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The map label for this gene is gcvT

Identifier: 41408049

GI number: 41408049

Start: 2152117

End: 2153220

Strand: Reverse

Name: gcvT

Synonym: MAP1951c

Alternate gene names: 41408049

Gene position: 2153220-2152117 (Counterclockwise)

Preceding gene: 41408050

Following gene: 41408048

Centisome position: 44.58

GC content: 71.29

Gene sequence:

>1104_bases
GTGAGCAACGAAGCCGACCTGCTGCACGGACCGCTGGAAGACCGCCACCGCGACCTGGGCGCCAGTTTCGCCGAGTTCGG
GGGTTGGCTGATGCCGGTGTCGTATGCGGGCACCGTCAGCGAGCACAACGCCACGCGCAACGCCGTCGGCCTGTTCGACG
TCAGCCATCTGGGCAAGGCGCTGGTCCGCGGGACGGGCGCGGCGCGGTTCGTCAACTCCGCGCTCACCAACGACCTGAAC
CGGATCGGGCCGGGCAAGGCGCAATACACGTTGTGCTGCAACGAATCCGGGGGAGTCATCGACGACCTGATCGCCTACTA
CGTCGACGACGACGAGATCTTTTTGGTGCCCAACGCGGCCAACACCGCCGCCGTGGTCGAGGCGCTGCAGGGCGCCGCCC
CGGCCGGGGTGACGGTGCGCAACCTGCATCGCTCGTATGCCGTGCTGGCCGTGCAGGGGCCGCGCTCGGCCAATGTGCTC
GCCGAGCTGGGGCTGCCGAGCGACATGGATTACATGGCCTACGCCGACACCTCGTTCCGGCAGGTGCCGGTGCGCGTCTG
CCGCACCGGCTACACCGGCGAGCACGGCTACGAGCTGCTGCCGCCGTGGGAGTCCGCCGGCGTGGTGTTCGACGCCCTGG
CCGCGGCGGTGTCGCAGGCCGGCGGCCAACCGGCGGGCCTGGGCGCCCGCGACACGCTGCGCACCGAGATGGGTTACCCG
CTGCACGGCCATGAACTGTCACCGGACATTTCGCCGCTGCAGGCCCGATGCGGCTGGGCGATCGGCTGGAAAAAGGAGGC
GTTCTTCGGCCGCGACGCGCTGCTGGCCGAAAAGGAGGCCGGGCCGCGACGGCTGCTGCGCGGGCTGCGGATGGTGGGCC
GCGGCGTGCTGCGGGCCGGGCTGACGGTGCTCGTCGGTGACACGCCGGTCGGGGTGACCACCTCGGGCACGTTCTCCCCG
ACGCTGCAGGCCGGGATCGCGCTGGCGCTGATCAACACCGACGCCGACGTGCGGGACGGTCAGGAAGTCACCGTCGACGT
CCGCGGCCGCGCCGCCACGTGCGAGGTGGTGCGGCCCCCGTTCGTCGCGGTGAAAACCCGGTAG

Upstream 100 bases:

>100_bases
AACGCCGCCTGGCCCGCGTCGTCTTCCACCACCTACACACCGACCACCAAAACCGAATCCAGCCTTGCCAACCGGCAGCG
GCTTGACATAGGAGAAACTC

Downstream 100 bases:

>100_bases
CGGCGCGGTCGCGCGGGCAAAATCCGATCGGACGCCCGGATATACAATCAGCGGATGACCAGTGGCTCCCTCGAGTTCAC
GGTTTCGCGCTCGACACGTC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSNEADLLHGPLEDRHRDLGASFAEFGGWLMPVSYAGTVSEHNATRNAVGLFDVSHLGKALVRGTGAARFVNSALTNDLN
RIGPGKAQYTLCCNESGGVIDDLIAYYVDDDEIFLVPNAANTAAVVEALQGAAPAGVTVRNLHRSYAVLAVQGPRSANVL
AELGLPSDMDYMAYADTSFRQVPVRVCRTGYTGEHGYELLPPWESAGVVFDALAAAVSQAGGQPAGLGARDTLRTEMGYP
LHGHELSPDISPLQARCGWAIGWKKEAFFGRDALLAEKEAGPRRLLRGLRMVGRGVLRAGLTVLVGDTPVGVTTSGTFSP
TLQAGIALALINTDADVRDGQEVTVDVRGRAATCEVVRPPFVAVKTR

Sequences:

>Translated_367_residues
MSNEADLLHGPLEDRHRDLGASFAEFGGWLMPVSYAGTVSEHNATRNAVGLFDVSHLGKALVRGTGAARFVNSALTNDLN
RIGPGKAQYTLCCNESGGVIDDLIAYYVDDDEIFLVPNAANTAAVVEALQGAAPAGVTVRNLHRSYAVLAVQGPRSANVL
AELGLPSDMDYMAYADTSFRQVPVRVCRTGYTGEHGYELLPPWESAGVVFDALAAAVSQAGGQPAGLGARDTLRTEMGYP
LHGHELSPDISPLQARCGWAIGWKKEAFFGRDALLAEKEAGPRRLLRGLRMVGRGVLRAGLTVLVGDTPVGVTTSGTFSP
TLQAGIALALINTDADVRDGQEVTVDVRGRAATCEVVRPPFVAVKTR
>Mature_366_residues
SNEADLLHGPLEDRHRDLGASFAEFGGWLMPVSYAGTVSEHNATRNAVGLFDVSHLGKALVRGTGAARFVNSALTNDLNR
IGPGKAQYTLCCNESGGVIDDLIAYYVDDDEIFLVPNAANTAAVVEALQGAAPAGVTVRNLHRSYAVLAVQGPRSANVLA
ELGLPSDMDYMAYADTSFRQVPVRVCRTGYTGEHGYELLPPWESAGVVFDALAAAVSQAGGQPAGLGARDTLRTEMGYPL
HGHELSPDISPLQARCGWAIGWKKEAFFGRDALLAEKEAGPRRLLRGLRMVGRGVLRAGLTVLVGDTPVGVTTSGTFSPT
LQAGIALALINTDADVRDGQEVTVDVRGRAATCEVVRPPFVAVKTR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=365, Percent_Identity=30.1369863013699, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI257796258, Length=334, Percent_Identity=30.2395209580838, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI257796254, Length=361, Percent_Identity=27.4238227146814, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=28.7539936102236, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI24797151, Length=343, Percent_Identity=26.2390670553936, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI197927446, Length=284, Percent_Identity=28.5211267605634, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI21361378, Length=284, Percent_Identity=28.5211267605634, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI194306651, Length=329, Percent_Identity=26.1398176291793, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789272, Length=362, Percent_Identity=38.6740331491713, Blast_Score=214, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17560118, Length=380, Percent_Identity=32.6315789473684, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71994052, Length=369, Percent_Identity=26.0162601626016, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994045, Length=369, Percent_Identity=26.0162601626016, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32563613, Length=394, Percent_Identity=22.3350253807107, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=377, Percent_Identity=29.973474801061, Blast_Score=145, Evalue=8e-36,
Organism=Drosophila melanogaster, GI20129441, Length=370, Percent_Identity=30.8108108108108, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI20130091, Length=350, Percent_Identity=25.4285714285714, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571104, Length=292, Percent_Identity=26.027397260274, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 38853; Mature: 38722

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEADLLHGPLEDRHRDLGASFAEFGGWLMPVSYAGTVSEHNATRNAVGLFDVSHLGKA
CCCCCCCEECCHHHHHHHHCCCHHHHCCEEEEEEECCCCHHCCCCCCEEEEEEHHHHHHH
LVRGTGAARFVNSALTNDLNRIGPGKAQYTLCCNESGGVIDDLIAYYVDDDEIFLVPNAA
HHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHEEECCCCEEEEECCC
NTAAVVEALQGAAPAGVTVRNLHRSYAVLAVQGPRSANVLAELGLPSDMDYMAYADTSFR
CHHHHHHHHHCCCCCCCCHHHHCCCEEEEEEECCCCCCHHEECCCCCCCCCEEECCCCHH
QVPVRVCRTGYTGEHGYELLPPWESAGVVFDALAAAVSQAGGQPAGLGARDTLRTEMGYP
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC
LHGHELSPDISPLQARCGWAIGWKKEAFFGRDALLAEKEAGPRRLLRGLRMVGRGVLRAG
CCCCCCCCCCCHHHHHCCEEECCCCHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
LTVLVGDTPVGVTTSGTFSPTLQAGIALALINTDADVRDGQEVTVDVRGRAATCEVVRPP
CEEEECCCCCCEEECCCCCHHHHCCEEEEEEECCCCCCCCCEEEEEECCCEEEEEEECCC
FVAVKTR
EEEEECC
>Mature Secondary Structure 
SNEADLLHGPLEDRHRDLGASFAEFGGWLMPVSYAGTVSEHNATRNAVGLFDVSHLGKA
CCCCCCEECCHHHHHHHHCCCHHHHCCEEEEEEECCCCHHCCCCCCEEEEEEHHHHHHH
LVRGTGAARFVNSALTNDLNRIGPGKAQYTLCCNESGGVIDDLIAYYVDDDEIFLVPNAA
HHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHEEECCCCEEEEECCC
NTAAVVEALQGAAPAGVTVRNLHRSYAVLAVQGPRSANVLAELGLPSDMDYMAYADTSFR
CHHHHHHHHHCCCCCCCCHHHHCCCEEEEEEECCCCCCHHEECCCCCCCCCEEECCCCHH
QVPVRVCRTGYTGEHGYELLPPWESAGVVFDALAAAVSQAGGQPAGLGARDTLRTEMGYP
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC
LHGHELSPDISPLQARCGWAIGWKKEAFFGRDALLAEKEAGPRRLLRGLRMVGRGVLRAG
CCCCCCCCCCCHHHHHCCEEECCCCHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
LTVLVGDTPVGVTTSGTFSPTLQAGIALALINTDADVRDGQEVTVDVRGRAATCEVVRPP
CEEEECCCCCCEEECCCCCHHHHCCEEEEEEECCCCCCCCCEEEEEECCCEEEEEEECCC
FVAVKTR
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA