Definition Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession NC_002944
Length 4,829,781

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The map label for this gene is fabG [C]

Identifier: 41409608

GI number: 41409608

Start: 3908122

End: 3909072

Strand: Direct

Name: fabG [C]

Synonym: MAP3510

Alternate gene names: 41409608

Gene position: 3908122-3909072 (Clockwise)

Preceding gene: 41409607

Following gene: 41409609

Centisome position: 80.92

GC content: 72.34

Gene sequence:

>951_bases
TTGAGCGAAACCCTCGCGCCCCCACTGCGATTCGACGACCGCGTGGCCGTGGTGACCGGAGCCGGCCGCGGGCTGGGCCG
CGCCTACGCTCACCTGCTCGCCGCGCGCGGCGCCAAGGTGGTGGTCAACGACGTCGGCGGAGCCCTGGACGGCGCGGGGG
TCGACACCGGTCCCGCCGCGCAGGTGGTCGACGAGATCACCGCGGCCGGCGGAGACGCGGTGGCGTGCACCGAATCGGTC
GCGACGCCGGAAGGCGGACGGGCGATCATCGAGACGGCGCTGGCACGCTACGGCCGCCTCGACGTGTTGGTGCACAACGC
CGGCAACGTCCGTCGCGCCTCGCTCAAACAGATGAGCTACGAGGACTTCGACGCCGTGCTCGACGTGCATCTGCGCGGCG
CGTTCCACGTGCTGCGTCCCGCGTTCCCGGTGATGTGCCGGGCGGGCTACGGCCGCATCGTGCTGACCTCGTCGATCGGC
GGGTTGTACGGCAACCAGGGGGTGGCCAACTACGCGGCCGCCAAGGCCGGCGTGATCGGCCTGTCCAACGTCGCCGCGCT
GGAGGGCGCCGCCGAGGGGGTGCGGTGCAATGTGATCGTGCCGGCCGCGCTGACCCGGATGGCCGACGGTATCGACACCT
CCGCCTACCCGCCGATGGGCGCGGAGCTCGTCGCGCCCGTGGTGGGCTGGCTGGCGCACGAATCCTGTTCGGTCAGTGGC
GAACTGTTCATCGCGCTGGCGGGCCGGGTGGCCCGGGCGGTCATCGCGGAAAGCCCCGGCGTGTGCCGGCCCGGGTGGAC
GGTCGAGGACGTCGGCGAGCACCTGGACGCGATCCGCTACGTCGAGGCGCCGCTGATCTTTCCGGTGGTCCCCGACGGGC
ACGCCGAGCACATCCGCTACAGCTTCGAGCTGGCGCAGCGCGCCAACGAGCAGGGGGCGCTGCATGGCTAA

Upstream 100 bases:

>100_bases
CTCACCTGGGTGAACCGTACGGTCCCGGCTTCTACGCCTTCGAGGACCTGCTGCGGGCCTGGCGCGACAAGGGTGATCTC
GAAGGGCTGGTGCTCGGCAG

Downstream 100 bases:

>100_bases
CGGTCGGGCGCGCCGAGCGTGGGCCCTGTGCACGCCATCGCAAGGCTTTTCGTGCATAACCCCCACGCTCGGCGAGAGCG
CACGGCAGCGGGCGCGGCAT

Product: hypothetical protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSETLAPPLRFDDRVAVVTGAGRGLGRAYAHLLAARGAKVVVNDVGGALDGAGVDTGPAAQVVDEITAAGGDAVACTESV
ATPEGGRAIIETALARYGRLDVLVHNAGNVRRASLKQMSYEDFDAVLDVHLRGAFHVLRPAFPVMCRAGYGRIVLTSSIG
GLYGNQGVANYAAAKAGVIGLSNVAALEGAAEGVRCNVIVPAALTRMADGIDTSAYPPMGAELVAPVVGWLAHESCSVSG
ELFIALAGRVARAVIAESPGVCRPGWTVEDVGEHLDAIRYVEAPLIFPVVPDGHAEHIRYSFELAQRANEQGALHG

Sequences:

>Translated_316_residues
MSETLAPPLRFDDRVAVVTGAGRGLGRAYAHLLAARGAKVVVNDVGGALDGAGVDTGPAAQVVDEITAAGGDAVACTESV
ATPEGGRAIIETALARYGRLDVLVHNAGNVRRASLKQMSYEDFDAVLDVHLRGAFHVLRPAFPVMCRAGYGRIVLTSSIG
GLYGNQGVANYAAAKAGVIGLSNVAALEGAAEGVRCNVIVPAALTRMADGIDTSAYPPMGAELVAPVVGWLAHESCSVSG
ELFIALAGRVARAVIAESPGVCRPGWTVEDVGEHLDAIRYVEAPLIFPVVPDGHAEHIRYSFELAQRANEQGALHG
>Mature_315_residues
SETLAPPLRFDDRVAVVTGAGRGLGRAYAHLLAARGAKVVVNDVGGALDGAGVDTGPAAQVVDEITAAGGDAVACTESVA
TPEGGRAIIETALARYGRLDVLVHNAGNVRRASLKQMSYEDFDAVLDVHLRGAFHVLRPAFPVMCRAGYGRIVLTSSIGG
LYGNQGVANYAAAKAGVIGLSNVAALEGAAEGVRCNVIVPAALTRMADGIDTSAYPPMGAELVAPVVGWLAHESCSVSGE
LFIALAGRVARAVIAESPGVCRPGWTVEDVGEHLDAIRYVEAPLIFPVVPDGHAEHIRYSFELAQRANEQGALHG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=249, Percent_Identity=48.5943775100402, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=35.2272727272727, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI40254992, Length=189, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI32483357, Length=200, Percent_Identity=28.5, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4758504, Length=201, Percent_Identity=30.3482587064677, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI126723191, Length=190, Percent_Identity=28.4210526315789, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=33.6032388663968, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082100, Length=210, Percent_Identity=31.4285714285714, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789208, Length=194, Percent_Identity=28.3505154639175, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787905, Length=216, Percent_Identity=29.1666666666667, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789057, Length=203, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788459, Length=211, Percent_Identity=29.8578199052133, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789378, Length=270, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=32.1428571428571, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786812, Length=193, Percent_Identity=31.0880829015544, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082160, Length=189, Percent_Identity=27.5132275132275, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787526, Length=255, Percent_Identity=27.0588235294118, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=272, Percent_Identity=41.9117647058824, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17560676, Length=198, Percent_Identity=32.3232323232323, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=209, Percent_Identity=35.8851674641148, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=204, Percent_Identity=32.3529411764706, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=197, Percent_Identity=30.9644670050761, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=256, Percent_Identity=28.90625, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=209, Percent_Identity=31.1004784688995, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=246, Percent_Identity=27.6422764227642, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=262, Percent_Identity=26.3358778625954, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508895, Length=210, Percent_Identity=25.7142857142857, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=255, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=199, Percent_Identity=30.1507537688442, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=216, Percent_Identity=31.9444444444444, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=205, Percent_Identity=29.2682926829268, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=261, Percent_Identity=27.2030651340996, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=204, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=263, Percent_Identity=28.1368821292776, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=208, Percent_Identity=29.3269230769231, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=275, Percent_Identity=27.6363636363636, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=227, Percent_Identity=29.5154185022026, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=206, Percent_Identity=27.1844660194175, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=207, Percent_Identity=27.536231884058, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=199, Percent_Identity=27.6381909547739, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=173, Percent_Identity=27.1676300578035, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=201, Percent_Identity=25.8706467661692, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=209, Percent_Identity=28.2296650717703, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=245, Percent_Identity=47.7551020408163, Blast_Score=210, Evalue=2e-55,
Organism=Drosophila melanogaster, GI18859837, Length=319, Percent_Identity=44.8275862068966, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21357041, Length=210, Percent_Identity=31.9047619047619, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571526, Length=195, Percent_Identity=33.8461538461538, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=32.6424870466321, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24639444, Length=192, Percent_Identity=35.9375, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644339, Length=194, Percent_Identity=32.4742268041237, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355319, Length=258, Percent_Identity=28.6821705426357, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17737361, Length=202, Percent_Identity=30.6930693069307, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357673, Length=239, Percent_Identity=24.6861924686192, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32651; Mature: 32520

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MSETLAPPLRFDDRVAVVTGAGRGLGRAYAHLLAARGAKVVVNDVGGALDGAGVDTGPAA
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHH
QVVDEITAAGGDAVACTESVATPEGGRAIIETALARYGRLDVLVHNAGNVRRASLKQMSY
HHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCH
EDFDAVLDVHLRGAFHVLRPAFPVMCRAGYGRIVLTSSIGGLYGNQGVANYAAAKAGVIG
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCEE
LSNVAALEGAAEGVRCNVIVPAALTRMADGIDTSAYPPMGAELVAPVVGWLAHESCSVSG
CCHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
ELFIALAGRVARAVIAESPGVCRPGWTVEDVGEHLDAIRYVEAPLIFPVVPDGHAEHIRY
EEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
SFELAQRANEQGALHG
HHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SETLAPPLRFDDRVAVVTGAGRGLGRAYAHLLAARGAKVVVNDVGGALDGAGVDTGPAA
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHH
QVVDEITAAGGDAVACTESVATPEGGRAIIETALARYGRLDVLVHNAGNVRRASLKQMSY
HHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCH
EDFDAVLDVHLRGAFHVLRPAFPVMCRAGYGRIVLTSSIGGLYGNQGVANYAAAKAGVIG
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCEE
LSNVAALEGAAEGVRCNVIVPAALTRMADGIDTSAYPPMGAELVAPVVGWLAHESCSVSG
CCHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
ELFIALAGRVARAVIAESPGVCRPGWTVEDVGEHLDAIRYVEAPLIFPVVPDGHAEHIRY
EEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
SFELAQRANEQGALHG
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]