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The map label for this gene is emrB [C]

Identifier: 41408632

GI number: 41408632

Start: 2847255

End: 2849270

Strand: Reverse

Name: emrB [C]

Synonym: MAP2534c

Alternate gene names: 41408632

Gene position: 2849270-2847255 (Counterclockwise)

Preceding gene: 41408637

Following gene: 41408625

Centisome position: 58.99

GC content: 71.53

Gene sequence:

>2016_bases
ATGACCACGGCTACGCCCCGCACGCCGGGGGGTGGGCGGCGCGCGCCGTCGGGGCCCGCCCCGGGCGCCCACCGCTGGGA
CCTCATCACCCGAAGCTCGGCGCACTCGCAGAACCCATGGAACCCGCTGTGGGCGATGATGATCGGCTTCTTCATGATCA
TGGTCGACTCGACCATCGTCGCCATCGCCAACCCGACCATCATGGCCGACCTGCACATCGGCTACGACACCGTGGTCTGG
GTGACCAGCGCCTATCTGCTGGGGTACGCGGTCGTGCTGTTGGTGGCCGGGCGTCTCGGCGACCGGTTCGGCACCAAGAA
CCTGTATCTGATCGGCCTGGCGGTGTTCACCGTCGCGTCGGTGTGGTGCGGGCTGGCCGGCAGCGCCGCCATGCTGATCG
CGGCCCGCGTCGTCCAGGGTGTCGGAGCCGGCGTGCTGACTCCGCAGACGTTGTCGACGATCACCCGGATCTTCCCGCCG
GAGCGGCGCGGCGTGGCGGTCAGCGTGTGGAGCGCCACCGCCGGGGCGGCCAGCCTGGTGGGGCCGCTGGCCGGTGGGGT
GCTGGTCGACGGGCTCGGGTGGCAGTGGATCTTCTTCGTCAACGTCCCGATCGGGGTGCTGGGGCTGGCCCTGGCGTACT
GGCTGGTTCCGGTGCTGCCCACCCAGTCGCACCGCTTCGACCTGGTCGGGGTCGGGTTGTCCGGGGTGGGCATGTTCCTG
ATCGTGTTCGGGCTGCAGCAGGGCCAGGCCGCGCACTGGCAACCCTGGATCTGGGCGCTGATCGTCGCGGGTGTCGGGTT
CGTGACGGTGTTCGTGTTCTGGCAATCGGTCAATGTCCGGGAGCCGCTGATCCCGCTGGTGATCTTCGCCGACCGCGACT
TCAGCCTGTGCAACATCGGCGTGGCCATCATCTCGTTCGCCGCGACGGCCATGATGCTGCCGCTGACGTTTTACGCCCAG
GCGGTGTGCGGCCTGTCGCCGACCCGCTCGGCCCTGCTGATCGCGCCGATGGCGATCGCCAACGGGGTGTTCGCGCCGTT
CGTCGGCAAGATCGTCGACCGCTACCACCCGCGCCCGGTGCTCGGTTTCGGGTTTTCGCTGCTGGCGATCGCGCTGACCT
GGCTCACCTTCGAGATGTCGCCGGCGACGCCGATCTGGCGGCTGGTGCTGCCGTTCTTCGCGATGGGTGTGGGGATGGCC
TTCGTGTGGTCGCCGCTGACGGCGACCGCGACGCGCAACCTGTCGGCGCAGCTGGCCGGCGCCGGGTCCGCGGTGTACAA
CTCGGTGCGTCAGCTGGGCGCCGTGCTGGGCAGCGCCGGCATGGCCGCGTTCATGACGTGGCGGATCGGCGCCGAGATGC
CGGGACAGCCCGCCGGCGGGGGTGAGGACTCGGCCGGGCCGGTGCTGCCCGAGTTCCTGCGCGGGCCGTTCGCGGCGGCG
ATGTCGCAGTCGGTGCTGCTGCCGGCGTTCATCGCGTTGTTCGGGATCGTCGCCGCGCTGTTCCTGGTGGGTTTTCGCCC
GTGGGCGCACCGCGACGGCGGGACCGACGCGTTCGGGCCGGACGACTACGGCGGCGACTATGACGACGACTACGACGACG
ATGACGCGTACGTCGAACTCATCCTGGTGCGTGAACCCGAACCCGAGGCGCAGCAACGCGCCGGGCAGCCGCGACGGCCG
CAGCCCGCCCCGGCACCGCCCGCCGACGTGCGCCGCCGTGACCCCGTCGAGTCCCGGCGCAGCGTGCTCGACGAACGGCC
CGCTCAGGTTCAGCCGATCGGCTTCGCGCACAACGGGTCTCACGTGGACGGCGGCAAGCGGCTGCGCCAGGTGGCGGTGC
GGCGCGCGCCCAAACCCGGCCCGCCCGCCGACCGGTTCACCCGGCCGCCGCGCCGCCACCACCCCGGCCCGGCGGGTCAC
CACTTGGGCGAAGGCGAGTCGCTGCGCGGCCAGCACCACCGTCCCGACCCGGACGACGACCCCACCGGTTACGGCCGGCA
CTCGTCGGGCAACTAG

Upstream 100 bases:

>100_bases
GGCCGCCGGGTGCCCTGGTTGCGGCCGGTCGGCCAGCGCGGGCCGATCCGGCGGAAACGGCGCCGGACAGGTTCGTCGGG
AGCGAAACGAGGTGGGGTGG

Downstream 100 bases:

>100_bases
CCGGTCAGCGCAGATCGGGCTGGGTGAGCGCCAGGAACGCGCCCAGCTCGATCAGCCCCGCCGGCGTGCCGGGCAGGTAC
TCCGTCAGCGTCGGCGACCG

Product: hypothetical protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MTTATPRTPGGGRRAPSGPAPGAHRWDLITRSSAHSQNPWNPLWAMMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVW
VTSAYLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIAARVVQGVGAGVLTPQTLSTITRIFPP
ERRGVAVSVWSATAGAASLVGPLAGGVLVDGLGWQWIFFVNVPIGVLGLALAYWLVPVLPTQSHRFDLVGVGLSGVGMFL
IVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREPLIPLVIFADRDFSLCNIGVAIISFAATAMMLPLTFYAQ
AVCGLSPTRSALLIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPATPIWRLVLPFFAMGVGMA
FVWSPLTATATRNLSAQLAGAGSAVYNSVRQLGAVLGSAGMAAFMTWRIGAEMPGQPAGGGEDSAGPVLPEFLRGPFAAA
MSQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYDDDYDDDDAYVELILVREPEPEAQQRAGQPRRP
QPAPAPPADVRRRDPVESRRSVLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPRRHHPGPAGH
HLGEGESLRGQHHRPDPDDDPTGYGRHSSGN

Sequences:

>Translated_671_residues
MTTATPRTPGGGRRAPSGPAPGAHRWDLITRSSAHSQNPWNPLWAMMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVW
VTSAYLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIAARVVQGVGAGVLTPQTLSTITRIFPP
ERRGVAVSVWSATAGAASLVGPLAGGVLVDGLGWQWIFFVNVPIGVLGLALAYWLVPVLPTQSHRFDLVGVGLSGVGMFL
IVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREPLIPLVIFADRDFSLCNIGVAIISFAATAMMLPLTFYAQ
AVCGLSPTRSALLIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPATPIWRLVLPFFAMGVGMA
FVWSPLTATATRNLSAQLAGAGSAVYNSVRQLGAVLGSAGMAAFMTWRIGAEMPGQPAGGGEDSAGPVLPEFLRGPFAAA
MSQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYDDDYDDDDAYVELILVREPEPEAQQRAGQPRRP
QPAPAPPADVRRRDPVESRRSVLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPRRHHPGPAGH
HLGEGESLRGQHHRPDPDDDPTGYGRHSSGN
>Mature_670_residues
TTATPRTPGGGRRAPSGPAPGAHRWDLITRSSAHSQNPWNPLWAMMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWV
TSAYLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIAARVVQGVGAGVLTPQTLSTITRIFPPE
RRGVAVSVWSATAGAASLVGPLAGGVLVDGLGWQWIFFVNVPIGVLGLALAYWLVPVLPTQSHRFDLVGVGLSGVGMFLI
VFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREPLIPLVIFADRDFSLCNIGVAIISFAATAMMLPLTFYAQA
VCGLSPTRSALLIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPATPIWRLVLPFFAMGVGMAF
VWSPLTATATRNLSAQLAGAGSAVYNSVRQLGAVLGSAGMAAFMTWRIGAEMPGQPAGGGEDSAGPVLPEFLRGPFAAAM
SQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYDDDYDDDDAYVELILVREPEPEAQQRAGQPRRPQ
PAPAPPADVRRRDPVESRRSVLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPRRHHPGPAGHH
LGEGESLRGQHHRPDPDDDPTGYGRHSSGN

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=402, Percent_Identity=29.8507462686567, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788710, Length=413, Percent_Identity=29.7820823244552, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI87081983, Length=417, Percent_Identity=29.7362110311751, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790195, Length=411, Percent_Identity=28.2238442822384, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788392, Length=401, Percent_Identity=31.1720698254364, Blast_Score=142, Evalue=1e-34,
Organism=Escherichia coli, GI1790146, Length=153, Percent_Identity=28.7581699346405, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=307, Percent_Identity=26.7100977198697, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321663, Length=158, Percent_Identity=33.5443037974684, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325455, Length=241, Percent_Identity=27.8008298755187, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323520, Length=286, Percent_Identity=25.1748251748252, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322958, Length=425, Percent_Identity=23.2941176470588, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323935, Length=377, Percent_Identity=25.4641909814324, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319770, Length=382, Percent_Identity=23.5602094240838, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319480, Length=199, Percent_Identity=27.6381909547739, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 71618; Mature: 71487

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTATPRTPGGGRRAPSGPAPGAHRWDLITRSSAHSQNPWNPLWAMMIGFFMIMVDSTIV
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCEE
AIANPTIMADLHIGYDTVVWVTSAYLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVAS
EEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHH
VWCGLAGSAAMLIAARVVQGVGAGVLTPQTLSTITRIFPPERRGVAVSVWSATAGAASLV
HHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHH
GPLAGGVLVDGLGWQWIFFVNVPIGVLGLALAYWLVPVLPTQSHRFDLVGVGLSGVGMFL
HHHHCCCEEECCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHH
IVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREPLIPLVIFADRDFSLCNIG
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHH
VAIISFAATAMMLPLTFYAQAVCGLSPTRSALLIAPMAIANGVFAPFVGKIVDRYHPRPV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
LGFGFSLLAIALTWLTFEMSPATPIWRLVLPFFAMGVGMAFVWSPLTATATRNLSAQLAG
HHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCC
AGSAVYNSVRQLGAVLGSAGMAAFMTWRIGAEMPGQPAGGGEDSAGPVLPEFLRGPFAAA
CCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHH
MSQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYDDDYDDDDAYVEL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ILVREPEPEAQQRAGQPRRPQPAPAPPADVRRRDPVESRRSVLDERPAQVQPIGFAHNGS
EEEECCCCHHHHHCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHCCCCCCCCEEECCCCC
HVDGGKRLRQVAVRRAPKPGPPADRFTRPPRRHHPGPAGHHLGEGESLRGQHHRPDPDDD
CCCHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PTGYGRHSSGN
CCCCCCCCCCC
>Mature Secondary Structure 
TTATPRTPGGGRRAPSGPAPGAHRWDLITRSSAHSQNPWNPLWAMMIGFFMIMVDSTIV
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCEE
AIANPTIMADLHIGYDTVVWVTSAYLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVAS
EEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHH
VWCGLAGSAAMLIAARVVQGVGAGVLTPQTLSTITRIFPPERRGVAVSVWSATAGAASLV
HHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHH
GPLAGGVLVDGLGWQWIFFVNVPIGVLGLALAYWLVPVLPTQSHRFDLVGVGLSGVGMFL
HHHHCCCEEECCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHH
IVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREPLIPLVIFADRDFSLCNIG
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHH
VAIISFAATAMMLPLTFYAQAVCGLSPTRSALLIAPMAIANGVFAPFVGKIVDRYHPRPV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
LGFGFSLLAIALTWLTFEMSPATPIWRLVLPFFAMGVGMAFVWSPLTATATRNLSAQLAG
HHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCC
AGSAVYNSVRQLGAVLGSAGMAAFMTWRIGAEMPGQPAGGGEDSAGPVLPEFLRGPFAAA
CCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHH
MSQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYDDDYDDDDAYVEL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ILVREPEPEAQQRAGQPRRPQPAPAPPADVRRRDPVESRRSVLDERPAQVQPIGFAHNGS
EEEECCCCHHHHHCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHCCCCCCCCEEECCCCC
HVDGGKRLRQVAVRRAPKPGPPADRFTRPPRRHHPGPAGHHLGEGESLRGQHHRPDPDDD
CCCHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PTGYGRHSSGN
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]