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The map label for this gene is nuoF

Identifier: 41409304

GI number: 41409304

Start: 3555050

End: 3556411

Strand: Direct

Name: nuoF

Synonym: MAP3206

Alternate gene names: 41409304

Gene position: 3555050-3556411 (Clockwise)

Preceding gene: 41409303

Following gene: 41409305

Centisome position: 73.61

GC content: 68.43

Gene sequence:

>1362_bases
ATGACAACGACTTCGGAGACTTCGGAGGCCTCCGGGGCCCCGCAGGCGACGCCGCTGACGCCGGTGATCAGCCGCTTCTG
GGACGATCCCGAGTCGTGGACGCTGCAGACGTACCACCGGCACGGCGGCTACACGGCGATGAAGAAGGCGCTGGCGATGG
AGCCCGACGCGGTCATCGGGATGGTCAAGGACTCCGGGCTGCGCGGGCGCGGCGGCGCGGGCTTCTCGACCGGCACCAAG
TGGTCGTTCATCCCGCAGGGCGACACCGGCGCGGCCGCCAAGCCGCACTACCTGGTGGTCAACGCCGACGAGTCGGAACC
CGGTACGTGCAAAGACATTCCGTTGATGCTGGCCACCCCGCACGTCCTGATCGAGGGGGTGATCATCGCGGCGTATGCGA
TCCGGGCCAACCACGCGTTCATCTATGTGCGCGGCGAGGTGCTGCCGGTGCTGCGCCGGCTGCAGAACGCCGTCGCCGAG
GCCTACGCCGCCGGCTACCTGGGCCGCGACATCGACGGCTCCGGCTTCGATCTGGAGCTGGTGGTGCACGCCGGCGCCGG
CGCCTACATCTGCGGCGAGGAGACCGCGCTGCTGGACTCGCTGGAGGGCCGCCGCGGCCAGCCCCGGCTGCGGCCGCCGT
TCCCGGCGGTGGCCGGGCTGTACGGCTGCCCCACGGTGATCAACAACGTCGAGACCATCGCCAGCGTGCCGTCCATCATC
GGCAACGGCGTGGACTGGTTCCGCTCGATGGGCAGTGAGAAATCGCCGGGTTTCACGCTGTATTCGCTGTCCGGCCACGT
CACTCGGCCCGGCCAGTACGAGGCGCCGCTGGGAATCACGTTGCGCGAGTTGCTCGATTACGCCGGCGGGGTGCGGGCCG
GGCACCGGCTCAAGTTCTGGACCCCCGGCGGCTCGTCGACCCCGCTGCTGACCGACGAACACCTCGACGTGCCACTGGAT
TACGAGGGCGTGGGCGGGGTCGGCTCGATGCTGGGCACCAAGGCGCTGGAGATCTTCGACGAGACCACCTGCGTGGTGCG
TGCGGTGCGCCGCTGGACCTACTTCTACAAGCACGAGTCGTGCGGCAAGTGCACGCCGTGCCGCGAGGGCACGTTCTGGC
TCGACCAGATCTACGAACGGCTGGAGACCGGTAAGGGCACGGCCGAGGACATCGACAAGCTGCTGGACATCTCCGACACC
ATCCTGGGAAAGTCGTTCTGCGCGTTGGGCGATGGCGCCGCCAGCCCGGTGATGTCGTCGATCAAGTACTTCCGCGACGA
GTACGTCGCCCACGTCGAGAACGGCAGATGCCCGTTCGACCCGCGAGACTCCATGCTGACACCGAACGGGAGCGACTCGT
GA

Upstream 100 bases:

>100_bases
CCGACCAGGGGCAGGGCGGCGCCGGCGCGGCGACCCTGGCCGGGCTGAAGGTCGCCAAGGAACACGGCATGCAGGCACCG
AACCCGGCGGAAGGCCAGCA

Downstream 100 bases:

>100_bases
CCCAAACTGCGGACACCGAAGGCCGCGTGACCCAGCCGGAGATGGTGACGCTGAGCATCGACGGCAACGAGATCAGCGTC
CCCAAGGGGACTCTGGTGAT

Product: hypothetical protein

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTTTSETSEASGAPQATPLTPVISRFWDDPESWTLQTYHRHGGYTAMKKALAMEPDAVIGMVKDSGLRGRGGAGFSTGTK
WSFIPQGDTGAAAKPHYLVVNADESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRANHAFIYVRGEVLPVLRRLQNAVAE
AYAAGYLGRDIDGSGFDLELVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSII
GNGVDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGVRAGHRLKFWTPGGSSTPLLTDEHLDVPLD
YEGVGGVGSMLGTKALEIFDETTCVVRAVRRWTYFYKHESCGKCTPCREGTFWLDQIYERLETGKGTAEDIDKLLDISDT
ILGKSFCALGDGAASPVMSSIKYFRDEYVAHVENGRCPFDPRDSMLTPNGSDS

Sequences:

>Translated_453_residues
MTTTSETSEASGAPQATPLTPVISRFWDDPESWTLQTYHRHGGYTAMKKALAMEPDAVIGMVKDSGLRGRGGAGFSTGTK
WSFIPQGDTGAAAKPHYLVVNADESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRANHAFIYVRGEVLPVLRRLQNAVAE
AYAAGYLGRDIDGSGFDLELVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSII
GNGVDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGVRAGHRLKFWTPGGSSTPLLTDEHLDVPLD
YEGVGGVGSMLGTKALEIFDETTCVVRAVRRWTYFYKHESCGKCTPCREGTFWLDQIYERLETGKGTAEDIDKLLDISDT
ILGKSFCALGDGAASPVMSSIKYFRDEYVAHVENGRCPFDPRDSMLTPNGSDS
>Mature_452_residues
TTTSETSEASGAPQATPLTPVISRFWDDPESWTLQTYHRHGGYTAMKKALAMEPDAVIGMVKDSGLRGRGGAGFSTGTKW
SFIPQGDTGAAAKPHYLVVNADESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRANHAFIYVRGEVLPVLRRLQNAVAEA
YAAGYLGRDIDGSGFDLELVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIIG
NGVDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGVRAGHRLKFWTPGGSSTPLLTDEHLDVPLDY
EGVGGVGSMLGTKALEIFDETTCVVRAVRRWTYFYKHESCGKCTPCREGTFWLDQIYERLETGKGTAEDIDKLLDISDTI
LGKSFCALGDGAASPVMSSIKYFRDEYVAHVENGRCPFDPRDSMLTPNGSDS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=398, Percent_Identity=46.9849246231156, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI260656005, Length=398, Percent_Identity=46.9849246231156, Blast_Score=365, Evalue=1e-101,
Organism=Escherichia coli, GI1788620, Length=422, Percent_Identity=47.8672985781991, Blast_Score=400, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17531727, Length=398, Percent_Identity=46.7336683417085, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19920794, Length=398, Percent_Identity=47.4874371859297, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI45550452, Length=396, Percent_Identity=47.4747474747475, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24653819, Length=396, Percent_Identity=35.6060606060606, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24653817, Length=349, Percent_Identity=34.9570200573066, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48856; Mature: 48724

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTSETSEASGAPQATPLTPVISRFWDDPESWTLQTYHRHGGYTAMKKALAMEPDAVIG
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEHHHCCCHHHHHHHHHCCCCCEEE
MVKDSGLRGRGGAGFSTGTKWSFIPQGDTGAAAKPHYLVVNADESEPGTCKDIPLMLATP
EEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECH
HVLIEGVIIAAYAIRANHAFIYVRGEVLPVLRRLQNAVAEAYAAGYLGRDIDGSGFDLEL
HHHHHHHHHHHEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
VVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSII
EEECCCCEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
GNGVDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGVRAGHRLKFW
CCCHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
TPGGSSTPLLTDEHLDVPLDYEGVGGVGSMLGTKALEIFDETTCVVRAVRRWTYFYKHES
CCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
CGKCTPCREGTFWLDQIYERLETGKGTAEDIDKLLDISDTILGKSFCALGDGAASPVMSS
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHH
IKYFRDEYVAHVENGRCPFDPRDSMLTPNGSDS
HHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCC
>Mature Secondary Structure 
TTTSETSEASGAPQATPLTPVISRFWDDPESWTLQTYHRHGGYTAMKKALAMEPDAVIG
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEHHHCCCHHHHHHHHHCCCCCEEE
MVKDSGLRGRGGAGFSTGTKWSFIPQGDTGAAAKPHYLVVNADESEPGTCKDIPLMLATP
EEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECH
HVLIEGVIIAAYAIRANHAFIYVRGEVLPVLRRLQNAVAEAYAAGYLGRDIDGSGFDLEL
HHHHHHHHHHHEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
VVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSII
EEECCCCEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
GNGVDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGVRAGHRLKFW
CCCHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
TPGGSSTPLLTDEHLDVPLDYEGVGGVGSMLGTKALEIFDETTCVVRAVRRWTYFYKHES
CCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
CGKCTPCREGTFWLDQIYERLETGKGTAEDIDKLLDISDTILGKSFCALGDGAASPVMSS
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHH
IKYFRDEYVAHVENGRCPFDPRDSMLTPNGSDS
HHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]