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The map label for this gene is mbtG

Identifier: 41408268

GI number: 41408268

Start: 2400549

End: 2401835

Strand: Reverse

Name: mbtG

Synonym: MAP2170c

Alternate gene names: 41408268

Gene position: 2401835-2400549 (Counterclockwise)

Preceding gene: 41408269

Following gene: 41408267

Centisome position: 49.73

GC content: 68.07

Gene sequence:

>1287_bases
ATGAGCACACTTGCGATCCTGGGCGCGGGAGCCAAGGCCGTGGCGGTGGCCGCCAAGGCTTCGGTGCTGCGCGACATGGG
TGTCGAGGTTCCCGACGTGGTCGCGGTGGAACGCATCGGCGTGGCGGCGAACTGGCAGGCCAGCGGCGGCTGGACCGACG
GCGCGCACCGGCTGGGTACCAGCCCGGAAAAGGACGTCGGCTTCCCCTACCGCTCGGCGCTGGTGCCGCGCCGCAACGCC
GAACTGGACGAGCGGATGACCCGCTACAGCTGGCAGTCCTATCTGATCGCGACGGCGTCGTTCGCCGAATGGATCGACCG
CGGCAGGCCGGCGCCGACGCACCGCCGGTGGAGCCAGTATCTGTCCTGGGTGGCCGACCACGTGGGGATGACCGTGGTGC
ACGGCGAGGTCGAACAACTGGCCGTCACCGGGGACCGCTGGGCGCTGCACACCCACGAAACCACCGTGCACGCCGACGCG
TTGATGATCACCGGCCCCGGCCAGGCCGAAAAGTCTTTGCTCCCAGGCAATCCGCGGATGCTGTCGATCGCCCAGTTCTG
GGATCGCGCCGCCAACCACGACCGGATCAGCGCCGAGCGGGTCGCGGTGATCGGCGGTGGAGAGACGGCCGCGGCGATGC
TCAACGAGTTGTTCCGGCACCGGGTGTCCAGCATCACCGTCATCTCGCCCCAGGCGACGCTGTTCACCCGGGGCGAAGGG
TATTTCGAGAACTCGCTGTTCTCCGACCCGACCAACTGGCCGGCCCTGACCCTGGCCGAACGCCGGGATGCGTTGGCCCG
CACCGATCGCGGGGTGTTCTCGTCGTCCGTGCAGGAAGCGCTGCTGGCCGACGACCGTATCCACCACCTTCGGGGACGGG
TCACCCACGCGGTGGGCGTGCAGGGACAGATCCGGCTGACGCTGTCCACCAACCGCGGCAGTGAGAACCTGGAGACCGTG
CACGGCTTCGACCTGGTGATCGACGGCTCCGGTGCCGACTCGCTTTGGTTCGCACCGCTTTTCAGCCAGGAGGCCCTCGA
TCTGCTGGAGCTCGGTCTGGGCGGACCCCTGAGCTCGGAGCGGCTGCAAGAGGCGATAGGTTATGACCTGGCCGTCACCG
ACGTCACCCCCAAGTTGTTCCTACCGAACCTGTCCGGGCTCACCCAGGGGCCCGGGTTCCCCAACCTGAGCTGCCTCGGC
TTGCTGTCCGACCGGGTGTTGGGATCGACCCTTGGCCCGACGAACTATCCCGCGCGAAGGAGACATGATGAGCGCCAACC
CCTTTGA

Upstream 100 bases:

>100_bases
TGCTGGCCGCGCAGTGGCGCACCCTGCCCGACATTCTCACAGACACGGATATCACTGCACTGCAAGAGCTTTGGGTCGAT
TCACTGCGGGAGATGGTGAC

Downstream 100 bases:

>100_bases
CGACGACACCGCGACCTTCGTGGTGCTGGTCAACGACGAGGACCAGCACAGCCTGTGGCCGACCTTCGCCGAGACGCCCC
CGGGCTGGCGCGTGGTCTTC

Product: MbtG

Products: NA

Alternate protein names: Lysine 6-N-hydroxylase; Lysine N(6)-hydroxylase; Lysine-N-oxygenase; Mycobactin synthase protein G

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSTLAILGAGAKAVAVAAKASVLRDMGVEVPDVVAVERIGVAANWQASGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNA
ELDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQYLSWVADHVGMTVVHGEVEQLAVTGDRWALHTHETTVHADA
LMITGPGQAEKSLLPGNPRMLSIAQFWDRAANHDRISAERVAVIGGGETAAAMLNELFRHRVSSITVISPQATLFTRGEG
YFENSLFSDPTNWPALTLAERRDALARTDRGVFSSSVQEALLADDRIHHLRGRVTHAVGVQGQIRLTLSTNRGSENLETV
HGFDLVIDGSGADSLWFAPLFSQEALDLLELGLGGPLSSERLQEAIGYDLAVTDVTPKLFLPNLSGLTQGPGFPNLSCLG
LLSDRVLGSTLGPTNYPARRRHDERQPL

Sequences:

>Translated_428_residues
MSTLAILGAGAKAVAVAAKASVLRDMGVEVPDVVAVERIGVAANWQASGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNA
ELDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQYLSWVADHVGMTVVHGEVEQLAVTGDRWALHTHETTVHADA
LMITGPGQAEKSLLPGNPRMLSIAQFWDRAANHDRISAERVAVIGGGETAAAMLNELFRHRVSSITVISPQATLFTRGEG
YFENSLFSDPTNWPALTLAERRDALARTDRGVFSSSVQEALLADDRIHHLRGRVTHAVGVQGQIRLTLSTNRGSENLETV
HGFDLVIDGSGADSLWFAPLFSQEALDLLELGLGGPLSSERLQEAIGYDLAVTDVTPKLFLPNLSGLTQGPGFPNLSCLG
LLSDRVLGSTLGPTNYPARRRHDERQPL
>Mature_427_residues
STLAILGAGAKAVAVAAKASVLRDMGVEVPDVVAVERIGVAANWQASGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNAE
LDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQYLSWVADHVGMTVVHGEVEQLAVTGDRWALHTHETTVHADAL
MITGPGQAEKSLLPGNPRMLSIAQFWDRAANHDRISAERVAVIGGGETAAAMLNELFRHRVSSITVISPQATLFTRGEGY
FENSLFSDPTNWPALTLAERRDALARTDRGVFSSSVQEALLADDRIHHLRGRVTHAVGVQGQIRLTLSTNRGSENLETVH
GFDLVIDGSGADSLWFAPLFSQEALDLLELGLGGPLSSERLQEAIGYDLAVTDVTPKLFLPNLSGLTQGPGFPNLSCLGL
LSDRVLGSTLGPTNYPARRRHDERQPL

Specific function: Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration. Is also able, but less efficiently, to hydroxylate L-lysine (no

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MBTG_MYCPA (Q73XY8)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_961104.1
- ProteinModelPortal:   Q73XY8
- EnsemblBacteria:   EBMYCT00000038805
- GeneID:   2719638
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP2170c
- NMPDR:   fig|262316.1.peg.2170
- GeneTree:   EBGT00050000017267
- HOGENOM:   HBG432039
- OMA:   SIAQFWH
- ProtClustDB:   CLSK791811
- BRENDA:   1.14.13.59
- GO:   GO:0005488

Pfam domain/function: NA

EC number: =1.14.13.59

Molecular weight: Translated: 46533; Mature: 46402

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLAILGAGAKAVAVAAKASVLRDMGVEVPDVVAVERIGVAANWQASGGWTDGAHRLGT
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEECCCCCCCCCCCHHHCCC
SPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQY
CCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LSWVADHVGMTVVHGEVEQLAVTGDRWALHTHETTVHADALMITGPGQAEKSLLPGNPRM
HHHHHHHCCEEEEECCCEEEEEECCEEEEEECCCEEEECEEEEECCCCHHCCCCCCCCCE
LSIAQFWDRAANHDRISAERVAVIGGGETAAAMLNELFRHRVSSITVISPQATLFTRGEG
EHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCEEEEECCCEEEEECCCC
YFENSLFSDPTNWPALTLAERRDALARTDRGVFSSSVQEALLADDRIHHLRGRVTHAVGV
CCCCCCCCCCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
QGQIRLTLSTNRGSENLETVHGFDLVIDGSGADSLWFAPLFSQEALDLLELGLGGPLSSE
CEEEEEEEECCCCCCCCCEEECEEEEEECCCCCCEEECHHHHHHHHHHHHHCCCCCCCHH
RLQEAIGYDLAVTDVTPKLFLPNLSGLTQGPGFPNLSCLGLLSDRVLGSTLGPTNYPARR
HHHHHHCCCEEEECCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHH
RHDERQPL
CCCCCCCC
>Mature Secondary Structure 
STLAILGAGAKAVAVAAKASVLRDMGVEVPDVVAVERIGVAANWQASGGWTDGAHRLGT
CCEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEECCCCCCCCCCCHHHCCC
SPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQY
CCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LSWVADHVGMTVVHGEVEQLAVTGDRWALHTHETTVHADALMITGPGQAEKSLLPGNPRM
HHHHHHHCCEEEEECCCEEEEEECCEEEEEECCCEEEECEEEEECCCCHHCCCCCCCCCE
LSIAQFWDRAANHDRISAERVAVIGGGETAAAMLNELFRHRVSSITVISPQATLFTRGEG
EHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCEEEEECCCEEEEECCCC
YFENSLFSDPTNWPALTLAERRDALARTDRGVFSSSVQEALLADDRIHHLRGRVTHAVGV
CCCCCCCCCCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
QGQIRLTLSTNRGSENLETVHGFDLVIDGSGADSLWFAPLFSQEALDLLELGLGGPLSSE
CEEEEEEEECCCCCCCCCEEECEEEEEECCCCCCEEECHHHHHHHHHHHHHCCCCCCCHH
RLQEAIGYDLAVTDVTPKLFLPNLSGLTQGPGFPNLSCLGLLSDRVLGSTLGPTNYPARR
HHHHHHCCCEEEECCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHH
RHDERQPL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA