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The map label for this gene is obgE

Identifier: 41408362

GI number: 41408362

Start: 2528547

End: 2530025

Strand: Reverse

Name: obgE

Synonym: MAP2264c

Alternate gene names: 41408362

Gene position: 2530025-2528547 (Counterclockwise)

Preceding gene: 41408363

Following gene: 41408361

Centisome position: 52.38

GC content: 71.53

Gene sequence:

>1479_bases
ATGCCTCGGTTCGTCGACCGCGTCGTCATCCATGCGCGCGCCGGGTCCGGGGGCAACGGCTGCGCCTCGGTCCATCGCGA
GAAGTTCAAGCCGCTGGGCGGCCCGGACGGGGGCAACGGCGGCCGCGGCGGCAGCATCGTCTTCGTCGTCGACCCCCAGG
TGCACACCCTGCTGGACTTCCACTTCCATCCGCACATCAGCGCGCCGTCCGGCAAACAGGGCATGGGCAACAACCGCGAC
GGCGCCGCCGGCGCCGACCTGGAAGTCAAGGTGCCCGACGGCACCGTCGTGCTCGACGAGAACGGCCGGCTGCTGGCCGA
TCTGGTGGGCGCGGGCACCCGCTTCGAGGCCGCCGCGGGCGGACGCGGCGGCCTGGGCAACGCCGCGCTGGCGTCGCGGG
CCCGCAAGGCCCCCGGGTTTGCGCTGCTGGGCGAGCCGGGCGAAACCCGTGAGCTGACACTGGAACTCAAGACCGTCGCG
GACGTCGGCTTGATCGGCTTCCCCTCGGCCGGCAAATCGTCGTTGGTGTCGGCGATCTCGGCGGCCAAGCCCAAGATCGC
CGACTACCCGTTCACCACGCTGGTGCCCAACCTGGGCGTGGTGTCGGCCGGCGAGCACACCTTCACCGTCGCCGACGTGC
CCGGCCTGATCCCGGGCGCATCGGCGGGCCGCGGCCTGGGCCTGGACTTCCTGCGGCACATCGAGCGCTGCGCGGTGCTG
GTGCACGTCATCGACTGCGCCACCGCCGATCCGGGCCGTGACCCGATCTCCGACATCGACGCGCTGGAAGCCGAACTCGC
CGCCTACACGCCCACCCTGCAAGGCGACGTGACGCTGGGTGATCTCACCGAGCGGCCCCGCGCGGTGGTGCTCAACAAGA
TCGACGTGCCCGAGGCGCGCGAGCTGGCCGAGTTCGTCCGTGACGAGATCGCCGAGCGCGGCTGGCCGGTGTTCCTGGTG
TCGACGGTGGCTCGAGAAGGGTTGCAGCCCTTGATCTTCGGGCTGTGGCAGATGATCTCCGAGTATCAGTCCGCCCAGCC
GGAGATCGTGCCGCGGCGCCCGGTGATCCGCCCGGTTCCCGTCGACGACAGCGGTTTTCGGGTGGAACCCGATCCGCGGC
AGCCGGGCGCGTTCGTGGTCAGCGGTGCGCGGCCCGAACGCTGGGTGCGCCAGACCAACTTCGACAACGACGAGGCGGTG
GGGTATCTCGCCGACCGGCTGGCCCGCCTCGGCGTCGAAGAGGAGTTGCTGCGGCTGGGCGCGCGACCCGGCTGCGCGGT
CACCATCGGGGACATGACGTTCGACTGGGAGCCGCAAACGCCTGCCGGACAACAGGTTGTGCTGTCCGGCCGCGGTACCG
ACGCGCGGCTGGAGCGCACCGAGCGGGTCGGCGCCGCCGAGCGCAAGGCCGCCCGCAGGCAGCGCCGCACCGGCGACGAT
GCAGAGCGCGGAACCACAGAACGCGGTGAGAACACGTGA

Upstream 100 bases:

>100_bases
CGCCGACTGAGCGCCGCGAGCGTGCACTCACCGCGATAATTCGAGGCAATTCTCGCGGTAGCTGCACGCTCGGCGAACGA
GACGGCTGAGAGGATCCACG

Downstream 100 bases:

>100_bases
CCGCCCACCGCGACGCCATCCGCACGGCGCGCAGCATGGTGGTCAAGGTGGGCACCAACGCGTTGACCACCCCGGCCGGG
GTGTTCGACGCCGGCCGGCT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MPRFVDRVVIHARAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDFHFHPHISAPSGKQGMGNNRD
GAAGADLEVKVPDGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNAALASRARKAPGFALLGEPGETRELTLELKTVA
DVGLIGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHTFTVADVPGLIPGASAGRGLGLDFLRHIERCAVL
VHVIDCATADPGRDPISDIDALEAELAAYTPTLQGDVTLGDLTERPRAVVLNKIDVPEARELAEFVRDEIAERGWPVFLV
STVAREGLQPLIFGLWQMISEYQSAQPEIVPRRPVIRPVPVDDSGFRVEPDPRQPGAFVVSGARPERWVRQTNFDNDEAV
GYLADRLARLGVEEELLRLGARPGCAVTIGDMTFDWEPQTPAGQQVVLSGRGTDARLERTERVGAAERKAARRQRRTGDD
AERGTTERGENT

Sequences:

>Translated_492_residues
MPRFVDRVVIHARAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDFHFHPHISAPSGKQGMGNNRD
GAAGADLEVKVPDGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNAALASRARKAPGFALLGEPGETRELTLELKTVA
DVGLIGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHTFTVADVPGLIPGASAGRGLGLDFLRHIERCAVL
VHVIDCATADPGRDPISDIDALEAELAAYTPTLQGDVTLGDLTERPRAVVLNKIDVPEARELAEFVRDEIAERGWPVFLV
STVAREGLQPLIFGLWQMISEYQSAQPEIVPRRPVIRPVPVDDSGFRVEPDPRQPGAFVVSGARPERWVRQTNFDNDEAV
GYLADRLARLGVEEELLRLGARPGCAVTIGDMTFDWEPQTPAGQQVVLSGRGTDARLERTERVGAAERKAARRQRRTGDD
AERGTTERGENT
>Mature_491_residues
PRFVDRVVIHARAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDFHFHPHISAPSGKQGMGNNRDG
AAGADLEVKVPDGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNAALASRARKAPGFALLGEPGETRELTLELKTVAD
VGLIGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHTFTVADVPGLIPGASAGRGLGLDFLRHIERCAVLV
HVIDCATADPGRDPISDIDALEAELAAYTPTLQGDVTLGDLTERPRAVVLNKIDVPEARELAEFVRDEIAERGWPVFLVS
TVAREGLQPLIFGLWQMISEYQSAQPEIVPRRPVIRPVPVDDSGFRVEPDPRQPGAFVVSGARPERWVRQTNFDNDEAVG
YLADRLARLGVEEELLRLGARPGCAVTIGDMTFDWEPQTPAGQQVVLSGRGTDARLERTERVGAAERKAARRQRRTGDDA
ERGTTERGENT

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=344, Percent_Identity=42.1511627906977, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI111955139, Length=400, Percent_Identity=31.25, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI111955063, Length=228, Percent_Identity=31.5789473684211, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI1789574, Length=350, Percent_Identity=43.1428571428571, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI1787454, Length=129, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=337, Percent_Identity=39.4658753709199, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17552324, Length=318, Percent_Identity=30.5031446540881, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17509631, Length=136, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=187, Percent_Identity=37.9679144385027, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321649, Length=141, Percent_Identity=31.2056737588652, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319281, Length=108, Percent_Identity=36.1111111111111, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321612, Length=107, Percent_Identity=37.3831775700935, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129375, Length=302, Percent_Identity=39.4039735099338, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24585318, Length=324, Percent_Identity=35.1851851851852, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=28.125, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=28.125, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=28.125, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 52252; Mature: 52120

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFVDRVVIHARAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDF
CCCHHEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEE
HFHPHISAPSGKQGMGNNRDGAAGADLEVKVPDGTVVLDENGRLLADLVGAGTRFEAAAG
ECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCEEHHHHCCCCEEEECCC
GRGGLGNAALASRARKAPGFALLGEPGETRELTLELKTVADVGLIGFPSAGKSSLVSAIS
CCCCCCHHHHHHHHHCCCCEEEECCCCCCEEEEEEEEEHHCCCEEECCCCCHHHHHHHHH
AAKPKIADYPFTTLVPNLGVVSAGEHTFTVADVPGLIPGASAGRGLGLDFLRHIERCAVL
HCCCCCCCCCHHHHCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
VHVIDCATADPGRDPISDIDALEAELAAYTPTLQGDVTLGDLTERPRAVVLNKIDVPEAR
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEECCCCCCHH
ELAEFVRDEIAERGWPVFLVSTVAREGLQPLIFGLWQMISEYQSAQPEIVPRRPVIRPVP
HHHHHHHHHHHHCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECC
VDDSGFRVEPDPRQPGAFVVSGARPERWVRQTNFDNDEAVGYLADRLARLGVEEELLRLG
CCCCCCEECCCCCCCCCEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHC
ARPGCAVTIGDMTFDWEPQTPAGQQVVLSGRGTDARLERTERVGAAERKAARRQRRTGDD
CCCCCEEEECCEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHCHHHHHHHHHHHCCCCC
AERGTTERGENT
HHCCCCCCCCCC
>Mature Secondary Structure 
PRFVDRVVIHARAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDF
CCHHEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEE
HFHPHISAPSGKQGMGNNRDGAAGADLEVKVPDGTVVLDENGRLLADLVGAGTRFEAAAG
ECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCEEHHHHCCCCEEEECCC
GRGGLGNAALASRARKAPGFALLGEPGETRELTLELKTVADVGLIGFPSAGKSSLVSAIS
CCCCCCHHHHHHHHHCCCCEEEECCCCCCEEEEEEEEEHHCCCEEECCCCCHHHHHHHHH
AAKPKIADYPFTTLVPNLGVVSAGEHTFTVADVPGLIPGASAGRGLGLDFLRHIERCAVL
HCCCCCCCCCHHHHCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
VHVIDCATADPGRDPISDIDALEAELAAYTPTLQGDVTLGDLTERPRAVVLNKIDVPEAR
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEECCCCCCHH
ELAEFVRDEIAERGWPVFLVSTVAREGLQPLIFGLWQMISEYQSAQPEIVPRRPVIRPVP
HHHHHHHHHHHHCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECC
VDDSGFRVEPDPRQPGAFVVSGARPERWVRQTNFDNDEAVGYLADRLARLGVEEELLRLG
CCCCCCEECCCCCCCCCEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHC
ARPGCAVTIGDMTFDWEPQTPAGQQVVLSGRGTDARLERTERVGAAERKAARRQRRTGDD
CCCCCEEEECCEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHCHHHHHHHHHHHCCCCC
AERGTTERGENT
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA