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The map label for this gene is norA [H]

Identifier: 41409243

GI number: 41409243

Start: 3499423

End: 3500661

Strand: Reverse

Name: norA [H]

Synonym: MAP3145c

Alternate gene names: 41409243

Gene position: 3500661-3499423 (Counterclockwise)

Preceding gene: 41409244

Following gene: 41409242

Centisome position: 72.48

GC content: 69.09

Gene sequence:

>1239_bases
TTGGGGGAGCGTGCGCCGCGTCCTGGTCCGCTGCCGCGCGAAGTCTGGATCCTGAGCTGGGCGAACGTCATGGTCGCCTT
GGGCTACGGGGTCATCTCGCCGGCGCTGCCGACCTTTGCACGCAGCTTCGGGGTGAGCATCAAGGCGGTGACTTTCCTGG
TCACCGTCTTTTCGTTGAGCCGGTTGTGTTTTGCGCCGATCAGCGGGCTGCTCACCGAACGATTGGGGGAGCGGCGAATC
TATATCGGGGGTTTGCTGATCGTGGCGGTGTCCACCGCCGCGTGCGCCTTTTCCCAGGCGTATTGGCAGTTGATGCTGTA
CCGGGTGTTCAGCGGCGTCGGGTCGACGATGTTCTACGTCTCGGCGCTGGGGCTGATGATCCACATCAGCCCTGCCGACG
CGCGTGGCCGGATCGCGGGACTGTTCACCACCTCGTTCATGGTGGGCGCGGTCGGCGGTCCGGCGGTCGGCGGCCTGGCG
GCGGGGTGGGGGTTGACCGCCCCGTTCGTCGTGTACGGCGTCGCGATGTTGGGTGTGGCGCTGGTGCTGTTCCTCGGCCT
GCGCAATTCCGCGCTGGCCGCACCGCGACCCCCGACGCGATCGACGGTCACGATGCGCGAAGCGCTGCGGGTGCGCGCGT
ACCGGTCGGCGCTGCTGTCCAATTTCGCGACCGGCTGGTCGGCCTTCGGGCTGCGCATGGCACTCGTCCCGCTGTTCGTC
TCCGACGTCATTGGTCGGGGTATCGGCACCATCGGCGTGGTGCTCGCCGCGTTCGCCGGCGGCAACGCGCTGGCGGTGGT
GCCCAGTGGCTACCTGTCGGATCGGATGGGGCGGCGAACGTTGTTGATCGTCGGGCTGGTGACGTCCGGGGCGGCGACGG
TCTGGCTGGGTTTTGTCGCGTCGCTGCCGGTGTTCCTGGTGGCGGCCGGCGTGGTCGGCGTGGTCACCGGGATCTACATG
TCGCCGCTGCAGGCCGCCGTCGCCGACATCCTCGGCAACGAGGCGCGCGCCGGCCTGCCGGTGGCCACCGTGCAGATGAT
GTCGGACCTGGGCGCCATCGTCGGGTCCATGGCGGTGGGCTGGGCGGCCGAGCAGATCGGCTACGGCTGGGGCTTTTTCA
TCAGCGGGGTGGTCCTGCTGATCGCCGCCGTCGGCTGGGTGATGGCGCCGGAAACGCGGACGGCGACGGAGCTGGAGGCC
GATCTGATGGCGGCGGAGTCGGACGTCGAGCCGGTGTGA

Upstream 100 bases:

>100_bases
AATCCTTCCACGGGCCGCAGCATTTGGCCGAGGTGCAGGAAACCGCGCGCGAGGTGGTTAATAAAGTCATCGGGTGACTT
TTTCCCTCCGTCCTGCGCGC

Downstream 100 bases:

>100_bases
ACAGCAACTTTGAAGGACGGTTACCGGTGGTGTAGCTTCGATGGGCACGACTTCTCGGGGCTATGGCGCAGCTGGTAGCG
CACCACACTGGCAGTGTGGG

Product: hypothetical protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MGERAPRPGPLPREVWILSWANVMVALGYGVISPALPTFARSFGVSIKAVTFLVTVFSLSRLCFAPISGLLTERLGERRI
YIGGLLIVAVSTAACAFSQAYWQLMLYRVFSGVGSTMFYVSALGLMIHISPADARGRIAGLFTTSFMVGAVGGPAVGGLA
AGWGLTAPFVVYGVAMLGVALVLFLGLRNSALAAPRPPTRSTVTMREALRVRAYRSALLSNFATGWSAFGLRMALVPLFV
SDVIGRGIGTIGVVLAAFAGGNALAVVPSGYLSDRMGRRTLLIVGLVTSGAATVWLGFVASLPVFLVAAGVVGVVTGIYM
SPLQAAVADILGNEARAGLPVATVQMMSDLGAIVGSMAVGWAAEQIGYGWGFFISGVVLLIAAVGWVMAPETRTATELEA
DLMAAESDVEPV

Sequences:

>Translated_412_residues
MGERAPRPGPLPREVWILSWANVMVALGYGVISPALPTFARSFGVSIKAVTFLVTVFSLSRLCFAPISGLLTERLGERRI
YIGGLLIVAVSTAACAFSQAYWQLMLYRVFSGVGSTMFYVSALGLMIHISPADARGRIAGLFTTSFMVGAVGGPAVGGLA
AGWGLTAPFVVYGVAMLGVALVLFLGLRNSALAAPRPPTRSTVTMREALRVRAYRSALLSNFATGWSAFGLRMALVPLFV
SDVIGRGIGTIGVVLAAFAGGNALAVVPSGYLSDRMGRRTLLIVGLVTSGAATVWLGFVASLPVFLVAAGVVGVVTGIYM
SPLQAAVADILGNEARAGLPVATVQMMSDLGAIVGSMAVGWAAEQIGYGWGFFISGVVLLIAAVGWVMAPETRTATELEA
DLMAAESDVEPV
>Mature_411_residues
GERAPRPGPLPREVWILSWANVMVALGYGVISPALPTFARSFGVSIKAVTFLVTVFSLSRLCFAPISGLLTERLGERRIY
IGGLLIVAVSTAACAFSQAYWQLMLYRVFSGVGSTMFYVSALGLMIHISPADARGRIAGLFTTSFMVGAVGGPAVGGLAA
GWGLTAPFVVYGVAMLGVALVLFLGLRNSALAAPRPPTRSTVTMREALRVRAYRSALLSNFATGWSAFGLRMALVPLFVS
DVIGRGIGTIGVVLAAFAGGNALAVVPSGYLSDRMGRRTLLIVGLVTSGAATVWLGFVASLPVFLVAAGVVGVVTGIYMS
PLQAAVADILGNEARAGLPVATVQMMSDLGAIVGSMAVGWAAEQIGYGWGFFISGVVLLIAAVGWVMAPETRTATELEAD
LMAAESDVEPV

Specific function: Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=148, Percent_Identity=29.0540540540541, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42800; Mature: 42669

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGERAPRPGPLPREVWILSWANVMVALGYGVISPALPTFARSFGVSIKAVTFLVTVFSLS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RLCFAPISGLLTERLGERRIYIGGLLIVAVSTAACAFSQAYWQLMLYRVFSGVGSTMFYV
HHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
SALGLMIHISPADARGRIAGLFTTSFMVGAVGGPAVGGLAAGWGLTAPFVVYGVAMLGVA
HHHHHEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
LVLFLGLRNSALAAPRPPTRSTVTMREALRVRAYRSALLSNFATGWSAFGLRMALVPLFV
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SDVIGRGIGTIGVVLAAFAGGNALAVVPSGYLSDRMGRRTLLIVGLVTSGAATVWLGFVA
HHHHHCCHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCEEEEEEEHHCCHHHHHHHHHH
SLPVFLVAAGVVGVVTGIYMSPLQAAVADILGNEARAGLPVATVQMMSDLGAIVGSMAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
WAAEQIGYGWGFFISGVVLLIAAVGWVMAPETRTATELEADLMAAESDVEPV
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GERAPRPGPLPREVWILSWANVMVALGYGVISPALPTFARSFGVSIKAVTFLVTVFSLS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RLCFAPISGLLTERLGERRIYIGGLLIVAVSTAACAFSQAYWQLMLYRVFSGVGSTMFYV
HHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
SALGLMIHISPADARGRIAGLFTTSFMVGAVGGPAVGGLAAGWGLTAPFVVYGVAMLGVA
HHHHHEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
LVLFLGLRNSALAAPRPPTRSTVTMREALRVRAYRSALLSNFATGWSAFGLRMALVPLFV
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SDVIGRGIGTIGVVLAAFAGGNALAVVPSGYLSDRMGRRTLLIVGLVTSGAATVWLGFVA
HHHHHCCHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCEEEEEEEHHCCHHHHHHHHHH
SLPVFLVAAGVVGVVTGIYMSPLQAAVADILGNEARAGLPVATVQMMSDLGAIVGSMAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
WAAEQIGYGWGFFISGVVLLIAAVGWVMAPETRTATELEADLMAAESDVEPV
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA