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The map label for this gene is mutM [C]

Identifier: 41408382

GI number: 41408382

Start: 2554673

End: 2555479

Strand: Reverse

Name: mutM [C]

Synonym: MAP2284c

Alternate gene names: 41408382

Gene position: 2555479-2554673 (Counterclockwise)

Preceding gene: 41408383

Following gene: 41408380

Centisome position: 52.91

GC content: 72.12

Gene sequence:

>807_bases
GTGCCCGAAGGCCATACCCTGCACCGGCTGGCCCGGCTGCATCAACGCCGATACGCCGGCGCGCCGGTGGCGGTGTCCAG
CCCGCAGGGCCGCTTCGCCGAGGCGGCCGCGGTGGTCGACGGCCGGGTGTTGCGGCGCACCAGCGCCTGGGGCAAACACC
TGTTTCACCACTACGCGGGCGGCCCGATCGTGCACGTGCACCTGGGACTGTACGGCTCCTTCAGCGAATGGGAACGTCCC
GGCGACGGGCCGTTGCCCGACCCGGTCGGGCAGGTGCGGATGCGCATGGTCGGCGCCGGCCACGGCACCGACCTGCGCGG
CCCGACGGTCTGCGAGGTCATCGACGAGGGGCAGGTCAGTGACGTGCTGGCCAGGCTGGGCCCCGACCCGTTGCGCGACG
ACGCCGACCCGTCCTGGGCCTGGCAGCGAATTGCCAAGTCGCGCAGACCTATTGGCGCGCTGCTGATGGACCAGACCGTG
ATGGCCGGGGTGGGCAACGTGTACCGCAGCGAGTTGTTGTTCCGGCACGGCATCGACCCGTACCGGGCGGGCCGCGACGT
GGGCGAGGCCGAGTTCGATGCGGCCTGGACCGATCTGGTGGCGCTGATGAAGGTGGGCCTGCGGCGCGGCAAGATCATCG
TGGTGCGGCCCGAACACGACCGCGGCGCCCCGTCCTATCGCCCCGACCGGCCGCGCACCTACGTGTACCGGCGGGCCGGC
GAGGCCTGCCGGGTGTGCGGCGAGCCCGTCCGGACCGCGGTGCTGGAGGGCCGAAACGTGTTCTGGTGCCCCACCTGTCA
AAAGTGA

Upstream 100 bases:

>100_bases
ACGCCACCAACGGCGTATCGACATACTGGCCGAATACGAACGCACCCACCAAGCCCCGCCGGTACCCGGCGCCGTGGGCT
GAGGTCGGCAGGGTCCGCGC

Downstream 100 bases:

>100_bases
GCCCGCCCGCTCGATTGCCTCGGTTGGCAGGAAGCTCACAGCACGAAACGCCGGGGCCATTGTTTAGCCAAAGCATCTAT
GCGGGTATGAGTGTTCTTCG

Product: hypothetical protein

Products: NA

Alternate protein names: Putative DNA-(apurinic or apyrimidinic site) lyase Rv2464c/MT2539; Putative AP lyase Rv2464c/MT2539 [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MPEGHTLHRLARLHQRRYAGAPVAVSSPQGRFAEAAAVVDGRVLRRTSAWGKHLFHHYAGGPIVHVHLGLYGSFSEWERP
GDGPLPDPVGQVRMRMVGAGHGTDLRGPTVCEVIDEGQVSDVLARLGPDPLRDDADPSWAWQRIAKSRRPIGALLMDQTV
MAGVGNVYRSELLFRHGIDPYRAGRDVGEAEFDAAWTDLVALMKVGLRRGKIIVVRPEHDRGAPSYRPDRPRTYVYRRAG
EACRVCGEPVRTAVLEGRNVFWCPTCQK

Sequences:

>Translated_268_residues
MPEGHTLHRLARLHQRRYAGAPVAVSSPQGRFAEAAAVVDGRVLRRTSAWGKHLFHHYAGGPIVHVHLGLYGSFSEWERP
GDGPLPDPVGQVRMRMVGAGHGTDLRGPTVCEVIDEGQVSDVLARLGPDPLRDDADPSWAWQRIAKSRRPIGALLMDQTV
MAGVGNVYRSELLFRHGIDPYRAGRDVGEAEFDAAWTDLVALMKVGLRRGKIIVVRPEHDRGAPSYRPDRPRTYVYRRAG
EACRVCGEPVRTAVLEGRNVFWCPTCQK
>Mature_267_residues
PEGHTLHRLARLHQRRYAGAPVAVSSPQGRFAEAAAVVDGRVLRRTSAWGKHLFHHYAGGPIVHVHLGLYGSFSEWERPG
DGPLPDPVGQVRMRMVGAGHGTDLRGPTVCEVIDEGQVSDVLARLGPDPLRDDADPSWAWQRIAKSRRPIGALLMDQTVM
AGVGNVYRSELLFRHGIDPYRAGRDVGEAEFDAAWTDLVALMKVGLRRGKIIVVRPEHDRGAPSYRPDRPRTYVYRRAGE
ACRVCGEPVRTAVLEGRNVFWCPTCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA b

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=220, Percent_Identity=32.2727272727273, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786932, Length=276, Percent_Identity=26.0869565217391, Blast_Score=92, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR012319
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 29705; Mature: 29574

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCHHHHHHHHCCCCEEECCCCCC
>Mature Secondary Structure 
PEGHTLHRLARLHQRRYAGAPVAVSSPQGRFAEAAAVVDGRVLRRTSAWGKHLFHHYAG
CCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPIVHVHLGLYGSFSEWERPGDGPLPDPVGQVRMRMVGAGHGTDLRGPTVCEVIDEGQVS
CCEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCHH
DVLARLGPDPLRDDADPSWAWQRIAKSRRPIGALLMDQTVMAGVGNVYRSELLFRHGIDP
HHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
YRAGRDVGEAEFDAAWTDLVALMKVGLRRGKIIVVRPEHDRGAPSYRPDRPRTYVYRRAG
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHC
EACRVCGEPVRTAVLEGRNVFWCPTCQK
HHHHHCCHHHHHHHHCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]