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The map label for this gene is pepR

Identifier: 41408988

GI number: 41408988

Start: 3219428

End: 3220750

Strand: Reverse

Name: pepR

Synonym: MAP2890c

Alternate gene names: 41408988

Gene position: 3220750-3219428 (Counterclockwise)

Preceding gene: 41408989

Following gene: 41408987

Centisome position: 66.69

GC content: 71.66

Gene sequence:

>1323_bases
CTGCGCGCCGGCAAGGTCGTCGAGGCGCAACCGCACCCGCACGCCGCCCTGCGGCGCAGCACGCTGCCCGGCGGCCTGCG
GGTGGTCACTGAGTACCTGCCCGCGGTGCGGTCCGCCTCGGTCGGGGTGTGGGTCGGCGTCGGCTCCCGCGACGAGGGTG
CCACCGTGGCCGGCGCCGCGCACTTCCTCGAGCACCTGCTGTTCAAGTCCACGCCCACCCGCACCGCGGTGGACATCGCG
CAGGCGATGGACGCCGTCGGGGGAGAACTGAACGCGTTCACCGCCAAGGAACACACCTGCTACTACGCGCACGTGCTGGA
CGCCGACCTGGAACTGGCCGTCGACCTGGTCGCCGACGTGGTGCTCAACGGCCGCTGCGCCGCCGAGGACGTCGAACTCG
AGCGCGACGTGGTGCTGGAAGAGATCGCGATGCGCGACGACGACCCCGAGGACGCGCTGGGGGACATGTTCCTGGGCGCG
CTGTTCGGCGACCACCCGGTGGGCCGGCCGGTCATCGGCACCGCGCGGTCGGTCGCGTCGATGACGCGGACGCAGCTGCA
CTCGTTTCACGTCCGCCGCTACACACCCGAACGGATGGTGGTGGCGGTGGCCGGCAACGTCGACCACGACGAGGTGGTGG
CGATGGTGCGCGAGCACTTCGGGCCGCACCTGGTCCGCGGGCGGCAACCGATCGCGCCGCGCAAGGGCGCCGGACGGGTG
AACGGCCGGCCCGGGCTGCTGCTGGGCACCCGGGACGCCGAGCAGACGCACGTGTCGCTGGGGGTGCGCACGCCCGGGCG
CGGCTGGCAGCATCGCTGGGCGCTGTCGGTACTGCACACCGCGCTGGGCGGGGGCCTGAGTTCGCGGCTGTTCCAAGAGA
TCCGGGAGCTGCGCGGGCTGGCCTACTCGGTCTACTCGACGGTGGACATCTTCGCCGACAGCGGCGCGCTGTCGGTGTAC
GCCGCCTGCCAACCGGAACGCTTCGCCGAGGTGATGGCGGTGACCAGCGGCGTGCTCGAATCGGTGGCCCGCGACGGCAT
CACCGAGTCGGAATGCCGGATCGCCAAGGGCTCGCTGCGCGGCGGCCTGGTGCTGGGTCTGGAGGATTCCGGCTCGCGGA
TGAGCCGGCTGGGCCGCAACGAACTCAACTACGGCCGGCACCGCAGCATCGAGCACACCCTGGCGCAAATCGACCGGGTG
AGCGTCGACGAGGTCAACGCGATCGCCCGCCGGCTGCTCACGCAGCACTACGGTGCCGCGGTCCTGGGCCCGTATGGCAC
CAAACGGTCACTGCCCCAACAACTTCGGGCGATGGTACGGTAA

Upstream 100 bases:

>100_bases
GAGGAAGACAACTCGGCACCCGCCGACACCCCGGCGGCCGCCCCTGCCGATGCCACCAGCTGACAGCAGAAGGCGAGCAG
CTGACTCATCGACCGGCGCC

Downstream 100 bases:

>100_bases
GCCAATGTCCGCCTCCTTACTCGCGCCGTGCCGGCGCTCGCCGTCGCCGGAGTAGCCCAATGGTGCTGGGCTTCTGGGAC
ATCACGGTGCCCATCGTCGG

Product: PepR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MRAGKVVEAQPHPHAALRRSTLPGGLRVVTEYLPAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTPTRTAVDIA
QAMDAVGGELNAFTAKEHTCYYAHVLDADLELAVDLVADVVLNGRCAAEDVELERDVVLEEIAMRDDDPEDALGDMFLGA
LFGDHPVGRPVIGTARSVASMTRTQLHSFHVRRYTPERMVVAVAGNVDHDEVVAMVREHFGPHLVRGRQPIAPRKGAGRV
NGRPGLLLGTRDAEQTHVSLGVRTPGRGWQHRWALSVLHTALGGGLSSRLFQEIRELRGLAYSVYSTVDIFADSGALSVY
AACQPERFAEVMAVTSGVLESVARDGITESECRIAKGSLRGGLVLGLEDSGSRMSRLGRNELNYGRHRSIEHTLAQIDRV
SVDEVNAIARRLLTQHYGAAVLGPYGTKRSLPQQLRAMVR

Sequences:

>Translated_440_residues
MRAGKVVEAQPHPHAALRRSTLPGGLRVVTEYLPAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTPTRTAVDIA
QAMDAVGGELNAFTAKEHTCYYAHVLDADLELAVDLVADVVLNGRCAAEDVELERDVVLEEIAMRDDDPEDALGDMFLGA
LFGDHPVGRPVIGTARSVASMTRTQLHSFHVRRYTPERMVVAVAGNVDHDEVVAMVREHFGPHLVRGRQPIAPRKGAGRV
NGRPGLLLGTRDAEQTHVSLGVRTPGRGWQHRWALSVLHTALGGGLSSRLFQEIRELRGLAYSVYSTVDIFADSGALSVY
AACQPERFAEVMAVTSGVLESVARDGITESECRIAKGSLRGGLVLGLEDSGSRMSRLGRNELNYGRHRSIEHTLAQIDRV
SVDEVNAIARRLLTQHYGAAVLGPYGTKRSLPQQLRAMVR
>Mature_440_residues
MRAGKVVEAQPHPHAALRRSTLPGGLRVVTEYLPAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTPTRTAVDIA
QAMDAVGGELNAFTAKEHTCYYAHVLDADLELAVDLVADVVLNGRCAAEDVELERDVVLEEIAMRDDDPEDALGDMFLGA
LFGDHPVGRPVIGTARSVASMTRTQLHSFHVRRYTPERMVVAVAGNVDHDEVVAMVREHFGPHLVRGRQPIAPRKGAGRV
NGRPGLLLGTRDAEQTHVSLGVRTPGRGWQHRWALSVLHTALGGGLSSRLFQEIRELRGLAYSVYSTVDIFADSGALSVY
AACQPERFAEVMAVTSGVLESVARDGITESECRIAKGSLRGGLVLGLEDSGSRMSRLGRNELNYGRHRSIEHTLAQIDRV
SVDEVNAIARRLLTQHYGAAVLGPYGTKRSLPQQLRAMVR

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=437, Percent_Identity=29.2906178489703, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI46593007, Length=430, Percent_Identity=30.6976744186047, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI24308013, Length=439, Percent_Identity=27.7904328018223, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI50592988, Length=429, Percent_Identity=22.3776223776224, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI155969707, Length=239, Percent_Identity=27.6150627615063, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1787770, Length=209, Percent_Identity=25.3588516746411, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71999683, Length=436, Percent_Identity=27.9816513761468, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17553678, Length=424, Percent_Identity=29.2452830188679, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17510601, Length=456, Percent_Identity=22.8070175438596, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323192, Length=428, Percent_Identity=30.8411214953271, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321813, Length=419, Percent_Identity=23.3890214797136, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21357875, Length=423, Percent_Identity=27.6595744680851, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24646943, Length=423, Percent_Identity=27.6595744680851, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19921772, Length=452, Percent_Identity=25.8849557522124, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47627; Mature: 47627

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAGKVVEAQPHPHAALRRSTLPGGLRVVTEYLPAVRSASVGVWVGVGSRDEGATVAGAA
CCCCCEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHH
HFLEHLLFKSTPTRTAVDIAQAMDAVGGELNAFTAKEHTCYYAHVLDADLELAVDLVADV
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEECCHHHHHHHHHHHH
VLNGRCAAEDVELERDVVLEEIAMRDDDPEDALGDMFLGALFGDHPVGRPVIGTARSVAS
HHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
MTRTQLHSFHVRRYTPERMVVAVAGNVDHDEVVAMVREHFGPHLVRGRQPIAPRKGAGRV
HHHHHHHHHHHHEECCCEEEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCC
NGRPGLLLGTRDAEQTHVSLGVRTPGRGWQHRWALSVLHTALGGGLSSRLFQEIRELRGL
CCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AYSVYSTVDIFADSGALSVYAACQPERFAEVMAVTSGVLESVARDGITESECRIAKGSLR
HHHHHHHHHHEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC
GGLVLGLEDSGSRMSRLGRNELNYGRHRSIEHTLAQIDRVSVDEVNAIARRLLTQHYGAA
CCEEEEECCCCHHHHHCCCHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCE
VLGPYGTKRSLPQQLRAMVR
EECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MRAGKVVEAQPHPHAALRRSTLPGGLRVVTEYLPAVRSASVGVWVGVGSRDEGATVAGAA
CCCCCEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHH
HFLEHLLFKSTPTRTAVDIAQAMDAVGGELNAFTAKEHTCYYAHVLDADLELAVDLVADV
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEECCHHHHHHHHHHHH
VLNGRCAAEDVELERDVVLEEIAMRDDDPEDALGDMFLGALFGDHPVGRPVIGTARSVAS
HHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
MTRTQLHSFHVRRYTPERMVVAVAGNVDHDEVVAMVREHFGPHLVRGRQPIAPRKGAGRV
HHHHHHHHHHHHEECCCEEEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCC
NGRPGLLLGTRDAEQTHVSLGVRTPGRGWQHRWALSVLHTALGGGLSSRLFQEIRELRGL
CCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AYSVYSTVDIFADSGALSVYAACQPERFAEVMAVTSGVLESVARDGITESECRIAKGSLR
HHHHHHHHHHEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC
GGLVLGLEDSGSRMSRLGRNELNYGRHRSIEHTLAQIDRVSVDEVNAIARRLLTQHYGAA
CCEEEEECCCCHHHHHCCCHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCE
VLGPYGTKRSLPQQLRAMVR
EECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]