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The map label for this gene is fpg

Identifier: 41409092

GI number: 41409092

Start: 3331191

End: 3332042

Strand: Reverse

Name: fpg

Synonym: MAP2994c

Alternate gene names: 41409092

Gene position: 3332042-3331191 (Counterclockwise)

Preceding gene: 41409093

Following gene: 41409090

Centisome position: 68.99

GC content: 70.89

Gene sequence:

>852_bases
ATGCCCGAACTGCCCGAAGTCGAGGTGGTGCGCCGCGGCCTGCACGCGCACGTGGTGGGCAAGACGATCGGCGCGGTGCG
GGTGCATCACCCCCGCGCGGTGCGCCGCCACGAAGCCGGCCCCGCCGACCTCACCGCCCGGCTGCTGGGCGCGCGGATCA
CCGGCACCGACCGGCGCGGCAAGTACCTGTGGCTGCTGCTGGACGGCTGCGATACCGCGCTGGTGGTGCACCTGGGCATG
AGCGGGCAGATGCTGCTCGGCGCGGTGCCGCGCGCCGAGCACGTCCGCATCTCGGCACTGCTCGACGACGGCACCGTGCT
GAGCTTCGCCGACCAACGCACCTTCGGCGGCTGGATGCTCGCCGACCTTCTCGAGGTGGACGGCAGCATCCTGCCCCGGC
CCGTCGCGCACCTGGCGCGCGACCCGCTCGATCCCCGCTTCGACGCCGCCGCGGTGGTAAAAGTGTTGCGGCGCAAGCAC
TCCGAAATCAAGCGACAGCTGCTCGATCAGCAGGTGGTGTCCGGGATCGGCAACATCTACGCCGACGAGGCGCTGTGGCG
GGCCAAGGTGCACGGCGCCCGGATCGCCGCCACGATGACCGGCAGGCAGCTGACCGCCGTGCTGGACGCCGCCGCCGAGG
TGATGCGCGACGCGCTGGCCCAGGGCGGAACCTCGTTCGATTCGCTGTACGTCAACGTCAACGGCGAATCCGGGTACTTC
GACCGATCGCTGGACGCCTACGGCCGGGAGGGCGAAAGCTGCCGGCGCTGCGGCGCGGTGATGCGCCGGGAGAAGTTCAT
GAACCGCTCGTCGTTCTACTGCCCGAAATGCCAACCGCGCCCGCGGCTTTGA

Upstream 100 bases:

>100_bases
AGGAGGCCGAGCAGAAGGCCGCGGCGGCGACCTGGAAGGCGCTCGACGTGCTCGACTCCGCCGCGCAGACGTCCGCCTAG
CCGGAGCCCGCCCCGGATCG

Downstream 100 bases:

>100_bases
GGACGATCAGTCGAAGATGTCGCGGCGCACGGTGCCCGTCGGCAACGCCGGGTCCACGAACCATTCGTGGCTGAACAGCG
CGCCGAACACCTGCGGCGGC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPELPEVEVVRRGLHAHVVGKTIGAVRVHHPRAVRRHEAGPADLTARLLGARITGTDRRGKYLWLLLDGCDTALVVHLGM
SGQMLLGAVPRAEHVRISALLDDGTVLSFADQRTFGGWMLADLLEVDGSILPRPVAHLARDPLDPRFDAAAVVKVLRRKH
SEIKRQLLDQQVVSGIGNIYADEALWRAKVHGARIAATMTGRQLTAVLDAAAEVMRDALAQGGTSFDSLYVNVNGESGYF
DRSLDAYGREGESCRRCGAVMRREKFMNRSSFYCPKCQPRPRL

Sequences:

>Translated_283_residues
MPELPEVEVVRRGLHAHVVGKTIGAVRVHHPRAVRRHEAGPADLTARLLGARITGTDRRGKYLWLLLDGCDTALVVHLGM
SGQMLLGAVPRAEHVRISALLDDGTVLSFADQRTFGGWMLADLLEVDGSILPRPVAHLARDPLDPRFDAAAVVKVLRRKH
SEIKRQLLDQQVVSGIGNIYADEALWRAKVHGARIAATMTGRQLTAVLDAAAEVMRDALAQGGTSFDSLYVNVNGESGYF
DRSLDAYGREGESCRRCGAVMRREKFMNRSSFYCPKCQPRPRL
>Mature_282_residues
PELPEVEVVRRGLHAHVVGKTIGAVRVHHPRAVRRHEAGPADLTARLLGARITGTDRRGKYLWLLLDGCDTALVVHLGMS
GQMLLGAVPRAEHVRISALLDDGTVLSFADQRTFGGWMLADLLEVDGSILPRPVAHLARDPLDPRFDAAAVVKVLRRKHS
EIKRQLLDQQVVSGIGNIYADEALWRAKVHGARIAATMTGRQLTAVLDAAAEVMRDALAQGGTSFDSLYVNVNGESGYFD
RSLDAYGREGESCRRCGAVMRREKFMNRSSFYCPKCQPRPRL

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=280, Percent_Identity=33.9285714285714, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1786932, Length=285, Percent_Identity=25.9649122807018, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_MYCPA (Q73VL9)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_961928.1
- ProteinModelPortal:   Q73VL9
- SMR:   Q73VL9
- EnsemblBacteria:   EBMYCT00000037047
- GeneID:   2721442
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP2994c
- NMPDR:   fig|262316.1.peg.2994
- GeneTree:   EBGT00050000016359
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31164; Mature: 31033

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 61-61 ACT_SITE 269-269 BINDING 94-94 BINDING 113-113 BINDING 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVVRRGLHAHVVGKTIGAVRVHHPRAVRRHEAGPADLTARLLGARITGTDRRG
CCCCCHHHHHHCCHHHHHHHHHHCEEEECCCHHHHHCCCCCHHHHHHHHHCEECCCCCCC
KYLWLLLDGCDTALVVHLGMSGQMLLGAVPRAEHVRISALLDDGTVLSFADQRTFGGWML
CEEEEEEECCCEEEEEEECCCCCEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCHHHH
ADLLEVDGSILPRPVAHLARDPLDPRFDAAAVVKVLRRKHSEIKRQLLDQQVVSGIGNIY
HHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEALWRAKVHGARIAATMTGRQLTAVLDAAAEVMRDALAQGGTSFDSLYVNVNGESGYF
HHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
DRSLDAYGREGESCRRCGAVMRREKFMNRSSFYCPKCQPRPRL
CCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVEVVRRGLHAHVVGKTIGAVRVHHPRAVRRHEAGPADLTARLLGARITGTDRRG
CCCCHHHHHHCCHHHHHHHHHHCEEEECCCHHHHHCCCCCHHHHHHHHHCEECCCCCCC
KYLWLLLDGCDTALVVHLGMSGQMLLGAVPRAEHVRISALLDDGTVLSFADQRTFGGWML
CEEEEEEECCCEEEEEEECCCCCEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCHHHH
ADLLEVDGSILPRPVAHLARDPLDPRFDAAAVVKVLRRKHSEIKRQLLDQQVVSGIGNIY
HHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEALWRAKVHGARIAATMTGRQLTAVLDAAAEVMRDALAQGGTSFDSLYVNVNGESGYF
HHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
DRSLDAYGREGESCRRCGAVMRREKFMNRSSFYCPKCQPRPRL
CCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA