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The map label for this gene is dxr [H]

Identifier: 41409038

GI number: 41409038

Start: 3275197

End: 3276456

Strand: Reverse

Name: dxr [H]

Synonym: MAP2940c

Alternate gene names: 41409038

Gene position: 3276456-3275197 (Counterclockwise)

Preceding gene: 41409039

Following gene: 41409037

Centisome position: 67.84

GC content: 72.86

Gene sequence:

>1260_bases
ATGGCCCGCGCCGGTGGCGGGCGGCACAATGAATGGGTGACCAACCCGACGAGCGACGGGCAGCCGCGCGGCCGCCTGCG
CGTACTGGTGCTGGGCAGCACCGGCTCGATCGGCACCCAGGCGCTGCAGGTGATCGCGGCCAACCCGGACCGCTTCGAGG
TCGTCGGCCTGGCCGCCGGGGGCGCCAACCTGGACACGCTGCTGCGGCAGCGGGCCGAGACGGGTGTGACCAACGTCGCC
GTCGCCGACGAACACGCCGCCCGGCGGGCCGGCGACATCCCGTTCTGCGGGCCCGAGGCGGCGACCCGGCTGGTCGAGGA
GACCGAGGCCGACGTCGTGCTCAACGCGCTGGTCGGGGCGCTGGGGCTGCGGCCCACGCTGGCCGCGCTGGAGTCGGGAG
CCCGGCTGGCGCTGGCCAACAAGGAGTCGCTGATCGCCGGCGGGCCGCTGGTGCTCGCGGCCGCCGCGCCCGGGCAGATC
GTGCCGGTGGACTCCGAGCATTCCGCGTTGGCCCAGTGCCTGCGCGGCGGCACCGGCGACGAGGTCGCCAAGCTGGTGCT
GACCGCCTCCGGCGGCCCGTTCCGCGGCTGGACGGCCGAGGAGCTCGAGCACGTCACGCCCGAGCAGGCGGGCGCCCACC
CGACCTGGTCGATGGGGCCGATGAACACGCTGAACTCGGCGTCGCTGGTCAACAAGGGCCTGGAGCTCATCGAAACCCAC
CTGCTGTTCGGCATCCCGTATGACCGCATCGAGGTGGTCGTGCACCCGCAGTCGATCGTTCATTCGATGGTCACCTTCGT
CGACGGCTCCACCCTGGCCCAGGCCAGCCCGCCGGACATGCGGCTGCCGATCTCGCTGGCCCTGGGCTGGCCGCACCGGG
TGCCCGGGGCGGCCGCCTGCTGCGACTTCTCCACCGCGTCGAGCTGGGAATTCGAGCCGCTGGACAACGAGGTCTTCCCC
GCCGTCGAGCTGGCCCGCCACGCCGGGCAGGCCGGCGGCTGCATGACCGCGATCTACAACGCCGCCAACGAGGAGGCCGC
CGCGGCGTTCCTGGCCGGACGGGTCTCCTTCGGCGCCATCGTCGAAACCATCGCCGACGTGCTGCACGCCGCCGACCAAT
GGGCGCCCAAATTCAGCGAAACACCCGCTAACGTGGATGACGTACTAGACGCGCAGCGCTGGGCACGGCAGCGGGCGCAG
CGTGCCGTCGCACAGGCACGGCCCGCCACGGCGTCAGCGAAAACCCCCGGAGTGGTGTGA

Upstream 100 bases:

>100_bases
CTCGGTACTGGCCACGGCGAATCCCCTTCGGATCGGATCGGCTTGTCGAACCCAGATTCTGGCACAACGGCCGGCCGGGC
TCGCGGGGCACGGCCGCATC

Downstream 100 bases:

>100_bases
GAAAGGTCCTCGCAGCCTAATGATGTTCGTCATCGGCATTGTGCTGTTCGCACTGGCCATCCTGATCTCGGTGGCCCTGC
ACGAGTGCGGGCACATGTGG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MARAGGGRHNEWVTNPTSDGQPRGRLRVLVLGSTGSIGTQALQVIAANPDRFEVVGLAAGGANLDTLLRQRAETGVTNVA
VADEHAARRAGDIPFCGPEAATRLVEETEADVVLNALVGALGLRPTLAALESGARLALANKESLIAGGPLVLAAAAPGQI
VPVDSEHSALAQCLRGGTGDEVAKLVLTASGGPFRGWTAEELEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETH
LLFGIPYDRIEVVVHPQSIVHSMVTFVDGSTLAQASPPDMRLPISLALGWPHRVPGAAACCDFSTASSWEFEPLDNEVFP
AVELARHAGQAGGCMTAIYNAANEEAAAAFLAGRVSFGAIVETIADVLHAADQWAPKFSETPANVDDVLDAQRWARQRAQ
RAVAQARPATASAKTPGVV

Sequences:

>Translated_419_residues
MARAGGGRHNEWVTNPTSDGQPRGRLRVLVLGSTGSIGTQALQVIAANPDRFEVVGLAAGGANLDTLLRQRAETGVTNVA
VADEHAARRAGDIPFCGPEAATRLVEETEADVVLNALVGALGLRPTLAALESGARLALANKESLIAGGPLVLAAAAPGQI
VPVDSEHSALAQCLRGGTGDEVAKLVLTASGGPFRGWTAEELEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETH
LLFGIPYDRIEVVVHPQSIVHSMVTFVDGSTLAQASPPDMRLPISLALGWPHRVPGAAACCDFSTASSWEFEPLDNEVFP
AVELARHAGQAGGCMTAIYNAANEEAAAAFLAGRVSFGAIVETIADVLHAADQWAPKFSETPANVDDVLDAQRWARQRAQ
RAVAQARPATASAKTPGVV
>Mature_418_residues
ARAGGGRHNEWVTNPTSDGQPRGRLRVLVLGSTGSIGTQALQVIAANPDRFEVVGLAAGGANLDTLLRQRAETGVTNVAV
ADEHAARRAGDIPFCGPEAATRLVEETEADVVLNALVGALGLRPTLAALESGARLALANKESLIAGGPLVLAAAAPGQIV
PVDSEHSALAQCLRGGTGDEVAKLVLTASGGPFRGWTAEELEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETHL
LFGIPYDRIEVVVHPQSIVHSMVTFVDGSTLAQASPPDMRLPISLALGWPHRVPGAAACCDFSTASSWEFEPLDNEVFPA
VELARHAGQAGGCMTAIYNAANEEAAAAFLAGRVSFGAIVETIADVLHAADQWAPKFSETPANVDDVLDAQRWARQRAQR
AVAQARPATASAKTPGVV

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=398, Percent_Identity=39.1959798994975, Blast_Score=241, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43607; Mature: 43475

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARAGGGRHNEWVTNPTSDGQPRGRLRVLVLGSTGSIGTQALQVIAANPDRFEVVGLAAG
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHEEEECCCCCEEEEEEECC
GANLDTLLRQRAETGVTNVAVADEHAARRAGDIPFCGPEAATRLVEETEADVVLNALVGA
CCCHHHHHHHHHHCCCCEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LGLRPTLAALESGARLALANKESLIAGGPLVLAAAAPGQIVPVDSEHSALAQCLRGGTGD
HCCCHHHHHHHCCCEEEEECCCCEEECCCEEEEECCCCCEEECCCCHHHHHHHHCCCCHH
EVAKLVLTASGGPFRGWTAEELEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETH
HHEEEEEEECCCCCCCCCHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LLFGIPYDRIEVVVHPQSIVHSMVTFVDGSTLAQASPPDMRLPISLALGWPHRVPGAAAC
HHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHH
CDFSTASSWEFEPLDNEVFPAVELARHAGQAGGCMTAIYNAANEEAAAAFLAGRVSFGAI
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHH
VETIADVLHAADQWAPKFSETPANVDDVLDAQRWARQRAQRAVAQARPATASAKTPGVV
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARAGGGRHNEWVTNPTSDGQPRGRLRVLVLGSTGSIGTQALQVIAANPDRFEVVGLAAG
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHEEEECCCCCEEEEEEECC
GANLDTLLRQRAETGVTNVAVADEHAARRAGDIPFCGPEAATRLVEETEADVVLNALVGA
CCCHHHHHHHHHHCCCCEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LGLRPTLAALESGARLALANKESLIAGGPLVLAAAAPGQIVPVDSEHSALAQCLRGGTGD
HCCCHHHHHHHCCCEEEEECCCCEEECCCEEEEECCCCCEEECCCCHHHHHHHHCCCCHH
EVAKLVLTASGGPFRGWTAEELEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETH
HHEEEEEEECCCCCCCCCHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LLFGIPYDRIEVVVHPQSIVHSMVTFVDGSTLAQASPPDMRLPISLALGWPHRVPGAAAC
HHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHH
CDFSTASSWEFEPLDNEVFPAVELARHAGQAGGCMTAIYNAANEEAAAAFLAGRVSFGAI
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHH
VETIADVLHAADQWAPKFSETPANVDDVLDAQRWARQRAQRAVAQARPATASAKTPGVV
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA