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The map label for this gene is mbtC

Identifier: 41408273

GI number: 41408273

Start: 2415850

End: 2417178

Strand: Reverse

Name: mbtC

Synonym: MAP2175c

Alternate gene names: 41408273

Gene position: 2417178-2415850 (Counterclockwise)

Preceding gene: 41408274

Following gene: 41408272

Centisome position: 50.05

GC content: 70.58

Gene sequence:

>1329_bases
GTGACGCCGATGTCTGAGAACGGGTTCGATGCCGCCGGCATCGACCCGGTGGTGATCGTGGGGATGGGTGTCGAGGCGCC
CGGCGGCATCGAGACCGCCGAAGACTACTGGGAGCTGCTGGCCCACGGCCGCGAGGCGCTGGGCCCTTTCCCCACCGACC
GCGGCTGGGCGGTGAGCGAACTGCTCGCCGGATCCCGGCGCAGCGGCTTCAAACAGATTCATGACCGCGGTGGCTTCCTC
AGCGGCGCAGCCACTTTCGATCCGGAGTTCTTCGGCGTCTCGCCCCGTGAAGCGGTGGTGATGGACCCCCAGCAGCGGGT
GGCGCTGCGGGTGGCCTGGCGCGCGCTGGAAAACAGCGGCATCAATCCCGACGACCTCGCCGGAGAGGACGTGGGCTGCT
ACGTCGGGGCGTCGGCCACCGGCTACGGACCGGAAATGGCCAGGTTCTCCGAGCACAGCGGTCATCTACTGGCCGGGACG
GCGCTCAGCGTCATCTCCGGCCGGATCGCCTACACGCTGGGATTGACCGGTCCGGCACTGACTGTGGACTCCTCGTGCGC
CTCGGCCCTGGTGGCGTTTCACGTGGCGGTGCGAGCGCTGCAGAACGGCGACTGCGACCTGGCCCTGGCCGGCGGGGTCA
ACGTGCTGGGCTCGCCGGGATTCTTCGTCGAGTTCTCCAAACAACACGCCCTCTCCGACGACGGACACTGCCGCCCGTAC
AGCGCCCAGGCCAGCGGAACCGTGTGGGCCGAGGGAGCGGCAATGTTTGTGCTGCAACGCAAATCGGTGGCGCTGCGCGC
CGGCCGGCGGGTCGTGGCGGAGGTGCGCGCCACCGCGATCAACCAGGACGGGCGCAGCGCCGGGCTCAGCGCGCCCAGCG
GCGATGCCCAGGTCCGGCTGTTCCGGCGGGCCCTCGGCGAATCCGGGGTCAAGCCCGCCGAAGTGGGCATGATCGAGGGG
CACGGTACCGGAACCAGGCTCGGCGACCGCACCGAGTTGCGCTCGCTGGCACAGACATACGGCGACACCGAACCCGGCGC
CGGTGCCCTGCTGGGGTCGGTGAAATCCAATCTCGGCCACTCGCTGGCCGCGGCCGGCGCGCTGGGCCTGGCCAAGGTGC
TGGTCTCCGCCGAACACGGCGCCGTCCCGCCCACCCTGCACGCCACCGAAGCCAGCGGCGAAATCGACTGGGAACACCAG
GGTTTGCGGTTGGCGCAGACGTTGACGCCGTGGCCGGCGATCGACGGGCAGCGCACCGCGGCCGCGTCCGCGTTCGGGAT
CGCGGGCACCAACGCGCACCTGATCGTCTCCATGCCCGAGGTCGCATGA

Upstream 100 bases:

>100_bases
AGAGGCACACCGCCGGATCCTTTGCCATGTCGCTGTACGACGGCGGGCACTTCTACCTCTACGACCACGTCGAAACGGTC
GCGGCGCAGGTGAATGCCGG

Downstream 100 bases:

>100_bases
TGCCGACCCACGGCCTGCCGGACGGGCGCATCCCGGTGCTGCTCAGTTCCCACGACCCGGAGCTGATCCGCCGCGACGCC
GCGGCGATCCTCGAGTATCT

Product: MbtC

Products: NA

Alternate protein names: 6-deoxyerythronolide B synthase I; DEBS 1; ORF 1 [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTPMSENGFDAAGIDPVVIVGMGVEAPGGIETAEDYWELLAHGREALGPFPTDRGWAVSELLAGSRRSGFKQIHDRGGFL
SGAATFDPEFFGVSPREAVVMDPQQRVALRVAWRALENSGINPDDLAGEDVGCYVGASATGYGPEMARFSEHSGHLLAGT
ALSVISGRIAYTLGLTGPALTVDSSCASALVAFHVAVRALQNGDCDLALAGGVNVLGSPGFFVEFSKQHALSDDGHCRPY
SAQASGTVWAEGAAMFVLQRKSVALRAGRRVVAEVRATAINQDGRSAGLSAPSGDAQVRLFRRALGESGVKPAEVGMIEG
HGTGTRLGDRTELRSLAQTYGDTEPGAGALLGSVKSNLGHSLAAAGALGLAKVLVSAEHGAVPPTLHATEASGEIDWEHQ
GLRLAQTLTPWPAIDGQRTAAASAFGIAGTNAHLIVSMPEVA

Sequences:

>Translated_442_residues
MTPMSENGFDAAGIDPVVIVGMGVEAPGGIETAEDYWELLAHGREALGPFPTDRGWAVSELLAGSRRSGFKQIHDRGGFL
SGAATFDPEFFGVSPREAVVMDPQQRVALRVAWRALENSGINPDDLAGEDVGCYVGASATGYGPEMARFSEHSGHLLAGT
ALSVISGRIAYTLGLTGPALTVDSSCASALVAFHVAVRALQNGDCDLALAGGVNVLGSPGFFVEFSKQHALSDDGHCRPY
SAQASGTVWAEGAAMFVLQRKSVALRAGRRVVAEVRATAINQDGRSAGLSAPSGDAQVRLFRRALGESGVKPAEVGMIEG
HGTGTRLGDRTELRSLAQTYGDTEPGAGALLGSVKSNLGHSLAAAGALGLAKVLVSAEHGAVPPTLHATEASGEIDWEHQ
GLRLAQTLTPWPAIDGQRTAAASAFGIAGTNAHLIVSMPEVA
>Mature_441_residues
TPMSENGFDAAGIDPVVIVGMGVEAPGGIETAEDYWELLAHGREALGPFPTDRGWAVSELLAGSRRSGFKQIHDRGGFLS
GAATFDPEFFGVSPREAVVMDPQQRVALRVAWRALENSGINPDDLAGEDVGCYVGASATGYGPEMARFSEHSGHLLAGTA
LSVISGRIAYTLGLTGPALTVDSSCASALVAFHVAVRALQNGDCDLALAGGVNVLGSPGFFVEFSKQHALSDDGHCRPYS
AQASGTVWAEGAAMFVLQRKSVALRAGRRVVAEVRATAINQDGRSAGLSAPSGDAQVRLFRRALGESGVKPAEVGMIEGH
GTGTRLGDRTELRSLAQTYGDTEPGAGALLGSVKSNLGHSLAAAGALGLAKVLVSAEHGAVPPTLHATEASGEIDWEHQG
LRLAQTLTPWPAIDGQRTAAASAFGIAGTNAHLIVSMPEVA

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Has A Preference For Short Chain Acid Substrates And May Function To Supply The Octanoic Substrates For Lipoic Acid Biosynthe

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI41872631, Length=427, Percent_Identity=34.6604215456674, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI8923559, Length=435, Percent_Identity=26.4367816091954, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=31.2925170068027, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787337, Length=285, Percent_Identity=26.6666666666667, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788663, Length=278, Percent_Identity=29.8561151079137, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI212642053, Length=370, Percent_Identity=34.5945945945946, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17550940, Length=426, Percent_Identity=30.7511737089202, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71983541, Length=277, Percent_Identity=26.3537906137184, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=26.5917602996255, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=21.1711711711712, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19920632, Length=431, Percent_Identity=32.2505800464037, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI221330659, Length=431, Percent_Identity=32.2505800464037, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24581345, Length=436, Percent_Identity=31.651376146789, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24644341, Length=356, Percent_Identity=26.685393258427, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR013968
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]

EC number: =2.3.1.94 [H]

Molecular weight: Translated: 45624; Mature: 45492

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPMSENGFDAAGIDPVVIVGMGVEAPGGIETAEDYWELLAHGREALGPFPTDRGWAVSE
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCHHHH
LLAGSRRSGFKQIHDRGGFLSGAATFDPEFFGVSPREAVVMDPQQRVALRVAWRALENSG
HHHCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCC
INPDDLAGEDVGCYVGASATGYGPEMARFSEHSGHLLAGTALSVISGRIAYTLGLTGPAL
CCHHHCCCCCCCEEECCCCCCCCHHHHHHHCCCCCEEEHHHHHHHCCCEEEEEECCCCCE
TVDSSCASALVAFHVAVRALQNGDCDLALAGGVNVLGSPGFFVEFSKQHALSDDGHCRPY
EECHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEECCCCCEEEEECHHHCCCCCCCCCCC
SAQASGTVWAEGAAMFVLQRKSVALRAGRRVVAEVRATAINQDGRSAGLSAPSGDAQVRL
CCCCCCCEEECCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
FRRALGESGVKPAEVGMIEGHGTGTRLGDRTELRSLAQTYGDTEPGAGALLGSVKSNLGH
HHHHHCCCCCCHHHEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCH
SLAAAGALGLAKVLVSAEHGAVPPTLHATEASGEIDWEHQGLRLAQTLTPWPAIDGQRTA
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCEEEEHHCCCCCCCCCCCHH
AASAFGIAGTNAHLIVSMPEVA
HHHHHEECCCCCEEEEECCCCC
>Mature Secondary Structure 
TPMSENGFDAAGIDPVVIVGMGVEAPGGIETAEDYWELLAHGREALGPFPTDRGWAVSE
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCHHHH
LLAGSRRSGFKQIHDRGGFLSGAATFDPEFFGVSPREAVVMDPQQRVALRVAWRALENSG
HHHCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCC
INPDDLAGEDVGCYVGASATGYGPEMARFSEHSGHLLAGTALSVISGRIAYTLGLTGPAL
CCHHHCCCCCCCEEECCCCCCCCHHHHHHHCCCCCEEEHHHHHHHCCCEEEEEECCCCCE
TVDSSCASALVAFHVAVRALQNGDCDLALAGGVNVLGSPGFFVEFSKQHALSDDGHCRPY
EECHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEECCCCCEEEEECHHHCCCCCCCCCCC
SAQASGTVWAEGAAMFVLQRKSVALRAGRRVVAEVRATAINQDGRSAGLSAPSGDAQVRL
CCCCCCCEEECCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
FRRALGESGVKPAEVGMIEGHGTGTRLGDRTELRSLAQTYGDTEPGAGALLGSVKSNLGH
HHHHHCCCCCCHHHEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCH
SLAAAGALGLAKVLVSAEHGAVPPTLHATEASGEIDWEHQGLRLAQTLTPWPAIDGQRTA
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCEEEEHHCCCCCCCCCCCHH
AASAFGIAGTNAHLIVSMPEVA
HHHHHEECCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2024119; 8386127 [H]