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The map label for this gene is mutT1

Identifier: 41409121

GI number: 41409121

Start: 3363332

End: 3364279

Strand: Direct

Name: mutT1

Synonym: MAP3023

Alternate gene names: 41409121

Gene position: 3363332-3364279 (Clockwise)

Preceding gene: 41409120

Following gene: 41409125

Centisome position: 69.64

GC content: 69.41

Gene sequence:

>948_bases
GTGCCGACCCAGAATTCGTCGACTGCTCGACGCGCCGGAACCCGGGTGGTCTACGCCGCCGGCGCGGTGCTGTGGCGACC
CGGCGACGCCGAGCCGGACGGCGGTGACGTCGAGGTCGCGATCATCCATCGCCCGCGCTATGACGACTGGTCACTGCCCA
AGGGCAAGGTGGACCCCGGCGAGACGGCGCCGGTTGCGGCGGTGCGCGAAGTGCGCGAGGAGACGGGCCAGTGCGCCGTG
CTCGGCAGACGGCTCGACACGGTGCGCTATCCGATCGAACAGGGCGTCAAGAAGGTCTACTACTGGTCGGCGCGCGCCAC
CGGCGGCGAATTCGTACCCGGCGACGAGGTCGACCAGTTGCTCTGGTTGCCGGTGGCCGAGGCGATGCAGCGGCTCAATT
ACACACAAGACCGAAAAGTGTTGCGGCACTTCAACAAAAAGCCCGCGGACACACACACCGTGCTGGTGGTGCGGCACGGC
ACGGCCGGGCGCAAATCTCGTTTCTCCGGCGACGACGCCAAGCGGCCGCTGGACAAGCGGGGCCGGGCGCAGGCCGAGGC
GCTGGTCCCGCAGCTGCTGGCGTTCGGTGCCTCACAGGTGCACGCGGCCGACCGGGTCCGCTGCCACCAGACCGTGCAAC
CGCTGGCCGAGGAGCTCGACGTGCCGGTGCACAACGAGACCACGCTCACCGAGGAGGCATACGCCAAGAACCCCAAGCGC
GCTCGGCACCGGATGCTCGAGATCGCCGGGGAGCCAGGCACACCGGTTGTCTGCACGCAGGGCAAGGTGATTCCGGACCT
GATCGCGTGGTGGTGTGATCGCGACGGAGTGCGGCCCGACAAGTCACGCAACCACAAGGGCAGCACCTGGGTGCTGTCGT
TGTCGGCCGGCCGGCTGGTGGCCGCCGATCACATCGGCGGCGCGCTGGCCGCCAACGTGCGCGCCTGA

Upstream 100 bases:

>100_bases
GCATCGCAGTCCCTAGCCCTGCGGGTGAGTTCGGAGTTGTTTTTCCGGCCGCAGCGTGATCCAGCGTGCGACTTGACCGA
ATTGACCTGCAGGAGTTGAG

Downstream 100 bases:

>100_bases
GTTCGCGGCGGCGTGCCCGCTCGCTAGCACACGAATACCCTCCGGGCGGCACCGCTGCCGGCCGAAGGGTATTCGTGTCT
AGGACGTGCTCTGCCTACTT

Product: MutT1

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MPTQNSSTARRAGTRVVYAAGAVLWRPGDAEPDGGDVEVAIIHRPRYDDWSLPKGKVDPGETAPVAAVREVREETGQCAV
LGRRLDTVRYPIEQGVKKVYYWSARATGGEFVPGDEVDQLLWLPVAEAMQRLNYTQDRKVLRHFNKKPADTHTVLVVRHG
TAGRKSRFSGDDAKRPLDKRGRAQAEALVPQLLAFGASQVHAADRVRCHQTVQPLAEELDVPVHNETTLTEEAYAKNPKR
ARHRMLEIAGEPGTPVVCTQGKVIPDLIAWWCDRDGVRPDKSRNHKGSTWVLSLSAGRLVAADHIGGALAANVRA

Sequences:

>Translated_315_residues
MPTQNSSTARRAGTRVVYAAGAVLWRPGDAEPDGGDVEVAIIHRPRYDDWSLPKGKVDPGETAPVAAVREVREETGQCAV
LGRRLDTVRYPIEQGVKKVYYWSARATGGEFVPGDEVDQLLWLPVAEAMQRLNYTQDRKVLRHFNKKPADTHTVLVVRHG
TAGRKSRFSGDDAKRPLDKRGRAQAEALVPQLLAFGASQVHAADRVRCHQTVQPLAEELDVPVHNETTLTEEAYAKNPKR
ARHRMLEIAGEPGTPVVCTQGKVIPDLIAWWCDRDGVRPDKSRNHKGSTWVLSLSAGRLVAADHIGGALAANVRA
>Mature_314_residues
PTQNSSTARRAGTRVVYAAGAVLWRPGDAEPDGGDVEVAIIHRPRYDDWSLPKGKVDPGETAPVAAVREVREETGQCAVL
GRRLDTVRYPIEQGVKKVYYWSARATGGEFVPGDEVDQLLWLPVAEAMQRLNYTQDRKVLRHFNKKPADTHTVLVVRHGT
AGRKSRFSGDDAKRPLDKRGRAQAEALVPQLLAFGASQVHAADRVRCHQTVQPLAEELDVPVHNETTLTEEAYAKNPKRA
RHRMLEIAGEPGTPVVCTQGKVIPDLIAWWCDRDGVRPDKSRNHKGSTWVLSLSAGRLVAADHIGGALAANVRA

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX; PF00300 PGAM [H]

EC number: NA

Molecular weight: Translated: 34643; Mature: 34511

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTQNSSTARRAGTRVVYAAGAVLWRPGDAEPDGGDVEVAIIHRPRYDDWSLPKGKVDPG
CCCCCCCHHHHHCCEEEEECCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
ETAPVAAVREVREETGQCAVLGRRLDTVRYPIEQGVKKVYYWSARATGGEFVPGDEVDQL
CCCHHHHHHHHHHHCCCEEEHHHHHHHHHCCHHHCHHEEEEEECCCCCCCCCCCCCHHHH
LWLPVAEAMQRLNYTQDRKVLRHFNKKPADTHTVLVVRHGTAGRKSRFSGDDAKRPLDKR
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHCCCHHHH
GRAQAEALVPQLLAFGASQVHAADRVRCHQTVQPLAEELDVPVHNETTLTEEAYAKNPKR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHH
ARHRMLEIAGEPGTPVVCTQGKVIPDLIAWWCDRDGVRPDKSRNHKGSTWVLSLSAGRLV
HHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEE
AADHIGGALAANVRA
EHHHCCCHHHCCCCC
>Mature Secondary Structure 
PTQNSSTARRAGTRVVYAAGAVLWRPGDAEPDGGDVEVAIIHRPRYDDWSLPKGKVDPG
CCCCCCHHHHHCCEEEEECCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
ETAPVAAVREVREETGQCAVLGRRLDTVRYPIEQGVKKVYYWSARATGGEFVPGDEVDQL
CCCHHHHHHHHHHHCCCEEEHHHHHHHHHCCHHHCHHEEEEEECCCCCCCCCCCCCHHHH
LWLPVAEAMQRLNYTQDRKVLRHFNKKPADTHTVLVVRHGTAGRKSRFSGDDAKRPLDKR
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHCCCHHHH
GRAQAEALVPQLLAFGASQVHAADRVRCHQTVQPLAEELDVPVHNETTLTEEAYAKNPKR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHH
ARHRMLEIAGEPGTPVVCTQGKVIPDLIAWWCDRDGVRPDKSRNHKGSTWVLSLSAGRLV
HHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEE
AADHIGGALAANVRA
EHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]