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The map label for this gene is clpB

Identifier: 41409951

GI number: 41409951

Start: 4314152

End: 4316698

Strand: Direct

Name: clpB

Synonym: MAP3853

Alternate gene names: 41409951

Gene position: 4314152-4316698 (Clockwise)

Preceding gene: 41409947

Following gene: 41409952

Centisome position: 89.32

GC content: 70.4

Gene sequence:

>2547_bases
GTGGACTCTTTCAACCCGACCACCAAGACGCAAGCGGCGTTGACCGCGGCGCTGCAGGCGGCCTCGGCCGCCGGCAACCC
CGAGATCCGGCCCGCCCACCTGCTGATGGCCCTGCTGACGCAGGCGGACGGGATCGCCGCGCCGTTATTGGAGGCCGTGG
GTGTCGAGCCCGCCACCATTCGCGCCGAGGCCGAGCGCATGCTGGCCCGGCTGCCGCAGGCCAGCGGCGCCAGCTCGCAA
CCGCAGCTGTCCCGCGAGTCGCTGGCCGCCATTACCACCGCCCAGCACCTGGCCACCGAGCTGGACGACGAATACGTCTC
CACCGAGCACCTGATGGTGGGCCTGGCCACCGGCGACTCCGACGTCGCCAAGCTGCTCACCGGGCACGGCGCGTCCCCGC
AGGCCCTGCGGGAGGCCTTCGTCAAGGTGCGCGGCAGCGCCCGGGTCACCAGCCCCGACCCCGAGGCCACTTACCAGGCG
CTGGAGAAGTACTCCACCGACCTCACCGCGCGGGCCCGCGAGGGCAAGCTCGACCCGGTCATCGGCCGTGACAACGAGAT
CCGCCGCGTCGTGCAGGTGCTCTCCCGTCGCACCAAGAACAACCCGGTGCTCATCGGTGAGCCCGGCGTCGGCAAGACCG
CGATCGTCGAGGGCCTGGCCCAGCGCATCGTGGCCGGCGACGTGCCGGAAAGCCTGCGCGACAAGACCGTCATCGCGCTG
GACCTCGGCTCGATGGTGGCCGGCGCCAAATACCGCGGCGAGTTCGAGGAACGGCTCAAGGCCGTCCTCGACGACATCAA
GAACTCCGCCGGGCAGATCATCACGTTCATCGACGAGCTGCACACCATCGTCGGCGCCGGCGCGACCGGCGAGGGCGCGA
TGGACGCCGGCAACATGATCAAGCCGATGCTGGCCCGCGGGGAGCTGCGCCTGGTCGGCGCCACCACGCTCGACGAGTAC
CGCAAATACATCGAGAAGGACGCCGCGCTGGAGCGCCGCTTCCAGCAGGTGTTCGTCGGCGAGCCGTCGGTGGAGGACAC
CGTCGGCATCCTGCGCGGGCTCAAGGACCGCTACGAGGTGCACCACGGGGTGCGCATCACCGACTCGGCGCTGGTCGCCG
CCGCCACGCTGTCCGACCGCTACATCACCGCCCGCTTCCTGCCCGACAAGGCCATCGACCTGGTCGACGAGGCCGCCAGC
CGGCTGAAGATGGAGATCGACTCGCGGCCCGTCGAGATCGACGAGGTCGAGCGGCTGGTGCGCCGCCTCGAGATCGAGGA
GATGGCCCTGGCCAAGGAGGAGGACGAGGCGTCCAAGGAGCGGCTGGAAAAGCTGCGCTCCGAGCTGGCCGACCAGAAGG
AAAAGCTGGCCGAACTGACCACCCGCTGGCAGAACGAGAAGAACGCCATCGACGTCGTCCGCGAGCTCAAGGAGCAGCTG
GAAACGCTGCGCGGCGAGTCCGACCGCGCCGAGCGCGACGGCGACCTGGCCAAGGCCGCCGAGCTGCGCTACGGCCGGAT
CCCGGAGGTGGAGAAGAAGCTCGAGGCCGCGCTGCCCCAGGCCGAGGCCCGCGAGAACGTGATGCTCAAGGAGGAGGTCG
GGCCCGACGACATCGCCGAGGTGGTGTCGGCGTGGACCGGGATCCCGGCCGGGCGGATGCTCGAGGGCGAGACCGCGAAG
CTGCTGCGCATGGAGGACGAGCTGGGCAAGCGCGTCGTCGGGCAGAAGCGGGCCGTGCAGGCGGTGTCCGACGCGGTGCG
GCGCGCCCGGGCCGGCGTGGCCGACCCGAACCGGCCGACCGGGTCGTTCATGTTCCTGGGACCCACCGGTGTCGGTAAGA
CCGAGCTGGCCAAGGCGCTGGCCGACTTCCTGTTCGACGACAAGCGGGCGATGGTCCGTATCGACATGAGCGAATACGGC
GAGAAGCACTCGGTGGCCCGCCTGGTCGGCGCGCCGCCGGGCTACATCGGCTACGACCAGGGCGGTCAGCTGACCGAGGC
GGTGCGCCGGCGTCCCTACACGGTGATCCTGTTCGACGAGATCGAGAAGGCGCACCCGGACGTGTTCGACGTGCTGCTGC
AGGTGCTCGACGAGGGCCGGCTCACCGACGGGCAGGGCCGCACCGTCGACTTCCGCAACACCATCCTGATCCTGACCTCC
AACCTGGGGTCGGGTGGCAGCGAGGAGCAGGTGATGGCCGCGGTGCGCTCGGCGTTCAAGCCCGAGTTCATCAACCGGCT
CGACGACGTCATCATCTTCCACGGCCTCGAGCCCGGCGAGCTGGTGCAGATCGTCGACATCCAGCTGGCCCAGCTGCAGA
AGCGGCTGGCGCAGCGCCGGCTCACGCTGGAGGTGTCGCTGCCGGCCAAGCAGTGGCTGGCCCACCGCGGCTTCGACCCG
GTCTACGGCGCCCGGCCGCTGCGCCGGCTGGTGCAGCAGGCCATCGGCGACCAGCTGGCCAAGCAGTTGCTGGCCGGTCA
GGTGCACGACGGCGACACCGTCCCGGTCAACGTCAGCCCGGACGGCGACTCGCTGATCCTGGGCTAG

Upstream 100 bases:

>100_bases
GGGCGCCCAAAACTCGATAGAGTTGAGCGGAACAGACTCAACCTTGACGGCGTTGAACAACCCGACAAGCATTTTTGCCA
CTACCCGAACGGAGGTCGTC

Downstream 100 bases:

>100_bases
TCGGTCGCGCGCGAACGTCGACTTGTTGCGGGGATTTCCCTCTTACCTTCTAGCGCTGGATGCAACAGCCTCTAGCTGAG
GGGTTGTTGATGAGGTCGTC

Product: ClpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 848; Mature: 848

Protein sequence:

>848_residues
MDSFNPTTKTQAALTAALQAASAAGNPEIRPAHLLMALLTQADGIAAPLLEAVGVEPATIRAEAERMLARLPQASGASSQ
PQLSRESLAAITTAQHLATELDDEYVSTEHLMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPDPEATYQA
LEKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTVIAL
DLGSMVAGAKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEY
RKYIEKDAALERRFQQVFVGEPSVEDTVGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAAS
RLKMEIDSRPVEIDEVERLVRRLEIEEMALAKEEDEASKERLEKLRSELADQKEKLAELTTRWQNEKNAIDVVRELKEQL
ETLRGESDRAERDGDLAKAAELRYGRIPEVEKKLEAALPQAEARENVMLKEEVGPDDIAEVVSAWTGIPAGRMLEGETAK
LLRMEDELGKRVVGQKRAVQAVSDAVRRARAGVADPNRPTGSFMFLGPTGVGKTELAKALADFLFDDKRAMVRIDMSEYG
EKHSVARLVGAPPGYIGYDQGGQLTEAVRRRPYTVILFDEIEKAHPDVFDVLLQVLDEGRLTDGQGRTVDFRNTILILTS
NLGSGGSEEQVMAAVRSAFKPEFINRLDDVIIFHGLEPGELVQIVDIQLAQLQKRLAQRRLTLEVSLPAKQWLAHRGFDP
VYGARPLRRLVQQAIGDQLAKQLLAGQVHDGDTVPVNVSPDGDSLILG

Sequences:

>Translated_848_residues
MDSFNPTTKTQAALTAALQAASAAGNPEIRPAHLLMALLTQADGIAAPLLEAVGVEPATIRAEAERMLARLPQASGASSQ
PQLSRESLAAITTAQHLATELDDEYVSTEHLMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPDPEATYQA
LEKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTVIAL
DLGSMVAGAKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEY
RKYIEKDAALERRFQQVFVGEPSVEDTVGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAAS
RLKMEIDSRPVEIDEVERLVRRLEIEEMALAKEEDEASKERLEKLRSELADQKEKLAELTTRWQNEKNAIDVVRELKEQL
ETLRGESDRAERDGDLAKAAELRYGRIPEVEKKLEAALPQAEARENVMLKEEVGPDDIAEVVSAWTGIPAGRMLEGETAK
LLRMEDELGKRVVGQKRAVQAVSDAVRRARAGVADPNRPTGSFMFLGPTGVGKTELAKALADFLFDDKRAMVRIDMSEYG
EKHSVARLVGAPPGYIGYDQGGQLTEAVRRRPYTVILFDEIEKAHPDVFDVLLQVLDEGRLTDGQGRTVDFRNTILILTS
NLGSGGSEEQVMAAVRSAFKPEFINRLDDVIIFHGLEPGELVQIVDIQLAQLQKRLAQRRLTLEVSLPAKQWLAHRGFDP
VYGARPLRRLVQQAIGDQLAKQLLAGQVHDGDTVPVNVSPDGDSLILG
>Mature_848_residues
MDSFNPTTKTQAALTAALQAASAAGNPEIRPAHLLMALLTQADGIAAPLLEAVGVEPATIRAEAERMLARLPQASGASSQ
PQLSRESLAAITTAQHLATELDDEYVSTEHLMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPDPEATYQA
LEKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTVIAL
DLGSMVAGAKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEY
RKYIEKDAALERRFQQVFVGEPSVEDTVGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAAS
RLKMEIDSRPVEIDEVERLVRRLEIEEMALAKEEDEASKERLEKLRSELADQKEKLAELTTRWQNEKNAIDVVRELKEQL
ETLRGESDRAERDGDLAKAAELRYGRIPEVEKKLEAALPQAEARENVMLKEEVGPDDIAEVVSAWTGIPAGRMLEGETAK
LLRMEDELGKRVVGQKRAVQAVSDAVRRARAGVADPNRPTGSFMFLGPTGVGKTELAKALADFLFDDKRAMVRIDMSEYG
EKHSVARLVGAPPGYIGYDQGGQLTEAVRRRPYTVILFDEIEKAHPDVFDVLLQVLDEGRLTDGQGRTVDFRNTILILTS
NLGSGGSEEQVMAAVRSAFKPEFINRLDDVIIFHGLEPGELVQIVDIQLAQLQKRLAQRRLTLEVSLPAKQWLAHRGFDP
VYGARPLRRLVQQAIGDQLAKQLLAGQVHDGDTVPVNVSPDGDSLILG

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=326, Percent_Identity=34.0490797546012, Blast_Score=196, Evalue=1e-49,
Organism=Escherichia coli, GI1788943, Length=847, Percent_Identity=56.3164108618654, Blast_Score=945, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=448, Percent_Identity=40.4017857142857, Blast_Score=295, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6320464, Length=719, Percent_Identity=53.2684283727399, Blast_Score=776, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=862, Percent_Identity=42.2273781902552, Blast_Score=677, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 92633; Mature: 92633

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSFNPTTKTQAALTAALQAASAAGNPEIRPAHLLMALLTQADGIAAPLLEAVGVEPATI
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHH
RAEAERMLARLPQASGASSQPQLSRESLAAITTAQHLATELDDEYVSTEHLMVGLATGDS
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCH
DVAKLLTGHGASPQALREAFVKVRGSARVTSPDPEATYQALEKYSTDLTARAREGKLDPV
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCC
IGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTVIAL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEE
DLGSMVAGAKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGEGAMDAGNMI
EHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
KPMLARGELRLVGATTLDEYRKYIEKDAALERRFQQVFVGEPSVEDTVGILRGLKDRYEV
HHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
HHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAASRLKMEIDSRPVEIDEVERLV
HCCCEEECHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RRLEIEEMALAKEEDEASKERLEKLRSELADQKEKLAELTTRWQNEKNAIDVVRELKEQL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ETLRGESDRAERDGDLAKAAELRYGRIPEVEKKLEAALPQAEARENVMLKEEVGPDDIAE
HHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCEEHHCCCHHHHHH
VVSAWTGIPAGRMLEGETAKLLRMEDELGKRVVGQKRAVQAVSDAVRRARAGVADPNRPT
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GSFMFLGPTGVGKTELAKALADFLFDDKRAMVRIDMSEYGEKHSVARLVGAPPGYIGYDQ
CCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHCCCCCCCCCCC
GGQLTEAVRRRPYTVILFDEIEKAHPDVFDVLLQVLDEGRLTDGQGRTVDFRNTILILTS
CCHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEE
NLGSGGSEEQVMAAVRSAFKPEFINRLDDVIIFHGLEPGELVQIVDIQLAQLQKRLAQRR
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LTLEVSLPAKQWLAHRGFDPVYGARPLRRLVQQAIGDQLAKQLLAGQVHDGDTVPVNVSP
EEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
DGDSLILG
CCCCEECC
>Mature Secondary Structure
MDSFNPTTKTQAALTAALQAASAAGNPEIRPAHLLMALLTQADGIAAPLLEAVGVEPATI
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHH
RAEAERMLARLPQASGASSQPQLSRESLAAITTAQHLATELDDEYVSTEHLMVGLATGDS
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCH
DVAKLLTGHGASPQALREAFVKVRGSARVTSPDPEATYQALEKYSTDLTARAREGKLDPV
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCC
IGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTVIAL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEE
DLGSMVAGAKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGEGAMDAGNMI
EHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
KPMLARGELRLVGATTLDEYRKYIEKDAALERRFQQVFVGEPSVEDTVGILRGLKDRYEV
HHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
HHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAASRLKMEIDSRPVEIDEVERLV
HCCCEEECHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RRLEIEEMALAKEEDEASKERLEKLRSELADQKEKLAELTTRWQNEKNAIDVVRELKEQL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ETLRGESDRAERDGDLAKAAELRYGRIPEVEKKLEAALPQAEARENVMLKEEVGPDDIAE
HHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCEEHHCCCHHHHHH
VVSAWTGIPAGRMLEGETAKLLRMEDELGKRVVGQKRAVQAVSDAVRRARAGVADPNRPT
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GSFMFLGPTGVGKTELAKALADFLFDDKRAMVRIDMSEYGEKHSVARLVGAPPGYIGYDQ
CCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHCCCCCCCCCCC
GGQLTEAVRRRPYTVILFDEIEKAHPDVFDVLLQVLDEGRLTDGQGRTVDFRNTILILTS
CCHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEE
NLGSGGSEEQVMAAVRSAFKPEFINRLDDVIIFHGLEPGELVQIVDIQLAQLQKRLAQRR
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LTLEVSLPAKQWLAHRGFDPVYGARPLRRLVQQAIGDQLAKQLLAGQVHDGDTVPVNVSP
EEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
DGDSLILG
CCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9692182; 12788972 [H]