Definition Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession NC_002944
Length 4,829,781

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The map label for this gene is fabG [H]

Identifier: 41409235

GI number: 41409235

Start: 3491395

End: 3492135

Strand: Reverse

Name: fabG [H]

Synonym: MAP3137c

Alternate gene names: 41409235

Gene position: 3492135-3491395 (Counterclockwise)

Preceding gene: 41409236

Following gene: 41409234

Centisome position: 72.3

GC content: 68.15

Gene sequence:

>741_bases
ATGAGGGTGGCGGTGGTGACCGGCGGCGCGTCGGGCATGGGCGAGGCGACCTGCCACGAGCTGGGTCGGCGCGGCATGAA
AATCGCCGTGCTCGACGTCAACGAGCATGCGGCGCAACGCGTCACCGACGACCTGCGCACCGACGGCGCGACCGCGCTGG
CGGTGGGCGCCGACGTCACCGACCGGGCCGCCGTCGAGCAGGCCTTCGCGAAGGTGCGCAGCGAGCTGGGGCCGGTGACC
GTCCTGGTGACCAGCGCCGGGATGTTCGGGTTCTCGCCGTTCCTGGACATCACCGCCGAATCCTGGTCGCGGATCATCGA
TGTCAATCTCACCGGGACGTTTCACTGCTGTCAGGTCGCGCTGCCGGACATGGTGGCGGCGAACTGGGGGCGGATCGTGA
TGATCTCCTCGTCGAGTGCTCAGCGCGGGTCGCCGTTCGCCGCCCACTATGCGGCGTCCAAGGGGGCGGTGATCACGTTG
ACGAAATCGCTGGCCCGCGAATACGCGCCGCACGGCATCACGGTCAACAACATTCCGCCGTCGGGCATCGAGACGCCGAT
GCAGCATCAGGGCCAGGCGGACGGTTACCTGCCCTCCAACGAGCAGATCGCGGCGAACATCCCGCTGGGCTACCTGGGCA
CCGGGGCGGATATCGCCGCGGCGGTGGGGTTTTTGACGTCTGACGAGGCGCGGTACATCACCGGCCAGGTCTTGGGTGTC
AACGGCGGAGCAGTGATGTGA

Upstream 100 bases:

>100_bases
TGATCAACAACGACGCGCTCGATCCGGAGGAGGTCGACGACGGCTGGGTGCTGACCTGTCAGGCGCTGCCCACCAGCCCG
ACGGTGCGGGTGGTCTACGA

Downstream 100 bases:

>100_bases
CAGTGAGGATTCGATGACCAGATCAGGTAGGCCACCGGAAGGCTCGTGGACCGAGCACTACCCCGAATTGGGAACGGGGC
CGGTCTCTTTCAAGGATTCG

Product: hypothetical protein

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MRVAVVTGGASGMGEATCHELGRRGMKIAVLDVNEHAAQRVTDDLRTDGATALAVGADVTDRAAVEQAFAKVRSELGPVT
VLVTSAGMFGFSPFLDITAESWSRIIDVNLTGTFHCCQVALPDMVAANWGRIVMISSSSAQRGSPFAAHYAASKGAVITL
TKSLAREYAPHGITVNNIPPSGIETPMQHQGQADGYLPSNEQIAANIPLGYLGTGADIAAAVGFLTSDEARYITGQVLGV
NGGAVM

Sequences:

>Translated_246_residues
MRVAVVTGGASGMGEATCHELGRRGMKIAVLDVNEHAAQRVTDDLRTDGATALAVGADVTDRAAVEQAFAKVRSELGPVT
VLVTSAGMFGFSPFLDITAESWSRIIDVNLTGTFHCCQVALPDMVAANWGRIVMISSSSAQRGSPFAAHYAASKGAVITL
TKSLAREYAPHGITVNNIPPSGIETPMQHQGQADGYLPSNEQIAANIPLGYLGTGADIAAAVGFLTSDEARYITGQVLGV
NGGAVM
>Mature_246_residues
MRVAVVTGGASGMGEATCHELGRRGMKIAVLDVNEHAAQRVTDDLRTDGATALAVGADVTDRAAVEQAFAKVRSELGPVT
VLVTSAGMFGFSPFLDITAESWSRIIDVNLTGTFHCCQVALPDMVAANWGRIVMISSSSAQRGSPFAAHYAASKGAVITL
TKSLAREYAPHGITVNNIPPSGIETPMQHQGQADGYLPSNEQIAANIPLGYLGTGADIAAAVGFLTSDEARYITGQVLGV
NGGAVM

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=34.5098039215686, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=32.2314049586777, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI19923817, Length=250, Percent_Identity=29.6, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI7705925, Length=244, Percent_Identity=32.7868852459016, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI32483357, Length=243, Percent_Identity=29.2181069958848, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI210032110, Length=172, Percent_Identity=27.906976744186, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI66933014, Length=230, Percent_Identity=30.4347826086957, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=30.2040816326531, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4758504, Length=259, Percent_Identity=30.8880308880309, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=29.3172690763052, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503817, Length=187, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI59889578, Length=226, Percent_Identity=30.9734513274336, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI226371731, Length=192, Percent_Identity=32.8125, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI142976729, Length=173, Percent_Identity=27.1676300578035, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=26.7206477732794, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI7706318, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4504505, Length=192, Percent_Identity=31.25, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI83715985, Length=183, Percent_Identity=32.7868852459016, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40807363, Length=190, Percent_Identity=28.9473684210526, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4503301, Length=218, Percent_Identity=28.4403669724771, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI20149619, Length=191, Percent_Identity=29.8429319371728, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=31.3829787234043, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7705855, Length=191, Percent_Identity=26.7015706806283, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI310128830, Length=177, Percent_Identity=29.3785310734463, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI310115468, Length=177, Percent_Identity=29.3785310734463, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4557649, Length=190, Percent_Identity=27.3684210526316, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI31542939, Length=193, Percent_Identity=27.979274611399, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=39.1836734693878, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=36.9477911646586, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=33.6, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=34.0080971659919, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790717, Length=242, Percent_Identity=29.7520661157025, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=30.4878048780488, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789208, Length=243, Percent_Identity=27.9835390946502, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=31.9066147859922, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=31.4285714285714, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI87082160, Length=245, Percent_Identity=27.3469387755102, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=28, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI2367365, Length=244, Percent_Identity=29.0983606557377, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1787820, Length=181, Percent_Identity=28.1767955801105, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787526, Length=246, Percent_Identity=24.7967479674797, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=35.2, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=33.8775510204082, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=30.5882352941176, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=30, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561402, Length=246, Percent_Identity=27.2357723577236, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17560676, Length=243, Percent_Identity=27.1604938271605, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17538182, Length=197, Percent_Identity=34.010152284264, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17567345, Length=189, Percent_Identity=27.5132275132275, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=30.7291666666667, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17536651, Length=252, Percent_Identity=28.968253968254, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561272, Length=210, Percent_Identity=31.4285714285714, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193203117, Length=166, Percent_Identity=28.9156626506024, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193203115, Length=166, Percent_Identity=28.9156626506024, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508895, Length=189, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=25.4826254826255, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=242, Percent_Identity=28.9256198347107, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=26.9662921348315, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=248, Percent_Identity=27.0161290322581, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=26.6409266409266, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=25.0950570342205, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17551412, Length=260, Percent_Identity=25.7692307692308, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=26.9961977186312, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=273, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=191, Percent_Identity=23.5602094240838, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=24.8091603053435, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=25.7575757575758, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=24.5210727969349, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=25.3846153846154, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=262, Percent_Identity=26.7175572519084, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=26.1363636363636, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=263, Percent_Identity=22.8136882129278, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=246, Percent_Identity=28.8617886178862, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6322861, Length=188, Percent_Identity=30.8510638297872, Blast_Score=92, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=33.6032388663968, Blast_Score=120, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28571526, Length=245, Percent_Identity=31.8367346938775, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=31.7269076305221, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=33.0645161290323, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355319, Length=243, Percent_Identity=29.2181069958848, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=30.0813008130081, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI18859837, Length=189, Percent_Identity=33.8624338624339, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=30.4878048780488, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24640492, Length=188, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24649181, Length=230, Percent_Identity=32.1739130434783, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17737361, Length=198, Percent_Identity=30.8080808080808, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355631, Length=167, Percent_Identity=31.7365269461078, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581726, Length=190, Percent_Identity=28.4210526315789, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356301, Length=190, Percent_Identity=26.8421052631579, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644337, Length=226, Percent_Identity=27.8761061946903, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640442, Length=205, Percent_Identity=27.8048780487805, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574402, Length=189, Percent_Identity=29.6296296296296, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24584744, Length=189, Percent_Identity=29.6296296296296, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24584752, Length=187, Percent_Identity=28.3422459893048, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281364892, Length=166, Percent_Identity=27.1084337349398, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI116007236, Length=203, Percent_Identity=26.1083743842365, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641388, Length=199, Percent_Identity=30.1507537688442, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25502; Mature: 25502

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MRVAVVTGGASGMGEATCHELGRRGMKIAVLDVNEHAAQRVTDDLRTDGATALAVGADVT
CEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCH
DRAAVEQAFAKVRSELGPVTVLVTSAGMFGFSPFLDITAESWSRIIDVNLTGTFHCCQVA
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHEEECCCCCEEEEEEECCCCCEEEHH
LPDMVAANWGRIVMISSSSAQRGSPFAAHYAASKGAVITLTKSLAREYAPHGITVNNIPP
CCHHHHCCCCEEEEEECCCCCCCCCCEEEHHCCCCEEEEEEHHHHHHHCCCCEEECCCCC
SGIETPMQHQGQADGYLPSNEQIAANIPLGYLGTGADIAAAVGFLTSDEARYITGQVLGV
CCCCCCHHHCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEC
NGGAVM
CCCCCC
>Mature Secondary Structure
MRVAVVTGGASGMGEATCHELGRRGMKIAVLDVNEHAAQRVTDDLRTDGATALAVGADVT
CEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCH
DRAAVEQAFAKVRSELGPVTVLVTSAGMFGFSPFLDITAESWSRIIDVNLTGTFHCCQVA
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHEEECCCCCEEEEEEECCCCCEEEHH
LPDMVAANWGRIVMISSSSAQRGSPFAAHYAASKGAVITLTKSLAREYAPHGITVNNIPP
CCHHHHCCCCEEEEEECCCCCCCCCCEEEHHCCCCEEEEEEHHHHHHHCCCCEEECCCCC
SGIETPMQHQGQADGYLPSNEQIAANIPLGYLGTGADIAAAVGFLTSDEARYITGQVLGV
CCCCCCHHHCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEC
NGGAVM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1556094; 8905232; 9278503; 1314802 [H]