Click here to switch to the map view.

The map label for this gene is mtrB

Identifier: 41409457

GI number: 41409457

Start: 3731171

End: 3732865

Strand: Reverse

Name: mtrB

Synonym: MAP3359c

Alternate gene names: 41409457

Gene position: 3732865-3731171 (Counterclockwise)

Preceding gene: 41409458

Following gene: 41409456

Centisome position: 77.29

GC content: 71.15

Gene sequence:

>1695_bases
ATGTGGGGCTCCCGGCGACGTACGCGGAGCCGCTGGGGGCGCTCCGGTCCGATGACTCGCGGCATGGGCGCGGTGAGCCG
GGCGGTGGGCACGGCCTGGCGGCGCTCGCTGCAGCTGCGGGTGGTGGCGCTGACCCTGGGACTGTCCCTGGCGGTCATCC
TGGCGCTGGGCTTCGTGCTGACGTCCCAGGTCACCAATCGCGTGCTCGACGTCAAGGTGAAGGCCGCCATCGAGCAGATC
GAGCGGGCCCGCACCACGGTCGGCGGGATCGTCAACGGCGAAGAGGCGCGCTCGCTGGACAGCAGCCTGCAGCTGGCCCG
CAACACGCTGACGTCTAAGACCGATTCAGCCTCGGGGGCGGGGACGGCCGGCACCTTCGACGCCGTGCTGATGGTGCCCG
GTGACGGCCCACGCGCGGCCACCACGGCCGGCCCCGTCGATCAGGTGCCCGCTTCGCTGCGGGGCTTCGTCAAGGCCGGG
CAGGCGTCCTACCAGTACGCCACCGTGCACACCGACGGGTTCTCCGGGCCGGCGCTGATCGTCGGCAGCCCGGCCTCCTC
CCAGGTGGCCAACCTGGAGCTGTACCTGATCTTCCCGCTGAAGAACGAACAGGCCACCATCCAGCTGGTGCGCGGCACCA
TGATCACCGGCGGCGCCGTGCTGCTGGTGCTGCTGGCCGGGATCGCGCTGCTGGTGTCGCGGCAGGTGGTGGTGCCGGTG
CGTTCGGCGTCGCGCATCGCCGAACGGTTCGCCGAGGGGCATCTGTCCGAGCGGATGCCGGTGCGCGGCGAGGACGACAT
GGCCCGGCTGGCGATGTCGTTCAACGACATGGCCGAGAGCCTGTCGCGGCAGATCACCCAACTGGAGGAGTTCGGAAACC
TGCAGCGCCGCTTCACTTCCGACGTGAGCCACGAGCTGCGCACCCCGCTGACCACGGTGCGCATGGCCGCCGACCTGATC
TACGACCACAGCGCCGACCTCGATCCGACGCTGGCGCGCTCCACCGAGCTGATGGTCAACGAGCTGGACCGGTTCGAGTC
GCTGCTCAACGACCTGCTGGAGATCTCCCGGCACGACGCCGGGGTCGCCGAGCTGTCCGTCGAGGCGGTCGACCTGCGCA
GCACGGTGCAGAGCGCGCTGAGCAACGTGGGGCATCTGGCCGAGGACGCCGGCATCGAACTGCAGGTGGAGCTGCCGGCC
GAGGAGGTCATCGCCGAGGTCGACACCCGCCGGGTGGAGCGGATCTTGCGCAACCTGATCGCCAACGCCATCGACCACGC
CGAGCACAAGCCGGTCAAGATCCGGATGGCCGCCGACGAGGACACCGTCGCGGTCACCGTCCGCGACTACGGGGTGGGGT
TGCGGCCCGGCGAGGAGAAGCTGGTGTTCAGCCGGTTCTGGCGGGCGGACCCGTCGCGGGTGCGCCGCTCCGGCGGCACC
GGCCTGGGCCTGGCGATCAGCATCGAGGACGCCCGGCTGCATCAGGGCCGGCTGGAGGCGTGGGGCGAACCGGGCGTCGG
CTCGTGCTTCCGGCTCACCCTGCCGCTGGTCCGCGGCCACAAGGTGACCACCAGCCCGCTGCCGATGAAGCCGATCCCGC
AGCCGTCCCCGTCCGGTGGGCAGTCCCCGTCGACCGGCCCGCAACACGCGAAAGACCGTGCGCGCCAACGCGAGCACGCC
GAAAGGTCGCTGTGA

Upstream 100 bases:

>100_bases
ACCGTTCGAGGAGTGGGTTACAAGGCCGGACCTCCGTGATCGCCGGCTGCGCCGGCGAAGATGCAGAACGGAGTGATGCT
GAGGGGCGGCGTCATTGATG

Downstream 100 bases:

>100_bases
TGGGGCGTAAGCTCCTGGGCCTGCTGATGCTGGCCGTGCTGCTCGCCGGCTGCGCCGGGGTGCCCAGTTCGTCGGCGCCG
CAAGCCATCGGCACCGTCGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MWGSRRRTRSRWGRSGPMTRGMGAVSRAVGTAWRRSLQLRVVALTLGLSLAVILALGFVLTSQVTNRVLDVKVKAAIEQI
ERARTTVGGIVNGEEARSLDSSLQLARNTLTSKTDSASGAGTAGTFDAVLMVPGDGPRAATTAGPVDQVPASLRGFVKAG
QASYQYATVHTDGFSGPALIVGSPASSQVANLELYLIFPLKNEQATIQLVRGTMITGGAVLLVLLAGIALLVSRQVVVPV
RSASRIAERFAEGHLSERMPVRGEDDMARLAMSFNDMAESLSRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLI
YDHSADLDPTLARSTELMVNELDRFESLLNDLLEISRHDAGVAELSVEAVDLRSTVQSALSNVGHLAEDAGIELQVELPA
EEVIAEVDTRRVERILRNLIANAIDHAEHKPVKIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRADPSRVRRSGGT
GLGLAISIEDARLHQGRLEAWGEPGVGSCFRLTLPLVRGHKVTTSPLPMKPIPQPSPSGGQSPSTGPQHAKDRARQREHA
ERSL

Sequences:

>Translated_564_residues
MWGSRRRTRSRWGRSGPMTRGMGAVSRAVGTAWRRSLQLRVVALTLGLSLAVILALGFVLTSQVTNRVLDVKVKAAIEQI
ERARTTVGGIVNGEEARSLDSSLQLARNTLTSKTDSASGAGTAGTFDAVLMVPGDGPRAATTAGPVDQVPASLRGFVKAG
QASYQYATVHTDGFSGPALIVGSPASSQVANLELYLIFPLKNEQATIQLVRGTMITGGAVLLVLLAGIALLVSRQVVVPV
RSASRIAERFAEGHLSERMPVRGEDDMARLAMSFNDMAESLSRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLI
YDHSADLDPTLARSTELMVNELDRFESLLNDLLEISRHDAGVAELSVEAVDLRSTVQSALSNVGHLAEDAGIELQVELPA
EEVIAEVDTRRVERILRNLIANAIDHAEHKPVKIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRADPSRVRRSGGT
GLGLAISIEDARLHQGRLEAWGEPGVGSCFRLTLPLVRGHKVTTSPLPMKPIPQPSPSGGQSPSTGPQHAKDRARQREHA
ERSL
>Mature_564_residues
MWGSRRRTRSRWGRSGPMTRGMGAVSRAVGTAWRRSLQLRVVALTLGLSLAVILALGFVLTSQVTNRVLDVKVKAAIEQI
ERARTTVGGIVNGEEARSLDSSLQLARNTLTSKTDSASGAGTAGTFDAVLMVPGDGPRAATTAGPVDQVPASLRGFVKAG
QASYQYATVHTDGFSGPALIVGSPASSQVANLELYLIFPLKNEQATIQLVRGTMITGGAVLLVLLAGIALLVSRQVVVPV
RSASRIAERFAEGHLSERMPVRGEDDMARLAMSFNDMAESLSRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLI
YDHSADLDPTLARSTELMVNELDRFESLLNDLLEISRHDAGVAELSVEAVDLRSTVQSALSNVGHLAEDAGIELQVELPA
EEVIAEVDTRRVERILRNLIANAIDHAEHKPVKIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRADPSRVRRSGGT
GLGLAISIEDARLHQGRLEAWGEPGVGSCFRLTLPLVRGHKVTTSPLPMKPIPQPSPSGGQSPSTGPQHAKDRARQREHA
ERSL

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1790346, Length=330, Percent_Identity=30.3030303030303, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1788393, Length=286, Percent_Identity=29.7202797202797, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1786783, Length=345, Percent_Identity=26.6666666666667, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1789149, Length=372, Percent_Identity=26.0752688172043, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1787894, Length=272, Percent_Identity=28.6764705882353, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI87081816, Length=432, Percent_Identity=27.3148148148148, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1786912, Length=325, Percent_Identity=27.6923076923077, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87082128, Length=315, Percent_Identity=26.031746031746, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=28.099173553719, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786600, Length=239, Percent_Identity=27.6150627615063, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=25.3164556962025, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=250, Percent_Identity=28, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=26.8, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=27.9279279279279, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI48994928, Length=227, Percent_Identity=29.5154185022026, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789403, Length=225, Percent_Identity=29.3333333333333, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=277, Percent_Identity=24.9097472924188, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=25, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=26.2626262626263, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTRB_MYCPA (Q93CB7)

Other databases:

- EMBL:   AF410884
- EMBL:   AE016958
- RefSeq:   NP_962293.1
- ProteinModelPortal:   Q93CB7
- SMR:   Q93CB7
- EnsemblBacteria:   EBMYCT00000039760
- GeneID:   2717963
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP3359c
- NMPDR:   fig|262316.1.peg.3359
- GeneTree:   EBGT00050000014826
- HOGENOM:   HBG428949
- OMA:   MVNELDR
- ProtClustDB:   CLSK792375
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 60942; Mature: 60942

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x106a181c)-; HASH(0x128cdfc4)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWGSRRRTRSRWGRSGPMTRGMGAVSRAVGTAWRRSLQLRVVALTLGLSLAVILALGFVL
CCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHH
TSQVTNRVLDVKVKAAIEQIERARTTVGGIVNGEEARSLDSSLQLARNTLTSKTDSASGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
GTAGTFDAVLMVPGDGPRAATTAGPVDQVPASLRGFVKAGQASYQYATVHTDGFSGPALI
CCCCCCEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCCEEE
VGSPASSQVANLELYLIFPLKNEQATIQLVRGTMITGGAVLLVLLAGIALLVSRQVVVPV
EECCCCCCEEEEEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEC
RSASRIAERFAEGHLSERMPVRGEDDMARLAMSFNDMAESLSRQITQLEEFGNLQRRFTS
HHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVSHELRTPLTTVRMAADLIYDHSADLDPTLARSTELMVNELDRFESLLNDLLEISRHDA
HHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GVAELSVEAVDLRSTVQSALSNVGHLAEDAGIELQVELPAEEVIAEVDTRRVERILRNLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHH
ANAIDHAEHKPVKIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRADPSRVRRSGGT
HHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHCCCC
GLGLAISIEDARLHQGRLEAWGEPGVGSCFRLTLPLVRGHKVTTSPLPMKPIPQPSPSGG
CEEEEEEECHHHHHCCHHHCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCC
QSPSTGPQHAKDRARQREHAERSL
CCCCCCCHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MWGSRRRTRSRWGRSGPMTRGMGAVSRAVGTAWRRSLQLRVVALTLGLSLAVILALGFVL
CCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHH
TSQVTNRVLDVKVKAAIEQIERARTTVGGIVNGEEARSLDSSLQLARNTLTSKTDSASGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
GTAGTFDAVLMVPGDGPRAATTAGPVDQVPASLRGFVKAGQASYQYATVHTDGFSGPALI
CCCCCCEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCCEEE
VGSPASSQVANLELYLIFPLKNEQATIQLVRGTMITGGAVLLVLLAGIALLVSRQVVVPV
EECCCCCCEEEEEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEC
RSASRIAERFAEGHLSERMPVRGEDDMARLAMSFNDMAESLSRQITQLEEFGNLQRRFTS
HHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVSHELRTPLTTVRMAADLIYDHSADLDPTLARSTELMVNELDRFESLLNDLLEISRHDA
HHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GVAELSVEAVDLRSTVQSALSNVGHLAEDAGIELQVELPAEEVIAEVDTRRVERILRNLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHH
ANAIDHAEHKPVKIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRADPSRVRRSGGT
HHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHCCCC
GLGLAISIEDARLHQGRLEAWGEPGVGSCFRLTLPLVRGHKVTTSPLPMKPIPQPSPSGG
CEEEEEEECHHHHHCCHHHCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCC
QSPSTGPQHAKDRARQREHAERSL
CCCCCCCHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA