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The map label for this gene is hemN

Identifier: 41408305

GI number: 41408305

Start: 2453382

End: 2454554

Strand: Reverse

Name: hemN

Synonym: MAP2207c

Alternate gene names: 41408305

Gene position: 2454554-2453382 (Counterclockwise)

Preceding gene: 41408308

Following gene: 41408303

Centisome position: 50.82

GC content: 70.59

Gene sequence:

>1173_bases
ATGGCCATTCGCGAGCAAACGGTCGAGCTGCCCGACGTGCGGGTGGTCGACGGGCACCCGTTCGGCCTCTATGTGCACGT
GCCGTTTTGCGTAACCCGTTGCGGTTACTGCGATTTCAACACCTACACACCGGCCGAGCTGGGCGGGGTCAATCCCGACG
CGTGGCTGGGGGCGCTGCGCACGGAACTGGAACTGGCCGCCGCGCGGCTGCGGCCCCCACCGGTGAACACCGTGTTCGTC
GGGGGCGGGACGCCCTCGCTGCTGGGGGGCGCGCGGCTGGCGCTGCTGCTGGACATGGTGCGCGAGCACTTCGCGCTGGC
GCCCGACGCGGAGATCACCACCGAGGCCAACCCCGAGTCGACGTGGCCGGAGTTCTTCGACGCCATCGGGGCGGCCGGCT
ACACCCGGGTGTCGCTGGGTATGCAGTCGGTGGCGCCGCGGGTGCTGGGTGTGCTGGACCGCATTCACACGCCGAACCGG
TCGGCGGACGCCGCCCGCGAGGCGCTGGCCGCCGGGTTCGAGCACGTCAGCCTCGATCTCATCTACGGGACGCCGGGGGA
GTCCGACGAGGACCTGCTGTGGTCGCTCGACACCGCGATCGAAAGCGGTGTGGACCACGTGTCCGCCTATGCGCTGGTGG
TCGAGGAAGGCACGGCGCTGGCCCGGAGGGTGCGCCGCGGTGAGCTGGCGGCGCCCGACGACGACGTGCTGGCGCACCGT
TACGAATTGGTCGACGCGCGGCTGTCGCAGGCGGGCCTGTCCTGGTACGAAGTCTCCAACTGGTCGCGCCCGGGCGGGCA
GTGCCGGCACAACCTCGGCTACTGGGACGGCGGTCAGTGGTGGGGCGCGGGTCCCGGTGCCCACGGCTACGTCGGCACGA
CGCGCTGGTGGAATGTCAAGCACCCCAACGCCTATGCCGAACGGCTCAACGCCGCGGCGCTGCCGGTGGCCGGATTCGAG
CAGCTCGGCTCCGAGGCCTTGCACACCGAAGACGTGCTACTGAAAATCCGCTTGCGCCAAGGGTTTCCGGTGGATCTGTT
GAATTCCGCGGAACGCGAACGCGCCCAGGGTGTGGTGGCCGACGGGTTGTTGGTGCGCGACGGCGACCGGCTGGTGCTCA
CGCCGCGCGGGCGGCTGCTGGCCGACGGCGTGGTGCGCACGCTGTTGGGGTGA

Upstream 100 bases:

>100_bases
TGCGAGCAGGTCAAATCTTGGCTCACGGTGATTTAAAACCCGGGCCGCAGCGGGCTCGCCGGCCGTCCCGGGCCGCCCGT
TCGCCGTGGGATCATGTGGC

Downstream 100 bases:

>100_bases
CGGCGGCGCCGGTCAGACCCCGTACCAGCGCTCGACGAGGCGGGCGATCTCGATGTAGAGCGGGATCCCCACCGTGACGT
TGTAGGAGAACGTCAGGCCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MAIREQTVELPDVRVVDGHPFGLYVHVPFCVTRCGYCDFNTYTPAELGGVNPDAWLGALRTELELAAARLRPPPVNTVFV
GGGTPSLLGGARLALLLDMVREHFALAPDAEITTEANPESTWPEFFDAIGAAGYTRVSLGMQSVAPRVLGVLDRIHTPNR
SADAAREALAAGFEHVSLDLIYGTPGESDEDLLWSLDTAIESGVDHVSAYALVVEEGTALARRVRRGELAAPDDDVLAHR
YELVDARLSQAGLSWYEVSNWSRPGGQCRHNLGYWDGGQWWGAGPGAHGYVGTTRWWNVKHPNAYAERLNAAALPVAGFE
QLGSEALHTEDVLLKIRLRQGFPVDLLNSAERERAQGVVADGLLVRDGDRLVLTPRGRLLADGVVRTLLG

Sequences:

>Translated_390_residues
MAIREQTVELPDVRVVDGHPFGLYVHVPFCVTRCGYCDFNTYTPAELGGVNPDAWLGALRTELELAAARLRPPPVNTVFV
GGGTPSLLGGARLALLLDMVREHFALAPDAEITTEANPESTWPEFFDAIGAAGYTRVSLGMQSVAPRVLGVLDRIHTPNR
SADAAREALAAGFEHVSLDLIYGTPGESDEDLLWSLDTAIESGVDHVSAYALVVEEGTALARRVRRGELAAPDDDVLAHR
YELVDARLSQAGLSWYEVSNWSRPGGQCRHNLGYWDGGQWWGAGPGAHGYVGTTRWWNVKHPNAYAERLNAAALPVAGFE
QLGSEALHTEDVLLKIRLRQGFPVDLLNSAERERAQGVVADGLLVRDGDRLVLTPRGRLLADGVVRTLLG
>Mature_389_residues
AIREQTVELPDVRVVDGHPFGLYVHVPFCVTRCGYCDFNTYTPAELGGVNPDAWLGALRTELELAAARLRPPPVNTVFVG
GGTPSLLGGARLALLLDMVREHFALAPDAEITTEANPESTWPEFFDAIGAAGYTRVSLGMQSVAPRVLGVLDRIHTPNRS
ADAAREALAAGFEHVSLDLIYGTPGESDEDLLWSLDTAIESGVDHVSAYALVVEEGTALARRVRRGELAAPDDDVLAHRY
ELVDARLSQAGLSWYEVSNWSRPGGQCRHNLGYWDGGQWWGAGPGAHGYVGTTRWWNVKHPNAYAERLNAAALPVAGFEQ
LGSEALHTEDVLLKIRLRQGFPVDLLNSAERERAQGVVADGLLVRDGDRLVLTPRGRLLADGVVRTLLG

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=267, Percent_Identity=40.0749063670412, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1789325, Length=383, Percent_Identity=34.7258485639687, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI87082341, Length=306, Percent_Identity=26.4705882352941, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42297; Mature: 42166

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIREQTVELPDVRVVDGHPFGLYVHVPFCVTRCGYCDFNTYTPAELGGVNPDAWLGALR
CCCCCCCCCCCCEEEECCCCEEEEEECHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHH
TELELAAARLRPPPVNTVFVGGGTPSLLGGARLALLLDMVREHFALAPDAEITTEANPES
HHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
TWPEFFDAIGAAGYTRVSLGMQSVAPRVLGVLDRIHTPNRSADAAREALAAGFEHVSLDL
CCHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEE
IYGTPGESDEDLLWSLDTAIESGVDHVSAYALVVEEGTALARRVRRGELAAPDDDVLAHR
EECCCCCCCCHHHHHHHHHHHHCHHHHEEEEEEEECCHHHHHHHHCCCCCCCCHHHHHHH
YELVDARLSQAGLSWYEVSNWSRPGGQCRHNLGYWDGGQWWGAGPGAHGYVGTTRWWNVK
HHHHHHHHHHHCCCEEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCC
HPNAYAERLNAAALPVAGFEQLGSEALHTEDVLLKIRLRQGFPVDLLNSAERERAQGVVA
CCHHHHHHHCCCCCCCCCHHHHCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEE
DGLLVRDGDRLVLTPRGRLLADGVVRTLLG
CCEEEECCCEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AIREQTVELPDVRVVDGHPFGLYVHVPFCVTRCGYCDFNTYTPAELGGVNPDAWLGALR
CCCCCCCCCCCEEEECCCCEEEEEECHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHH
TELELAAARLRPPPVNTVFVGGGTPSLLGGARLALLLDMVREHFALAPDAEITTEANPES
HHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
TWPEFFDAIGAAGYTRVSLGMQSVAPRVLGVLDRIHTPNRSADAAREALAAGFEHVSLDL
CCHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEE
IYGTPGESDEDLLWSLDTAIESGVDHVSAYALVVEEGTALARRVRRGELAAPDDDVLAHR
EECCCCCCCCHHHHHHHHHHHHCHHHHEEEEEEEECCHHHHHHHHCCCCCCCCHHHHHHH
YELVDARLSQAGLSWYEVSNWSRPGGQCRHNLGYWDGGQWWGAGPGAHGYVGTTRWWNVK
HHHHHHHHHHHCCCEEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCC
HPNAYAERLNAAALPVAGFEQLGSEALHTEDVLLKIRLRQGFPVDLLNSAERERAQGVVA
CCHHHHHHHCCCCCCCCCHHHHCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEE
DGLLVRDGDRLVLTPRGRLLADGVVRTLLG
CCEEEECCCEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]