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The map label for this gene is fabG2 [H]

Identifier: 41408735

GI number: 41408735

Start: 2970849

End: 2971613

Strand: Reverse

Name: fabG2 [H]

Synonym: MAP2637c

Alternate gene names: 41408735

Gene position: 2971613-2970849 (Counterclockwise)

Preceding gene: 41408736

Following gene: 41408733

Centisome position: 61.53

GC content: 70.46

Gene sequence:

>765_bases
ATGGAGATCAAGGACGCCGTCGCCGTTGTCACCGGGGGTGCCTCCGGTCTGGGTCTGGCCACCACCAAACGCCTGCTCGA
CCGCGGCGCGCAGGTGGTGGTCATCGACCTGCGCGGCGAAGACGCGGTTCGCGAGCTGGGGGACCGGGCGCGGTTCGTGC
AGGCCGACGTCACCGACGAGGCCGCCGTCGGCAAGGCGCTGGACACCGCGGAGTCGATGGGACCGCTGCGTATCAACGTC
AACTGCGCCGGCATCGGCAACGCCATCAAGACGCTGTCCAAGGACGGCCCGTTCCCGCTGGACGCGTTCAAGAAGGTGGT
CGGGGTGAACCTGATCGGCACCTTCAACGTGCTGCGGCTGGCCGCCGAGCGGATCGCCAAGACCGAGCCGATCGGGCCCG
GAACAAGCCCGGAGCGCGGCGTCATCATCAACACCGCCTCGGTCGCGGCGTTCGAAGGCCAGATCGGCCAGGCCGCCTAC
TCGGCGTCCAAGGGCGGCGTGGTGGGCATGACGCTGCCCATCGCCCGCGACCTGGCCCGCGAGCTCATCCGGGTGGTGAC
CATCGCGCCGGGGCTGTTCAAGACCCCGCTGCTGGGCTCGCTGCCCGAGGAGGCGCAGGCCTCGCTGGGCAAGCAGGTGC
CGCACCCGGCTCGGCTGGGCGATCCCGACGAGTACGGCGCCCTGGCCGTGCACATCGTCGAGAACCCGATGCTCAACGGC
GAGGTCATCCGCTTGGACGGCGCCATTCGCATGGCGCCCCGCTGA

Upstream 100 bases:

>100_bases
TGACCGACGCGACGGCCATACTCGACGAGTGGGTATAGTCCCGACCAACCAGTTGGCTGGCTAGGGCTCGGGATTCGAAG
GGAATTCAGGAAGGACTCGC

Downstream 100 bases:

>100_bases
GCCACACCGCTACGCAAACGAATGGGCCCCCGCATCCGCGGGGGCCCATTCGGGAGAACAATGGTTACTTGCGGAACCAT
CGACTGACAGCGGGTTCGGC

Product: hypothetical protein

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MEIKDAVAVVTGGASGLGLATTKRLLDRGAQVVVIDLRGEDAVRELGDRARFVQADVTDEAAVGKALDTAESMGPLRINV
NCAGIGNAIKTLSKDGPFPLDAFKKVVGVNLIGTFNVLRLAAERIAKTEPIGPGTSPERGVIINTASVAAFEGQIGQAAY
SASKGGVVGMTLPIARDLARELIRVVTIAPGLFKTPLLGSLPEEAQASLGKQVPHPARLGDPDEYGALAVHIVENPMLNG
EVIRLDGAIRMAPR

Sequences:

>Translated_254_residues
MEIKDAVAVVTGGASGLGLATTKRLLDRGAQVVVIDLRGEDAVRELGDRARFVQADVTDEAAVGKALDTAESMGPLRINV
NCAGIGNAIKTLSKDGPFPLDAFKKVVGVNLIGTFNVLRLAAERIAKTEPIGPGTSPERGVIINTASVAAFEGQIGQAAY
SASKGGVVGMTLPIARDLARELIRVVTIAPGLFKTPLLGSLPEEAQASLGKQVPHPARLGDPDEYGALAVHIVENPMLNG
EVIRLDGAIRMAPR
>Mature_254_residues
MEIKDAVAVVTGGASGLGLATTKRLLDRGAQVVVIDLRGEDAVRELGDRARFVQADVTDEAAVGKALDTAESMGPLRINV
NCAGIGNAIKTLSKDGPFPLDAFKKVVGVNLIGTFNVLRLAAERIAKTEPIGPGTSPERGVIINTASVAAFEGQIGQAAY
SASKGGVVGMTLPIARDLARELIRVVTIAPGLFKTPLLGSLPEEAQASLGKQVPHPARLGDPDEYGALAVHIVENPMLNG
EVIRLDGAIRMAPR

Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=258, Percent_Identity=59.6899224806201, Blast_Score=268, Evalue=4e-72,
Organism=Homo sapiens, GI83715985, Length=258, Percent_Identity=56.9767441860465, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI15277342, Length=267, Percent_Identity=31.0861423220974, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI40254992, Length=254, Percent_Identity=30.3149606299213, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI31542939, Length=265, Percent_Identity=26.0377358490566, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI10190704, Length=197, Percent_Identity=31.4720812182741, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI59889578, Length=219, Percent_Identity=29.6803652968037, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=30.5882352941176, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=27.906976744186, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=29.8850574712644, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=29.7297297297297, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI2367175, Length=206, Percent_Identity=32.0388349514563, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789208, Length=259, Percent_Identity=29.7297297297297, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=26.4822134387352, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=28.515625, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=254, Percent_Identity=50.3937007874016, Blast_Score=223, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI25147288, Length=258, Percent_Identity=30.2325581395349, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17555706, Length=232, Percent_Identity=31.0344827586207, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=30.2325581395349, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=29.6153846153846, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=206, Percent_Identity=32.5242718446602, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=55.6420233463035, Blast_Score=271, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=30.3501945525292, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI28571526, Length=241, Percent_Identity=28.6307053941909, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221331218, Length=215, Percent_Identity=27.906976744186, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24665243, Length=215, Percent_Identity=27.906976744186, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26413; Mature: 26413

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKDAVAVVTGGASGLGLATTKRLLDRGAQVVVIDLRGEDAVRELGDRARFVQADVTDE
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHEEEECCCCCH
AAVGKALDTAESMGPLRINVNCAGIGNAIKTLSKDGPFPLDAFKKVVGVNLIGTFNVLRL
HHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHH
AAERIAKTEPIGPGTSPERGVIINTASVAAFEGQIGQAAYSASKGGVVGMTLPIARDLAR
HHHHHHCCCCCCCCCCCCCCEEEEECCEEECCCCCCHHHHCCCCCCEEEEEHHHHHHHHH
ELIRVVTIAPGLFKTPLLGSLPEEAQASLGKQVPHPARLGDPDEYGALAVHIVENPMLNG
HHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
EVIRLDGAIRMAPR
EEEEECCEEEECCC
>Mature Secondary Structure
MEIKDAVAVVTGGASGLGLATTKRLLDRGAQVVVIDLRGEDAVRELGDRARFVQADVTDE
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHEEEECCCCCH
AAVGKALDTAESMGPLRINVNCAGIGNAIKTLSKDGPFPLDAFKKVVGVNLIGTFNVLRL
HHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHH
AAERIAKTEPIGPGTSPERGVIINTASVAAFEGQIGQAAYSASKGGVVGMTLPIARDLAR
HHHHHHCCCCCCCCCCCCCCEEEEECCEEECCCCCCHHHHCCCCCCEEEEEHHHHHHHHH
ELIRVVTIAPGLFKTPLLGSLPEEAQASLGKQVPHPARLGDPDEYGALAVHIVENPMLNG
HHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
EVIRLDGAIRMAPR
EEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]