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The map label for this gene is rmlA2

Identifier: 41409476

GI number: 41409476

Start: 3751630

End: 3752706

Strand: Reverse

Name: rmlA2

Synonym: MAP3378c

Alternate gene names: 41409476

Gene position: 3752706-3751630 (Counterclockwise)

Preceding gene: 41409477

Following gene: 41409470

Centisome position: 77.7

GC content: 72.7

Gene sequence:

>1077_bases
GTGGGAACTCCCGAAGTCGACGTGGTGATCCTGGTGGGCGGCAAGGGCACCCGGCTGCGGCCGCTGACCCTGTCGGCGCC
CAAGCCGATGCTGCCCACCGCCGGGCTGCCGTTCCTCACCCATCTGCTGTCCCGGATCGCCGCGGCCGGCATCGAGCACG
TCATCCTGAGCACGTCGTATCAGGCCGCGGTGTTCGAGGCGGAATTCGGCGACGGCTCCAAGCTGGGTCTGCAGATCGAG
TACGTGACCGAGGAGCGGCCGCTGGGCACCGGCGGCGGCATCGCCAACGTCGCCGGCCAGCTGCGGCACGACACCGTGAT
GGTGTTCAACGGCGACGTGCTCTCCGGTGCCGACCTGGGCCAGATGCTCGACTTCCACGCCGCGCAGCAGGCCGACGTCA
CCCTGCACCTGGTCCGGGTGAGCGATCCGCGCGCGTTCGGCTGCGTGACCACCGAGGACGGCCGGGTCACCGCGTTCCTG
GAGAAGACCCAGGACCCGCCGACCGACCAGATCAACGCCGGCTGCTACGTCTTCGCCCGCCGCGTCATCGACCGGATCCC
GCGCGGCCGCGAGGTGTCGGTGGAGCGCGAGGTGTTCCCCGCGCTGCTGTCCGATCCCGATGTCAAGGTGTGCGGCTACG
TCGACGCCACCTATTGGCGCGACATGGGCACCCCCGAGGACTTCGTGCGCGGCTCGGCGGATCTGGTGCGCGGCATCGCG
CCGTCGCCGGCCCTGCACGGCCACCGCGGCGAGCAGCTGGTGCACGACGGCGCGGCGGTGTCGCCGGGCGCCGTGCTGAT
CGGCGGCACCGTCGTCGGCCGGGGCGCCGAGATCGGCCCCGGCGTCCGGCTGGACGGCGCGGTGATCTTCGACGGCGTCA
AGGTGGAGGCCGGCAGCGTGATCGAGCGCTCGATCGTCGGGTTCGGCGCGCGCATCGGCCCGCGGGCGCTGATCCGCGAC
GGGGTGATCGGCGACGGCGCCGACATCGGGGCGCGCTGCGAGCTGCTGCGCGGCGCCCGGGTGTGGCCCGGCGTGTCGAT
CCCCGACGGCGGGATTCGCTACTCCTCCGACGTCTGA

Upstream 100 bases:

>100_bases
CTGCGCTGGGCGCTGCGCGCGTCGCTGGCGGTGCGCGCCCGGCTGATGGTGCGCAGCGCGCTGCGCGAGTCCGGGCGGCG
GGTAGAAGGGCGGCACTGAG

Downstream 100 bases:

>100_bases
GGCTCGCGTTCGCTTTCGCGTTCGCTCTCGCGTTCGCTTTCGCCGGGCGTCACGCCAGCGTGACGCCCGGCGCCGGCGGC
CACGCTAGCGTGACGCTCGC

Product: RmlA2

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MGTPEVDVVILVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILSTSYQAAVFEAEFGDGSKLGLQIE
YVTEERPLGTGGGIANVAGQLRHDTVMVFNGDVLSGADLGQMLDFHAAQQADVTLHLVRVSDPRAFGCVTTEDGRVTAFL
EKTQDPPTDQINAGCYVFARRVIDRIPRGREVSVEREVFPALLSDPDVKVCGYVDATYWRDMGTPEDFVRGSADLVRGIA
PSPALHGHRGEQLVHDGAAVSPGAVLIGGTVVGRGAEIGPGVRLDGAVIFDGVKVEAGSVIERSIVGFGARIGPRALIRD
GVIGDGADIGARCELLRGARVWPGVSIPDGGIRYSSDV

Sequences:

>Translated_358_residues
MGTPEVDVVILVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILSTSYQAAVFEAEFGDGSKLGLQIE
YVTEERPLGTGGGIANVAGQLRHDTVMVFNGDVLSGADLGQMLDFHAAQQADVTLHLVRVSDPRAFGCVTTEDGRVTAFL
EKTQDPPTDQINAGCYVFARRVIDRIPRGREVSVEREVFPALLSDPDVKVCGYVDATYWRDMGTPEDFVRGSADLVRGIA
PSPALHGHRGEQLVHDGAAVSPGAVLIGGTVVGRGAEIGPGVRLDGAVIFDGVKVEAGSVIERSIVGFGARIGPRALIRD
GVIGDGADIGARCELLRGARVWPGVSIPDGGIRYSSDV
>Mature_357_residues
GTPEVDVVILVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILSTSYQAAVFEAEFGDGSKLGLQIEY
VTEERPLGTGGGIANVAGQLRHDTVMVFNGDVLSGADLGQMLDFHAAQQADVTLHLVRVSDPRAFGCVTTEDGRVTAFLE
KTQDPPTDQINAGCYVFARRVIDRIPRGREVSVEREVFPALLSDPDVKVCGYVDATYWRDMGTPEDFVRGSADLVRGIAP
SPALHGHRGEQLVHDGAAVSPGAVLIGGTVVGRGAEIGPGVRLDGAVIFDGVKVEAGSVIERSIVGFGARIGPRALIRDG
VIGDGADIGARCELLRGARVWPGVSIPDGGIRYSSDV

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=361, Percent_Identity=34.0720221606648, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI11761619, Length=352, Percent_Identity=33.2386363636364, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI31881779, Length=399, Percent_Identity=26.8170426065163, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI45447090, Length=399, Percent_Identity=26.8170426065163, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1788351, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790224, Length=181, Percent_Identity=30.939226519337, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI133931050, Length=356, Percent_Identity=32.8651685393258, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17509979, Length=331, Percent_Identity=26.8882175226586, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17509981, Length=323, Percent_Identity=25.6965944272446, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320148, Length=354, Percent_Identity=29.6610169491525, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21355443, Length=350, Percent_Identity=34, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24644084, Length=350, Percent_Identity=34, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24653912, Length=369, Percent_Identity=27.10027100271, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 37643; Mature: 37512

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTPEVDVVILVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILSTSY
CCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCHHEEEEECCC
QAAVFEAEFGDGSKLGLQIEYVTEERPLGTGGGIANVAGQLRHDTVMVFNGDVLSGADLG
EEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCEECCCCHH
QMLDFHAAQQADVTLHLVRVSDPRAFGCVTTEDGRVTAFLEKTQDPPTDQINAGCYVFAR
HHHHHHCCCCCCEEEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHH
RVIDRIPRGREVSVEREVFPALLSDPDVKVCGYVDATYWRDMGTPEDFVRGSADLVRGIA
HHHHHCCCCCEEEEHHHHHHHHHCCCCEEEEEEECHHHHHCCCCHHHHHCCCHHHHHCCC
PSPALHGHRGEQLVHDGAAVSPGAVLIGGTVVGRGAEIGPGVRLDGAVIFDGVKVEAGSV
CCCCCCCCCCCHHHHCCCCCCCCEEEEECEEEECCCCCCCCEEECCEEEEECEEECCCHH
IERSIVGFGARIGPRALIRDGVIGDGADIGARCELLRGARVWPGVSIPDGGIRYSSDV
HHHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEECCCC
>Mature Secondary Structure 
GTPEVDVVILVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILSTSY
CCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCHHEEEEECCC
QAAVFEAEFGDGSKLGLQIEYVTEERPLGTGGGIANVAGQLRHDTVMVFNGDVLSGADLG
EEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCEECCCCHH
QMLDFHAAQQADVTLHLVRVSDPRAFGCVTTEDGRVTAFLEKTQDPPTDQINAGCYVFAR
HHHHHHCCCCCCEEEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHH
RVIDRIPRGREVSVEREVFPALLSDPDVKVCGYVDATYWRDMGTPEDFVRGSADLVRGIA
HHHHHCCCCCEEEEHHHHHHHHHCCCCEEEEEEECHHHHHCCCCHHHHHCCCHHHHHCCC
PSPALHGHRGEQLVHDGAAVSPGAVLIGGTVVGRGAEIGPGVRLDGAVIFDGVKVEAGSV
CCCCCCCCCCCHHHHCCCCCCCCEEEEECEEEECCCCCCCCEEECCEEEEECEEECCCHH
IERSIVGFGARIGPRALIRDGVIGDGADIGARCELLRGARVWPGVSIPDGGIRYSSDV
HHHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]