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The map label for this gene is lexA

Identifier: 41408934

GI number: 41408934

Start: 3163571

End: 3164224

Strand: Direct

Name: lexA

Synonym: MAP2836

Alternate gene names: 41408934

Gene position: 3163571-3164224 (Clockwise)

Preceding gene: 41408930

Following gene: 41408942

Centisome position: 65.5

GC content: 70.64

Gene sequence:

>654_bases
CTGCACGCCGTGGATCCCTCGCTGACCGAACGGCAGCGCACCATCCTGAACGTCATCCGCTCCTCGGTGACCAGCCGCGG
CTACCCGCCGAGCATCCGGGAGATCGGCGACGCCGTCGGCCTGACGTCGACCTCCTCGGTGGCCCACCAGCTGCGCACCC
TGGAACGCAAGGGCTATCTGCGCCGCGACCCCAACCGGCCGCGCGCGGTCGATGTCCGCGGCGTGGACGACGACGTGGCC
GCGCCCGCCACCGAGGTGGCCGGCTCCGACGCGCTGCCCGAACCCACCTTCGTCCCGGTGCTCGGGCGGATCGCGGCCGG
CGGGCCCATCCTCGCCGAGGAGGCCGTCGAGGACGTCTTTCCGCTGCCGCGCGAGTTGGTCGGCGACGGAACGCTTTTCC
TGCTCAAGGTGGTCGGTGACTCGATGGTCGAGGCGGCGATCTGCGACGGCGACTGGGTGGTGGTGCGCCAGCAGCACGTC
GCCGACAACGCCGACATCGTCGCGGCCATGATCGACGGCGAGGCCACCGTCAAGACGTTCAAACGCGCCGGCGGTCAGGT
CTGGCTGATGCCGCACAACCCGGCGTTCGACCCCATTCCCGGTAACGACGCGACCGTGCTGGGCAAGGTGGTCACGGTGA
TCCGCAAGGTGTGA

Upstream 100 bases:

>100_bases
ACGCCAGTCGAACACATGTTTGATTCTCGTCGGCGACGGGGTTACATTCGGTGCCATGGACGACAGCAACGACAGTTCAT
CAGCCGGACCGGACGGCCGG

Downstream 100 bases:

>100_bases
CGCCGGTCAGTCGGCCTTGGTGAAACCGTTGGCCTGCGCGACCTCTTCGCTGGACAGCCACAGCTCGGGCAGCGTGTCCC
GGTACAGGTCGCTGCCCGGC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MHAVDPSLTERQRTILNVIRSSVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVDVRGVDDDVA
APATEVAGSDALPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGDGTLFLLKVVGDSMVEAAICDGDWVVVRQQHV
ADNADIVAAMIDGEATVKTFKRAGGQVWLMPHNPAFDPIPGNDATVLGKVVTVIRKV

Sequences:

>Translated_217_residues
MHAVDPSLTERQRTILNVIRSSVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVDVRGVDDDVA
APATEVAGSDALPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGDGTLFLLKVVGDSMVEAAICDGDWVVVRQQHV
ADNADIVAAMIDGEATVKTFKRAGGQVWLMPHNPAFDPIPGNDATVLGKVVTVIRKV
>Mature_217_residues
MHAVDPSLTERQRTILNVIRSSVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVDVRGVDDDVA
APATEVAGSDALPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGDGTLFLLKVVGDSMVEAAICDGDWVVVRQQHV
ADNADIVAAMIDGEATVKTFKRAGGQVWLMPHNPAFDPIPGNDATVLGKVVTVIRKV

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=213, Percent_Identity=32.3943661971831, Blast_Score=103, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23187; Mature: 23187

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAVDPSLTERQRTILNVIRSSVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYL
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
RRDPNRPRAVDVRGVDDDVAAPATEVAGSDALPEPTFVPVLGRIAAGGPILAEEAVEDVF
CCCCCCCCEEEECCCCCHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHC
PLPRELVGDGTLFLLKVVGDSMVEAAICDGDWVVVRQQHVADNADIVAAMIDGEATVKTF
CCCHHHHCCCCEEHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCEEEEEECCHHHHHHH
KRAGGQVWLMPHNPAFDPIPGNDATVLGKVVTVIRKV
HHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MHAVDPSLTERQRTILNVIRSSVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYL
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
RRDPNRPRAVDVRGVDDDVAAPATEVAGSDALPEPTFVPVLGRIAAGGPILAEEAVEDVF
CCCCCCCCEEEECCCCCHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHC
PLPRELVGDGTLFLLKVVGDSMVEAAICDGDWVVVRQQHVADNADIVAAMIDGEATVKTF
CCCHHHHCCCCEEHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCEEEEEECCHHHHHHH
KRAGGQVWLMPHNPAFDPIPGNDATVLGKVVTVIRKV
HHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA