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The map label for this gene is metC

Identifier: 41409555

GI number: 41409555

Start: 3838860

End: 3840230

Strand: Direct

Name: metC

Synonym: MAP3457

Alternate gene names: 41409555

Gene position: 3838860-3840230 (Clockwise)

Preceding gene: 41409552

Following gene: 41409556

Centisome position: 79.48

GC content: 69.29

Gene sequence:

>1371_bases
GTGAGCTCCGAGAACACCGATCACGACACCGACCCCAGCGCGCACTGGTCGTTCGAGACCAAGCAGGTGCACGCCGGCCA
GCACCCCGACTCGGCCACCAACGCCCGGGCCCTGCCGATCTACCAGACCACGTCGTACACCTTCGACGACACCACCCACG
CCGCCGCCCTGTTCGGGCTGGAGGTGCCGGGCAACATCTACACCCGGATCGGCAACCCGACCACCGACGTCGTCGAGCAG
CGCATCGCCGCCCTGGAGGGCGGGGTGGCGGCGCTGTTTCTGAGCTCCGGTCAGGCCGCTGAGACTTTCGCCATATTGAA
CCTGGCAAGTGCCGGAGATCACATCGTCTCCAGCCCGCGGCTCTACGGCGGCACCTACAACCTGTTCCACTATTCGCTGG
CCAAGCTCGGTATCGAGGTCAGCTTCGTGGAGGATCCCGACGACCTGGATTCCTGGCAGGCCGCGGTCCGGCCGAACACC
AAGGCGTTCTTCGCCGAGACCATCTCCAACCCGCAGATCGACATCCTGGACATCCCTGGCGTCTCGGGCGTCGCCCACGC
CAACGGCGTGCCGCTGATCGTCGACAACACCATCGCCACGCCGTACCTGATCCAGCCGTTCGCGCACGGCGCCGACATCG
TGGTGCACTCGGCCACCAAGTACCTCGGCGGTCACGGCTCGGCGATCGCCGGCGTGATCGTCGACGGCGGCACCTTCGAC
TGGACGCAGGGCCGGTTCCCGGGCTTCACCACCCCCGACCCGAGCTACCACGGCGTGGTGTTCGCGGAGCTGGGGCCGCC
GGCGTACGCGCTCAAGGCCCGCGTGCAGTTGCTGCGCGACCTCGGCTCGGCCGCGGCGCCGTTCAACGCGTTCCTGGTCG
CCCAGGGCATCGAGACGCTGAGCCTGCGCATGGAGCGGCACGTCGCCAACGCGCAGCGGGTGGCCGAGTTCCTGGCCTCT
CATGACGGCGTGCTGTCGGTGAACTACGCGGGACTGCCCGGCTCGCCGTGGCACGAGCGGGCAAAGAAGCTGGCGCCCAA
GGGAACCGGGGCGGTGCTGTCGTTCGAGTTGGCCGGCGGGGTGGAGGCCGGCAAGGCGTTCGTGAACGCGCTGAAGCTGC
ACAGCCACGTCGCCAACATCGGCGACGTCCGCTCGCTGGTCATCCACCCGGCCTCGACCACGCACGCCCAACTGTCCCCG
GCCGAGCAGCTGAGCACCGGGGTCAGCCCGGGCCTGGTGCGGCTGGCGGTCGGCATCGAGGGAATCGACGACATCCTGGC
CGACCTGGAGCTCGGTTTCGCCGCGGCCGCCAAATTCGGTGCGAACGCGGACACCTCCGGCGCCGACCCGCACGCCGTGG
CGGCGTTCTGA

Upstream 100 bases:

>100_bases
TCGATCGCGCCCGCGCGTGCGTCGCTGCTGACGGCTGCCCGCCGGATTCTTCTTCCGACTTCTTCCGACCGACTTCTTCC
GACCGAGAGAAAGCACCCCC

Downstream 100 bases:

>100_bases
CGGACCCGGCCATGACCATCCCCGACGTTCCCACCCAGACGCTGCCCGACGAAGGCGAAATCGGCTTCGTCCACATCGGC
TCGCTGACCACCGAGGCCGG

Product: O-acetylhomoserine aminocarboxypropyltransferase

Products: NA

Alternate protein names: L-methioninase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSSENTDHDTDPSAHWSFETKQVHAGQHPDSATNARALPIYQTTSYTFDDTTHAAALFGLEVPGNIYTRIGNPTTDVVEQ
RIAALEGGVAALFLSSGQAAETFAILNLASAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVEDPDDLDSWQAAVRPNT
KAFFAETISNPQIDILDIPGVSGVAHANGVPLIVDNTIATPYLIQPFAHGADIVVHSATKYLGGHGSAIAGVIVDGGTFD
WTQGRFPGFTTPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAAAPFNAFLVAQGIETLSLRMERHVANAQRVAEFLAS
HDGVLSVNYAGLPGSPWHERAKKLAPKGTGAVLSFELAGGVEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSP
AEQLSTGVSPGLVRLAVGIEGIDDILADLELGFAAAAKFGANADTSGADPHAVAAF

Sequences:

>Translated_456_residues
MSSENTDHDTDPSAHWSFETKQVHAGQHPDSATNARALPIYQTTSYTFDDTTHAAALFGLEVPGNIYTRIGNPTTDVVEQ
RIAALEGGVAALFLSSGQAAETFAILNLASAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVEDPDDLDSWQAAVRPNT
KAFFAETISNPQIDILDIPGVSGVAHANGVPLIVDNTIATPYLIQPFAHGADIVVHSATKYLGGHGSAIAGVIVDGGTFD
WTQGRFPGFTTPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAAAPFNAFLVAQGIETLSLRMERHVANAQRVAEFLAS
HDGVLSVNYAGLPGSPWHERAKKLAPKGTGAVLSFELAGGVEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSP
AEQLSTGVSPGLVRLAVGIEGIDDILADLELGFAAAAKFGANADTSGADPHAVAAF
>Mature_455_residues
SSENTDHDTDPSAHWSFETKQVHAGQHPDSATNARALPIYQTTSYTFDDTTHAAALFGLEVPGNIYTRIGNPTTDVVEQR
IAALEGGVAALFLSSGQAAETFAILNLASAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVEDPDDLDSWQAAVRPNTK
AFFAETISNPQIDILDIPGVSGVAHANGVPLIVDNTIATPYLIQPFAHGADIVVHSATKYLGGHGSAIAGVIVDGGTFDW
TQGRFPGFTTPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAAAPFNAFLVAQGIETLSLRMERHVANAQRVAEFLASH
DGVLSVNYAGLPGSPWHERAKKLAPKGTGAVLSFELAGGVEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPA
EQLSTGVSPGLVRLAVGIEGIDDILADLELGFAAAAKFGANADTSGADPHAVAAF

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG2873

COG function: function code E; O-acetylhomoserine sulfhydrylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=403, Percent_Identity=33.7468982630273, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI299473759, Length=403, Percent_Identity=30.0248138957816, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI25453487, Length=402, Percent_Identity=29.8507462686567, Blast_Score=159, Evalue=7e-39,
Organism=Escherichia coli, GI1790375, Length=420, Percent_Identity=33.8095238095238, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1789383, Length=424, Percent_Identity=26.8867924528302, Blast_Score=135, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71980708, Length=410, Percent_Identity=33.9024390243902, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17538055, Length=408, Percent_Identity=34.8039215686275, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17560056, Length=411, Percent_Identity=35.7664233576642, Blast_Score=217, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6323333, Length=432, Percent_Identity=48.8425925925926, Blast_Score=352, Evalue=5e-98,
Organism=Saccharomyces cerevisiae, GI6319307, Length=427, Percent_Identity=33.9578454332553, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321170, Length=339, Percent_Identity=28.023598820059, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321254, Length=438, Percent_Identity=26.9406392694064, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6321904, Length=418, Percent_Identity=26.555023923445, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI19922554, Length=424, Percent_Identity=33.7264150943396, Blast_Score=221, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006237
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.11 [H]

Molecular weight: Translated: 47749; Mature: 47618

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSENTDHDTDPSAHWSFETKQVHAGQHPDSATNARALPIYQTTSYTFDDTTHAAALFGL
CCCCCCCCCCCCCCCEEEECCEEECCCCCCCCCCCEEEEEEEECCEECCCCCCEEEEEEE
EVPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLASAGDHIVSSPR
ECCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCCHHHCCCE
LYGGTYNLFHYSLAKLGIEVSFVEDPDDLDSWQAAVRPNTKAFFAETISNPQIDILDIPG
EECCCHHHHHHHHHHHCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCC
VSGVAHANGVPLIVDNTIATPYLIQPFAHGADIVVHSATKYLGGHGSAIAGVIVDGGTFD
CCCCCCCCCCCEEEECCCCCCCEECCCCCCCEEEEEEHHHHHCCCCCEEEEEEEECCEEC
WTQGRFPGFTTPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAAAPFNAFLVAQGIETL
CCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHH
SLRMERHVANAQRVAEFLASHDGVLSVNYAGLPGSPWHERAKKLAPKGTGAVLSFELAGG
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEEECCC
VEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLSTGVSPGLVRLAVGIE
CHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCEEEEEECCC
GIDDILADLELGFAAAAKFGANADTSGADPHAVAAF
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
>Mature Secondary Structure 
SSENTDHDTDPSAHWSFETKQVHAGQHPDSATNARALPIYQTTSYTFDDTTHAAALFGL
CCCCCCCCCCCCCCEEEECCEEECCCCCCCCCCCEEEEEEEECCEECCCCCCEEEEEEE
EVPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLASAGDHIVSSPR
ECCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCCHHHCCCE
LYGGTYNLFHYSLAKLGIEVSFVEDPDDLDSWQAAVRPNTKAFFAETISNPQIDILDIPG
EECCCHHHHHHHHHHHCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCC
VSGVAHANGVPLIVDNTIATPYLIQPFAHGADIVVHSATKYLGGHGSAIAGVIVDGGTFD
CCCCCCCCCCCEEEECCCCCCCEECCCCCCCEEEEEEHHHHHCCCCCEEEEEEEECCEEC
WTQGRFPGFTTPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAAAPFNAFLVAQGIETL
CCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHH
SLRMERHVANAQRVAEFLASHDGVLSVNYAGLPGSPWHERAKKLAPKGTGAVLSFELAGG
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEEECCC
VEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLSTGVSPGLVRLAVGIE
CHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCEEEEEECCC
GIDDILADLELGFAAAAKFGANADTSGADPHAVAAF
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8586629; 9190812; 3365412 [H]