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The map label for this gene is fgd1 [H]

Identifier: 41409982

GI number: 41409982

Start: 4344842

End: 4345852

Strand: Direct

Name: fgd1 [H]

Synonym: MAP3884

Alternate gene names: 41409982

Gene position: 4344842-4345852 (Clockwise)

Preceding gene: 41409980

Following gene: 41409983

Centisome position: 89.96

GC content: 67.56

Gene sequence:

>1011_bases
GTGGCTGAACTCAAACTCGGATACAAAGCGTCCGCCGAACAATTTGCACCACGCGAGCTGGTCGAACTCGCCGTCGCCGC
CGAAGCCCACGGCATGGACAGCGCCACTGTCAGCGACCACTTCCAGCCGTGGCGACACGAGGGCGGCCACGCCCCGTTCT
CGCTGGCCTGGATGACCGCCGTCGGGGAACGCACCACGCGGATCACACTGGGCACCTCGGTGCTCACGCCGACCTTCCGC
TACAACCCGGCCGTCGTCGCACAGGCCTTCGCCACCATGGCCTGCCTGTACCCGGGCCGCATCTTCCTCGGGGTGGGCAC
CGGCGAGGCGCTGAACGAGATCGCCACCGGATACCAGGGCGAGTGGCCGGAGTTCAAGGAGCGCTTCGCCCGGCTGCGCG
AATCGGTGCGGTTGATGCGCGAGCTGTGGCGCGGCGACCGCGTCGACTTCGACGGCGAGTACTACCGGCTCAAGGGCGCC
TCGATCTACGACGTGCCCGACGGCGGCGTCCCGATCTATATCGCCGCCGGCGGCCCCGCGGTGGCCAAATACGCCGGCCG
GGCCGGCGACGGCTTCATCTGCACCTCCGGCAAGGGCGAGGAGCTGTACAAGGACAAGCTGATCCCCGCGGTCAAGGAGG
GCGCGGCGATCAACGACCGCAATGTCGACGACATCGACAAGATGATCGAGATCAAGATCTCCTACGACCCCGACCCGGAA
CTGGCGCTGGAGAACACCCGGTTCTGGGCGCCGCTGTCGCTGACCGCCGAGCAGAAGCACAGCATCGACGACCCGATCGA
AATGGAGAAGGCGGCCGACGCGCTGCCCATCGAGCAGGTGGCCAAGCGCTGGATCGTGGCCTCGGACCCCGACGAGGCGG
TGGCCAAGGTCAAGGACTACGTCGACTGGGGCCTCAACCACCTGGTGTTCCACGCGCCCGGCCACGACCAGCGCCGGTTC
CTGGAGCTCTTCGAAAAGGACCTGGCGCCCAGGCTTCGGCGACTTGGCTGA

Upstream 100 bases:

>100_bases
GTCCAGTTGACCGCGTCCCCCCGGGCGAGGTGCACCGCGTCGGTGACCTGAACTAGCTCCGCCATGCCCGCGAGTGTAAG
CGGAGGAGTAGAAATGACCC

Downstream 100 bases:

>100_bases
CATTTCGGCGATCTACGTTGCCGCTCCCGAACCGGAGACCGGCAAGTCCACCGTCGCGCTGGGCCTGCTGCACCGGCTGA
CCGCGACGGTCGCCAAAGTC

Product: hypothetical protein

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTTRITLGTSVLTPTFR
YNPAVVAQAFATMACLYPGRIFLGVGTGEALNEIATGYQGEWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLKGA
SIYDVPDGGVPIYIAAGGPAVAKYAGRAGDGFICTSGKGEELYKDKLIPAVKEGAAINDRNVDDIDKMIEIKISYDPDPE
LALENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVAKVKDYVDWGLNHLVFHAPGHDQRRF
LELFEKDLAPRLRRLG

Sequences:

>Translated_336_residues
MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTTRITLGTSVLTPTFR
YNPAVVAQAFATMACLYPGRIFLGVGTGEALNEIATGYQGEWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLKGA
SIYDVPDGGVPIYIAAGGPAVAKYAGRAGDGFICTSGKGEELYKDKLIPAVKEGAAINDRNVDDIDKMIEIKISYDPDPE
LALENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVAKVKDYVDWGLNHLVFHAPGHDQRRF
LELFEKDLAPRLRRLG
>Mature_335_residues
AELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTTRITLGTSVLTPTFRY
NPAVVAQAFATMACLYPGRIFLGVGTGEALNEIATGYQGEWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLKGAS
IYDVPDGGVPIYIAAGGPAVAKYAGRAGDGFICTSGKGEELYKDKLIPAVKEGAAINDRNVDDIDKMIEIKISYDPDPEL
ALENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVAKVKDYVDWGLNHLVFHAPGHDQRRFL
ELFEKDLAPRLRRLG

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 37355; Mature: 37223

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMTA
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHCCCCCCEEHHHHHH
VGERTTRITLGTSVLTPTFRYNPAVVAQAFATMACLYPGRIFLGVGTGEALNEIATGYQG
HCCCEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCC
EWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLKGASIYDVPDGGVPIYIAAGGPA
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCEEEEEECCCCH
VAKYAGRAGDGFICTSGKGEELYKDKLIPAVKEGAAINDRNVDDIDKMIEIKISYDPDPE
HHHHCCCCCCCEEEECCCCHHHHHHHCCHHHHCCCCCCCCCHHHHHCEEEEEEECCCCCC
LALENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVAKVKDY
EEECCCEEEEEEECCCHHHCCCCCCHHHHHHHCCCCHHHHHHHCEECCCCHHHHHHHHHH
VDWGLNHLVFHAPGHDQRRFLELFEKDLAPRLRRLG
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMTA
CCCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHCCCCCCEEHHHHHH
VGERTTRITLGTSVLTPTFRYNPAVVAQAFATMACLYPGRIFLGVGTGEALNEIATGYQG
HCCCEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCC
EWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLKGASIYDVPDGGVPIYIAAGGPA
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCEEEEEECCCCH
VAKYAGRAGDGFICTSGKGEELYKDKLIPAVKEGAAINDRNVDDIDKMIEIKISYDPDPE
HHHHCCCCCCCEEEECCCCHHHHHHHCCHHHHCCCCCCCCCHHHHHCEEEEEEECCCCCC
LALENTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQVAKRWIVASDPDEAVAKVKDY
EEECCCEEEEEEECCCHHHCCCCCCHHHHHHHCCCCHHHHHHHCEECCCCHHHHHHHHHH
VDWGLNHLVFHAPGHDQRRFLELFEKDLAPRLRRLG
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]