAAMLLERMDADRRLGEAET
PGLRVDATATQLRATVTSPGGTTAAGLRELERGGLRAAVDAAVQAAKMRSEQLRITSE
>Mature_297_residues
SAMLSGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVVERVPERAKYLADTYSVLITSVADAVENASFVVVAVKPADVE
SVMSEIARAAGQAESDTAEQVFVTVAAGVTIGYFESRLPAGTPVVRAMPNAAVLVGAGVTALAKGRFVTAPQLEGVSALF
DSVGGVLSVPESQMDAVTALSGSGPAYFFLLVEALVDAGVAAGLSREVAADLTAQTMAGSAAMLLERMDADRRLGEAETP
GLRVDATATQLRATVTSPGGTTAAGLRELERGGLRAAVDAAVQAAKMRSEQLRITSE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=285, Percent_Identity=33.3333333333333, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI21361454, Length=241, Percent_Identity=36.0995850622407, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI24797095, Length=236, Percent_Identity=36.4406779661017, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI24797097, Length=235, Percent_Identity=37.0212765957447, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1786585, Length=286, Percent_Identity=33.2167832167832, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=285, Percent_Identity=37.1929824561403, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17540664, Length=295, Percent_Identity=29.8305084745763, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320861, Length=309, Percent_Identity=27.831715210356, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21358587, Length=292, Percent_Identity=35.958904109589, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24648116, Length=290, Percent_Identity=31.3793103448276, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24647700, Length=185, Percent_Identity=40, Blast_Score=121, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 30393; Mature: 30262

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAMLSGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVVERVPERAKYLADTYSVLITS
CCHHHHCCEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
VADAVENASFVVVAVKPADVESVMSEIARAAGQAESDTAEQVFVTVAAGVTIGYFESRLP
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEHHHHCCC
AGTPVVRAMPNAAVLVGAGVTALAKGRFVTAPQLEGVSALFDSVGGVLSVPESQMDAVTA
CCCCHHHCCCCCEEEEECCHHHHHCCCEECCCCCCHHHHHHHHCCCEEECCHHHHHHHHH
LSGSGPAYFFLLVEALVDAGVAAGLSREVAADLTAQTMAGSAAMLLERMDADRRLGEAET
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
PGLRVDATATQLRATVTSPGGTTAAGLRELERGGLRAAVDAAVQAAKMRSEQLRITSE
CCEEEECHHHHHEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCEEECCC
>Mature Secondary Structure 
SAMLSGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVVERVPERAKYLADTYSVLITS
CHHHHCCEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
VADAVENASFVVVAVKPADVESVMSEIARAAGQAESDTAEQVFVTVAAGVTIGYFESRLP
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEHHHHCCC
AGTPVVRAMPNAAVLVGAGVTALAKGRFVTAPQLEGVSALFDSVGGVLSVPESQMDAVTA
CCCCHHHCCCCCEEEEECCHHHHHCCCEECCCCCCHHHHHHHHCCCEEECCHHHHHHHHH
LSGSGPAYFFLLVEALVDAGVAAGLSREVAADLTAQTMAGSAAMLLERMDADRRLGEAET
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
PGLRVDATATQLRATVTSPGGTTAAGLRELERGGLRAAVDAAVQAAKMRSEQLRITSE
CCEEEECHHHHHEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]