Click here to switch to the map view.

The map label for this gene is clpP

Identifier: 41408379

GI number: 41408379

Start: 2550519

End: 2551118

Strand: Reverse

Name: clpP

Synonym: MAP2281c

Alternate gene names: 41408379

Gene position: 2551118-2550519 (Counterclockwise)

Preceding gene: 41408380

Following gene: 41408378

Centisome position: 52.82

GC content: 65.0

Gene sequence:

>600_bases
GTGTCTGACATGCGTTCGCCCTCGCAGGGTCTCAACCTCACGGACTCGGTCTATGAGCGCTTGCTGTCCGAGCGCATCAT
CTTCCTGGGTTCGGAGGTCAACGACGACGTCGCCAACCGGCTGTGCGCGCAGATCCTGCTGCTCGCCGCCGAAGACCCCA
CCAAGGACATCTCGCTCTACATCAACTCCCCGGGCGGTTCGATCAGCGCCGGCATGGCCATCTACGACACCATGGTGCTG
GCGCCCTGCGACATCGCCACCTACGCGATGGGCATGGCCGCCTCGATGGGCGAGTTCTTGTTGGCGGCGGGCACCAAGGG
CAAGCGCTACGCGCTGCCGCACGCCCGCATCCTGATGCACCAGCCGCTCGGCGGGGTCACCGGCAGCGCGGCCGACATCG
CCATCCAGGCCGAGCAGTTCCACGTCATCAAAAAGGAGATGTTCCGGCTCAACGCCGAATTCACCGGACAGTCGATCGAA
CGCATCGAGGCCGACTCCGACCGCGACCGCTGGTTCACCGCCCAGGAAGCCCTCGAGTACGGGTTCGTCGACCACATCAT
CACCCGCGCCGCCACCATCACCAACGGAGAAGCACAGTGA

Upstream 100 bases:

>100_bases
GCGAACGCGCCCCGTTTCCGGGGTGCGTGGCCGCGAAACGGCGGGCCCGGTTGGTTAGTGTCGGTGCAGAGAAGAACTCG
AGAAAGCAGGTAACCCAGTC

Downstream 100 bases:

>100_bases
ACCCTCAGATCCAGCCCCAGGCGCGCTACATCCTGCCGTCGTTCATCGAGCACTCCAGCTTCGGGATCAAGGAATCCAAC
CCGTACAACAAGCTGTTCGA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MSDMRSPSQGLNLTDSVYERLLSERIIFLGSEVNDDVANRLCAQILLLAAEDPTKDISLYINSPGGSISAGMAIYDTMVL
APCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGVTGSAADIAIQAEQFHVIKKEMFRLNAEFTGQSIE
RIEADSDRDRWFTAQEALEYGFVDHIITRAATITNGEAQ

Sequences:

>Translated_199_residues
MSDMRSPSQGLNLTDSVYERLLSERIIFLGSEVNDDVANRLCAQILLLAAEDPTKDISLYINSPGGSISAGMAIYDTMVL
APCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGVTGSAADIAIQAEQFHVIKKEMFRLNAEFTGQSIE
RIEADSDRDRWFTAQEALEYGFVDHIITRAATITNGEAQ
>Mature_198_residues
SDMRSPSQGLNLTDSVYERLLSERIIFLGSEVNDDVANRLCAQILLLAAEDPTKDISLYINSPGGSISAGMAIYDTMVLA
PCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGVTGSAADIAIQAEQFHVIKKEMFRLNAEFTGQSIER
IEADSDRDRWFTAQEALEYGFVDHIITRAATITNGEAQ

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=172, Percent_Identity=47.6744186046512, Blast_Score=174, Evalue=5e-44,
Organism=Escherichia coli, GI1786641, Length=172, Percent_Identity=56.9767441860465, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17538017, Length=180, Percent_Identity=45.5555555555556, Blast_Score=170, Evalue=4e-43,
Organism=Drosophila melanogaster, GI20129427, Length=171, Percent_Identity=45.0292397660819, Blast_Score=163, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21665; Mature: 21534

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMRSPSQGLNLTDSVYERLLSERIIFLGSEVNDDVANRLCAQILLLAAEDPTKDISLY
CCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEE
INSPGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMH
EECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHEEE
QPLGGVTGSAADIAIQAEQFHVIKKEMFRLNAEFTGQSIERIEADSDRDRWFTAQEALEY
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHH
GFVDHIITRAATITNGEAQ
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDMRSPSQGLNLTDSVYERLLSERIIFLGSEVNDDVANRLCAQILLLAAEDPTKDISLY
CCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEE
INSPGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMH
EECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHEEE
QPLGGVTGSAADIAIQAEQFHVIKKEMFRLNAEFTGQSIERIEADSDRDRWFTAQEALEY
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHH
GFVDHIITRAATITNGEAQ
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]