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The map label for this gene is aofH [H]

Identifier: 41409326

GI number: 41409326

Start: 3581361

End: 3582707

Strand: Direct

Name: aofH [H]

Synonym: MAP3228

Alternate gene names: 41409326

Gene position: 3581361-3582707 (Clockwise)

Preceding gene: 41409323

Following gene: 41409330

Centisome position: 74.15

GC content: 74.16

Gene sequence:

>1347_bases
GTGTCAGGGCCGCCGCGGATCGTCGACGTCGTCGTGGTCGGCGCCGGCTTTGCCGGGCTGGCCGCCGCCCGCGAGCTCAA
CCGGCAGGGCCATGACGTGGTGGTCTTCGAGGGCCGCGACCGGGTGGGCGGGCGGTCGTTCACCGGCAGCGTCGCCGGGC
TGCCGGCCGATCTGGGCGGGACGTTCGTCGGGCCCACCCAGGACGCGGTGCTGGCGTTGGCGGCCGAACTCGAGGTGCCG
ACCACCCCGACGCACCACGAGGGCAAGAACCTGATCCACTGGCGCGGCTGGACGCACGCCTACCACGGCACCATTCCCAA
GCTGTCCCTGACCGGCCTGCTGGACATCGGCCGGCTGCGCTGGCAGTTCGACCGGATCGCCCGCAGCATTCCGCTGGCGG
CGCCGTGGGAGGCCCGGCGGGCGGCCGAACTGGACGGCCTGTCGCTGGGCGGCTGGCTGCGCTCGGTGCGCGCCACCGCC
TCGTCGCACGCGCTGCTGGCGATGGTGGCCCGGGTGACCTGGGGATGTGAGCCCGACGAGGTGTCGATGCTGCACGCCGC
CCGGTACGCGCACGCGGCCGGCGGGCTGGACCGGCTGCTCGACGTCGAGGACGGCGCCCAACAGGACCGCTTCCCCGGCG
GCACCCAGCAGATCGCCGCGGCCGCGGCCGCCGAACTGGGCGCACGGGTGGTGCTGGGCGCGCCGGTGCGCCGGATCGAG
CGGCACGGTGCGGGCGTGACCGTGCGCACCGACCTCGGCGACACCGAGGCCGGGTTCGTCATCGTGGCCATCCCGCCGGC
GCATCGCGCCGCGATCGAGTTCGCCCCGCCGCTGCCCGCCGAGTACGAGCAGCTGGCCCGGCACTGGCCGCAGGGCCGGC
TCAGCAAGGCCTACGCGGCCTATTCCACCCCGTTTTGGCGGGCCGACGGTTTCTCCGGGCAGGCGCTGTCGGACGAGGGC
CCGGTTTTCATCACCTTCGACGTCAGCCCGCACCCGGACGGCCCGGGCATCCTGATGGGTTTCGTGGACGCCCGCGCCTT
CGACTCGCTGCCCGCCGACCAGCGCCGCCGCGACGCATTGCGTTGTTTCGCAACGCTTTTCGGCGACGACGCGCTCAAGC
CCCTCGACTATGTCGATCACCGTTGGGGCGCTGAGGAATTCGCGCCCGGCGGACCCACCGCGGCGGTGCCGCCGGGGTCG
TGGACGCGGTTCGGGCGGTGGCTGCGCGAACCCGTCGGGCCGATCCACTGGGCCGGCACCGAAACCGCCGACGAGTGGAC
CGGATTCCTCGACGGCGCCATCCGCTCCGGCCGGCGCGCCGCCGCCGAGGTTATCGCCCTGCTATGA

Upstream 100 bases:

>100_bases
CGAATGTTTGCCATCGCCGTGATGCGAACGCCGGGCGGATGCGCTGGGGCTTTGCCGCAATTCGCCGACAAACCCCGCGA
AATGCGGTTCACTAGAGCGC

Downstream 100 bases:

>100_bases
GCTGATCCGGTGGGTGGGCAGGTTGCGGGTCGCCGATTCGGCGAGCGCCCGCAGCCGCCGGTTCACCTCCCGCGGGTGTT
CCAGCATCGAGCAGTGCCCG

Product: hypothetical protein

Products: RCHO; NH3; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSGPPRIVDVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGGRSFTGSVAGLPADLGGTFVGPTQDAVLALAAELEVP
TTPTHHEGKNLIHWRGWTHAYHGTIPKLSLTGLLDIGRLRWQFDRIARSIPLAAPWEARRAAELDGLSLGGWLRSVRATA
SSHALLAMVARVTWGCEPDEVSMLHAARYAHAAGGLDRLLDVEDGAQQDRFPGGTQQIAAAAAAELGARVVLGAPVRRIE
RHGAGVTVRTDLGDTEAGFVIVAIPPAHRAAIEFAPPLPAEYEQLARHWPQGRLSKAYAAYSTPFWRADGFSGQALSDEG
PVFITFDVSPHPDGPGILMGFVDARAFDSLPADQRRRDALRCFATLFGDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGS
WTRFGRWLREPVGPIHWAGTETADEWTGFLDGAIRSGRRAAAEVIALL

Sequences:

>Translated_448_residues
MSGPPRIVDVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGGRSFTGSVAGLPADLGGTFVGPTQDAVLALAAELEVP
TTPTHHEGKNLIHWRGWTHAYHGTIPKLSLTGLLDIGRLRWQFDRIARSIPLAAPWEARRAAELDGLSLGGWLRSVRATA
SSHALLAMVARVTWGCEPDEVSMLHAARYAHAAGGLDRLLDVEDGAQQDRFPGGTQQIAAAAAAELGARVVLGAPVRRIE
RHGAGVTVRTDLGDTEAGFVIVAIPPAHRAAIEFAPPLPAEYEQLARHWPQGRLSKAYAAYSTPFWRADGFSGQALSDEG
PVFITFDVSPHPDGPGILMGFVDARAFDSLPADQRRRDALRCFATLFGDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGS
WTRFGRWLREPVGPIHWAGTETADEWTGFLDGAIRSGRRAAAEVIALL
>Mature_447_residues
SGPPRIVDVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGGRSFTGSVAGLPADLGGTFVGPTQDAVLALAAELEVPT
TPTHHEGKNLIHWRGWTHAYHGTIPKLSLTGLLDIGRLRWQFDRIARSIPLAAPWEARRAAELDGLSLGGWLRSVRATAS
SHALLAMVARVTWGCEPDEVSMLHAARYAHAAGGLDRLLDVEDGAQQDRFPGGTQQIAAAAAAELGARVVLGAPVRRIER
HGAGVTVRTDLGDTEAGFVIVAIPPAHRAAIEFAPPLPAEYEQLARHWPQGRLSKAYAAYSTPFWRADGFSGQALSDEGP
VFITFDVSPHPDGPGILMGFVDARAFDSLPADQRRRDALRCFATLFGDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGSW
TRFGRWLREPVGPIHWAGTETADEWTGFLDGAIRSGRRAAAEVIALL

Specific function: Unknown

COG id: COG1231

COG function: function code E; Monoamine oxidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the flavin monoamine oxidase family [H]

Homologues:

Organism=Homo sapiens, GI4557735, Length=450, Percent_Identity=34.8888888888889, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI38202207, Length=438, Percent_Identity=34.9315068493151, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI23821023, Length=464, Percent_Identity=24.3534482758621, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI27477089, Length=464, Percent_Identity=24.3534482758621, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001613
- InterPro:   IPR002937 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: 1.4.3.4

Molecular weight: Translated: 47977; Mature: 47845

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPPRIVDVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGGRSFTGSVAGLPADLGG
CCCCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCCC
TFVGPTQDAVLALAAELEVPTTPTHHEGKNLIHWRGWTHAYHGTIPKLSLTGLLDIGRLR
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHHCCCCCCEEHHHHHHHHHHH
WQFDRIARSIPLAAPWEARRAAELDGLSLGGWLRSVRATASSHALLAMVARVTWGCEPDE
HHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHH
VSMLHAARYAHAAGGLDRLLDVEDGAQQDRFPGGTQQIAAAAAAELGARVVLGAPVRRIE
HHHHHHHHHHHHHCCHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCHHHHHH
RHGAGVTVRTDLGDTEAGFVIVAIPPAHRAAIEFAPPLPAEYEQLARHWPQGRLSKAYAA
HCCCCEEEEECCCCCCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHCCCCHHHHHHHH
YSTPFWRADGFSGQALSDEGPVFITFDVSPHPDGPGILMGFVDARAFDSLPADQRRRDAL
HCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHHCCCCCHHHHHHHH
RCFATLFGDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGSWTRFGRWLREPVGPIHWAGT
HHHHHHHCCCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCC
ETADEWTGFLDGAIRSGRRAAAEVIALL
CCHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
SGPPRIVDVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGGRSFTGSVAGLPADLGG
CCCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCCC
TFVGPTQDAVLALAAELEVPTTPTHHEGKNLIHWRGWTHAYHGTIPKLSLTGLLDIGRLR
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHHCCCCCCEEHHHHHHHHHHH
WQFDRIARSIPLAAPWEARRAAELDGLSLGGWLRSVRATASSHALLAMVARVTWGCEPDE
HHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHH
VSMLHAARYAHAAGGLDRLLDVEDGAQQDRFPGGTQQIAAAAAAELGARVVLGAPVRRIE
HHHHHHHHHHHHHCCHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCHHHHHH
RHGAGVTVRTDLGDTEAGFVIVAIPPAHRAAIEFAPPLPAEYEQLARHWPQGRLSKAYAA
HCCCCEEEEECCCCCCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHCCCCHHHHHHHH
YSTPFWRADGFSGQALSDEGPVFITFDVSPHPDGPGILMGFVDARAFDSLPADQRRRDAL
HCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHHCCCCCHHHHHHHH
RCFATLFGDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGSWTRFGRWLREPVGPIHWAGT
HHHHHHHCCCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCC
ETADEWTGFLDGAIRSGRRAAAEVIALL
CCHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: RCH2NH2; H2O; O2

Specific reaction: RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]