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The map label for this gene is echA11

Identifier: 41408737

GI number: 41408737

Start: 2972878

End: 2973690

Strand: Direct

Name: echA11

Synonym: MAP2639

Alternate gene names: 41408737

Gene position: 2972878-2973690 (Clockwise)

Preceding gene: 41408734

Following gene: 41408740

Centisome position: 61.55

GC content: 70.48

Gene sequence:

>813_bases
ATGCCTTCATCCGCGATCGCCACCCTCGCCCCCGTCGCAGGCCTCGACGTCACGCTGTCCGACGGCGTGTTCTCGGTGAC
CATCAACCGGCCCGACAGCCTGAATTCCCTGACCGTTCCGGTGATCACCGGCATCGCCGACGCGATGGAGTACGCCGCCA
CCGACCCCGAGGTCAAGGTGGTGCGGATCGGCGGGGCGGGCCGCGGCTTCAGCTCCGGGGCGGGCATCAGCGCCGACGAC
GTCTCCGACGGCGGCGGCGTCCCGCCGGACGAGATCATCCTCGAGATCAACCGGCTGGTGCGGGCGATCGCCGCGCTGCC
CCACCCGGTGGTCGCCGTCGTGCAGGGCCCGGCGGCCGGCGTCGGCGTCTCCATCGCGTTGGCCTGCGACGTCGTATTGG
CTTCGGAGAACGCGTTTTTCATGCTTGCCTTCACCAAGATCGGGTTGATGCCCGACGGCGGCGCGTCGGCGTTGGTGGCC
GCCGCGGTGGGCCGGATCCGGGCCATGCAGATGGCGCTGCTGCCCGAACGGCTGCCGGCCGCCGAGGCGTTGGCCTGGGG
GCTGGTCACCGCCGTCTACCCGGCCGACGAGTTCGAGGCCGAGGTGGACAAGGTGATCGCACGGTTGCTCAGCGGTCCGG
CCGTCGCGTTCGCCAAGACCAAGCTGGCGATCAACGCGGCCACGCTCACCGAGCTGGACCCGGCCCTGCAGCGTGAATTC
GACGGACAGTCGGTGCTGCTGAAGTCCCCCGACTTCGTCGAGGGCGCCACCGCCTTCCAGCAGCGGCGCACCCCCAACTT
CACCGATCGCTGA

Upstream 100 bases:

>100_bases
CGCTCTGACGCCGTCGACCGTTCGCCTCTAACAACCGGTCGATCGACATCTTCGCAGCCGTGCCGTAAGCCCGCGCACCC
CGGTCACTTATGGTGAGCCC

Downstream 100 bases:

>100_bases
ATCCCGTTGCGCCGCAACGGCGCAACGGATTGGTCAGAGCCCGAACACGGGCGGCAGGGCCAGCACCATGATCAGGCCCC
ACCCGCAGTGCGTCAGAACC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MPSSAIATLAPVAGLDVTLSDGVFSVTINRPDSLNSLTVPVITGIADAMEYAATDPEVKVVRIGGAGRGFSSGAGISADD
VSDGGGVPPDEIILEINRLVRAIAALPHPVVAVVQGPAAGVGVSIALACDVVLASENAFFMLAFTKIGLMPDGGASALVA
AAVGRIRAMQMALLPERLPAAEALAWGLVTAVYPADEFEAEVDKVIARLLSGPAVAFAKTKLAINAATLTELDPALQREF
DGQSVLLKSPDFVEGATAFQQRRTPNFTDR

Sequences:

>Translated_270_residues
MPSSAIATLAPVAGLDVTLSDGVFSVTINRPDSLNSLTVPVITGIADAMEYAATDPEVKVVRIGGAGRGFSSGAGISADD
VSDGGGVPPDEIILEINRLVRAIAALPHPVVAVVQGPAAGVGVSIALACDVVLASENAFFMLAFTKIGLMPDGGASALVA
AAVGRIRAMQMALLPERLPAAEALAWGLVTAVYPADEFEAEVDKVIARLLSGPAVAFAKTKLAINAATLTELDPALQREF
DGQSVLLKSPDFVEGATAFQQRRTPNFTDR
>Mature_269_residues
PSSAIATLAPVAGLDVTLSDGVFSVTINRPDSLNSLTVPVITGIADAMEYAATDPEVKVVRIGGAGRGFSSGAGISADDV
SDGGGVPPDEIILEINRLVRAIAALPHPVVAVVQGPAAGVGVSIALACDVVLASENAFFMLAFTKIGLMPDGGASALVAA
AVGRIRAMQMALLPERLPAAEALAWGLVTAVYPADEFEAEVDKVIARLLSGPAVAFAKTKLAINAATLTELDPALQREFD
GQSVLLKSPDFVEGATAFQQRRTPNFTDR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=248, Percent_Identity=29.0322580645161, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4757968, Length=254, Percent_Identity=28.740157480315, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI49355787, Length=254, Percent_Identity=28.740157480315, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI25453481, Length=254, Percent_Identity=28.740157480315, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI51538573, Length=254, Percent_Identity=28.740157480315, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI4757966, Length=228, Percent_Identity=30.7017543859649, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI51538581, Length=228, Percent_Identity=30.7017543859649, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI45643119, Length=196, Percent_Identity=31.1224489795918, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI260275230, Length=196, Percent_Identity=31.1224489795918, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI260274832, Length=196, Percent_Identity=31.1224489795918, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI221136756, Length=254, Percent_Identity=27.9527559055118, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI221136753, Length=254, Percent_Identity=27.9527559055118, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI221307494, Length=254, Percent_Identity=27.9527559055118, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI31542718, Length=253, Percent_Identity=26.8774703557312, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI116235487, Length=207, Percent_Identity=29.4685990338164, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI70995211, Length=186, Percent_Identity=27.9569892473118, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4502327, Length=255, Percent_Identity=28.6274509803922, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1787660, Length=252, Percent_Identity=37.6984126984127, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1787659, Length=259, Percent_Identity=32.4324324324324, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1788597, Length=254, Percent_Identity=30.7086614173228, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI221142681, Length=269, Percent_Identity=26.3940520446097, Blast_Score=78, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=245, Percent_Identity=29.3877551020408, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI25145438, Length=249, Percent_Identity=28.1124497991968, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=29.5238095238095, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17536985, Length=262, Percent_Identity=26.3358778625954, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=190, Percent_Identity=31.0526315789474, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=226, Percent_Identity=30.9734513274336, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=220, Percent_Identity=29.5454545454545, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=255, Percent_Identity=27.843137254902, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=244, Percent_Identity=27.8688524590164, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=28.0487804878049, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=28.0487804878049, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24654903, Length=238, Percent_Identity=26.0504201680672, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653139, Length=255, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19920382, Length=185, Percent_Identity=26.4864864864865, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922422, Length=260, Percent_Identity=23.8461538461538, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR011968 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27718; Mature: 27587

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSAIATLAPVAGLDVTLSDGVFSVTINRPDSLNSLTVPVITGIADAMEYAATDPEVKV
CCCCHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
VRIGGAGRGFSSGAGISADDVSDGGGVPPDEIILEINRLVRAIAALPHPVVAVVQGPAAG
EEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
VGVSIALACDVVLASENAFFMLAFTKIGLMPDGGASALVAAAVGRIRAMQMALLPERLPA
CCEEEEEEEEEEEECCCCEEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
AEALAWGLVTAVYPADEFEAEVDKVIARLLSGPAVAFAKTKLAINAATLTELDPALQREF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEHEEEEEHHHHHHCCHHHHHCC
DGQSVLLKSPDFVEGATAFQQRRTPNFTDR
CCCEEEECCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PSSAIATLAPVAGLDVTLSDGVFSVTINRPDSLNSLTVPVITGIADAMEYAATDPEVKV
CCCHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
VRIGGAGRGFSSGAGISADDVSDGGGVPPDEIILEINRLVRAIAALPHPVVAVVQGPAAG
EEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
VGVSIALACDVVLASENAFFMLAFTKIGLMPDGGASALVAAAVGRIRAMQMALLPERLPA
CCEEEEEEEEEEEECCCCEEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
AEALAWGLVTAVYPADEFEAEVDKVIARLLSGPAVAFAKTKLAINAATLTELDPALQREF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEHEEEEEHHHHHHCCHHHHHCC
DGQSVLLKSPDFVEGATAFQQRRTPNFTDR
CCCEEEECCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]