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The map label for this gene is nuoN

Identifier: 41409312

GI number: 41409312

Start: 3565207

End: 3566790

Strand: Direct

Name: nuoN

Synonym: MAP3214

Alternate gene names: 41409312

Gene position: 3565207-3566790 (Clockwise)

Preceding gene: 41409311

Following gene: 41409314

Centisome position: 73.82

GC content: 68.31

Gene sequence:

>1584_bases
ATGATGACCCTGCCCACCCCGAGCATCCAGTACTTCCTGCTGTGCCCGACGCTGATCGTGTTCGGCGTCGCCGTGGCCGG
TGTTCTGGCGGAAGCGTTCCTGCCCAGGCGGATTCGCTACACCGCCCAGGTGACGCTGGCTCTGGGCGGTCTGGTCGCCG
CACTGTTCGCCGTGATCGAGGTGGCCGAGTCCCTCCCGGCCTCCGGGCGGGCCGCGGTGCTGGGCGCCATGGCCATCGAC
CGCCCGACGCTGTACCTGCAGGGCACCGTGCTGCTGGTCGCGGTGATGGCGGTGATCTTCATCGCCGAACGCACCCAGAC
CAAGTCGGACAGCAAGGTTGCGGTGGTGGCGGGATCTGGCGGCCTGGACTCGTTCACCCCGCAGGCCTCGGCGGTGCCCG
ACAGCGACGCCGAGCGGGAGGCCGAGCGCGCCGGCGCGGCCCAGACCGAGCTGTTCCCGCTGGCCATGCTGTCGGTCGGC
GGCATGATGGTCTTCCCCGCGTCCAACGATCTGCTGACTATGTTCGTCGCGCTGGAAGTGCTGTCGCTGCCGCTGTATCT
GATGTGCGGCCTGGCCCGGCACCGGCGGCTGCTGTCGCAGGAAGCGGCCATGAAATACTTTCTGCTGGGCGCCTTTTCGT
CCGCGTTCTTCCTCTACGGTGTGGCGCTGCTCTACGGTGCGACCGGCACCCTGCTGCTGACCGGTATCCGCGACGCGCTC
ATCACCCGCGGTGACACCTCGTTGGCCCTGGTGGGCGTCGCGCTGCTGTCGGTCGGACTGCTGTTCAAGGTCGGCGCGGT
CCCGTTCCACTCCTGGATACCCGACGTGTATCAGGGTGCGCCCACGCCGATCACCGGGTTCATGGCGGCGGCCACCAAGG
TCGCGGCTTTCGGTGCCCTGCTGCGGGTGGTCTACGTCGCGCTGCCGCCGCTGCACGATCAGTGGCGTCCGGTGCTTTGG
ACCATCTCGATCCTGACCATGGCGGTGGGCACCATCACCGCGGTGAATCAGGGCGACGTCAAACGGATGCTGGCGTATTC
GTCGGTCGCCCACGTCGGGTTCATCCTGACCGGAGTGATCGCCGACAACCACACCGGCCTGTCGGCCACCCTGTTCTACC
TGCTGGCCTACAGCTTCTCCACCGTCGGCGCGTTCGCCATCGTCGGCCTGATCCGCGACGCCGACGGGGTCGAGGACGCC
ACCCTCTCGCACTGGGCGGCGCTGGGTCAGCGCTCTCCCATTGTGGGCGTGATGTTTTCGATGTTCTTGCTGGCGTTCGC
CGGGATCCCGTTGACCAGTGGCTTCGTCAGCAAGCTGGCCGTGTTCAAGGCCGCCGCCCAGGGCGGCGCCGTGCCCCTGG
TGATCGTCGGTGTGGTCGCCAGCGGGGTCGCCGCCTACTTCTACGTGCGGGTGATCGTGTCGATGTTCTTCACCGAGGCC
ACCGAGGATACCCCGCACGTGGTGGCGCCGGGCATCTTGAGCAAGGCCGCGATCGCGGTGTGCGCCGCGGTCACCGTGGC
GCTGGGCGTCTTCCCGCAGCCGCTGCTCGACCTGGCCGACCAGGCGGCCCAGCTGCTGCACTGA

Upstream 100 bases:

>100_bases
TCATCAACCCCGCCGTCGAGAACACCATGACCACCATCGGTCAGCACGACCCCGCTCCGAGCGTGCCGATGGGCACGCCG
CGGACAGCCGAAGGACGGCG

Downstream 100 bases:

>100_bases
GTCGGCCGGCGAGGTCGTCGCGGGCAGACTTGGCCTGCTCGGGCGTCAGCAGCGGATTCGAATAGATGTCGACCAGGATG
GCCGCGACCCGCAGATCGCC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MMTLPTPSIQYFLLCPTLIVFGVAVAGVLAEAFLPRRIRYTAQVTLALGGLVAALFAVIEVAESLPASGRAAVLGAMAID
RPTLYLQGTVLLVAVMAVIFIAERTQTKSDSKVAVVAGSGGLDSFTPQASAVPDSDAEREAERAGAAQTELFPLAMLSVG
GMMVFPASNDLLTMFVALEVLSLPLYLMCGLARHRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLLLTGIRDAL
ITRGDTSLALVGVALLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLW
TISILTMAVGTITAVNQGDVKRMLAYSSVAHVGFILTGVIADNHTGLSATLFYLLAYSFSTVGAFAIVGLIRDADGVEDA
TLSHWAALGQRSPIVGVMFSMFLLAFAGIPLTSGFVSKLAVFKAAAQGGAVPLVIVGVVASGVAAYFYVRVIVSMFFTEA
TEDTPHVVAPGILSKAAIAVCAAVTVALGVFPQPLLDLADQAAQLLH

Sequences:

>Translated_527_residues
MMTLPTPSIQYFLLCPTLIVFGVAVAGVLAEAFLPRRIRYTAQVTLALGGLVAALFAVIEVAESLPASGRAAVLGAMAID
RPTLYLQGTVLLVAVMAVIFIAERTQTKSDSKVAVVAGSGGLDSFTPQASAVPDSDAEREAERAGAAQTELFPLAMLSVG
GMMVFPASNDLLTMFVALEVLSLPLYLMCGLARHRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLLLTGIRDAL
ITRGDTSLALVGVALLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLW
TISILTMAVGTITAVNQGDVKRMLAYSSVAHVGFILTGVIADNHTGLSATLFYLLAYSFSTVGAFAIVGLIRDADGVEDA
TLSHWAALGQRSPIVGVMFSMFLLAFAGIPLTSGFVSKLAVFKAAAQGGAVPLVIVGVVASGVAAYFYVRVIVSMFFTEA
TEDTPHVVAPGILSKAAIAVCAAVTVALGVFPQPLLDLADQAAQLLH
>Mature_527_residues
MMTLPTPSIQYFLLCPTLIVFGVAVAGVLAEAFLPRRIRYTAQVTLALGGLVAALFAVIEVAESLPASGRAAVLGAMAID
RPTLYLQGTVLLVAVMAVIFIAERTQTKSDSKVAVVAGSGGLDSFTPQASAVPDSDAEREAERAGAAQTELFPLAMLSVG
GMMVFPASNDLLTMFVALEVLSLPLYLMCGLARHRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLLLTGIRDAL
ITRGDTSLALVGVALLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLW
TISILTMAVGTITAVNQGDVKRMLAYSSVAHVGFILTGVIADNHTGLSATLFYLLAYSFSTVGAFAIVGLIRDADGVEDA
TLSHWAALGQRSPIVGVMFSMFLLAFAGIPLTSGFVSKLAVFKAAAQGGAVPLVIVGVVASGVAAYFYVRVIVSMFFTEA
TEDTPHVVAPGILSKAAIAVCAAVTVALGVFPQPLLDLADQAAQLLH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=286, Percent_Identity=25.8741258741259, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI145693160, Length=399, Percent_Identity=34.8370927318296, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1788831, Length=318, Percent_Identity=25.7861635220126, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788613, Length=380, Percent_Identity=23.9473684210526, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788827, Length=407, Percent_Identity=26.2899262899263, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788614, Length=338, Percent_Identity=25.4437869822485, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788829, Length=323, Percent_Identity=24.4582043343653, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55077; Mature: 55077

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTLPTPSIQYFLLCPTLIVFGVAVAGVLAEAFLPRRIRYTAQVTLALGGLVAALFAVIE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
VAESLPASGRAAVLGAMAIDRPTLYLQGTVLLVAVMAVIFIAERTQTKSDSKVAVVAGSG
HHHHCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
GLDSFTPQASAVPDSDAEREAERAGAAQTELFPLAMLSVGGMMVFPASNDLLTMFVALEV
CCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
LSLPLYLMCGLARHRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLLLTGIRDAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ITRGDTSLALVGVALLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGAL
HCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHH
LRVVYVALPPLHDQWRPVLWTISILTMAVGTITAVNQGDVKRMLAYSSVAHVGFILTGVI
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHH
ADNHTGLSATLFYLLAYSFSTVGAFAIVGLIRDADGVEDATLSHWAALGQRSPIVGVMFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHH
MFLLAFAGIPLTSGFVSKLAVFKAAAQGGAVPLVIVGVVASGVAAYFYVRVIVSMFFTEA
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TEDTPHVVAPGILSKAAIAVCAAVTVALGVFPQPLLDLADQAAQLLH
CCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMTLPTPSIQYFLLCPTLIVFGVAVAGVLAEAFLPRRIRYTAQVTLALGGLVAALFAVIE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
VAESLPASGRAAVLGAMAIDRPTLYLQGTVLLVAVMAVIFIAERTQTKSDSKVAVVAGSG
HHHHCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
GLDSFTPQASAVPDSDAEREAERAGAAQTELFPLAMLSVGGMMVFPASNDLLTMFVALEV
CCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
LSLPLYLMCGLARHRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLLLTGIRDAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ITRGDTSLALVGVALLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGAL
HCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHH
LRVVYVALPPLHDQWRPVLWTISILTMAVGTITAVNQGDVKRMLAYSSVAHVGFILTGVI
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHH
ADNHTGLSATLFYLLAYSFSTVGAFAIVGLIRDADGVEDATLSHWAALGQRSPIVGVMFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHH
MFLLAFAGIPLTSGFVSKLAVFKAAAQGGAVPLVIVGVVASGVAAYFYVRVIVSMFFTEA
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TEDTPHVVAPGILSKAAIAVCAAVTVALGVFPQPLLDLADQAAQLLH
CCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]