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The map label for this gene is lpd [H]

Identifier: 41410054

GI number: 41410054

Start: 4416335

End: 4417630

Strand: Direct

Name: lpd [H]

Synonym: MAP3956

Alternate gene names: 41410054

Gene position: 4416335-4417630 (Clockwise)

Preceding gene: 41410053

Following gene: 41410055

Centisome position: 91.44

GC content: 66.13

Gene sequence:

>1296_bases
GTGACTTCTCACTATGACGTCGTCGTCCTCGGGGCCGGTCCCGGCGGATATGTGGCAGCCATCCGCGCCGCCCAGCTGGG
GCTGAGCACCGCCATCGTCGAACCGAAATACTGGGGCGGAGTCTGCCTCAACGTCGGCTGCATTCCGTCCAAGGCGCTGC
TGCGCAACGCCGAACTCGCCCACATCTTCACCAAAGAGGCCAAGACGTTCGGCATCAACGGCGAGGCGACCTTCGACTAC
GGCGCCGCCTTCGACCGCAGCCGCAAGGTGGCCGAGGGCCGCGTCGCCGGCGTGCACTTCCTGATGAAGAAGAACAAGAT
CACCGAGATCCACGGCTACGGCCGGTTCACCGATCCGCACACGCTGGCGGTCGAGCTCAACGACGGCGGGACCGAGACGG
TCACGTTCGACAACGCGATCATCGCCACCGGCAGCAGCACCCGGCTGGTTCCGGGCACGTCGCTGTCGGCCAACGTGGTC
ACCTACGAGGAACAGATTCTGTCCCGGGAGTTGCCCGAGTCGATCATCATCGCCGGCGCCGGCGCCATCGGCATGGAGTT
CGGCTACGTGCTGCACAACTACGGCGTCGAGGTGACCATCGTCGAGTTCCTGCCGCGCGCGCTGCCCAACGAGGACGCCG
ACGTGTCCAAGGAGATCGAGAAGCAGTTCAAGAAGCTGGGCGTCAAGATCCTCACCGGCACCAAGGTCGAATCCATCTCC
GATGACGGCTCGCAAGTGACGGTGGTGGTCAGCAAGGACGGCAACAGCCAGGAACTCAAGGCCGCAAAGGTGTTGCAGGC
CATCGGTTTTGCGCCCAACGTCGAGGGCTACGGCCTGGAGGCGGCCGGGGTCGCGCTGACCGACCGCAAGGCCATCGGCA
TCACCGACTACATGCGCACCAACATCGAGCACATCTACGCCATCGGCGACGTCACCGGCAAGCTGCAGCTGGCCCACGTC
GCAGAGGCCCAAGGCGTGGTGGCCGCCGAAACCATCGCCGGCGCAGAGACTTTGGCGCTCGGCGACTACCGGATGATGCC
GCGCGCCACCTTCTGCCAGCCCAACGTCGCCAGCTTCGGGCTCACCGAACAGCAGGCCCGCGACGAGGGGCACGACGTGG
TGGTGGCCAAGTTCCCGTTCACCGCGAACGGCAAGGCGCACGGCGTGGGCGACCCCAGCGGGTTCGTCAAGCTGATCGCC
GACGCGAATACGGTGAGCTGCTGGGCGGGCACCTGGTCGGCCACGACGTCTCCGAGCTGCTGCCGGAGCTCACCCTGGCG
CAGAAGTGGGACCTGA

Upstream 100 bases:

>100_bases
GTTCCGTACTGACGTGATTCGAGGCCACCGCTCGGCGCGTTGGGAGCGGCGCGACTCACGGCGTTGTCCGCTGCCAGCCG
GCGCCCACTAGGGTGGGCAC

Downstream 100 bases:

>100_bases
CGGCCACCGAGCTGGCCCGCAACGTGCACACCCACCCGACCATGTCCGAGGCGCTGCAGGAATGCTTCCACGGCCTGACC
GGGCACATGATCAACTTCTG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of alpha keto acid dehydrogenase complexes [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTSHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELAHIFTKEAKTFGINGEATFDY
GAAFDRSRKVAEGRVAGVHFLMKKNKITEIHGYGRFTDPHTLAVELNDGGTETVTFDNAIIATGSSTRLVPGTSLSANVV
TYEEQILSRELPESIIIAGAGAIGMEFGYVLHNYGVEVTIVEFLPRALPNEDADVSKEIEKQFKKLGVKILTGTKVESIS
DDGSQVTVVVSKDGNSQELKAAKVLQAIGFAPNVEGYGLEAAGVALTDRKAIGITDYMRTNIEHIYAIGDVTGKLQLAHV
AEAQGVVAAETIAGAETLALGDYRMMPRATFCQPNVASFGLTEQQARDEGHDVVVAKFPFTANGKAHGVGDPSGFVKLIA
DANTVSCWAGTWSATTSPSCCRSSPWRRSGT

Sequences:

>Translated_431_residues
MTSHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELAHIFTKEAKTFGINGEATFDY
GAAFDRSRKVAEGRVAGVHFLMKKNKITEIHGYGRFTDPHTLAVELNDGGTETVTFDNAIIATGSSTRLVPGTSLSANVV
TYEEQILSRELPESIIIAGAGAIGMEFGYVLHNYGVEVTIVEFLPRALPNEDADVSKEIEKQFKKLGVKILTGTKVESIS
DDGSQVTVVVSKDGNSQELKAAKVLQAIGFAPNVEGYGLEAAGVALTDRKAIGITDYMRTNIEHIYAIGDVTGKLQLAHV
AEAQGVVAAETIAGAETLALGDYRMMPRATFCQPNVASFGLTEQQARDEGHDVVVAKFPFTANGKAHGVGDPSGFVKLIA
DANTVSCWAGTWSATTSPSCCRSSPWRRSGT
>Mature_430_residues
TSHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELAHIFTKEAKTFGINGEATFDYG
AAFDRSRKVAEGRVAGVHFLMKKNKITEIHGYGRFTDPHTLAVELNDGGTETVTFDNAIIATGSSTRLVPGTSLSANVVT
YEEQILSRELPESIIIAGAGAIGMEFGYVLHNYGVEVTIVEFLPRALPNEDADVSKEIEKQFKKLGVKILTGTKVESISD
DGSQVTVVVSKDGNSQELKAAKVLQAIGFAPNVEGYGLEAAGVALTDRKAIGITDYMRTNIEHIYAIGDVTGKLQLAHVA
EAQGVVAAETIAGAETLALGDYRMMPRATFCQPNVASFGLTEQQARDEGHDVVVAKFPFTANGKAHGVGDPSGFVKLIAD
ANTVSCWAGTWSATTSPSCCRSSPWRRSGT

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=407, Percent_Identity=36.1179361179361, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI50301238, Length=380, Percent_Identity=28.9473684210526, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI33519430, Length=344, Percent_Identity=27.0348837209302, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI33519428, Length=344, Percent_Identity=27.0348837209302, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI33519426, Length=344, Percent_Identity=27.0348837209302, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI148277071, Length=344, Percent_Identity=27.0348837209302, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI148277065, Length=344, Percent_Identity=27.0348837209302, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI22035672, Length=383, Percent_Identity=28.4595300261097, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI291045266, Length=340, Percent_Identity=24.1176470588235, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI291045268, Length=309, Percent_Identity=23.6245954692557, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786307, Length=407, Percent_Identity=37.8378378378378, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI87081717, Length=405, Percent_Identity=29.8765432098765, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789915, Length=387, Percent_Identity=30.2325581395349, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI87082354, Length=407, Percent_Identity=28.2555282555283, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=408, Percent_Identity=37.9901960784314, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17557007, Length=396, Percent_Identity=26.7676767676768, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=390, Percent_Identity=26.9230769230769, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71983419, Length=350, Percent_Identity=26.2857142857143, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71983429, Length=350, Percent_Identity=26.2857142857143, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17559934, Length=257, Percent_Identity=29.9610894941634, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=419, Percent_Identity=38.4248210023866, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6325166, Length=399, Percent_Identity=28.0701754385965, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=375, Percent_Identity=28.2666666666667, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21358499, Length=410, Percent_Identity=39.2682926829268, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24640551, Length=382, Percent_Identity=29.0575916230367, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24640553, Length=382, Percent_Identity=29.0575916230367, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24640549, Length=382, Percent_Identity=29.0575916230367, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17737741, Length=387, Percent_Identity=26.3565891472868, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 45660; Mature: 45529

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELA
CCCCEEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCCHHHHCCCCEE
HIFTKEAKTFGINGEATFDYGAAFDRSRKVAEGRVAGVHFLMKKNKITEIHGYGRFTDPH
EEEECCCCEECCCCCEEECCCCCCCCCCHHHCCCEEEEEEEEECCCEEEEECCCCCCCCE
TLAVELNDGGTETVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPESIIIAGA
EEEEEECCCCCEEEEECCEEEEECCCCEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEEC
GAIGMEFGYVLHNYGVEVTIVEFLPRALPNEDADVSKEIEKQFKKLGVKILTGTKVESIS
CHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCEEECCC
DDGSQVTVVVSKDGNSQELKAAKVLQAIGFAPNVEGYGLEAAGVALTDRKAIGITDYMRT
CCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCEEEECCCCCCCHHHHHC
NIEHIYAIGDVTGKLQLAHVAEAQGVVAAETIAGAETLALGDYRMMPRATFCQPNVASFG
CCEEEEEEECCCCEEEEEEECCCCCEEEEHHHCCCCEEEECCEEECCCCCCCCCCCHHCC
LTEQQARDEGHDVVVAKFPFTANGKAHGVGDPSGFVKLIADANTVSCWAGTWSATTSPSC
CCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCHH
CRSSPWRRSGT
HCCCCCCCCCC
>Mature Secondary Structure 
TSHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELA
CCCEEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCCHHHHCCCCEE
HIFTKEAKTFGINGEATFDYGAAFDRSRKVAEGRVAGVHFLMKKNKITEIHGYGRFTDPH
EEEECCCCEECCCCCEEECCCCCCCCCCHHHCCCEEEEEEEEECCCEEEEECCCCCCCCE
TLAVELNDGGTETVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPESIIIAGA
EEEEEECCCCCEEEEECCEEEEECCCCEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEEC
GAIGMEFGYVLHNYGVEVTIVEFLPRALPNEDADVSKEIEKQFKKLGVKILTGTKVESIS
CHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCEEECCC
DDGSQVTVVVSKDGNSQELKAAKVLQAIGFAPNVEGYGLEAAGVALTDRKAIGITDYMRT
CCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCEEEECCCCCCCHHHHHC
NIEHIYAIGDVTGKLQLAHVAEAQGVVAAETIAGAETLALGDYRMMPRATFCQPNVASFG
CCEEEEEEECCCCEEEEEEECCCCCEEEEHHHCCCCEEEECCEEECCCCCCCCCCCHHCC
LTEQQARDEGHDVVVAKFPFTANGKAHGVGDPSGFVKLIADANTVSCWAGTWSATTSPSC
CCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCHH
CRSSPWRRSGT
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]