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The map label for this gene is fabD

Identifier: 41408094

GI number: 41408094

Start: 2202645

End: 2203553

Strand: Direct

Name: fabD

Synonym: MAP1996

Alternate gene names: 41408094

Gene position: 2202645-2203553 (Clockwise)

Preceding gene: 41408093

Following gene: 41408095

Centisome position: 45.61

GC content: 73.38

Gene sequence:

>909_bases
GTGATTGCATTGCTTGCGCCCGGACAGGGTTCGCAGACCGAGGGGATGCTCTCGCCGTGGCTGGAGCTCGACGGCGCCGC
CGACCAGTTGGCGCTGTGGTCCAAGGCCAGCGGCCTCGACCTGGTTCGCCTGGGCACCACCGCATCGACCGAAGAGATCA
CCGACACCGCGGTCACCCAGCCGCTGGTCGTCGCCGCCACGCTGCTCGCCCACCAGGAGCTGACCCGGCGCGGCCTGCTC
GCCGACGCCGACCTGGTCGTGGCGGGCCACTCCGTCGGGGAGATCGCCGCCTACGCGATCGCCGGCGTGATGGCCGCTGA
CGACGCCGTCGCGCTGGCCGCCACCCGCGGCGCCGAGATGGCCAAGGCGTGCGCGGTCGAGCCGACCGGCATGTCCGCGG
TGCTCGGCGGCGACGAGGCCGAGGTCCTCGCCCGGCTCGAGCAGCTCGACCTGTTCCCCGCCAACCGCAACGCCGCCGGC
CAGATCGTGGCCGCCGGGTCGCTGGCCGCGCTGGAGAAGCTGGCCGAGGATCCCCCGGCGAAGGCCCGGGTGCGCGCCCT
CGGGGTGGCCGGAGCGTTCCACACCAAGTACATGGCCTCGGCGCTCGACGGCTACGCCGCCGCGGCGGCCGCCGTCCAGA
CGGCCGAGCCCACCGCCACGCTGCTGTCCAACCGCGACGGCAAGCCGGTCGCCTCGGCGGCCGCGGCGATGGAGGCGCTG
GTCGCCCAGCTGACCCAGCCGGTCCGCTGGGACCTGTGCACCGCCACGCTGCGTGAGCTGGAAGTCGCAGCGGCCGTGGA
GTTCCCGCCCGCGGGCACTCTCACCGGCATCGCCAAACGAGAACTTCGGGGGGTTTCGGCACGAGCCGTGAAGTCACCCG
CAGACCTGGACGCTTTGGCTGAGCTTTAA

Upstream 100 bases:

>100_bases
GCTTACCGAGCTATTTTGTAGGGTGTACACAAAAACCTAAGACGAGGTTCATAATCTGTTACACCCGCCAAAACCGTTTC
CACAGTGTTCTCTTAAACAC

Downstream 100 bases:

>100_bases
AAGCCAGCTCGACCAGTACAACCGCATAACACACGTCAGTTCGACTGAATCACAACACATTACGAAGGGAAATGCTGTGG
CTGTCAGCCAGGAAGAAATC

Product: acyl-carrier-protein S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MIALLAPGQGSQTEGMLSPWLELDGAADQLALWSKASGLDLVRLGTTASTEEITDTAVTQPLVVAATLLAHQELTRRGLL
ADADLVVAGHSVGEIAAYAIAGVMAADDAVALAATRGAEMAKACAVEPTGMSAVLGGDEAEVLARLEQLDLFPANRNAAG
QIVAAGSLAALEKLAEDPPAKARVRALGVAGAFHTKYMASALDGYAAAAAAVQTAEPTATLLSNRDGKPVASAAAAMEAL
VAQLTQPVRWDLCTATLRELEVAAAVEFPPAGTLTGIAKRELRGVSARAVKSPADLDALAEL

Sequences:

>Translated_302_residues
MIALLAPGQGSQTEGMLSPWLELDGAADQLALWSKASGLDLVRLGTTASTEEITDTAVTQPLVVAATLLAHQELTRRGLL
ADADLVVAGHSVGEIAAYAIAGVMAADDAVALAATRGAEMAKACAVEPTGMSAVLGGDEAEVLARLEQLDLFPANRNAAG
QIVAAGSLAALEKLAEDPPAKARVRALGVAGAFHTKYMASALDGYAAAAAAVQTAEPTATLLSNRDGKPVASAAAAMEAL
VAQLTQPVRWDLCTATLRELEVAAAVEFPPAGTLTGIAKRELRGVSARAVKSPADLDALAEL
>Mature_302_residues
MIALLAPGQGSQTEGMLSPWLELDGAADQLALWSKASGLDLVRLGTTASTEEITDTAVTQPLVVAATLLAHQELTRRGLL
ADADLVVAGHSVGEIAAYAIAGVMAADDAVALAATRGAEMAKACAVEPTGMSAVLGGDEAEVLARLEQLDLFPANRNAAG
QIVAAGSLAALEKLAEDPPAKARVRALGVAGAFHTKYMASALDGYAAAAAAVQTAEPTATLLSNRDGKPVASAAAAMEAL
VAQLTQPVRWDLCTATLRELEVAAAVEFPPAGTLTGIAKRELRGVSARAVKSPADLDALAEL

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=322, Percent_Identity=28.2608695652174, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1787334, Length=313, Percent_Identity=32.5878594249201, Blast_Score=111, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71984332, Length=271, Percent_Identity=27.3062730627306, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24665753, Length=284, Percent_Identity=31.3380281690141, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 30635; Mature: 30635

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALLAPGQGSQTEGMLSPWLELDGAADQLALWSKASGLDLVRLGTTASTEEITDTAVTQ
CEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
PLVVAATLLAHQELTRRGLLADADLVVAGHSVGEIAAYAIAGVMAADDAVALAATRGAEM
HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEHHHCCHHH
AKACAVEPTGMSAVLGGDEAEVLARLEQLDLFPANRNAAGQIVAAGSLAALEKLAEDPPA
HHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHCCCCH
KARVRALGVAGAFHTKYMASALDGYAAAAAAVQTAEPTATLLSNRDGKPVASAAAAMEAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHH
VAQLTQPVRWDLCTATLRELEVAAAVEFPPAGTLTGIAKRELRGVSARAVKSPADLDALA
HHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCHHHHHCCCCCHHHHH
EL
CC
>Mature Secondary Structure
MIALLAPGQGSQTEGMLSPWLELDGAADQLALWSKASGLDLVRLGTTASTEEITDTAVTQ
CEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
PLVVAATLLAHQELTRRGLLADADLVVAGHSVGEIAAYAIAGVMAADDAVALAATRGAEM
HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEHHHCCHHH
AKACAVEPTGMSAVLGGDEAEVLARLEQLDLFPANRNAAGQIVAAGSLAALEKLAEDPPA
HHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHCCCCH
KARVRALGVAGAFHTKYMASALDGYAAAAAAVQTAEPTATLLSNRDGKPVASAAAAMEAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHH
VAQLTQPVRWDLCTATLRELEVAAAVEFPPAGTLTGIAKRELRGVSARAVKSPADLDALA
HHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCHHHHHCCCCCHHHHH
EL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]