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The map label for this gene is ddn [H]

Identifier: 41408280

GI number: 41408280

Start: 2424369

End: 2424803

Strand: Reverse

Name: ddn [H]

Synonym: MAP2182c

Alternate gene names: 41408280

Gene position: 2424803-2424369 (Counterclockwise)

Preceding gene: 41408281

Following gene: 41408279

Centisome position: 50.21

GC content: 65.98

Gene sequence:

>435_bases
ATGTCTGAACCCGGCTACACACCGCCCGACCTGATGCTGGTCGGCGACGACCACGTGCGCGCATACCGCGAAACCGGCGG
CGAGACCGGCTATCTGTGGAACGGCGTTCCGATCTTGCTGCTCACGGTGACCGGGCGTCGCACCGGCCGCGCACTCACGT
CGGCGCTGATCTTCGGCCGCGACGGCGACGACTATCTGGTGGTGGCCTCCATGGGCGGCGCGCCGCGGCACCCGTCGTGG
TATCTGAATCTGCAAGCCAATCCGGCGGCCGGAATTCAGGTGCAAGCCGACGAGTTGGCGGTCGTGGCGCGCACCGCGTC
GGCCGCCGAGAAGCCGCGGTTTTGGAAGATCATGACTGACGTGTGGCCCAACTACGACGTCTACCAGTCACGAACCGACC
GCGACATTCCCGTCGTTGTACTCACACCGGCATGA

Upstream 100 bases:

>100_bases
CTCGACCGGCTGCCCAACCTGCGGCTGGATCCCGACGCCGAACCGCCCCGCTTCGTCGGAATGTACGAGCGCGGGGCGAC
CGCCATACCGGTGGTGTTCG

Downstream 100 bases:

>100_bases
CCACGGCTAGCATTTCTTCGGTGTCACGTGCTGAAGAACGGGCCGCGGAGCGGTCGGCGGCGGTGCAGCGTTCGCGCGAA
CGCATCGCCAACCAAGTCAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MSEPGYTPPDLMLVGDDHVRAYRETGGETGYLWNGVPILLLTVTGRRTGRALTSALIFGRDGDDYLVVASMGGAPRHPSW
YLNLQANPAAGIQVQADELAVVARTASAAEKPRFWKIMTDVWPNYDVYQSRTDRDIPVVVLTPA

Sequences:

>Translated_144_residues
MSEPGYTPPDLMLVGDDHVRAYRETGGETGYLWNGVPILLLTVTGRRTGRALTSALIFGRDGDDYLVVASMGGAPRHPSW
YLNLQANPAAGIQVQADELAVVARTASAAEKPRFWKIMTDVWPNYDVYQSRTDRDIPVVVLTPA
>Mature_143_residues
SEPGYTPPDLMLVGDDHVRAYRETGGETGYLWNGVPILLLTVTGRRTGRALTSALIFGRDGDDYLVVASMGGAPRHPSWY
LNLQANPAAGIQVQADELAVVARTASAAEKPRFWKIMTDVWPNYDVYQSRTDRDIPVVVLTPA

Specific function: Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites;

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deazaflavin-dependent nitroreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012349
- InterPro:   IPR009002
- InterPro:   IPR004378 [H]

Pfam domain/function: PF04075 DUF385 [H]

EC number: NA

Molecular weight: Translated: 15789; Mature: 15658

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPGYTPPDLMLVGDDHVRAYRETGGETGYLWNGVPILLLTVTGRRTGRALTSALIFGR
CCCCCCCCCCEEEECCHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCCHHEEEEEEECC
DGDDYLVVASMGGAPRHPSWYLNLQANPAAGIQVQADELAVVARTASAAEKPRFWKIMTD
CCCCEEEEEECCCCCCCCCEEEEEECCCCCCEEEECCCEEEEEECCCCCCCCCEEEEEEC
VWPNYDVYQSRTDRDIPVVVLTPA
CCCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure 
SEPGYTPPDLMLVGDDHVRAYRETGGETGYLWNGVPILLLTVTGRRTGRALTSALIFGR
CCCCCCCCCEEEECCHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCCHHEEEEEEECC
DGDDYLVVASMGGAPRHPSWYLNLQANPAAGIQVQADELAVVARTASAAEKPRFWKIMTD
CCCCEEEEEECCCCCCCCCEEEEEECCCCCCEEEECCCEEEEEECCCCCCCCCEEEEEEC
VWPNYDVYQSRTDRDIPVVVLTPA
CCCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]