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The map label for this gene is menE [H]

Identifier: 41409757

GI number: 41409757

Start: 4064469

End: 4065998

Strand: Direct

Name: menE [H]

Synonym: MAP3659

Alternate gene names: 41409757

Gene position: 4064469-4065998 (Clockwise)

Preceding gene: 41409756

Following gene: 41409758

Centisome position: 84.15

GC content: 70.85

Gene sequence:

>1530_bases
ATGAGCATTTCGCTGCTGCTCGAGATGGCCGCGTCGAGCAACGCCGAGCGCACGGCGGTGGTCTCGCAAGACGTGCGGCT
GACCACCCAAGAGCTCAGCGATCTCGCCGACGGCGGCGCGGCGGTGGTGGCCGGTTCGAACGCCAAGCACCTGGTCTACG
TGGGCACCGGCGGCGTGCTGCTGCCGGTGCTGATCTTCGCCGCGGCGCGCGCCGGGGTGGCCTTCACGCCGATCAACTAC
CGGCTCTCCGCCGAGGGCATCCGGGCGCTGATCGAGCGGCTGCCCGAGCCGTTGGTGGTGGTCGACGCCCGCTACCGCGA
CATGGTCGGGGAGGCGCCGGGCGGGGTCATGGACTCCGACGACTTCCTGGCCGCCGCCCGCGCCGCCGAGCCCGCCGCGG
ACGCGTTTGCCGACCCGGACTCCGTCGCGATCGTGCTGTTCACCTCGGGCACCACCTCGCAGCCCAAGGCCGTCGAGCTC
TCGCACAACAACCTGACCAGCTACATCACCGGGACCGTCGAATTCGGGGCGGCCGACGAAACCGACGCCGCGCTGATCTG
CGTCCCGCCGTACCACATCGCCGGGGTCAGCGCCGCGCTGTCGAATCTGTATGCCGGCCGCAAGATGGTGTACCTGCCGA
ATTTCGATGCGCGGGAATGGGTTCGGCTGATCAACGCCGAGAACGTGACGACCGCGACGGTGGTGCCCACCATGCTCGAC
CGCATCGTCACGGTGCTGGAGAACGGCGACCCGGACACCGGGGCGCCGATCGAGCTGCCGTCGCTGCGCAACCTGGCCTA
CGGCGGCTCCAAGGTCGGCCTGCCGCTGGTGCGCCGGGCGCTGGAGCTGCTGCCCCACGTCGGCTTCGTCAACGCCTACG
GCCTCACCGAGACCAGCTCGACCATCGCGGTGCTGACCCCCGACGACCACCGCGCGGCGCTGGCGGCGACCACCCCCGAG
GCCGCGCGGCGGCTCGGATCGGTGGGGCAGGCGGTGGCCGGCATCGAGCTGCAGATCCGCGACGAAGCCGGAAATGTGTT
GCCGCCCGGGGAAACCGGGGAACTGTTCGTGCGCGGCGAGCAGGTCTCGGGCCGCTACACCGGGATCGGCTCGGTGCTCG
ACGAGGACGGCTGGTTCCCGACGCGCGACATCGCCATGCTCGACGACGAGGGCTACCTGTTCATCGGCGGGCGCAGCGAC
GACACCATCATCCGCGGCGGGGAGAACATCGCGCCCGCCGAGCTGGAGGAGGTCCTGGTCGAGCATCCCCACGTGCGCGA
CGTCGCGGTGGTCGGCGTCGAGGACCCGCAGTGGGGCCAGGCCATCGTCGCGGTGGTGGTGCCGGCGGCCGGTGTCGACC
CCGATCCCGAGGAATTGCGCGAGTTCGTCCGCAAGAGTTTGCGCGGTTCGCGCACGCCCGACGAGGTAGTGTTTCGCGAC
GAGCTGCCCACCACCGCCACCGGCAAGGTGTTGCGGCGGGAGATCATCGCGACCCTAGCCGGATTGCGCGCCGCACCGGC
CCAGCAGTAA

Upstream 100 bases:

>100_bases
CGGGCACCTGATCGGTCCCGGGCGGTGATCTAAGCTACAGTCGGACATGACACTTTTGGCCGGCTTTTTGTAACGTGCTG
ACACCGCAGGAAGACCGAGG

Downstream 100 bases:

>100_bases
GCGATCAAGGACGGAAATCAATGATCAAGAACGGGAACTCGTCTCGCCAGCCAGGTGTGCGACACCCAGGTGATCGTCGT
CAGGAGTGCGGACAGCCTCG

Product: hypothetical protein

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSISLLLEMAASSNAERTAVVSQDVRLTTQELSDLADGGAAVVAGSNAKHLVYVGTGGVLLPVLIFAAARAGVAFTPINY
RLSAEGIRALIERLPEPLVVVDARYRDMVGEAPGGVMDSDDFLAAARAAEPAADAFADPDSVAIVLFTSGTTSQPKAVEL
SHNNLTSYITGTVEFGAADETDAALICVPPYHIAGVSAALSNLYAGRKMVYLPNFDAREWVRLINAENVTTATVVPTMLD
RIVTVLENGDPDTGAPIELPSLRNLAYGGSKVGLPLVRRALELLPHVGFVNAYGLTETSSTIAVLTPDDHRAALAATTPE
AARRLGSVGQAVAGIELQIRDEAGNVLPPGETGELFVRGEQVSGRYTGIGSVLDEDGWFPTRDIAMLDDEGYLFIGGRSD
DTIIRGGENIAPAELEEVLVEHPHVRDVAVVGVEDPQWGQAIVAVVVPAAGVDPDPEELREFVRKSLRGSRTPDEVVFRD
ELPTTATGKVLRREIIATLAGLRAAPAQQ

Sequences:

>Translated_509_residues
MSISLLLEMAASSNAERTAVVSQDVRLTTQELSDLADGGAAVVAGSNAKHLVYVGTGGVLLPVLIFAAARAGVAFTPINY
RLSAEGIRALIERLPEPLVVVDARYRDMVGEAPGGVMDSDDFLAAARAAEPAADAFADPDSVAIVLFTSGTTSQPKAVEL
SHNNLTSYITGTVEFGAADETDAALICVPPYHIAGVSAALSNLYAGRKMVYLPNFDAREWVRLINAENVTTATVVPTMLD
RIVTVLENGDPDTGAPIELPSLRNLAYGGSKVGLPLVRRALELLPHVGFVNAYGLTETSSTIAVLTPDDHRAALAATTPE
AARRLGSVGQAVAGIELQIRDEAGNVLPPGETGELFVRGEQVSGRYTGIGSVLDEDGWFPTRDIAMLDDEGYLFIGGRSD
DTIIRGGENIAPAELEEVLVEHPHVRDVAVVGVEDPQWGQAIVAVVVPAAGVDPDPEELREFVRKSLRGSRTPDEVVFRD
ELPTTATGKVLRREIIATLAGLRAAPAQQ
>Mature_508_residues
SISLLLEMAASSNAERTAVVSQDVRLTTQELSDLADGGAAVVAGSNAKHLVYVGTGGVLLPVLIFAAARAGVAFTPINYR
LSAEGIRALIERLPEPLVVVDARYRDMVGEAPGGVMDSDDFLAAARAAEPAADAFADPDSVAIVLFTSGTTSQPKAVELS
HNNLTSYITGTVEFGAADETDAALICVPPYHIAGVSAALSNLYAGRKMVYLPNFDAREWVRLINAENVTTATVVPTMLDR
IVTVLENGDPDTGAPIELPSLRNLAYGGSKVGLPLVRRALELLPHVGFVNAYGLTETSSTIAVLTPDDHRAALAATTPEA
ARRLGSVGQAVAGIELQIRDEAGNVLPPGETGELFVRGEQVSGRYTGIGSVLDEDGWFPTRDIAMLDDEGYLFIGGRSDD
TIIRGGENIAPAELEEVLVEHPHVRDVAVVGVEDPQWGQAIVAVVVPAAGVDPDPEELREFVRKSLRGSRTPDEVVFRDE
LPTTATGKVLRREIIATLAGLRAAPAQQ

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=387, Percent_Identity=29.4573643410853, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI187761343, Length=387, Percent_Identity=29.4573643410853, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI156151445, Length=550, Percent_Identity=27.8181818181818, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI38505220, Length=372, Percent_Identity=30.3763440860215, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI115511026, Length=520, Percent_Identity=24.8076923076923, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI58082049, Length=513, Percent_Identity=24.9512670565302, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI157311624, Length=513, Percent_Identity=24.5614035087719, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI157311622, Length=513, Percent_Identity=24.5614035087719, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI122937307, Length=249, Percent_Identity=31.7269076305221, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI13375727, Length=444, Percent_Identity=25.2252252252252, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI42544132, Length=381, Percent_Identity=25.1968503937008, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI8923896, Length=120, Percent_Identity=35.8333333333333, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI253970489, Length=120, Percent_Identity=35.8333333333333, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI28416953, Length=395, Percent_Identity=26.0759493670886, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI145693145, Length=375, Percent_Identity=31.4666666666667, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI221142682, Length=457, Percent_Identity=26.9146608315098, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788107, Length=368, Percent_Identity=31.25, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786810, Length=540, Percent_Identity=26.1111111111111, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788595, Length=347, Percent_Identity=26.5129682997118, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790505, Length=437, Percent_Identity=27.6887871853547, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1786529, Length=404, Percent_Identity=28.4653465346535, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17558820, Length=368, Percent_Identity=31.25, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71994703, Length=375, Percent_Identity=32, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71994690, Length=374, Percent_Identity=31.8181818181818, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71994694, Length=375, Percent_Identity=31.7333333333333, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17531443, Length=459, Percent_Identity=27.0152505446623, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17557194, Length=456, Percent_Identity=25.219298245614, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32563687, Length=456, Percent_Identity=26.9736842105263, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17538037, Length=448, Percent_Identity=25.2232142857143, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560308, Length=392, Percent_Identity=29.0816326530612, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17559526, Length=405, Percent_Identity=27.9012345679012, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI71996755, Length=464, Percent_Identity=25, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71985884, Length=425, Percent_Identity=24.7058823529412, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17560140, Length=365, Percent_Identity=24.9315068493151, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25141359, Length=492, Percent_Identity=20.7317073170732, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=371, Percent_Identity=31.266846361186, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319264, Length=405, Percent_Identity=28.1481481481481, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24581924, Length=400, Percent_Identity=30.5, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21355181, Length=401, Percent_Identity=28.428927680798, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI18859661, Length=408, Percent_Identity=28.6764705882353, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24653035, Length=489, Percent_Identity=26.3803680981595, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21356947, Length=480, Percent_Identity=26.4583333333333, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161076582, Length=484, Percent_Identity=26.2396694214876, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20130357, Length=371, Percent_Identity=27.4932614555256, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24648260, Length=366, Percent_Identity=29.2349726775956, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24648257, Length=379, Percent_Identity=28.4960422163588, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24648255, Length=370, Percent_Identity=25.9459459459459, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281365686, Length=333, Percent_Identity=25.8258258258258, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922652, Length=479, Percent_Identity=24.8434237995825, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24648253, Length=370, Percent_Identity=25.6756756756757, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24656500, Length=497, Percent_Identity=24.5472837022133, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21358303, Length=495, Percent_Identity=23.8383838383838, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21356441, Length=429, Percent_Identity=24.009324009324, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355225, Length=416, Percent_Identity=24.7596153846154, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI62472339, Length=397, Percent_Identity=26.7002518891688, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667959, Length=397, Percent_Identity=26.7002518891688, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667955, Length=397, Percent_Identity=26.7002518891688, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 53751; Mature: 53620

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISLLLEMAASSNAERTAVVSQDVRLTTQELSDLADGGAAVVAGSNAKHLVYVGTGGVL
CCHHHEEEHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEECCHHH
LPVLIFAAARAGVAFTPINYRLSAEGIRALIERLPEPLVVVDARYRDMVGEAPGGVMDSD
HHHHHHHHHHCCEEECCCCEEECHHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCCCC
DFLAAARAAEPAADAFADPDSVAIVLFTSGTTSQPKAVELSHNNLTSYITGTVEFGAADE
HHHHHHHCCCCHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCEEEEEEEEEEECCCCC
TDAALICVPPYHIAGVSAALSNLYAGRKMVYLPNFDAREWVRLINAENVTTATVVPTMLD
CCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEHHHHHHHHH
RIVTVLENGDPDTGAPIELPSLRNLAYGGSKVGLPLVRRALELLPHVGFVNAYGLTETSS
HHHHHHHCCCCCCCCCEECCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCC
TIAVLTPDDHRAALAATTPEAARRLGSVGQAVAGIELQIRDEAGNVLPPGETGELFVRGE
EEEEECCCCCCEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEEEEC
QVSGRYTGIGSVLDEDGWFPTRDIAMLDDEGYLFIGGRSDDTIIRGGENIAPAELEEVLV
CCCCEEECCCHHHCCCCCCCCCCEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHHHHH
EHPHVRDVAVVGVEDPQWGQAIVAVVVPAAGVDPDPEELREFVRKSLRGSRTPDEVVFRD
CCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEC
ELPTTATGKVLRREIIATLAGLRAAPAQQ
CCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SISLLLEMAASSNAERTAVVSQDVRLTTQELSDLADGGAAVVAGSNAKHLVYVGTGGVL
CHHHEEEHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEECCHHH
LPVLIFAAARAGVAFTPINYRLSAEGIRALIERLPEPLVVVDARYRDMVGEAPGGVMDSD
HHHHHHHHHHCCEEECCCCEEECHHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCCCC
DFLAAARAAEPAADAFADPDSVAIVLFTSGTTSQPKAVELSHNNLTSYITGTVEFGAADE
HHHHHHHCCCCHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCEEEEEEEEEEECCCCC
TDAALICVPPYHIAGVSAALSNLYAGRKMVYLPNFDAREWVRLINAENVTTATVVPTMLD
CCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEHHHHHHHHH
RIVTVLENGDPDTGAPIELPSLRNLAYGGSKVGLPLVRRALELLPHVGFVNAYGLTETSS
HHHHHHHCCCCCCCCCEECCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCC
TIAVLTPDDHRAALAATTPEAARRLGSVGQAVAGIELQIRDEAGNVLPPGETGELFVRGE
EEEEECCCCCCEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEEEEC
QVSGRYTGIGSVLDEDGWFPTRDIAMLDDEGYLFIGGRSDDTIIRGGENIAPAELEEVLV
CCCCEEECCCHHHCCCCCCCCCCEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHHHHH
EHPHVRDVAVVGVEDPQWGQAIVAVVVPAAGVDPDPEELREFVRKSLRGSRTPDEVVFRD
CCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEC
ELPTTATGKVLRREIIATLAGLRAAPAQQ
CCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA