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The map label for this gene is nrdE

Identifier: 41409198

GI number: 41409198

Start: 3447754

End: 3449934

Strand: Reverse

Name: nrdE

Synonym: MAP3100c

Alternate gene names: 41409198

Gene position: 3449934-3447754 (Counterclockwise)

Preceding gene: 41409199

Following gene: 41409197

Centisome position: 71.43

GC content: 61.85

Gene sequence:

>2181_bases
TTGGAAGGAACAGACGTGTCACCAACCGTCGCTGCAGAGCCTGTAACCGCCGGCGCTCATGGCTTGCCCGACGAAACGGA
CTACCATGCGCTGAACGCGATGCTGAACCTGTACGACGCGGACGGCAAGATCCAGTTCGACAAGGACGTCCTCGCCGCGC
GCCAGTACTTTCTGCAGCACGTCAACCAGAACACCGTCTTCTTTCACAATCAGGACGAGAAACTCGACTACCTGATCCGC
GAAAACTATTACGAGCGTGAGGTTCTCGACCAGTACTCGCGCAACTTCGTCAAGTCGTTGCTGGACCGCGCCTACGCCAA
GAAGTTCCGCTTCCCGACCTTTCTCGGCGCCTTCAAGTACTACACCTCCTACACGCTGAAGACGTTCGACGGGAAGCGCT
ATCTGGAGCGCTTCGAGGACCGCGTGGTCATGGTGGCGCTCACGCTGGCGGCCGGCGACACCGGGCTGGCCGAGAAGCTG
GTCGACGAGATCATCGAGGGCCGTTTCCAGCCGGCCACGCCGACGTTTTTGAACTCCGGCAAGAAGCAGCGCGGCGAGCC
GGTGAGCTGCTTTCTGCTGCGCATCGAGGACAACATGGAGTCCATCGGGCGTTCGATCAACTCCGCGCTGCAGCTGTCCA
AGCGCGGCGGCGGAGTCGCGTTGCTGCTGACCAACATTCGCGAGCACGGCGCGCCGATCAAGAACATCGAGAACCAGTCC
TCGGGCGTCATCCCCATCATGAAGCTGCTGGAGGACTCGTTCTCCTACGCCAATCAGCTCGGGGCGCGCCAGGGGGCCGG
CGCGGTGTACCTGCACGCCCATCACCCCGACATCTACCGCTTCCTGGACACCAAGCGGGAGAACGCCGACGAGAAGATCC
GGATCAAGACGCTGAGCCTGGGCGTGGTGATCCCCGACATCACCTTCGAGCTGGCCAAGAAGAACGAGGACATGTACCTG
TTCTCGCCGTACGACGTGGAACGCGTCTACGGGCTGCCGTTCGCCGACATCTCGGTGACCGAGAAGTACTACGAGATGGT
CGACGACGCCCGCATCCGCAAGACCAAGATCAAGGCGCGGGAGTTCTTCCAGACGCTGGCCGAGCTGCAGTTCGAGTCGG
GCTACCCGTACATCATGTTCGAGGACACGGTGAACCGGGCCAATCCCATCGACGGCAAGATCACCCACTCCAACCTGTGC
TCGGAGATCCTGCAGGTCTCCACGCCGTCGTTGTTCAACGACGACCTGTCGTATGCCAAAGTGGGCAAGGACATTTCGTG
CAACCTGGGTTCGCTGAACATCGCCAAGACGATGGACTCGCCCGACTTCGCCCAGACCATCGAGGTGGCCATCCGGGCGC
TGACCGCCGTTAGCGACCAGACGCACATCACCTCGGTGCCCTCAATCGAGCAGGGCAACAACGATTCTCACGCGATCGGG
CTCGGGCAGATGAACCTGCACGGGTACCTGGCCCGCGAGGGCATCTTCTACGGCTCCGAAGAGGGCATCGACTTCACCAA
CATCTACTTCTACACGGTGCTCTATCACGCGCTGCGCGCGTCGAACCGCATCGCGATCGAACGCGGCACGCACTTCAAGG
GTTTCGAGCGCTCCAAGTACGCGTCGGGGGAGTTCTTCGACAAGTACACCGAGCAGGTGTGGGAGCCGGCGACCGAGAAG
GTGCGCCAACTCTTCGCCGATGCCGGCATCCGCATCCCCACCCAGGACGACTGGAAGCGGCTGAAGGAGTCGGTGCAGGC
GCACGGCATCTACAACCAGAACCTGCAGGCGGTGCCGCCGACCGGGTCGATCTCCTACATCAACCACTCGACGAGCTCGA
TCCACCCGATCGTGTCGAAGGTCGAGATCCGCAAGGAGGGCAAGATCGGGCGGGTCTACTACCCGGCGCCCTACATGACC
AACGACAACCTGGAGTACTACCAGGACGCCTACGAGATCGGTTACGAGAAGATCATCGACACCTACGCCGCGGCCACCCA
GCACGTCGACCAGGGGCTGAGCCTGACGCTGTTCTTCAAGGACACCGCCACCACCCGCGACGTCAACAAGGCGCAGATCT
ACGCCTGGCGCAAGGGCATCAAGACGCTCTACTACATCCGGTTGCGCCAGATGGCGCTGGAGGGAACCGAGGTCGAGGGC
TGCGTGTCCTGCATGCTGTGA

Upstream 100 bases:

>100_bases
ACGTGGTCTCGCGCAAGTGCGGCGTTCCGTACCTCTACCGCTTCGAACTGATGGGAACCCAGGACGACGTGGACGCCGTC
CGAGCGGGCTTAGCTGAATT

Downstream 100 bases:

>100_bases
TCCCTCCCGCCGAACGTGTAGCTGTTGCGACTTTTCGGCTCGAATTTCGCAACCAGCGCACGTTCGGCGAGGTGCGGACG
CGCCGATCTGCCCAGGTCAG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase R1 subunit [H]

Number of amino acids: Translated: 726; Mature: 726

Protein sequence:

>726_residues
MEGTDVSPTVAAEPVTAGAHGLPDETDYHALNAMLNLYDADGKIQFDKDVLAARQYFLQHVNQNTVFFHNQDEKLDYLIR
ENYYEREVLDQYSRNFVKSLLDRAYAKKFRFPTFLGAFKYYTSYTLKTFDGKRYLERFEDRVVMVALTLAAGDTGLAEKL
VDEIIEGRFQPATPTFLNSGKKQRGEPVSCFLLRIEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQS
SGVIPIMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKKNEDMYL
FSPYDVERVYGLPFADISVTEKYYEMVDDARIRKTKIKAREFFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLC
SEILQVSTPSLFNDDLSYAKVGKDISCNLGSLNIAKTMDSPDFAQTIEVAIRALTAVSDQTHITSVPSIEQGNNDSHAIG
LGQMNLHGYLAREGIFYGSEEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGFERSKYASGEFFDKYTEQVWEPATEK
VRQLFADAGIRIPTQDDWKRLKESVQAHGIYNQNLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMT
NDNLEYYQDAYEIGYEKIIDTYAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEG
CVSCML

Sequences:

>Translated_726_residues
MEGTDVSPTVAAEPVTAGAHGLPDETDYHALNAMLNLYDADGKIQFDKDVLAARQYFLQHVNQNTVFFHNQDEKLDYLIR
ENYYEREVLDQYSRNFVKSLLDRAYAKKFRFPTFLGAFKYYTSYTLKTFDGKRYLERFEDRVVMVALTLAAGDTGLAEKL
VDEIIEGRFQPATPTFLNSGKKQRGEPVSCFLLRIEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQS
SGVIPIMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKKNEDMYL
FSPYDVERVYGLPFADISVTEKYYEMVDDARIRKTKIKAREFFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLC
SEILQVSTPSLFNDDLSYAKVGKDISCNLGSLNIAKTMDSPDFAQTIEVAIRALTAVSDQTHITSVPSIEQGNNDSHAIG
LGQMNLHGYLAREGIFYGSEEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGFERSKYASGEFFDKYTEQVWEPATEK
VRQLFADAGIRIPTQDDWKRLKESVQAHGIYNQNLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMT
NDNLEYYQDAYEIGYEKIIDTYAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEG
CVSCML
>Mature_726_residues
MEGTDVSPTVAAEPVTAGAHGLPDETDYHALNAMLNLYDADGKIQFDKDVLAARQYFLQHVNQNTVFFHNQDEKLDYLIR
ENYYEREVLDQYSRNFVKSLLDRAYAKKFRFPTFLGAFKYYTSYTLKTFDGKRYLERFEDRVVMVALTLAAGDTGLAEKL
VDEIIEGRFQPATPTFLNSGKKQRGEPVSCFLLRIEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQS
SGVIPIMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKKNEDMYL
FSPYDVERVYGLPFADISVTEKYYEMVDDARIRKTKIKAREFFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLC
SEILQVSTPSLFNDDLSYAKVGKDISCNLGSLNIAKTMDSPDFAQTIEVAIRALTAVSDQTHITSVPSIEQGNNDSHAIG
LGQMNLHGYLAREGIFYGSEEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGFERSKYASGEFFDKYTEQVWEPATEK
VRQLFADAGIRIPTQDDWKRLKESVQAHGIYNQNLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMT
NDNLEYYQDAYEIGYEKIIDTYAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEG
CVSCML

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase large chain family [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=686, Percent_Identity=26.0932944606414, Blast_Score=192, Evalue=9e-49,
Organism=Escherichia coli, GI1789030, Length=713, Percent_Identity=72.9312762973352, Blast_Score=1098, Evalue=0.0,
Organism=Escherichia coli, GI2367133, Length=561, Percent_Identity=27.807486631016, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17555242, Length=643, Percent_Identity=26.905132192846, Blast_Score=197, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320914, Length=658, Percent_Identity=25.8358662613982, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6322123, Length=657, Percent_Identity=26.027397260274, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI17352481, Length=642, Percent_Identity=25.5451713395639, Blast_Score=186, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926
- InterPro:   IPR013554 [H]

Pfam domain/function: PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN; PF08343 RNR_N [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 82377; Mature: 82377

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGTDVSPTVAAEPVTAGAHGLPDETDYHALNAMLNLYDADGKIQFDKDVLAARQYFLQH
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHH
VNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKSLLDRAYAKKFRFPTFLGAFKY
CCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YTSYTLKTFDGKRYLERFEDRVVMVALTLAAGDTGLAEKLVDEIIEGRFQPATPTFLNSG
HHHEEEEECCCHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHCCC
KKQRGEPVSCFLLRIEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQS
CHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCCCCCCC
SGVIPIMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSL
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEEE
GVVIPDITFELAKKNEDMYLFSPYDVERVYGLPFADISVTEKYYEMVDDARIRKTKIKAR
EEEECCCHHHHHCCCCCEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EFFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLCSEILQVSTPSLFNDDLSYAK
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHH
VGKDISCNLGSLNIAKTMDSPDFAQTIEVAIRALTAVSDQTHITSVPSIEQGNNDSHAIG
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEE
LGQMNLHGYLAREGIFYGSEEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGFERSKY
ECCCCCCCEEECCCEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
ASGEFFDKYTEQVWEPATEKVRQLFADAGIRIPTQDDWKRLKESVQAHGIYNQNLQAVPP
CCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCC
TGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLEYYQDAYEIGYEKIID
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
TYAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEG
HHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
CVSCML
HHHHCC
>Mature Secondary Structure
MEGTDVSPTVAAEPVTAGAHGLPDETDYHALNAMLNLYDADGKIQFDKDVLAARQYFLQH
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHH
VNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKSLLDRAYAKKFRFPTFLGAFKY
CCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YTSYTLKTFDGKRYLERFEDRVVMVALTLAAGDTGLAEKLVDEIIEGRFQPATPTFLNSG
HHHEEEEECCCHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHCCC
KKQRGEPVSCFLLRIEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQS
CHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCCCCCCC
SGVIPIMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSL
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEEE
GVVIPDITFELAKKNEDMYLFSPYDVERVYGLPFADISVTEKYYEMVDDARIRKTKIKAR
EEEECCCHHHHHCCCCCEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EFFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLCSEILQVSTPSLFNDDLSYAK
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHH
VGKDISCNLGSLNIAKTMDSPDFAQTIEVAIRALTAVSDQTHITSVPSIEQGNNDSHAIG
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEE
LGQMNLHGYLAREGIFYGSEEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGFERSKY
ECCCCCCCEEECCCEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
ASGEFFDKYTEQVWEPATEKVRQLFADAGIRIPTQDDWKRLKESVQAHGIYNQNLQAVPP
CCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCC
TGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLEYYQDAYEIGYEKIID
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
TYAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEG
HHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
CVSCML
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]