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The map label for this gene is nuoL

Identifier: 41409310

GI number: 41409310

Start: 3561759

End: 3563645

Strand: Direct

Name: nuoL

Synonym: MAP3212

Alternate gene names: 41409310

Gene position: 3561759-3563645 (Clockwise)

Preceding gene: 41409309

Following gene: 41409311

Centisome position: 73.75

GC content: 68.63

Gene sequence:

>1887_bases
ATGACTCACTACACTCCGCTGCTGGTGGCGCTGCCGCTGGCGGGTGCCGCGATCCTGTTGTTCGGCGGGCGACGCACCGA
CCGGTGGGGGCATTGGCTGGGTTGCGCCACCGCCGTGGCGGCGTTCGTGGTCGGCGTGGGCCTGCTGGATGAGTTGCTCG
GCCGTCCCGCCGACCAGCGCGCCATCCACGAAAGGGTGTTCAGCTGGATCCAGGTCGGCCAACTGCAGGTGGACCTGGGG
TTGCAGATCGACCAGCTGTCGGTGTGTTTCGTGTTGCTGATCACCGGGGTGGGGTCGCTGATCCACATCTACTCGGTGGC
CTACATGGCCGAAGATGCCGACCGCCGAAGGTTTTTCGGCTACCTCAACCTGTTCCTGGCGTCCATGCTGCTGCTGGTGA
TCGCCGACAACTACGTGGTGCTCTACGTCGGCTGGGAGGGCGTGGGCCTGGCGTCCTATCTGCTGATCGGGTTCTGGTAC
CACAAGCCGACGGCGGCCACCGCGGCCAAGAAGGCGTTCGTGATGAACCGGGTCGGCGACGCCGGGCTGGCATTGGGAAT
GTTCTTGATGTTCAGCACTTTCGGGACGCTGTCCTACGCCGGGGTGTTCGCGGGGGCGCCGGCGGCCGGTCGGGGCGCGC
TGACCGCGATGGGTCTGCTGCTGCTGCTGGGGGCCTGCGCCAAATCCGCGCAGGTGCCGCTGCAGGCCTGGCTGGGCGAC
GCCATGGAGGGCCCCACCCCGGTGTCCGCGCTGATCCACGCCGCCACCATGGTGACCGCGGGCGTGTACCTGATCGTGCG
GTCCAACCCGCTGTACAACCTGTCGCCGGATGCGCAACTGGCGGTGGTGATCGTGGGTGCGGTCACCTTGCTGCTGGGTG
CTTTCATCGGCTGCGCCAAGGACGACATCAAACGGGCGCTGGCGGCTTCGACGATGAGCCAGATCGGCTACATGGTGCTG
GCCGCGGGGTTGGGCCCGACCGGCTACGCGTTCGCGATCATGCATCTGCTGACCCACGGGTTCTTCAAAGCCGGCCTGTT
CCTCGGCTCCGGCGCGGTGATCCACGCGATGCACGAGGAGCAGGACATGCGGCGCTACGGCGGGCTGCGGGCCGCGCTGC
CGGTCACGTTCGTCACCTTCGGGTTGGGCTACCTGGCCATCATCGGGGTGCCGCCGTTCGCGGGCTTCTTCTCCAAGGAC
GCCATCATCGAGGCCGCGCTGGCCGCCGGCGGCGGCCGCGGGTACCTGCTCGGCGGGGCGGCGCTGCTGGGCGCCGGCGT
CACCGCGTTCTACATGACCCGGGTGATGCTGATGACCTTCTTCGGCGAAAAGCGTTGGGCCCCAGGCAGCCATCCGCACG
AGGCGCCGGGGCTGATGACCTGGCCGATGATCCTGCTGGCCATCGGGTCGCTGTTCTCCGGCGGACTGTTCGCGGTGGGC
GGCACGCTGCAGCGCTGGCTGGAGCCGGTGGTCGGCAGGCACGAAGAGGTGACTCACGCCGTCCCGGTGTGGATCAGCAC
CGCGCTGGCGCTGGGCGTCGTGGCCATCGGCATCGCGGTGGCCTACCGGCTCTACGCCACCGCGCCCATCCCCAGGGTGG
CGCCGTTGTCGGTGTCGCCGCTGACCACGGCGGTCCGTAACGACTTCTACGGCGATGCCTTCAACGAGGAGGTGTTCATG
CGCCCCGGCGCGCAACTGACCCACGCGCTCGTCGAGGTCGACGACGCGGGCGTCGACGGCTCGGTCAACGCACTGGCGGC
GTTGGTGAGCGCGACGTCGAATCGCTTGCGGGGCCTGCAAACCGGCTTCGCCCGCAACTATGCCCTGTCGATGCTGACCG
GCGCCGTGCTGGTGATCGCGCTGATCCTGGCGGTGCGGCTGTGGTGA

Upstream 100 bases:

>100_bases
GAGGTGGTCATCGGCCTGGCCATCATCATGACCATTTTCCGTACCCGCAAATCGGCGTCCGTCGACGACGCGAACCTACT
CAAAGGCTGAGCACGCCAAC

Downstream 100 bases:

>100_bases
ATCACCTGCCCTGGCTGAGCATCCTGTGGCTGGTGCCGCTGGCCGGCTCGGTACTGATCATCCTGATGCCGCCCGGGCTG
CGGCAGCTCGCCAAGTGGAC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MTHYTPLLVALPLAGAAILLFGGRRTDRWGHWLGCATAVAAFVVGVGLLDELLGRPADQRAIHERVFSWIQVGQLQVDLG
LQIDQLSVCFVLLITGVGSLIHIYSVAYMAEDADRRRFFGYLNLFLASMLLLVIADNYVVLYVGWEGVGLASYLLIGFWY
HKPTAATAAKKAFVMNRVGDAGLALGMFLMFSTFGTLSYAGVFAGAPAAGRGALTAMGLLLLLGACAKSAQVPLQAWLGD
AMEGPTPVSALIHAATMVTAGVYLIVRSNPLYNLSPDAQLAVVIVGAVTLLLGAFIGCAKDDIKRALAASTMSQIGYMVL
AAGLGPTGYAFAIMHLLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFVTFGLGYLAIIGVPPFAGFFSKD
AIIEAALAAGGGRGYLLGGAALLGAGVTAFYMTRVMLMTFFGEKRWAPGSHPHEAPGLMTWPMILLAIGSLFSGGLFAVG
GTLQRWLEPVVGRHEEVTHAVPVWISTALALGVVAIGIAVAYRLYATAPIPRVAPLSVSPLTTAVRNDFYGDAFNEEVFM
RPGAQLTHALVEVDDAGVDGSVNALAALVSATSNRLRGLQTGFARNYALSMLTGAVLVIALILAVRLW

Sequences:

>Translated_628_residues
MTHYTPLLVALPLAGAAILLFGGRRTDRWGHWLGCATAVAAFVVGVGLLDELLGRPADQRAIHERVFSWIQVGQLQVDLG
LQIDQLSVCFVLLITGVGSLIHIYSVAYMAEDADRRRFFGYLNLFLASMLLLVIADNYVVLYVGWEGVGLASYLLIGFWY
HKPTAATAAKKAFVMNRVGDAGLALGMFLMFSTFGTLSYAGVFAGAPAAGRGALTAMGLLLLLGACAKSAQVPLQAWLGD
AMEGPTPVSALIHAATMVTAGVYLIVRSNPLYNLSPDAQLAVVIVGAVTLLLGAFIGCAKDDIKRALAASTMSQIGYMVL
AAGLGPTGYAFAIMHLLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFVTFGLGYLAIIGVPPFAGFFSKD
AIIEAALAAGGGRGYLLGGAALLGAGVTAFYMTRVMLMTFFGEKRWAPGSHPHEAPGLMTWPMILLAIGSLFSGGLFAVG
GTLQRWLEPVVGRHEEVTHAVPVWISTALALGVVAIGIAVAYRLYATAPIPRVAPLSVSPLTTAVRNDFYGDAFNEEVFM
RPGAQLTHALVEVDDAGVDGSVNALAALVSATSNRLRGLQTGFARNYALSMLTGAVLVIALILAVRLW
>Mature_627_residues
THYTPLLVALPLAGAAILLFGGRRTDRWGHWLGCATAVAAFVVGVGLLDELLGRPADQRAIHERVFSWIQVGQLQVDLGL
QIDQLSVCFVLLITGVGSLIHIYSVAYMAEDADRRRFFGYLNLFLASMLLLVIADNYVVLYVGWEGVGLASYLLIGFWYH
KPTAATAAKKAFVMNRVGDAGLALGMFLMFSTFGTLSYAGVFAGAPAAGRGALTAMGLLLLLGACAKSAQVPLQAWLGDA
MEGPTPVSALIHAATMVTAGVYLIVRSNPLYNLSPDAQLAVVIVGAVTLLLGAFIGCAKDDIKRALAASTMSQIGYMVLA
AGLGPTGYAFAIMHLLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFVTFGLGYLAIIGVPPFAGFFSKDA
IIEAALAAGGGRGYLLGGAALLGAGVTAFYMTRVMLMTFFGEKRWAPGSHPHEAPGLMTWPMILLAIGSLFSGGLFAVGG
TLQRWLEPVVGRHEEVTHAVPVWISTALALGVVAIGIAVAYRLYATAPIPRVAPLSVSPLTTAVRNDFYGDAFNEEVFMR
PGAQLTHALVEVDDAGVDGSVNALAALVSATSNRLRGLQTGFARNYALSMLTGAVLVIALILAVRLW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=520, Percent_Identity=34.0384615384615, Blast_Score=281, Evalue=2e-75,
Organism=Escherichia coli, GI1788614, Length=623, Percent_Identity=40.4494382022472, Blast_Score=355, Evalue=4e-99,
Organism=Escherichia coli, GI1788829, Length=487, Percent_Identity=31.4168377823409, Blast_Score=155, Evalue=1e-38,
Organism=Escherichia coli, GI1788831, Length=361, Percent_Identity=32.409972299169, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI1788827, Length=426, Percent_Identity=29.5774647887324, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1788613, Length=422, Percent_Identity=27.4881516587678, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI2367154, Length=435, Percent_Identity=24.1379310344828, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693160, Length=434, Percent_Identity=22.8110599078341, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66292; Mature: 66161

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHYTPLLVALPLAGAAILLFGGRRTDRWGHWLGCATAVAAFVVGVGLLDELLGRPADQR
CCCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AIHERVFSWIQVGQLQVDLGLQIDQLSVCFVLLITGVGSLIHIYSVAYMAEDADRRRFFG
HHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
YLNLFLASMLLLVIADNYVVLYVGWEGVGLASYLLIGFWYHKPTAATAAKKAFVMNRVGD
HHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
AGLALGMFLMFSTFGTLSYAGVFAGAPAAGRGALTAMGLLLLLGACAKSAQVPLQAWLGD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
AMEGPTPVSALIHAATMVTAGVYLIVRSNPLYNLSPDAQLAVVIVGAVTLLLGAFIGCAK
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCH
DDIKRALAASTMSQIGYMVLAAGLGPTGYAFAIMHLLTHGFFKAGLFLGSGAVIHAMHEE
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHH
QDMRRYGGLRAALPVTFVTFGLGYLAIIGVPPFAGFFSKDAIIEAALAAGGGRGYLLGGA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHH
ALLGAGVTAFYMTRVMLMTFFGEKRWAPGSHPHEAPGLMTWPMILLAIGSLFSGGLFAVG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHH
GTLQRWLEPVVGRHEEVTHAVPVWISTALALGVVAIGIAVAYRLYATAPIPRVAPLSVSP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
LTTAVRNDFYGDAFNEEVFMRPGAQLTHALVEVDDAGVDGSVNALAALVSATSNRLRGLQ
HHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
TGFARNYALSMLTGAVLVIALILAVRLW
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
THYTPLLVALPLAGAAILLFGGRRTDRWGHWLGCATAVAAFVVGVGLLDELLGRPADQR
CCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AIHERVFSWIQVGQLQVDLGLQIDQLSVCFVLLITGVGSLIHIYSVAYMAEDADRRRFFG
HHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
YLNLFLASMLLLVIADNYVVLYVGWEGVGLASYLLIGFWYHKPTAATAAKKAFVMNRVGD
HHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
AGLALGMFLMFSTFGTLSYAGVFAGAPAAGRGALTAMGLLLLLGACAKSAQVPLQAWLGD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
AMEGPTPVSALIHAATMVTAGVYLIVRSNPLYNLSPDAQLAVVIVGAVTLLLGAFIGCAK
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCH
DDIKRALAASTMSQIGYMVLAAGLGPTGYAFAIMHLLTHGFFKAGLFLGSGAVIHAMHEE
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHH
QDMRRYGGLRAALPVTFVTFGLGYLAIIGVPPFAGFFSKDAIIEAALAAGGGRGYLLGGA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHH
ALLGAGVTAFYMTRVMLMTFFGEKRWAPGSHPHEAPGLMTWPMILLAIGSLFSGGLFAVG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHH
GTLQRWLEPVVGRHEEVTHAVPVWISTALALGVVAIGIAVAYRLYATAPIPRVAPLSVSP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
LTTAVRNDFYGDAFNEEVFMRPGAQLTHALVEVDDAGVDGSVNALAALVSATSNRLRGLQ
HHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
TGFARNYALSMLTGAVLVIALILAVRLW
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]