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The map label for this gene is proA

Identifier: 41408345

GI number: 41408345

Start: 2510249

End: 2511556

Strand: Reverse

Name: proA

Synonym: MAP2247c

Alternate gene names: 41408345

Gene position: 2511556-2510249 (Counterclockwise)

Preceding gene: 41408346

Following gene: 41408344

Centisome position: 52.0

GC content: 71.41

Gene sequence:

>1308_bases
ATGGGTCTGCAAGCACCATTCCGCAGCGGTGGCGGCACCTCGCGCCCGCAGGGCCGGGCCGCACCCCGCGCGGTCGACCT
GCGCCGGGAGGTGCACGACGCGGCGCGGCGCGCCCGGGTGGCTTCCCGGGTGCTGGCGCTGTTGCCCGCCGTCGCCAAGG
ACCAGGCGCTGCGCTCGGCCGCGGACGCGATCGCCGGCCACGCCGAATTGATTCTGTCGGCCAACGCCGAGGACCTCGAG
ACGGCCCGGGCTGCCGGCACGCCCAGCGCCATGCTGGACCGATTGGCGTTGGACACCAAGCGGGTCGAGGGCATCGCCGC
CGGGCTGCGCCAGGTGGCCGGGCTGCCCGACCCGGTCGGGGAGGTGCTCCGCGGCTACACGTTGCCGAACGGGCTGCAGC
TGCGCCAGCAGCGGGTTCCGCTCGGCGTGGTCGGAATGATCTACGAGGGCCGGCCCAACGTGACCGTGGATGCGTTCGGT
TTGGCGCTCAAGTCCGGCAACGCAGTGCTGTTGCGGGGCAGCTCCTCGGCGACGCGGTCCAACCAGGCGCTGGTCCAGGT
GTTGCGGGCCTCGCTGGTCAGCGAGGACCTGCCCGCCGACGCGGTGCAGCTGCTGTCGGCCGACGACCGCGCCACGGTGA
CGCACCTGATCCAGGCCCGCGGCTTGGTGGACGTGGTGATTCCGCGCGGCGGGGCGAACCTGATCAACGCGGTGGTGCGC
GACGCCCAGGTGCCCACCATCGAGACCGGGGTGGGCAACTGCCACGTGTACGTGCACGAAGGCGCCGACCTGGAGGTGGC
GGAGCGCGTGCTGCTGAATTCCAAGACGCGCCGGCCCAGCGTCTGCAATGCGGCCGAGACGCTGCTGGTGGACGCCGCCA
TCGCCGAGGAGGCGTTGCCCCGGCTGGTGACCGCGCTGCAGGACGCCGGGGTGACTGTGCACGGCGGCTTCGCCCGCGAC
GCCACCGAGGACGACCTGCGGCGCGAGTACCTGTCGATGGACATCGCGGTGGCGGTAGTCGACGGCGTCGACGCCGCGAT
CGCCCACATCAACGAGTACGGCACCGGGCACACCGAGGCCATTGTCACGACGAATATGGCTGCGGCGCAACGGTTTACCG
ACGGCGTCGATGCCGCCGCGGTGATGGTGAACGCGTCCACCGCGTTCACCGACGGCGAGCAGTTCGGGTTCGGCGCCGAG
ATCGGCATCTCCACCCAGAAATTGCACGCCCGCGGTCCCATGGGGCTGCCCGAATTGACGTCGACCAAATGGATTGCGTG
GGGAGACGGACAGACCCGTCCGGCCTGA

Upstream 100 bases:

>100_bases
GTGCGCGGCGCCCGGCGCGGCGAGCGGGTCGGCTAGGGGCCGGCCGGGCCCGGCAGCGGGCCGCCTCACCCGGGCGTTTG
CGGCCCGATACCCTGGTTCA

Downstream 100 bases:

>100_bases
TCCGCATCCGAAAGTGCTTGAGGAGAACCGATTGTGAGTGTGCCCGCCCGGCCCAGGCCGCTGTTCGCCGACATCGACGA
CGTCTCGCGGCGGTTGGCCG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MGLQAPFRSGGGTSRPQGRAAPRAVDLRREVHDAARRARVASRVLALLPAVAKDQALRSAADAIAGHAELILSANAEDLE
TARAAGTPSAMLDRLALDTKRVEGIAAGLRQVAGLPDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFG
LALKSGNAVLLRGSSSATRSNQALVQVLRASLVSEDLPADAVQLLSADDRATVTHLIQARGLVDVVIPRGGANLINAVVR
DAQVPTIETGVGNCHVYVHEGADLEVAERVLLNSKTRRPSVCNAAETLLVDAAIAEEALPRLVTALQDAGVTVHGGFARD
ATEDDLRREYLSMDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNMAAAQRFTDGVDAAAVMVNASTAFTDGEQFGFGAE
IGISTQKLHARGPMGLPELTSTKWIAWGDGQTRPA

Sequences:

>Translated_435_residues
MGLQAPFRSGGGTSRPQGRAAPRAVDLRREVHDAARRARVASRVLALLPAVAKDQALRSAADAIAGHAELILSANAEDLE
TARAAGTPSAMLDRLALDTKRVEGIAAGLRQVAGLPDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFG
LALKSGNAVLLRGSSSATRSNQALVQVLRASLVSEDLPADAVQLLSADDRATVTHLIQARGLVDVVIPRGGANLINAVVR
DAQVPTIETGVGNCHVYVHEGADLEVAERVLLNSKTRRPSVCNAAETLLVDAAIAEEALPRLVTALQDAGVTVHGGFARD
ATEDDLRREYLSMDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNMAAAQRFTDGVDAAAVMVNASTAFTDGEQFGFGAE
IGISTQKLHARGPMGLPELTSTKWIAWGDGQTRPA
>Mature_434_residues
GLQAPFRSGGGTSRPQGRAAPRAVDLRREVHDAARRARVASRVLALLPAVAKDQALRSAADAIAGHAELILSANAEDLET
ARAAGTPSAMLDRLALDTKRVEGIAAGLRQVAGLPDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFGL
ALKSGNAVLLRGSSSATRSNQALVQVLRASLVSEDLPADAVQLLSADDRATVTHLIQARGLVDVVIPRGGANLINAVVRD
AQVPTIETGVGNCHVYVHEGADLEVAERVLLNSKTRRPSVCNAAETLLVDAAIAEEALPRLVTALQDAGVTVHGGFARDA
TEDDLRREYLSMDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNMAAAQRFTDGVDAAAVMVNASTAFTDGEQFGFGAEI
GISTQKLHARGPMGLPELTSTKWIAWGDGQTRPA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=408, Percent_Identity=37.2549019607843, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI62912457, Length=408, Percent_Identity=37.2549019607843, Blast_Score=244, Evalue=2e-64,
Organism=Escherichia coli, GI1786438, Length=410, Percent_Identity=48.780487804878, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17569967, Length=413, Percent_Identity=36.0774818401937, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17569969, Length=413, Percent_Identity=36.0774818401937, Blast_Score=251, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=36.214953271028, Blast_Score=253, Evalue=5e-68,
Organism=Drosophila melanogaster, GI21357643, Length=405, Percent_Identity=36.7901234567901, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_MYCPA (Q73XR2)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_961181.1
- ProteinModelPortal:   Q73XR2
- SMR:   Q73XR2
- EnsemblBacteria:   EBMYCT00000038060
- GeneID:   2718562
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP2247c
- NMPDR:   fig|262316.1.peg.2247
- GeneTree:   EBGT00050000015663
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45525; Mature: 45394

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLQAPFRSGGGTSRPQGRAAPRAVDLRREVHDAARRARVASRVLALLPAVAKDQALRSA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADAIAGHAELILSANAEDLETARAAGTPSAMLDRLALDTKRVEGIAAGLRQVAGLPDPVG
HHHHCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
EVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFGLALKSGNAVLLRGSSSATRS
HHHHCCCCCCCHHHHHHCCCEEEEEEEECCCCCEEEEEEEEEEECCCEEEEECCCCCCHH
NQALVQVLRASLVSEDLPADAVQLLSADDRATVTHLIQARGLVDVVIPRGGANLINAVVR
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
DAQVPTIETGVGNCHVYVHEGADLEVAERVLLNSKTRRPSVCNAAETLLVDAAIAEEALP
CCCCCEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RLVTALQDAGVTVHGGFARDATEDDLRREYLSMDIAVAVVDGVDAAIAHINEYGTGHTEA
HHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCCCCE
IVTTNMAAAQRFTDGVDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELT
EEECCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
STKWIAWGDGQTRPA
CCCEEEECCCCCCCC
>Mature Secondary Structure 
GLQAPFRSGGGTSRPQGRAAPRAVDLRREVHDAARRARVASRVLALLPAVAKDQALRSA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADAIAGHAELILSANAEDLETARAAGTPSAMLDRLALDTKRVEGIAAGLRQVAGLPDPVG
HHHHCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
EVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFGLALKSGNAVLLRGSSSATRS
HHHHCCCCCCCHHHHHHCCCEEEEEEEECCCCCEEEEEEEEEEECCCEEEEECCCCCCHH
NQALVQVLRASLVSEDLPADAVQLLSADDRATVTHLIQARGLVDVVIPRGGANLINAVVR
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
DAQVPTIETGVGNCHVYVHEGADLEVAERVLLNSKTRRPSVCNAAETLLVDAAIAEEALP
CCCCCEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RLVTALQDAGVTVHGGFARDATEDDLRREYLSMDIAVAVVDGVDAAIAHINEYGTGHTEA
HHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCCCCE
IVTTNMAAAQRFTDGVDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELT
EEECCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
STKWIAWGDGQTRPA
CCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA