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The map label for this gene is entC

Identifier: 41409414

GI number: 41409414

Start: 3686845

End: 3687939

Strand: Direct

Name: entC

Synonym: MAP3316

Alternate gene names: 41409414

Gene position: 3686845-3687939 (Clockwise)

Preceding gene: 41409413

Following gene: 41409415

Centisome position: 76.34

GC content: 72.79

Gene sequence:

>1095_bases
GTGAACGACGAACCGACGTTCGCGCTGTGCGGGCCGACGCAAACCCTGGTCGCCGACGGCGTACGGCGAAGCTACCGCGA
CGTGGCCGCCGCGCAGGCCGCGCTGCGCTCCCAAGAAGTGTCAATTGTGTTGGGCGCGTTGCCTTTCGACGTGCGCCGAC
CGGCCGCCCTGCTGACCCCGGATACCGTGAGCGTCAGCGACGGCCCACCGGACTGGCCGGCCCGGAAGCTGCCGTCGGTG
CGGGTTGCCGCCGCCCTCCCCCCGCCGATCGACTACCGGGACCGGATCTGCCGGGCCCGCGAGCAGCTCGCCGCAACCGA
CAACCCGCTGCACAAGGTGGTGCTGGCCCGCGCCCTGCACCTGGTCGCCGACGCCCCGCTGGATGCCCGCACCATCCTGC
GCCGGCTGATCGCCGCCGACCCGGGCGCGTACGGCTATCTCGTCGACCTCAGCGCCGCCGGCCACGACCATGCGGGCGTG
GCGCTGGTGGGCGCCAGCCCCGAGCTTCTGGTGGCGCGCACCGGCGACCGGGTCGAGTGCCGGCCGTTCGCCGGGTCGGC
CCCGCGTGCCGCCGATCCGGACACCGACGCGGCCAACGGTGCCGCGCTGGCGTCGTCGGCCAAGAACCGCCACGAGCATC
AGCTGGTGATCGAGACCATCAGGGCCGCCTTGGAGCCGCTGTGCGACGACCTGTCCATCGCGGCCGAACCGCAGCTGAGC
CGCACCGCCACGGTGTGGCACCTGTGCACGCCGATCAGCGGGCGGCTGCACGATAGGTCAACCACCGCAATCGATTTGGC
GCTGGCGTTGCACCCCACACCGGCGGTCGGCGGGGTGCCGACCGACGCCGCCGTCGAGCTGATCGCCGACCTGGAGGGCG
ACCGCGGCTTCTACGCCGGCGCGGTGGGATGGTGTGACGCCCGCGGCGACGGCCGCTGGGTGGTGTCCATCCGCTGCGCG
CAGTTGTCGGCCGACCGGCGCAGCGCGCTGGCGCGGGCCGGCGGCGGTATCGTCGCCGAATCCGATCCCGACGACGAAGT
CGCGGAAACCACAACGAAATTCGCCACCATACTCAACGCCCTGGACGTCCGATGA

Upstream 100 bases:

>100_bases
TGCCGCTCGCCGAAGGCAGCCGCTTCGCCATGATCACCGCGTCGATCGCGGTCTGCGGATTCGAGCACGGGGTGCGGCAA
CTGCGGGCGCTCGGGTTGAC

Downstream 100 bases:

>100_bases
GCCACCGAATCCGCCACGCCGCACCGCACGACGCCGCCGCCATCACCGAAATGATCCATGCGCTGGCCGAATTCGAGCGC
GCCGCCGATCAGTGCATGGT

Product: isochorismate synthase

Products: NA

Alternate protein names: Isochorismate mutase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MNDEPTFALCGPTQTLVADGVRRSYRDVAAAQAALRSQEVSIVLGALPFDVRRPAALLTPDTVSVSDGPPDWPARKLPSV
RVAAALPPPIDYRDRICRAREQLAATDNPLHKVVLARALHLVADAPLDARTILRRLIAADPGAYGYLVDLSAAGHDHAGV
ALVGASPELLVARTGDRVECRPFAGSAPRAADPDTDAANGAALASSAKNRHEHQLVIETIRAALEPLCDDLSIAAEPQLS
RTATVWHLCTPISGRLHDRSTTAIDLALALHPTPAVGGVPTDAAVELIADLEGDRGFYAGAVGWCDARGDGRWVVSIRCA
QLSADRRSALARAGGGIVAESDPDDEVAETTTKFATILNALDVR

Sequences:

>Translated_364_residues
MNDEPTFALCGPTQTLVADGVRRSYRDVAAAQAALRSQEVSIVLGALPFDVRRPAALLTPDTVSVSDGPPDWPARKLPSV
RVAAALPPPIDYRDRICRAREQLAATDNPLHKVVLARALHLVADAPLDARTILRRLIAADPGAYGYLVDLSAAGHDHAGV
ALVGASPELLVARTGDRVECRPFAGSAPRAADPDTDAANGAALASSAKNRHEHQLVIETIRAALEPLCDDLSIAAEPQLS
RTATVWHLCTPISGRLHDRSTTAIDLALALHPTPAVGGVPTDAAVELIADLEGDRGFYAGAVGWCDARGDGRWVVSIRCA
QLSADRRSALARAGGGIVAESDPDDEVAETTTKFATILNALDVR
>Mature_364_residues
MNDEPTFALCGPTQTLVADGVRRSYRDVAAAQAALRSQEVSIVLGALPFDVRRPAALLTPDTVSVSDGPPDWPARKLPSV
RVAAALPPPIDYRDRICRAREQLAATDNPLHKVVLARALHLVADAPLDARTILRRLIAADPGAYGYLVDLSAAGHDHAGV
ALVGASPELLVARTGDRVECRPFAGSAPRAADPDTDAANGAALASSAKNRHEHQLVIETIRAALEPLCDDLSIAAEPQLS
RTATVWHLCTPISGRLHDRSTTAIDLALALHPTPAVGGVPTDAAVELIADLEGDRGFYAGAVGWCDARGDGRWVVSIRCA
QLSADRRSALARAGGGIVAESDPDDEVAETTTKFATILNALDVR

Specific function: Might be involved in the biosynthesis of menaquinone. Converts chorismate to isochorismate [H]

COG id: COG1169

COG function: function code HQ; Isochorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786809, Length=328, Percent_Identity=39.3292682926829, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1788114, Length=275, Percent_Identity=27.6363636363636, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787518, Length=264, Percent_Identity=29.9242424242424, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082077, Length=260, Percent_Identity=31.1538461538462, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=324, Percent_Identity=29.9382716049383, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324361, Length=311, Percent_Identity=21.5434083601286, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR015890
- InterPro:   IPR004561 [H]

Pfam domain/function: PF00425 Chorismate_bind [H]

EC number: =5.4.4.2 [H]

Molecular weight: Translated: 38307; Mature: 38307

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDEPTFALCGPTQTLVADGVRRSYRDVAAAQAALRSQEVSIVLGALPFDVRRPAALLTP
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEECC
DTVSVSDGPPDWPARKLPSVRVAAALPPPIDYRDRICRAREQLAATDNPLHKVVLARALH
CEEECCCCCCCCCHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LVADAPLDARTILRRLIAADPGAYGYLVDLSAAGHDHAGVALVGASPELLVARTGDRVEC
HHHCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEECCCCEEE
RPFAGSAPRAADPDTDAANGAALASSAKNRHEHQLVIETIRAALEPLCDDLSIAAEPQLS
EECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
RTATVWHLCTPISGRLHDRSTTAIDLALALHPTPAVGGVPTDAAVELIADLEGDRGFYAG
HHEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEC
AVGWCDARGDGRWVVSIRCAQLSADRRSALARAGGGIVAESDPDDEVAETTTKFATILNA
CEEEEECCCCCEEEEEEEEEHHCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHH
LDVR
HCCC
>Mature Secondary Structure
MNDEPTFALCGPTQTLVADGVRRSYRDVAAAQAALRSQEVSIVLGALPFDVRRPAALLTP
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEECC
DTVSVSDGPPDWPARKLPSVRVAAALPPPIDYRDRICRAREQLAATDNPLHKVVLARALH
CEEECCCCCCCCCHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LVADAPLDARTILRRLIAADPGAYGYLVDLSAAGHDHAGVALVGASPELLVARTGDRVEC
HHHCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEECCCCEEE
RPFAGSAPRAADPDTDAANGAALASSAKNRHEHQLVIETIRAALEPLCDDLSIAAEPQLS
EECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
RTATVWHLCTPISGRLHDRSTTAIDLALALHPTPAVGGVPTDAAVELIADLEGDRGFYAG
HHEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEC
AVGWCDARGDGRWVVSIRCAQLSADRRSALARAGGGIVAESDPDDEVAETTTKFATILNA
CEEEEECCCCCEEEEEEEEEHHCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHH
LDVR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]