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The map label for this gene is fadA4

Identifier: 41408534

GI number: 41408534

Start: 2736327

End: 2737496

Strand: Reverse

Name: fadA4

Synonym: MAP2436c

Alternate gene names: 41408534

Gene position: 2737496-2736327 (Counterclockwise)

Preceding gene: 41408536

Following gene: 41408533

Centisome position: 56.68

GC content: 69.83

Gene sequence:

>1170_bases
GTGATCGTTGCTGGAGCGCGGACACCCATCGGCAAGCTGATGGGTTCGCTGAAGGATTTCTCCGCCAGCGACCTGGGTGC
CATCGCCATCGCCGGCGCGCTGGAGAAGGCCGACGTCCCGGCCGACCTGGTCGAGTACGTGATCATGGGGCAGGTGTTGA
CGGCCGGGGCCGGTCAGATGCCGGCCCGGCAGGCGGCCGTGGCGGCCGGCATCGGCTGGGACGTGCCGGCGTTGAGCATC
AACAAGATGTGTCTGTCCGGGATCGACGCCATCGCCCTGGCCGACCAGCTGATTCGCGCCGGAGAGTTCGACGTGGTGGT
AGCCGGCGGTCAGGAGTCGATGACCAAGGCGCCGCACCTGCTGATGGACAGCCGCGCGGGCTACAAGTACGGCGACGTGA
CGGTCCTGGACCACATGGCCTACGACGGCCTGCACGACGTGTTCACCGACCAGCCGATGGGCGCGCTCACCGAGCAGCGC
AACGACGTCGACAAGTTCACCCGCGAAGAGCAGGACCAGTACGCCGCACGGTCGCATCAGCGGGCGGCCGCGGCGTGGAA
GGACGGCGTGTTCACCGACGAGGTGGTGCCGGTGAACATCCCGCAGCGCAAGGGCGATCCGCTGCAGTTCACCGAGGACG
AGGGCATCCGCGCCAACACCACCGCCGAGTCGCTGGCCGGCCTCAAGCCGGCGTTCCGCAAGGACGGCACCATTACCGCC
GGGTCGGCCTCGCAGATCTCCGACGGCGCGGCCGCGGTGGTCGTGATGAGCAAGGCCAAGGCCCAGCAGCTCGGGCTGAG
CTGGCTGGCCGAGATCGGTGCGCACGGGGTGGTCGCCGGACCGGACTCCACCCTGCAGTCGCAGCCGGCCAACGCCATCA
AGAAGGCGCTCGGTCGCGAGGGCATCTCCGTCGACCAGCTCGACGTGGTGGAGATCAACGAGGCGTTTGCGGCCGTGGCG
CTGGCCTCGACCCGCGAACTCGGCGTGAATCCCGACATCGTCAACGTCAACGGCGGTGCGATCGCGGTCGGGCACCCGAT
CGGGATGTCGGGGGCGCGGATCACCCTGCATGCCGCGCTGGAACTGTCGCGGCGCGGCTCGGGCTACGCGGTCGCGGCCC
TGTGCGGGGCCGGCGGGCAGGGCGACGCGCTGATTCTGCGGGCGGGTTAG

Upstream 100 bases:

>100_bases
TCGTCATCTCATAACGGTAACCTGACGGCAAAGATTGCGCTTCTCCGGGAGGCTCCCGGGAGGCATTAGCAGGCCTGAGG
AGAGAGTCATGACGACGTCG

Downstream 100 bases:

>100_bases
CCAGCGGTCGCGGCGTTCGCCGAGGTTGCTGGCATTCGCCCGCCGTGACGAAGTGTGATCTTCGTCATATCGGCCGATCA
CACCGCTTTTTCGGGGCTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MIVAGARTPIGKLMGSLKDFSASDLGAIAIAGALEKADVPADLVEYVIMGQVLTAGAGQMPARQAAVAAGIGWDVPALSI
NKMCLSGIDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRAGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQR
NDVDKFTREEQDQYAARSHQRAAAAWKDGVFTDEVVPVNIPQRKGDPLQFTEDEGIRANTTAESLAGLKPAFRKDGTITA
GSASQISDGAAAVVVMSKAKAQQLGLSWLAEIGAHGVVAGPDSTLQSQPANAIKKALGREGISVDQLDVVEINEAFAAVA
LASTRELGVNPDIVNVNGGAIAVGHPIGMSGARITLHAALELSRRGSGYAVAALCGAGGQGDALILRAG

Sequences:

>Translated_389_residues
MIVAGARTPIGKLMGSLKDFSASDLGAIAIAGALEKADVPADLVEYVIMGQVLTAGAGQMPARQAAVAAGIGWDVPALSI
NKMCLSGIDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRAGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQR
NDVDKFTREEQDQYAARSHQRAAAAWKDGVFTDEVVPVNIPQRKGDPLQFTEDEGIRANTTAESLAGLKPAFRKDGTITA
GSASQISDGAAAVVVMSKAKAQQLGLSWLAEIGAHGVVAGPDSTLQSQPANAIKKALGREGISVDQLDVVEINEAFAAVA
LASTRELGVNPDIVNVNGGAIAVGHPIGMSGARITLHAALELSRRGSGYAVAALCGAGGQGDALILRAG
>Mature_389_residues
MIVAGARTPIGKLMGSLKDFSASDLGAIAIAGALEKADVPADLVEYVIMGQVLTAGAGQMPARQAAVAAGIGWDVPALSI
NKMCLSGIDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRAGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQR
NDVDKFTREEQDQYAARSHQRAAAAWKDGVFTDEVVPVNIPQRKGDPLQFTEDEGIRANTTAESLAGLKPAFRKDGTITA
GSASQISDGAAAVVVMSKAKAQQLGLSWLAEIGAHGVVAGPDSTLQSQPANAIKKALGREGISVDQLDVVEINEAFAAVA
LASTRELGVNPDIVNVNGGAIAVGHPIGMSGARITLHAALELSRRGSGYAVAALCGAGGQGDALILRAG

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=44.2159383033419, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=41.3881748071979, Blast_Score=271, Evalue=6e-73,
Organism=Homo sapiens, GI4557237, Length=389, Percent_Identity=40.3598971722365, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=37.2448979591837, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=31.9148936170213, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=27.4111675126904, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI87082165, Length=386, Percent_Identity=45.5958549222798, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1788554, Length=388, Percent_Identity=45.1030927835052, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1787663, Length=394, Percent_Identity=39.5939086294416, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=36.0201511335013, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1788683, Length=429, Percent_Identity=33.3333333333333, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI133906874, Length=387, Percent_Identity=41.6020671834625, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=39.5348837209302, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=37.2750642673522, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=31.9148936170213, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=34.3434343434343, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=392, Percent_Identity=41.5816326530612, Blast_Score=269, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=36.8686868686869, Blast_Score=212, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24655093, Length=389, Percent_Identity=44.4730077120823, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24640423, Length=387, Percent_Identity=41.343669250646, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=36.2467866323907, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17137578, Length=421, Percent_Identity=32.3040380047506, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40132; Mature: 40132

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVAGARTPIGKLMGSLKDFSASDLGAIAIAGALEKADVPADLVEYVIMGQVLTAGAGQM
CEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
PARQAAVAAGIGWDVPALSINKMCLSGIDAIALADQLIRAGEFDVVVAGGQESMTKAPHL
CHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCHHHHHCCHH
LMDSRAGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQRNDVDKFTREEQDQYAARSHQ
EEECCCCCCCCCEEEEHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAAAWKDGVFTDEVVPVNIPQRKGDPLQFTEDEGIRANTTAESLAGLKPAFRKDGTITA
HHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCEEC
GSASQISDGAAAVVVMSKAKAQQLGLSWLAEIGAHGVVAGPDSTLQSQPANAIKKALGRE
CCHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCEEECCCCHHHCCCHHHHHHHHCCC
GISVDQLDVVEINEAFAAVALASTRELGVNPDIVNVNGGAIAVGHPIGMSGARITLHAAL
CCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCCCEEEEEEEE
ELSRRGSGYAVAALCGAGGQGDALILRAG
EHHCCCCCEEEEEEECCCCCCCEEEEECC
>Mature Secondary Structure
MIVAGARTPIGKLMGSLKDFSASDLGAIAIAGALEKADVPADLVEYVIMGQVLTAGAGQM
CEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
PARQAAVAAGIGWDVPALSINKMCLSGIDAIALADQLIRAGEFDVVVAGGQESMTKAPHL
CHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCHHHHHCCHH
LMDSRAGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQRNDVDKFTREEQDQYAARSHQ
EEECCCCCCCCCEEEEHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAAAWKDGVFTDEVVPVNIPQRKGDPLQFTEDEGIRANTTAESLAGLKPAFRKDGTITA
HHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCEEC
GSASQISDGAAAVVVMSKAKAQQLGLSWLAEIGAHGVVAGPDSTLQSQPANAIKKALGRE
CCHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCEEECCCCHHHCCCHHHHHHHHCCC
GISVDQLDVVEINEAFAAVALASTRELGVNPDIVNVNGGAIAVGHPIGMSGARITLHAAL
CCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCCCEEEEEEEE
ELSRRGSGYAVAALCGAGGQGDALILRAG
EHHCCCCCEEEEEEECCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA