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The map label for this gene is sthA [H]

Identifier: 41408927

GI number: 41408927

Start: 3156289

End: 3157704

Strand: Direct

Name: sthA [H]

Synonym: MAP2829

Alternate gene names: 41408927

Gene position: 3156289-3157704 (Clockwise)

Preceding gene: 41408924

Following gene: 41408929

Centisome position: 65.35

GC content: 67.66

Gene sequence:

>1416_bases
ATGAGCTCGCCGCAAGAGTACGACATGGTGGTCATCGGGTCGGGGCCCGGCGGGCAGAAGGCCGCGATCGCGTCGGCCAA
GCTGGGCAAGTCCGTCGCGGTCGTCGAACGCGGACAGATGCTCGGCGGCGTGTGCGTCAACACCGGCACCATCCCGTCGA
AAACGTTGCGCGAGGCGGTCCTCTACCTCACCGGCATGAGCCAGCGCGAACTCTACGGCGCCAGCTACCGGGTGAAGGAG
AAGATCACCCCCGCCGACCTGCTGGCCCGCACCCAGCACGTGATCGGCAAGGAGATCGACGTGGTGCGCAACCAGTTGAT
GCGCAACCGCATCGACCTGCTGATCGGACACGGCCGCTTCGTCGACCCGCACACCATCGAGGTCGAGGACCCGTCCCGGC
GCGAAAAGATCACCATCAGCGGCAAATACGTCGTCATCGCCACCGGCACCCGGCCGGCGCGGCCCTCAGGCGTCGAGTTC
GACGAGGACCGGGTGCTCGACTCCGACGGGATCCTGGACCTCAAGTCGCTGCCCACCTCGATGGTGGTGGTCGGCGCCGG
CGTGATCGGCATCGAGTACGCCTCGATGTTCGCCGCCCTGGGCACCAAGGTGACCGTGGTGGAGAAGCGGGACGACATGC
TCGACTTCTGCGACCCCGAGGTGGTCGAGGCGCTCAAGTTCCACCTGCGCGACCTGGCGGTGACGTTCCGGTTCGGCGAG
GAGGTGACCGCGGTCGACGTCGGGTCGGCGGGCACCGTCACCACCCTGGCCAGCGGCAAGCAGATTCCCGCCGAGACGGT
GATGTACTCGGCCGGCAGGCAGGGCCAGACCGACCATCTGGACCTGCACAACGCCGAGCTGGAGGCCGACAACCGGGGCC
GCATCTTCGTCGACGACAACTTCCAGACCAAGGTGCCGCACATCTACGCCGTCGGGGACGTGATCGGCTTCCCGGCGCTG
GCCGCCACGTCGATGGAGCAGGGCCGGCTGGCCGCCTACCACGCGTTCGGGGAGGCGTCCGACGGCATCACCGAGCTGCA
GCCGATCGGCATCTACTCCATCCCCGAGGTCTCCTACGTCGGGGCCACCGAGGTGGAGCTCACCAAGGACGCGATCCCCT
ACGAGGTGGGGGTGGCCCGGTACCGGGAGCTGGCCCGCGGCCAGATCGCCGGCGACTCCTACGGCATGCTCAAGCTGCTG
GTGTCCACCCAGGACCTCAAGGTGCTCGGCGTGCACATCTTCGGCACCAGCGCCACCGAGATGGTGCACATCGGGCAGGC
CGTGATGGGCTGCGGCGGCACGGTGGAATACCTGGTCGACGCGGTGTTCAACTACCCCACTTTTTCCGAGGCCTACAAGG
TGGCGGCGCTGGACGTGATGAACAAGGTGCGCGCGCTCAACCAGTTCCGCCGCTGA

Upstream 100 bases:

>100_bases
CACGCTGACGGCCGCCACCGTCACCGGGTGCGCGCCCGCGCGGCAGCACAGCTGTGGATGAACCCAGCACTGTGAGTTGA
GCTGCTCTACTGTTTAGCCC

Downstream 100 bases:

>100_bases
TCTGCTAGCAGGCGTCCTGCAGGTCGTTGGGGATCGGGTCGCCCGGTCCGCCGGCCTCGGCGCGGGCCAGCAACTCCGCG
GTCTGCGCGTCGAACGGCGC

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSSPQEYDMVVIGSGPGGQKAAIASAKLGKSVAVVERGQMLGGVCVNTGTIPSKTLREAVLYLTGMSQRELYGASYRVKE
KITPADLLARTQHVIGKEIDVVRNQLMRNRIDLLIGHGRFVDPHTIEVEDPSRREKITISGKYVVIATGTRPARPSGVEF
DEDRVLDSDGILDLKSLPTSMVVVGAGVIGIEYASMFAALGTKVTVVEKRDDMLDFCDPEVVEALKFHLRDLAVTFRFGE
EVTAVDVGSAGTVTTLASGKQIPAETVMYSAGRQGQTDHLDLHNAELEADNRGRIFVDDNFQTKVPHIYAVGDVIGFPAL
AATSMEQGRLAAYHAFGEASDGITELQPIGIYSIPEVSYVGATEVELTKDAIPYEVGVARYRELARGQIAGDSYGMLKLL
VSTQDLKVLGVHIFGTSATEMVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKVRALNQFRR

Sequences:

>Translated_471_residues
MSSPQEYDMVVIGSGPGGQKAAIASAKLGKSVAVVERGQMLGGVCVNTGTIPSKTLREAVLYLTGMSQRELYGASYRVKE
KITPADLLARTQHVIGKEIDVVRNQLMRNRIDLLIGHGRFVDPHTIEVEDPSRREKITISGKYVVIATGTRPARPSGVEF
DEDRVLDSDGILDLKSLPTSMVVVGAGVIGIEYASMFAALGTKVTVVEKRDDMLDFCDPEVVEALKFHLRDLAVTFRFGE
EVTAVDVGSAGTVTTLASGKQIPAETVMYSAGRQGQTDHLDLHNAELEADNRGRIFVDDNFQTKVPHIYAVGDVIGFPAL
AATSMEQGRLAAYHAFGEASDGITELQPIGIYSIPEVSYVGATEVELTKDAIPYEVGVARYRELARGQIAGDSYGMLKLL
VSTQDLKVLGVHIFGTSATEMVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKVRALNQFRR
>Mature_470_residues
SSPQEYDMVVIGSGPGGQKAAIASAKLGKSVAVVERGQMLGGVCVNTGTIPSKTLREAVLYLTGMSQRELYGASYRVKEK
ITPADLLARTQHVIGKEIDVVRNQLMRNRIDLLIGHGRFVDPHTIEVEDPSRREKITISGKYVVIATGTRPARPSGVEFD
EDRVLDSDGILDLKSLPTSMVVVGAGVIGIEYASMFAALGTKVTVVEKRDDMLDFCDPEVVEALKFHLRDLAVTFRFGEE
VTAVDVGSAGTVTTLASGKQIPAETVMYSAGRQGQTDHLDLHNAELEADNRGRIFVDDNFQTKVPHIYAVGDVIGFPALA
ATSMEQGRLAAYHAFGEASDGITELQPIGIYSIPEVSYVGATEVELTKDAIPYEVGVARYRELARGQIAGDSYGMLKLLV
STQDLKVLGVHIFGTSATEMVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKVRALNQFRR

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=31.6017316017316, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=27.3504273504274, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI291045266, Length=496, Percent_Identity=27.8225806451613, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI291045268, Length=468, Percent_Identity=26.9230769230769, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=29.5116772823779, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI148277065, Length=430, Percent_Identity=27.4418604651163, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI33519430, Length=430, Percent_Identity=27.4418604651163, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI33519428, Length=430, Percent_Identity=27.4418604651163, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI33519426, Length=430, Percent_Identity=27.4418604651163, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI148277071, Length=430, Percent_Identity=27.4418604651163, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI87082354, Length=467, Percent_Identity=43.4689507494647, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1786307, Length=483, Percent_Identity=32.5051759834368, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI87081717, Length=459, Percent_Identity=27.6688453159041, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1789915, Length=438, Percent_Identity=27.1689497716895, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=32.4675324675325, Blast_Score=228, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17557007, Length=491, Percent_Identity=26.2729124236253, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=460, Percent_Identity=28.0434782608696, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71983429, Length=460, Percent_Identity=28.0434782608696, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71982272, Length=461, Percent_Identity=25.3796095444685, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=30.2966101694915, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=31.0126582278481, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=25.9100642398287, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=32.1199143468951, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI24640553, Length=479, Percent_Identity=28.6012526096033, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24640549, Length=478, Percent_Identity=28.8702928870293, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=28.6610878661088, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17737741, Length=483, Percent_Identity=28.9855072463768, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 50912; Mature: 50781

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPQEYDMVVIGSGPGGQKAAIASAKLGKSVAVVERGQMLGGVCVNTGTIPSKTLREAV
CCCCCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEECCCEECCEEEECCCCCHHHHHHHH
LYLTGMSQRELYGASYRVKEKITPADLLARTQHVIGKEIDVVRNQLMRNRIDLLIGHGRF
HHHCCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEECCCC
VDPHTIEVEDPSRREKITISGKYVVIATGTRPARPSGVEFDEDRVLDSDGILDLKSLPTS
CCCEEEEECCCCCCCEEEEECEEEEEECCCCCCCCCCCCCCCCCEECCCCCEEHHHCCCE
MVVVGAGVIGIEYASMFAALGTKVTVVEKRDDMLDFCDPEVVEALKFHLRDLAVTFRFGE
EEEEECCHHHHHHHHHHHHHCCEEEEEECCCCCHHCCCHHHHHHHHHHHHHHEEEEEECC
EVTAVDVGSAGTVTTLASGKQIPAETVMYSAGRQGQTDHLDLHNAELEADNRGRIFVDDN
EEEEEECCCCCCEEEECCCCCCCHHHHHCCCCCCCCCCCEECCCCEECCCCCCEEEECCC
FQTKVPHIYAVGDVIGFPALAATSMEQGRLAAYHAFGEASDGITELQPIGIYSIPEVSYV
CCCCCCEEEEEHHHHCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCEEEC
GATEVELTKDAIPYEVGVARYRELARGQIAGDSYGMLKLLVSTQDLKVLGVHIFGTSATE
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEEEEEEEECCCHHH
MVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKVRALNQFRR
HHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSPQEYDMVVIGSGPGGQKAAIASAKLGKSVAVVERGQMLGGVCVNTGTIPSKTLREAV
CCCCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEECCCEECCEEEECCCCCHHHHHHHH
LYLTGMSQRELYGASYRVKEKITPADLLARTQHVIGKEIDVVRNQLMRNRIDLLIGHGRF
HHHCCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEECCCC
VDPHTIEVEDPSRREKITISGKYVVIATGTRPARPSGVEFDEDRVLDSDGILDLKSLPTS
CCCEEEEECCCCCCCEEEEECEEEEEECCCCCCCCCCCCCCCCCEECCCCCEEHHHCCCE
MVVVGAGVIGIEYASMFAALGTKVTVVEKRDDMLDFCDPEVVEALKFHLRDLAVTFRFGE
EEEEECCHHHHHHHHHHHHHCCEEEEEECCCCCHHCCCHHHHHHHHHHHHHHEEEEEECC
EVTAVDVGSAGTVTTLASGKQIPAETVMYSAGRQGQTDHLDLHNAELEADNRGRIFVDDN
EEEEEECCCCCCEEEECCCCCCCHHHHHCCCCCCCCCCCEECCCCEECCCCCCEEEECCC
FQTKVPHIYAVGDVIGFPALAATSMEQGRLAAYHAFGEASDGITELQPIGIYSIPEVSYV
CCCCCCEEEEEHHHHCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCEEEC
GATEVELTKDAIPYEVGVARYRELARGQIAGDSYGMLKLLVSTQDLKVLGVHIFGTSATE
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEEEEEEEECCCHHH
MVHIGQAVMGCGGTVEYLVDAVFNYPTFSEAYKVAALDVMNKVRALNQFRR
HHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]