Click here to switch to the map view.

The map label for this gene is cysH_1

Identifier: 41408134

GI number: 41408134

Start: 2244993

End: 2245736

Strand: Direct

Name: cysH_1

Synonym: MAP2036

Alternate gene names: 41408134

Gene position: 2244993-2245736 (Clockwise)

Preceding gene: 41408133

Following gene: 41408135

Centisome position: 46.48

GC content: 69.49

Gene sequence:

>744_bases
ATGAGCGACGTGGCAACCGACTTCACCGAGGAACAGCTGCGCGAGCTGGCCGAGCGCGGCGCCTCGGAGCTGGAGGGCGC
CAGCGCGATCGACATCCTGCGCTGGACCGACGAGCACTTCGGGCCCGTCGACGGGCCGCGCGGCTGGGCCACCTGCAAAT
ACGTGGTGGCCTGCAACATGCAGGACGCGGTGACGGTGTCGCTGGCCTCAGACGTGCGCCCCGGCGTGCCGGTGTTGTTC
CTGGACACCGGCTATCACTTCGCCGAGACCATCGGCACCCGCGACGCCGTCGAGGCGGTCTACGACATCCACCTGCTCAA
CGTCACCCCGGAGCACACCGTGGCCGAGCAGGACGAGCTGCTGGGCAAGGACCTGTTCGCCCGGGACCCCAACGAATGCT
GCCGGCTGCGCAAGGTGGAGCCGCTGCGCAGGGCGCTGCGCGGCTACGCGGCGTGGGTGAGCGGGCTGCGCCGGGTGGAG
GCGCCCACCCGCGCCGACGCCCCGCTGATCAGCTTCGACGAGTCGTTCAAGGTGGTTAAGGTCAACCCGATCGCCGCCTG
GACCGACGAGCAGGTCGACGAATACATCGAGCGCAACCGGGTTTTGGTCAACCCGCTGGTGCAGGAGGGCTACCCGTCGA
TCGGCTGCGCCCCGTGCACCGCCAAGCCGGCACCGGGCGAGGATCCGCGCAGCGGGCGTTGGCGGGGACGAAACAAGGTC
GAATGCGGGTTACACGCCTCATGA

Upstream 100 bases:

>100_bases
TGACGCGCAAGTACCTCGAGGGCCGCAACGACGGTGAGACGTTCGCGTCCTGGGCGTTGCGCGCCGACGAGGAAGAGCTG
CGCTGAGGTCCGAGGTCGAA

Downstream 100 bases:

>100_bases
GCACCCTGGTACTCACCGCGCACGGCAGCCGCGATCCGCGGTCGGCCGCCAATGCCGAGGCCGTCGCCGATCGGCTTCGG
CGGATGCGGCCCGGCCTCGA

Product: phosphoadenosine phosphosulfate reductase

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSDVATDFTEEQLRELAERGASELEGASAIDILRWTDEHFGPVDGPRGWATCKYVVACNMQDAVTVSLASDVRPGVPVLF
LDTGYHFAETIGTRDAVEAVYDIHLLNVTPEHTVAEQDELLGKDLFARDPNECCRLRKVEPLRRALRGYAAWVSGLRRVE
APTRADAPLISFDESFKVVKVNPIAAWTDEQVDEYIERNRVLVNPLVQEGYPSIGCAPCTAKPAPGEDPRSGRWRGRNKV
ECGLHAS

Sequences:

>Translated_247_residues
MSDVATDFTEEQLRELAERGASELEGASAIDILRWTDEHFGPVDGPRGWATCKYVVACNMQDAVTVSLASDVRPGVPVLF
LDTGYHFAETIGTRDAVEAVYDIHLLNVTPEHTVAEQDELLGKDLFARDPNECCRLRKVEPLRRALRGYAAWVSGLRRVE
APTRADAPLISFDESFKVVKVNPIAAWTDEQVDEYIERNRVLVNPLVQEGYPSIGCAPCTAKPAPGEDPRSGRWRGRNKV
ECGLHAS
>Mature_246_residues
SDVATDFTEEQLRELAERGASELEGASAIDILRWTDEHFGPVDGPRGWATCKYVVACNMQDAVTVSLASDVRPGVPVLFL
DTGYHFAETIGTRDAVEAVYDIHLLNVTPEHTVAEQDELLGKDLFARDPNECCRLRKVEPLRRALRGYAAWVSGLRRVEA
PTRADAPLISFDESFKVVKVNPIAAWTDEQVDEYIERNRVLVNPLVQEGYPSIGCAPCTAKPAPGEDPRSGRWRGRNKVE
CGLHAS

Specific function: Reduction of activated sulfate into sulfite [H]

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789121, Length=199, Percent_Identity=32.6633165829146, Blast_Score=99, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325425, Length=202, Percent_Identity=33.1683168316832, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011798
- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01507 PAPS_reduct [H]

EC number: =1.8.4.8 [H]

Molecular weight: Translated: 27349; Mature: 27218

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVATDFTEEQLRELAERGASELEGASAIDILRWTDEHFGPVDGPRGWATCKYVVACNM
CCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHEECCCCCCCCCCCCCCCCEEEEEEEECC
QDAVTVSLASDVRPGVPVLFLDTGYHFAETIGTRDAVEAVYDIHLLNVTPEHTVAEQDEL
CCCEEEEEHHCCCCCCCEEEEECCCHHHHHHCCHHHHHHHHHEEEEECCCCCHHHHHHHH
LGKDLFARDPNECCRLRKVEPLRRALRGYAAWVSGLRRVEAPTRADAPLISFDESFKVVK
HHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEE
VNPIAAWTDEQVDEYIERNRVLVNPLVQEGYPSIGCAPCTAKPAPGEDPRSGRWRGRNKV
ECCCCCCCHHHHHHHHHHCCEEECHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ECGLHAS
CCCCCCC
>Mature Secondary Structure 
SDVATDFTEEQLRELAERGASELEGASAIDILRWTDEHFGPVDGPRGWATCKYVVACNM
CCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHEECCCCCCCCCCCCCCCCEEEEEEEECC
QDAVTVSLASDVRPGVPVLFLDTGYHFAETIGTRDAVEAVYDIHLLNVTPEHTVAEQDEL
CCCEEEEEHHCCCCCCCEEEEECCCHHHHHHCCHHHHHHHHHEEEEECCCCCHHHHHHHH
LGKDLFARDPNECCRLRKVEPLRRALRGYAAWVSGLRRVEAPTRADAPLISFDESFKVVK
HHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEE
VNPIAAWTDEQVDEYIERNRVLVNPLVQEGYPSIGCAPCTAKPAPGEDPRSGRWRGRNKV
ECCCCCCCHHHHHHHHHHCCEEECHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ECGLHAS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]