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The map label for this gene is uvrD2

Identifier: 41409395

GI number: 41409395

Start: 3663512

End: 3665623

Strand: Reverse

Name: uvrD2

Synonym: MAP3297c

Alternate gene names: 41409395

Gene position: 3665623-3663512 (Counterclockwise)

Preceding gene: 41409397

Following gene: 41409394

Centisome position: 75.9

GC content: 72.49

Gene sequence:

>2112_bases
ATGCCAACCCTCGCCGATCCCTTGACCGCCGGGCTGGACGACGAGCAACGCGAAGCCGTGCTGGCCCCGCGCGGCCCGGT
CTGCGTGCTGGCCGGCGCCGGCACCGGCAAGACCCGCACCATCACCCACCGGATCGCCCAGCTGGTCGCGGGCGGTCATG
TCGCCGCCAATCAGGTGCTGGCGGTCACCTTCACCCAGCGCGCGGCGGGGGAGATGCGCTCGCGGCTGCGGGTGCTCGCC
GCCGCGGCGGGCACCGACGCGGCGGTGGGCTCGGTCTCGGCGCTGACCTTTCACGCCGCCGCCCACCGGCAGCTGCGCTA
TTTCTGGCCGCGGGTGGTCGGCGACACCGGCTGGCAGCTGCTGGACAGCAAGTTCGCGGTGGTGGCCCGGGCGGCCAGCC
GCACCCGGATCAACGCCAGCACCGACGACGTGCGCGACCTGGCCGGCGAGATCGAGTGGGCCAAGGCGTCGCTGATCGGC
CCGGAGGAATACCCGGCCGCGGTGGCCGCCGCCGGGCGGGACATTCCGCTGGACGCCGCGAGGGTCGCCGGCGTGTACGC
CGCCTACGAAGCCCTCAAGGCCCGCGGCGACCACGTCACCCTGCTCGATTTCGACGACCTGCTGCTGCACACCGCGGCGG
CGATCGAAAACGACCCGGCGGTCGCCGAGGAGTTCCGCGACCGCTACCGCTGCTTCGTGGTCGACGAATACCAGGACGTC
ACCCCGTTGCAGCAGCGGGTGCTGGCCGCCTGGCTGGGCGATCGCGACGACTTGACCGTGGTGGGGGACGCCAACCAGAC
CATCTACTCGTTCACCGGGGCCTCCCCGAGGTTCCTGCTCGACTTCTCCCGCCGGTTCCCCGACGCGACCGTGGTGCGGC
TGGAACGCGACTACCGCTCCACCCCGCAGGTGGTGTCGCTGGCCAACCAGGTGATCGCCGCGGCCCGCGGACGGGTGGCC
GGCAGCAAGCTGCACCTGGTCGGGCAGCGGCCGCCGGGTCCGGTGCCGACCTTCCACGAGCACTCCGACGAACCGGCCGA
GGCCGCCGCCGTCGCCAAATCGATTGCGCGGCTGATCGAATCAGGCACCCCCGCCTCGGAGATCGCGGTGCTCTACCGGG
TCAACGCCCAGTCGGAGATCTACGAGGAGGCGCTGACCGAGGCCGGCATCCCCTATCAGGTTCGCGGCGGCGAGGGGTTC
TTCAACCGCCAGGAGATCAAGCAGGCCCTGCTGGCGCTGCAGCGCGCCGCCGAGCGCGAGGGCGAAGACGCCCGAGAAGA
GCCGCTGCCCGCGGTGGTGCGCGCGGTGCTGGAACCGCTGGGGCTGACGGCCGAAGAGCCGGTCGGCACCCGGGCCAGGG
AGCGCTGGGAGGCGCTGCGCGCGCTGGCCGAACTGGTCGACGACGAGGTGGCGCGGCGTCCGCAGCTGGACTTCGCCGGC
CTGCTGACCGAACTGCGGATGCGCGCCGACGCCCGGCACCCACCCGTGGTGCAGGGCGTCGCGCTGGCGTCGCTGCACGC
CGCCAAGGGACTCGAGTGGGACGCGGTGTTTCTGGTCGGCCTGGCCGACGGCACGCTACCCATCTCGCACGCGCTGGCGC
ACGGCGCCGACAGCGAGGCGGTCGAGGAGGAGCGGCGGCTGCTCTACGTCGGAATCACCAGGGCCAGAACACATTTGGCG
CTCAGCTGGGCGTTGGCCCGCAGCCCGGGCGGGCGGCAGAGCCGCAAGCCGTCGCGATTCCTCAACGGCATCGCACCCCA
GACCCGGGCCGAGGCGGCGCCGGCCAGGTCCCGCCGCAACCGCAGCACCGCCACCCGCTGCCGGATCTGCAACAACAACC
TGACCACCCCGGCGGCCGTCATGCTGCGACGTTGCGAGACGTGTGCCGCCGACATCGACGAGGACCTGCTGGTGCGGCTC
AAGGCGTGGCGGCTGGACGTCGCCAAGGAACAGAAGGTGCCCGCCTACGTCGTGTTCACCGACAACACCCTGATCGCCAT
CGCCGAGCTGCGGCCCGGCGACGAACAGGCGCTGATCGCGATTCCCGGCATCGGCGCGCGCAAGCTCGAGCAGTACGGCC
CCGACGTGCTGGAGCTGGTCCGCGGTCGCTGA

Upstream 100 bases:

>100_bases
ATTCCGCGCAGCGGGGTGCGCAGGAGCGGGCCGACTCGCCGGGGCGCGATGCATCCCGTTCGTCACCGACTTGTCAGTAT
GGGAAGCCAAGATGGACCCC

Downstream 100 bases:

>100_bases
CTGGCGAATCCGCAGGTCACAAAATCGGTTGTGATGGCCGACGGTCACCGTTTACCCTCGATACCGCAACCCGGCAGTAC
GGAAACTCAGCGGGACGGAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 703; Mature: 702

Protein sequence:

>703_residues
MPTLADPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAQLVAGGHVAANQVLAVTFTQRAAGEMRSRLRVLA
AAAGTDAAVGSVSALTFHAAAHRQLRYFWPRVVGDTGWQLLDSKFAVVARAASRTRINASTDDVRDLAGEIEWAKASLIG
PEEYPAAVAAAGRDIPLDAARVAGVYAAYEALKARGDHVTLLDFDDLLLHTAAAIENDPAVAEEFRDRYRCFVVDEYQDV
TPLQQRVLAAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDATVVRLERDYRSTPQVVSLANQVIAAARGRVA
GSKLHLVGQRPPGPVPTFHEHSDEPAEAAAVAKSIARLIESGTPASEIAVLYRVNAQSEIYEEALTEAGIPYQVRGGEGF
FNRQEIKQALLALQRAAEREGEDAREEPLPAVVRAVLEPLGLTAEEPVGTRARERWEALRALAELVDDEVARRPQLDFAG
LLTELRMRADARHPPVVQGVALASLHAAKGLEWDAVFLVGLADGTLPISHALAHGADSEAVEEERRLLYVGITRARTHLA
LSWALARSPGGRQSRKPSRFLNGIAPQTRAEAAPARSRRNRSTATRCRICNNNLTTPAAVMLRRCETCAADIDEDLLVRL
KAWRLDVAKEQKVPAYVVFTDNTLIAIAELRPGDEQALIAIPGIGARKLEQYGPDVLELVRGR

Sequences:

>Translated_703_residues
MPTLADPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAQLVAGGHVAANQVLAVTFTQRAAGEMRSRLRVLA
AAAGTDAAVGSVSALTFHAAAHRQLRYFWPRVVGDTGWQLLDSKFAVVARAASRTRINASTDDVRDLAGEIEWAKASLIG
PEEYPAAVAAAGRDIPLDAARVAGVYAAYEALKARGDHVTLLDFDDLLLHTAAAIENDPAVAEEFRDRYRCFVVDEYQDV
TPLQQRVLAAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDATVVRLERDYRSTPQVVSLANQVIAAARGRVA
GSKLHLVGQRPPGPVPTFHEHSDEPAEAAAVAKSIARLIESGTPASEIAVLYRVNAQSEIYEEALTEAGIPYQVRGGEGF
FNRQEIKQALLALQRAAEREGEDAREEPLPAVVRAVLEPLGLTAEEPVGTRARERWEALRALAELVDDEVARRPQLDFAG
LLTELRMRADARHPPVVQGVALASLHAAKGLEWDAVFLVGLADGTLPISHALAHGADSEAVEEERRLLYVGITRARTHLA
LSWALARSPGGRQSRKPSRFLNGIAPQTRAEAAPARSRRNRSTATRCRICNNNLTTPAAVMLRRCETCAADIDEDLLVRL
KAWRLDVAKEQKVPAYVVFTDNTLIAIAELRPGDEQALIAIPGIGARKLEQYGPDVLELVRGR
>Mature_702_residues
PTLADPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAQLVAGGHVAANQVLAVTFTQRAAGEMRSRLRVLAA
AAGTDAAVGSVSALTFHAAAHRQLRYFWPRVVGDTGWQLLDSKFAVVARAASRTRINASTDDVRDLAGEIEWAKASLIGP
EEYPAAVAAAGRDIPLDAARVAGVYAAYEALKARGDHVTLLDFDDLLLHTAAAIENDPAVAEEFRDRYRCFVVDEYQDVT
PLQQRVLAAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDATVVRLERDYRSTPQVVSLANQVIAAARGRVAG
SKLHLVGQRPPGPVPTFHEHSDEPAEAAAVAKSIARLIESGTPASEIAVLYRVNAQSEIYEEALTEAGIPYQVRGGEGFF
NRQEIKQALLALQRAAEREGEDAREEPLPAVVRAVLEPLGLTAEEPVGTRARERWEALRALAELVDDEVARRPQLDFAGL
LTELRMRADARHPPVVQGVALASLHAAKGLEWDAVFLVGLADGTLPISHALAHGADSEAVEEERRLLYVGITRARTHLAL
SWALARSPGGRQSRKPSRFLNGIAPQTRAEAAPARSRRNRSTATRCRICNNNLTTPAAVMLRRCETCAADIDEDLLVRLK
AWRLDVAKEQKVPAYVVFTDNTLIAIAELRPGDEQALIAIPGIGARKLEQYGPDVLELVRGR

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=461, Percent_Identity=34.2733188720174, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI48994965, Length=405, Percent_Identity=33.0864197530864, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322369, Length=443, Percent_Identity=25.5079006772009, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324477, Length=388, Percent_Identity=23.4536082474227, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR002121
- InterPro:   IPR014016
- InterPro:   IPR010997 [H]

Pfam domain/function: PF00570 HRDC; PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 76229; Mature: 76098

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLADPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAQLVAGGHVAANQVL
CCCCCCCHHCCCCCHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHCCEE
AVTFTQRAAGEMRSRLRVLAAAAGTDAAVGSVSALTFHAAAHRQLRYFWPRVVGDTGWQL
EEEEHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LDSKFAVVARAASRTRINASTDDVRDLAGEIEWAKASLIGPEEYPAAVAAAGRDIPLDAA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCHHCCHHHHHCCCCCCCHHH
RVAGVYAAYEALKARGDHVTLLDFDDLLLHTAAAIENDPAVAEEFRDRYRCFVVDEYQDV
HHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEECCCCC
TPLQQRVLAAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDATVVRLERDYRS
CHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEHHHHHHCCCCEEEEEEHHCCC
TPQVVSLANQVIAAARGRVAGSKLHLVGQRPPGPVPTFHEHSDEPAEAAAVAKSIARLIE
CHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
SGTPASEIAVLYRVNAQSEIYEEALTEAGIPYQVRGGEGFFNRQEIKQALLALQRAAERE
CCCCHHHEEEEEEECCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHC
GEDAREEPLPAVVRAVLEPLGLTAEEPVGTRARERWEALRALAELVDDEVARRPQLDFAG
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LLTELRMRADARHPPVVQGVALASLHAAKGLEWDAVFLVGLADGTLPISHALAHGADSEA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHH
VEEERRLLYVGITRARTHLALSWALARSPGGRQSRKPSRFLNGIAPQTRAEAAPARSRRN
HHHHCCEEEEEEHHHHHHHHEEHHHHCCCCCCCCCCHHHHHHCCCCCHHHHCCCHHHHCC
RSTATRCRICNNNLTTPAAVMLRRCETCAADIDEDLLVRLKAWRLDVAKEQKVPAYVVFT
CCHHHHHEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHCCCCCEEEEEE
DNTLIAIAELRPGDEQALIAIPGIGARKLEQYGPDVLELVRGR
CCCEEEEEECCCCCCCEEEEECCCCHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure 
PTLADPLTAGLDDEQREAVLAPRGPVCVLAGAGTGKTRTITHRIAQLVAGGHVAANQVL
CCCCCCHHCCCCCHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHCCEE
AVTFTQRAAGEMRSRLRVLAAAAGTDAAVGSVSALTFHAAAHRQLRYFWPRVVGDTGWQL
EEEEHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LDSKFAVVARAASRTRINASTDDVRDLAGEIEWAKASLIGPEEYPAAVAAAGRDIPLDAA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCHHCCHHHHHCCCCCCCHHH
RVAGVYAAYEALKARGDHVTLLDFDDLLLHTAAAIENDPAVAEEFRDRYRCFVVDEYQDV
HHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEECCCCC
TPLQQRVLAAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDATVVRLERDYRS
CHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEHHHHHHCCCCEEEEEEHHCCC
TPQVVSLANQVIAAARGRVAGSKLHLVGQRPPGPVPTFHEHSDEPAEAAAVAKSIARLIE
CHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
SGTPASEIAVLYRVNAQSEIYEEALTEAGIPYQVRGGEGFFNRQEIKQALLALQRAAERE
CCCCHHHEEEEEEECCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHC
GEDAREEPLPAVVRAVLEPLGLTAEEPVGTRARERWEALRALAELVDDEVARRPQLDFAG
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LLTELRMRADARHPPVVQGVALASLHAAKGLEWDAVFLVGLADGTLPISHALAHGADSEA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHH
VEEERRLLYVGITRARTHLALSWALARSPGGRQSRKPSRFLNGIAPQTRAEAAPARSRRN
HHHHCCEEEEEEHHHHHHHHEEHHHHCCCCCCCCCCHHHHHHCCCCCHHHHCCCHHHHCC
RSTATRCRICNNNLTTPAAVMLRRCETCAADIDEDLLVRLKAWRLDVAKEQKVPAYVVFT
CCHHHHHEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHCCCCCEEEEEE
DNTLIAIAELRPGDEQALIAIPGIGARKLEQYGPDVLELVRGR
CCCEEEEEECCCCCCCEEEEECCCCHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]