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The map label for this gene is bacA [H]

Identifier: 41409839

GI number: 41409839

Start: 4172693

End: 4173538

Strand: Direct

Name: bacA [H]

Synonym: MAP3741

Alternate gene names: 41409839

Gene position: 4172693-4173538 (Clockwise)

Preceding gene: 41409838

Following gene: 41409840

Centisome position: 86.4

GC content: 64.07

Gene sequence:

>846_bases
ATGACCGCGGCCGAGCTCGTCGACCACCTGCGGGGTATCGGCGTCCAACTGTGGGCCGACGGTGAGAATTTGCGCTACCG
AGCACCGCAACAAGTCCTCACCGCGGACCTGAAAGCTCAACTGGCGGCGGTCAAAACGGACGTGATTACCCTGCTGGCGG
AAGAGACGACCCTGCTGCGCGCGCCGCAGGACCGGTTCGAGCCGTTTCCGCTCACCGACGTGCAAGCCGCATATCTGGTC
GGGCGCACGTCGGCGTTTCAGTGGGGCGGGGTAGGCTGCCACGGCTACGCCGAGTTCGCGGTCGACCACACCGTGGCAAC
ACCGAGCGCCGAGCAATATCGGGAGGCGTGGCGCAAGGTTGCCGACCGCCACGACATGTTGCGCTGCGTCGTTCATCCCG
AGGGGTATCAGGTGATATGCCCCGACGTGCCCGACGACGGGCTGGTCATCCATCAGTGTCACACGGTCGAAGACGTTGCC
GGCGTACGTGCCGGGGTCACGGAACATCTGCGTAACCGGATATATCCGCTGGGCGAAGCGCCGATGTATGACCTGGTGAT
CACGATGGGCCCTGACGACACCGTGGTCCATCTGTCCGTTGACCTGCTGATCGCCGACTTCGTCAGCATCTCCATCCTGA
TGACCGACTTTCAGCAGTGCTTGCTTGACCCCGAATGCGACCTTGCGCCCGTCGATTTCAGCTTCCGCGACTACCTGCTG
AATCTCGCTCGCGAGCGAAGCTCGGCCGCCGGTAGTGCCCGCCGGGAACGCGATCTCGCCTACTGGCGGGATCGGCTCGA
TCAGCTGCCGTCACCACTGTCGTTACCGGTGCTGCCCGACGACTAG

Upstream 100 bases:

>100_bases
GACTGCTGTTCGCCAATCCGGTGATCGGCGACTTCGCCGCCAAAATCGCCGACACTGACAACGCCGACGAACCCGACCTG
ACCGTTGAGGAGGGCATGTT

Downstream 100 bases:

>100_bases
ACGCCGTCAGCGTCGCGGACGGCACCGACCTTTTCACGGCGTTCGATGCGCCTGTCGGCCGAGCGTTTCGAGGTGCTCAG
CCGGCGCGCGGCAGAGCACG

Product: hypothetical protein

Products: NA

Alternate protein names: BA1; ATP-dependent isoleucine adenylase; IleA; Isoleucine activase; ATP-dependent cysteine adenylase; CysA; Cysteine activase; ATP-dependent leucine adenylase; LeuA; Leucine activase; ATP-dependent glutamate adenylase; GluA; Glutamate activase; ATP-dependent isoleucine adenylase; IleA; Isoleucine activase; Glutamate racemase [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTAAELVDHLRGIGVQLWADGENLRYRAPQQVLTADLKAQLAAVKTDVITLLAEETTLLRAPQDRFEPFPLTDVQAAYLV
GRTSAFQWGGVGCHGYAEFAVDHTVATPSAEQYREAWRKVADRHDMLRCVVHPEGYQVICPDVPDDGLVIHQCHTVEDVA
GVRAGVTEHLRNRIYPLGEAPMYDLVITMGPDDTVVHLSVDLLIADFVSISILMTDFQQCLLDPECDLAPVDFSFRDYLL
NLARERSSAAGSARRERDLAYWRDRLDQLPSPLSLPVLPDD

Sequences:

>Translated_281_residues
MTAAELVDHLRGIGVQLWADGENLRYRAPQQVLTADLKAQLAAVKTDVITLLAEETTLLRAPQDRFEPFPLTDVQAAYLV
GRTSAFQWGGVGCHGYAEFAVDHTVATPSAEQYREAWRKVADRHDMLRCVVHPEGYQVICPDVPDDGLVIHQCHTVEDVA
GVRAGVTEHLRNRIYPLGEAPMYDLVITMGPDDTVVHLSVDLLIADFVSISILMTDFQQCLLDPECDLAPVDFSFRDYLL
NLARERSSAAGSARRERDLAYWRDRLDQLPSPLSLPVLPDD
>Mature_280_residues
TAAELVDHLRGIGVQLWADGENLRYRAPQQVLTADLKAQLAAVKTDVITLLAEETTLLRAPQDRFEPFPLTDVQAAYLVG
RTSAFQWGGVGCHGYAEFAVDHTVATPSAEQYREAWRKVADRHDMLRCVVHPEGYQVICPDVPDDGLVIHQCHTVEDVAG
VRAGVTEHLRNRIYPLGEAPMYDLVITMGPDDTVVHLSVDLLIADFVSISILMTDFQQCLLDPECDLAPVDFSFRDYLLN
LARERSSAAGSARRERDLAYWRDRLDQLPSPLSLPVLPDD

Specific function: Activates five amino acids, incorporates two D-amino acids, releases and cyclizes the mature bacitracin [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 5 acyl carrier domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013624
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF08415 NRPS; PF00550 PP-binding [H]

EC number: =5.1.1.3 [H]

Molecular weight: Translated: 31335; Mature: 31204

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAELVDHLRGIGVQLWADGENLRYRAPQQVLTADLKAQLAAVKTDVITLLAEETTLLR
CCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APQDRFEPFPLTDVQAAYLVGRTSAFQWGGVGCHGYAEFAVDHTVATPSAEQYREAWRKV
CCHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
ADRHDMLRCVVHPEGYQVICPDVPDDGLVIHQCHTVEDVAGVRAGVTEHLRNRIYPLGEA
HHHHHHEEEEECCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
PMYDLVITMGPDDTVVHLSVDLLIADFVSISILMTDFQQCLLDPECDLAPVDFSFRDYLL
CCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHH
NLARERSSAAGSARRERDLAYWRDRLDQLPSPLSLPVLPDD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TAAELVDHLRGIGVQLWADGENLRYRAPQQVLTADLKAQLAAVKTDVITLLAEETTLLR
CHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APQDRFEPFPLTDVQAAYLVGRTSAFQWGGVGCHGYAEFAVDHTVATPSAEQYREAWRKV
CCHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
ADRHDMLRCVVHPEGYQVICPDVPDDGLVIHQCHTVEDVAGVRAGVTEHLRNRIYPLGEA
HHHHHHEEEEECCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
PMYDLVITMGPDDTVVHLSVDLLIADFVSISILMTDFQQCLLDPECDLAPVDFSFRDYLL
CCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHH
NLARERSSAAGSARRERDLAYWRDRLDQLPSPLSLPVLPDD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9427658 [H]