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The map label for this gene is guaA

Identifier: 41409587

GI number: 41409587

Start: 3878538

End: 3880115

Strand: Reverse

Name: guaA

Synonym: MAP3489c

Alternate gene names: 41409587

Gene position: 3880115-3878538 (Counterclockwise)

Preceding gene: 41409593

Following gene: 41409586

Centisome position: 80.34

GC content: 70.6

Gene sequence:

>1578_bases
GTGGCCGAATCCCCCCCCACCGAGGTGCCCGAACCGCCCGCTCGACCCGTGTTGGTGGTCGACTTCGGTGCCCAGTACGC
GCAGCTGATCGCCCGGCGGGTGCGTGAGGCGCGGGTCTTCTCCGAGGTCATTCCACACACCGCGACGATCGAGGAGATCA
AGGCCCGCCAGCCGCGGGCGCTGGTGCTCTCCGGCGGCCCGTCCAGCGTCTACGAGCCGGGCGCCCCGCAGCTGGATCCG
GCGGTGTTCGACCTGGGGGTGCCGGTGTTCGGCATCTGCTACGGATTTCAGGCCATGGCGCAGGCTTTGGGCGGCACCGT
CGCGCACACCGGCACCAGCGAATACGGTCGCACCGAGCTGAAAGTGCTTGGCGGCGAACTGCATTCGGGGCTGCCGGGCG
TGCAGCCGGTCTGGATGAGCCACGGTGATGCGGTCACCGCCGCGCCGGACGGTTTCGAGGTGGTGGCCAGCAGCCCCGGC
GCCGTGGTGGCCGCGTTCGAGAACCGGGCCCGCCGCCTGGCCGGGGTGCAGTACCACCCGGAGGTGATGCACACCCCGCA
TGGCCAGCAGGTGCTGAGCCGGTTCCTGCACGACTTCGCCGGGCTGGGCGCGGACTGGACGGCCGCCAACATCGCCGGTG
TGCTGGTGGAGCAGGTCCGCGCGCAGATCGGCGACGGCCATGCGATCTGCGGATTGTCCGGCGGGGTGGATTCCGCGGTG
GCCGCCGCCCTGGTGCAGCGCGCCATCGGCGATCGCTTGACGTGTGTGTTCGTCGACCACGGGTTGTTGCGTGCCGGTGA
ACGCGCGCAGGTGCAGCGCGATTTCGTGGCCGCCACCGGCGCCAACCTGGTCACCGTCGACGCGGCGGACACCTTCCTGC
AGGCGCTGGCCGGGGTGACCAACCCGGAGGGCAAGCGCAAGATCATCGGCCGGCAGTTCATCCGGGCGTTCGAGGGCGCG
GTGCGAGATGTGTTGGGGGACAAGCCGGTCGAGTTCCTGGTGCAGGGCACGCTGTATCCCGACGTGGTGGAGTCCGGCGG
GGGCAGCGGCACCGCGAACATCAAGAGCCACCACAACGTCGGGGGGCTGCCCGGCGACCTGAAGTTCACCCTCGTCGAGC
CGCTGCGGCTGCTGTTCAAGGACGAGGTGCGCGCGGTCGGCCGGGAACTGGGGCTGCCGGAGGAAATCGTTGCGCGCCAA
CCCTTTCCGGGTCCCGGCCTGGGCATCCGGATCGTCGGCGAGGTCACCGCGACGCGGCTGGACACGCTGCGGCGGGCGGA
CTCGATCGCGCGCGAGGAACTCACCGCCGCCGGCTTGGACTCGCTGATCTGGCAGTGCCCGGTGGTGCTGCTCGGTGAGG
TCCGCTCGGTGGGGGTGCAGGGCGACAACCGCACCTACGGGCATCCGATCGTGCTGCGGCCGGTGACCAGTGAGGACGCC
ATGACCGCGGACTGGACCCGGGTCCCCTACGAGGTGCTGGAGCGGATCTCGACCCGGATCACCAACGAGGTCCCCGAGGT
CAACCGCGTGGTGCTGGACATCACCAGCAAGCCGCCCGGCACCATCGAGTGGGAGTAG

Upstream 100 bases:

>100_bases
CGGGAGGCTCATATCGAAGGCATAGAATTCGCTCGGTGCCGCGCTTTCGCTGCGGGCCTCGGGGGCCGGGGCCGGCGGAG
GCGGCCACTAGACTTCTGGC

Downstream 100 bases:

>100_bases
CCGCCCCGCCGGAAATGGGCTCGGGCTGCCGTCAGCCGGACGGGATGGTCGCCGCGCCGCCGCCGAGGGCGCGCGGCGCG
ATCCGCCGCTGTGCGGTCTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MAESPPTEVPEPPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTATIEEIKARQPRALVLSGGPSSVYEPGAPQLDP
AVFDLGVPVFGICYGFQAMAQALGGTVAHTGTSEYGRTELKVLGGELHSGLPGVQPVWMSHGDAVTAAPDGFEVVASSPG
AVVAAFENRARRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGADWTAANIAGVLVEQVRAQIGDGHAICGLSGGVDSAV
AAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAADTFLQALAGVTNPEGKRKIIGRQFIRAFEGA
VRDVLGDKPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPGDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQ
PFPGPGLGIRIVGEVTATRLDTLRRADSIAREELTAAGLDSLIWQCPVVLLGEVRSVGVQGDNRTYGHPIVLRPVTSEDA
MTADWTRVPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE

Sequences:

>Translated_525_residues
MAESPPTEVPEPPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTATIEEIKARQPRALVLSGGPSSVYEPGAPQLDP
AVFDLGVPVFGICYGFQAMAQALGGTVAHTGTSEYGRTELKVLGGELHSGLPGVQPVWMSHGDAVTAAPDGFEVVASSPG
AVVAAFENRARRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGADWTAANIAGVLVEQVRAQIGDGHAICGLSGGVDSAV
AAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAADTFLQALAGVTNPEGKRKIIGRQFIRAFEGA
VRDVLGDKPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPGDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQ
PFPGPGLGIRIVGEVTATRLDTLRRADSIAREELTAAGLDSLIWQCPVVLLGEVRSVGVQGDNRTYGHPIVLRPVTSEDA
MTADWTRVPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE
>Mature_524_residues
AESPPTEVPEPPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTATIEEIKARQPRALVLSGGPSSVYEPGAPQLDPA
VFDLGVPVFGICYGFQAMAQALGGTVAHTGTSEYGRTELKVLGGELHSGLPGVQPVWMSHGDAVTAAPDGFEVVASSPGA
VVAAFENRARRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGADWTAANIAGVLVEQVRAQIGDGHAICGLSGGVDSAVA
AALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAADTFLQALAGVTNPEGKRKIIGRQFIRAFEGAV
RDVLGDKPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPGDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQP
FPGPGLGIRIVGEVTATRLDTLRRADSIAREELTAAGLDSLIWQCPVVLLGEVRSVGVQGDNRTYGHPIVLRPVTSEDAM
TADWTRVPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=36.5454545454545, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1788854, Length=520, Percent_Identity=49.6153846153846, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1789760, Length=155, Percent_Identity=34.1935483870968, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787517, Length=186, Percent_Identity=28.494623655914, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133901714, Length=584, Percent_Identity=35.7876712328767, Blast_Score=294, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI71992717, Length=584, Percent_Identity=35.7876712328767, Blast_Score=294, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI71992710, Length=584, Percent_Identity=35.7876712328767, Blast_Score=294, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6323873, Length=515, Percent_Identity=45.4368932038835, Blast_Score=455, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6322638, Length=159, Percent_Identity=29.559748427673, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281365319, Length=541, Percent_Identity=34.5656192236599, Blast_Score=275, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_MYCPA (Q73U79)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_962423.1
- ProteinModelPortal:   Q73U79
- EnsemblBacteria:   EBMYCT00000036569
- GeneID:   2721170
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP3489c
- NMPDR:   fig|262316.1.peg.3489
- GeneTree:   EBGT00050000015860
- HOGENOM:   HBG391775
- OMA:   PSTIEPC
- ProtClustDB:   PRK00074
- BRENDA:   6.3.5.2
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 55907; Mature: 55776

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 93-93 ACT_SITE 179-179 ACT_SITE 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESPPTEVPEPPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTATIEEIKARQPRA
CCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCE
LVLSGGPSSVYEPGAPQLDPAVFDLGVPVFGICYGFQAMAQALGGTVAHTGTSEYGRTEL
EEEECCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEE
KVLGGELHSGLPGVQPVWMSHGDAVTAAPDGFEVVASSPGAVVAAFENRARRLAGVQYHP
EEECCHHHCCCCCCCCHHHCCCCEEEECCCCCEEEECCCCCEEEHHHHHHHHHHCCCCCC
EVMHTPHGQQVLSRFLHDFAGLGADWTAANIAGVLVEQVRAQIGDGHAICGLSGGVDSAV
HHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
AAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAADTFLQALAGVT
HHHHHHHHHCCCEEEEEECCHHHHCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHCCC
NPEGKRKIIGRQFIRAFEGAVRDVLGDKPVEFLVQGTLYPDVVESGGGSGTANIKSHHNV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCHHHHHCCCCCCCCCCCCCCCC
GGLPGDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIVGEVTATRL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEECHHHHHHH
DTLRRADSIAREELTAAGLDSLIWQCPVVLLGEVRSVGVQGDNRTYGHPIVLRPVTSEDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCC
MTADWTRVPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE
CCCCHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
AESPPTEVPEPPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTATIEEIKARQPRA
CCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCE
LVLSGGPSSVYEPGAPQLDPAVFDLGVPVFGICYGFQAMAQALGGTVAHTGTSEYGRTEL
EEEECCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEE
KVLGGELHSGLPGVQPVWMSHGDAVTAAPDGFEVVASSPGAVVAAFENRARRLAGVQYHP
EEECCHHHCCCCCCCCHHHCCCCEEEECCCCCEEEECCCCCEEEHHHHHHHHHHCCCCCC
EVMHTPHGQQVLSRFLHDFAGLGADWTAANIAGVLVEQVRAQIGDGHAICGLSGGVDSAV
HHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
AAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAADTFLQALAGVT
HHHHHHHHHCCCEEEEEECCHHHHCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHCCC
NPEGKRKIIGRQFIRAFEGAVRDVLGDKPVEFLVQGTLYPDVVESGGGSGTANIKSHHNV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCHHHHHCCCCCCCCCCCCCCCC
GGLPGDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIVGEVTATRL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEECHHHHHHH
DTLRRADSIAREELTAAGLDSLIWQCPVVLLGEVRSVGVQGDNRTYGHPIVLRPVTSEDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCC
MTADWTRVPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE
CCCCHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA