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The map label for this gene is glyS

Identifier: 41408235

GI number: 41408235

Start: 2367619

End: 2369010

Strand: Reverse

Name: glyS

Synonym: MAP2137c

Alternate gene names: 41408235

Gene position: 2369010-2367619 (Counterclockwise)

Preceding gene: 41408238

Following gene: 41408234

Centisome position: 49.05

GC content: 65.09

Gene sequence:

>1392_bases
GTGCACCGCCTCGTGGCGTCCGTCATCGACACCGTAGTGAACCTGGCCAAACGGCGCGGCTTCGTCTATCCCTCGGGGGA
GATCTACGGTGGCACCCGCTCGGCCTGGGACTACGGCCCGCTGGGCGTGGAGTTCAAGGAGAACATCAAGCGGCAGTGGT
GGCGCTCGGTGGTCACCGGCCGCGAGGACGTCGTCGGCCTGGATTCGTCGATCATCCTGCCCCGCCAGGTGTGGGTGGCC
TCCGGCCATGTCGAGGTCTTCCACGACCCGCTGGTCGAGTCGTTGATCACCCACAAGCGCTACCGCGCCGACCATCTCAT
CGAGGCCTACGAGGCCAAACACGGCCACCCGCCGCCCAACGGGCTGGCCGACATCCGCGACCCGGACACCGGCGAACCCG
GCCGGTGGACCGAACCGCGCGAGTTCAACATGATGCTCAAGACCTACCTCGGACCCATCGAGACCGAGGAAGGCCTGCAC
TATCTGCGCCCGGAGACCGCGCAGGGTATTTTCGTCAACTTCGCCAACGTGGTGACGACCGCACGCAAGAAGCCGCCGTT
CGGCATCGGCCAGATCGGCAAGAGCTTTCGCAACGAGATCACCCCGGGCAACTTCATTTTCCGCACCCGCGAGTTCGAGC
AAATGGAAATGGAGTTCTTCGTCGAGCCCTCGACCGCCAAGGAATGGCATCAGTATTGGATCGACACCCGGCTGCAATGG
TATGTCGAATTGGGTATCGATCCGCAGAACCTGCGGCTGTTCGAGCATCCCGCCGACAAGCTGTCGCATTACTCCGACCG
CACCGTCGACATCGAGTACAAGTTCGGCTTCGCCGGTAACCCGTGGGGCGAGCTGGAGGGGGTCGCCAACCGCACGGACT
TCGACTTGTCCACGCACTCAAAGCATTCCGGGGTCGACCTGTCCTTCTACGACCAGGCCACCGACTCCCGCTACATCCCG
TACGTGATCGAGCCGGCGGCCGGCCTGACCCGGTCGTTCATGGCCTTTCTGATCGACGCCTACGTTGAGGACGAGGCGCC
GAATGCCAAGGGCAAGATGGAAAAGCGCGCCGTGTTGCGGCTGGACCCGCGGCTGGCTCCGGTCAAGGCGGCGGTGCTTC
CGCTGTCGCGGCACGCCGACCTGAGTCCCAAGGCCCGCGACCTGGCGGCCGAGCTGCGCCGGTTCTGGAATATCGAATTC
GACGACGCGGGCGCCATCGGCCGGCGGTATCGGCGCCAGGACGAGATCGGCACACCGTTTTGCGTGACGGTGGATTTCGA
CTCGCTGGAGGACAATGCCGTGACGGTGCGCCGGCGCGACGACATGTCCCAGGAGCGGATCGGCATGGACGCCGTGGCCG
ACTACCTGTCGGCGCGGCTCAAGGGCTGCTAG

Upstream 100 bases:

>100_bases
ATGACGCATGTCAAAGGTGGCGGGGCCGATCGCTACCATGACTGATGCTCTGCGCACCGCGGTCGATCGCCGCGCGTGCC
CGCCCGAACACGGAAAGGGA

Downstream 100 bases:

>100_bases
CGCCGTCGTGGCCGACGCCTCCGCAGGCCCGGATTCGGGAAATAAGGTTTGCGTAAATTCCGGCTTCCGACGCTAAGGGT
GCCTTAGGATCTGCTCTGGG

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MHRLVASVIDTVVNLAKRRGFVYPSGEIYGGTRSAWDYGPLGVEFKENIKRQWWRSVVTGREDVVGLDSSIILPRQVWVA
SGHVEVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPNGLADIRDPDTGEPGRWTEPREFNMMLKTYLGPIETEEGLH
YLRPETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAKEWHQYWIDTRLQW
YVELGIDPQNLRLFEHPADKLSHYSDRTVDIEYKFGFAGNPWGELEGVANRTDFDLSTHSKHSGVDLSFYDQATDSRYIP
YVIEPAAGLTRSFMAFLIDAYVEDEAPNAKGKMEKRAVLRLDPRLAPVKAAVLPLSRHADLSPKARDLAAELRRFWNIEF
DDAGAIGRRYRRQDEIGTPFCVTVDFDSLEDNAVTVRRRDDMSQERIGMDAVADYLSARLKGC

Sequences:

>Translated_463_residues
MHRLVASVIDTVVNLAKRRGFVYPSGEIYGGTRSAWDYGPLGVEFKENIKRQWWRSVVTGREDVVGLDSSIILPRQVWVA
SGHVEVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPNGLADIRDPDTGEPGRWTEPREFNMMLKTYLGPIETEEGLH
YLRPETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAKEWHQYWIDTRLQW
YVELGIDPQNLRLFEHPADKLSHYSDRTVDIEYKFGFAGNPWGELEGVANRTDFDLSTHSKHSGVDLSFYDQATDSRYIP
YVIEPAAGLTRSFMAFLIDAYVEDEAPNAKGKMEKRAVLRLDPRLAPVKAAVLPLSRHADLSPKARDLAAELRRFWNIEF
DDAGAIGRRYRRQDEIGTPFCVTVDFDSLEDNAVTVRRRDDMSQERIGMDAVADYLSARLKGC
>Mature_463_residues
MHRLVASVIDTVVNLAKRRGFVYPSGEIYGGTRSAWDYGPLGVEFKENIKRQWWRSVVTGREDVVGLDSSIILPRQVWVA
SGHVEVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPNGLADIRDPDTGEPGRWTEPREFNMMLKTYLGPIETEEGLH
YLRPETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAKEWHQYWIDTRLQW
YVELGIDPQNLRLFEHPADKLSHYSDRTVDIEYKFGFAGNPWGELEGVANRTDFDLSTHSKHSGVDLSFYDQATDSRYIP
YVIEPAAGLTRSFMAFLIDAYVEDEAPNAKGKMEKRAVLRLDPRLAPVKAAVLPLSRHADLSPKARDLAAELRRFWNIEF
DDAGAIGRRYRRQDEIGTPFCVTVDFDSLEDNAVTVRRRDDMSQERIGMDAVADYLSARLKGC

Specific function: Catalyzes the attachment of glycine to tRNA(Gly)

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI116805340, Length=385, Percent_Identity=30.3896103896104, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI70887790, Length=474, Percent_Identity=21.5189873417722, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI32564541, Length=364, Percent_Identity=30.2197802197802, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17554996, Length=364, Percent_Identity=30.2197802197802, Blast_Score=158, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6325338, Length=370, Percent_Identity=29.7297297297297, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6319597, Length=223, Percent_Identity=34.0807174887892, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI21357965, Length=363, Percent_Identity=33.3333333333333, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24664462, Length=363, Percent_Identity=33.3333333333333, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYG_MYCPA (Q73Y21)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_961071.1
- ProteinModelPortal:   Q73Y21
- SMR:   Q73Y21
- EnsemblBacteria:   EBMYCT00000039993
- GeneID:   2720577
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP2137c
- NMPDR:   fig|262316.1.peg.2137
- GeneTree:   EBGT00050000016577
- HOGENOM:   HBG319978
- OMA:   GSEWGEL
- ProtClustDB:   PRK04173
- BRENDA:   6.1.1.14
- GO:   GO:0005737
- HAMAP:   MF_00253_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR10745
- PRINTS:   PR01043
- TIGRFAMs:   TIGR00389

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.14

Molecular weight: Translated: 52971; Mature: 52971

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50862 AA_TRNA_LIGASE_II; PS00041 HTH_ARAC_FAMILY_1 ; PS00307 LECTIN_LEGUME_BETA

Important sites: BINDING 102-102 BINDING 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRLVASVIDTVVNLAKRRGFVYPSGEIYGGTRSAWDYGPLGVEFKENIKRQWWRSVVTG
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
REDVVGLDSSIILPRQVWVASGHVEVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPN
CCCEECCCCCEECCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLADIRDPDTGEPGRWTEPREFNMMLKTYLGPIETEEGLHYLRPETAQGIFVNFANVVTT
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHH
ARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAKEWHQYWIDTRLQW
HCCCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHCCEEEEECCCCHHHHHHHHHCCEEEE
YVELGIDPQNLRLFEHPADKLSHYSDRTVDIEYKFGFAGNPWGELEGVANRTDFDLSTHS
EEEECCCHHHCEEEECCHHHHHCCCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCC
KHSGVDLSFYDQATDSRYIPYVIEPAAGLTRSFMAFLIDAYVEDEAPNAKGKMEKRAVLR
CCCCCCEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEE
LDPRLAPVKAAVLPLSRHADLSPKARDLAAELRRFWNIEFDDAGAIGRRYRRQDEIGTPF
ECCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCE
CVTVDFDSLEDNAVTVRRRDDMSQERIGMDAVADYLSARLKGC
EEEEECCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHRLVASVIDTVVNLAKRRGFVYPSGEIYGGTRSAWDYGPLGVEFKENIKRQWWRSVVTG
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
REDVVGLDSSIILPRQVWVASGHVEVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPN
CCCEECCCCCEECCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLADIRDPDTGEPGRWTEPREFNMMLKTYLGPIETEEGLHYLRPETAQGIFVNFANVVTT
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHH
ARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPSTAKEWHQYWIDTRLQW
HCCCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHCCEEEEECCCCHHHHHHHHHCCEEEE
YVELGIDPQNLRLFEHPADKLSHYSDRTVDIEYKFGFAGNPWGELEGVANRTDFDLSTHS
EEEECCCHHHCEEEECCHHHHHCCCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCC
KHSGVDLSFYDQATDSRYIPYVIEPAAGLTRSFMAFLIDAYVEDEAPNAKGKMEKRAVLR
CCCCCCEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEE
LDPRLAPVKAAVLPLSRHADLSPKARDLAAELRRFWNIEFDDAGAIGRRYRRQDEIGTPF
ECCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCE
CVTVDFDSLEDNAVTVRRRDDMSQERIGMDAVADYLSARLKGC
EEEEECCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA