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The map label for this gene is uvrC [C]

Identifier: 41408028

GI number: 41408028

Start: 2130722

End: 2132653

Strand: Direct

Name: uvrC [C]

Synonym: MAP1930

Alternate gene names: 41408028

Gene position: 2130722-2132653 (Clockwise)

Preceding gene: 41408023

Following gene: 41408030

Centisome position: 44.12

GC content: 76.14

Gene sequence:

>1932_bases
GTGTCGGTCGTGCTGCCTACCGTCACCACCGTGGCCTCCGACGGTGCGACTCAGCTGAGCTTCGCCGACGTGGGACCGGC
GTTCGGCCCCGACGAGGTCGCGCTGCGCGACACCACCTTCGTGGTGGTCGACCTGGAAACCACCGGCGGACGCAGCACCA
GCACCGAGGAAACCGCGCCCGACGCCATCACCGAGATCGGGGCGGTCAAGGTGCGCGGCGGCGTGGTGCTCGGCGAGTTC
GCCACCCTGGTCGACCCGCAGCGCAGCATCCCGCCCCAGATCATGCGACTGACCGGCATCACCACGGCGATGGTGTCGGA
CGCGCCGGCCATCGACGCGGTGCTGCCGATGTTCCTCGAGTTCGCCGGCTTGGACCGCGGGGCGGTGCTGGTCGCCCACA
ACGCCGGTTTCGATGTCGGGTTCCTGCGCGCGGCCGCGCAGCAGTGCGACATCGCCTGGCCGCGACCGCGGGTGCTGTGC
ACGGTCCGGTTGGCCCGCCGGGTGCTCAGCCGCGAGGAGGCCCCCAGCGTGCGGCTGGCCTCGCTGGCCCGGCTGTTCGC
CGTAACCACCCAACCCACCCACCGCGCCCTCGACGACGCCCGGGCCACCGTCGACGTGCTGCACGCCCTCATCGAGCGGG
TCGGCAACCAGGGCGTGCACACCTACGCCGACCTGCGCGGCTACCTGCCCGACGTGACGCCCACCCAGCGCCGCAAACGG
GTGCTGGCCGAGGGGTTGCCGCGCCGGCCGGGGGTGTACCTGTTCCGCGGGCCGTCGGGCGAGGTGCTCTATATCGGCAC
CGCCGTCGACCTGCGGCGCCGGGTCGCCCAGTACTTCACCGGCGCCGATCCGCGCGGCCGGATGAAGGAGATGGTCGCGC
TGGCCGGCGCGGTCGACCACGTCGAGTGCGCGCACGCGCTCGAGGCCGGGGTGCGCGAGCTGCGGCTGCTGGCCGCCCAC
GCCCCGCCCTACAACCGGCGCTCCCGCTTCCCGCAGCGGTGGTGGTGGGTGGCGCTCACCGACGAGGCGTACCCCCGGCT
CGCGGTGGTCCGGGCGCCGCGGCACGACCGGGCCGTCGGGCCGTTCCGGGCCCGCGCCGACGCCGCCGACACCGCCGAGC
TGCTGGCCCGGTTCGCCGGGCTGCGCACCTGCACCAACCGGCTGGGCCGGGCAGCGTTGCACGGGCCGCTGTGCCCGGAG
GCGGAGGTGGCGCCGTGCCCGGCCGCCCGCGGCGTCACGGCCACCCAATACGCGGCCGCGGTGGCGAGGGTCGCGGCGTT
GATCGACGGCGCCGACAACAGCGCGCTGGCCGCCGCGGTGGACCAGGTCGCTGCGCTGGCCGAGCGGCGTCACTTCGAAA
GCGCCGCCCGGCTGCGCGACCGCACCGCCACCGCGGTCGAGACGCTGTGGCGCGGCCAGCGGCTGCGGGCCCTGGCCTCG
TTGCCGGAGCTGGTTGCCGCCGCGCCCGACGGGCAGGGCGGCTATCAGCTGGCCGTCGTCCGCTACGGCCGGCTCGCCGC
GGCGGGCAACGCCCGGCGCGGGGTGCCACCGATGCCGGTGGTTGACGCGATCACCGCTGCGGCGCAAGCGATTTGGCCCG
AGCCGGGGCCGCTGGGCGGCGCGCTGGTCGAGGAGACGGCGCTGATCGCGCGCTGGCTGGAGGCCCCGGGGGTGCGCATC
GTCCGGGTAAAGGGCACCCCGGACGCGGCGGGCTGGGCCTCCCCGCTGCGCTCGGCCGGGGCCTGGGCGGCGTGGGCGGC
GGCGGCGCGCTCGGCCCGGCTGGCAAGCGAGCAGGCCCTGCGGGCGTCAGAGCTGCTGACCGAACCGCACCCAACGCGCG
AGCAGCTGTTCGGCCGCGCCGGAGTCGATGGCGGCGCTGGCGCGGGCCAGCCCGTCCTCCCAGGCCGGCAACCATTCGGC
GCGGCTGGATAA

Upstream 100 bases:

>100_bases
CGGGCCGGCGCACATCGCGCCGGGCTGACCGAACGGTAACGGCGGCCACCGACATCGACCGCCGACCCCGACGGCCCGGA
CCGGCGTGGCAGCCGCCCGG

Downstream 100 bases:

>100_bases
CCCGGCGTGCGCCACGATCGCGCCGGCGGCGTTGAGGACGACGGCGTCGCGCACCGGGCCCTGGCCGCCGGCCAGCACCG
CCCGCACCTCCGCGGCGTTG

Product: hypothetical protein

Products: diphosphate; DNAn+1

Alternate protein names: NA

Number of amino acids: Translated: 643; Mature: 642

Protein sequence:

>643_residues
MSVVLPTVTTVASDGATQLSFADVGPAFGPDEVALRDTTFVVVDLETTGGRSTSTEETAPDAITEIGAVKVRGGVVLGEF
ATLVDPQRSIPPQIMRLTGITTAMVSDAPAIDAVLPMFLEFAGLDRGAVLVAHNAGFDVGFLRAAAQQCDIAWPRPRVLC
TVRLARRVLSREEAPSVRLASLARLFAVTTQPTHRALDDARATVDVLHALIERVGNQGVHTYADLRGYLPDVTPTQRRKR
VLAEGLPRRPGVYLFRGPSGEVLYIGTAVDLRRRVAQYFTGADPRGRMKEMVALAGAVDHVECAHALEAGVRELRLLAAH
APPYNRRSRFPQRWWWVALTDEAYPRLAVVRAPRHDRAVGPFRARADAADTAELLARFAGLRTCTNRLGRAALHGPLCPE
AEVAPCPAARGVTATQYAAAVARVAALIDGADNSALAAAVDQVAALAERRHFESAARLRDRTATAVETLWRGQRLRALAS
LPELVAAAPDGQGGYQLAVVRYGRLAAAGNARRGVPPMPVVDAITAAAQAIWPEPGPLGGALVEETALIARWLEAPGVRI
VRVKGTPDAAGWASPLRSAGAWAAWAAAARSARLASEQALRASELLTEPHPTREQLFGRAGVDGGAGAGQPVLPGRQPFG
AAG

Sequences:

>Translated_643_residues
MSVVLPTVTTVASDGATQLSFADVGPAFGPDEVALRDTTFVVVDLETTGGRSTSTEETAPDAITEIGAVKVRGGVVLGEF
ATLVDPQRSIPPQIMRLTGITTAMVSDAPAIDAVLPMFLEFAGLDRGAVLVAHNAGFDVGFLRAAAQQCDIAWPRPRVLC
TVRLARRVLSREEAPSVRLASLARLFAVTTQPTHRALDDARATVDVLHALIERVGNQGVHTYADLRGYLPDVTPTQRRKR
VLAEGLPRRPGVYLFRGPSGEVLYIGTAVDLRRRVAQYFTGADPRGRMKEMVALAGAVDHVECAHALEAGVRELRLLAAH
APPYNRRSRFPQRWWWVALTDEAYPRLAVVRAPRHDRAVGPFRARADAADTAELLARFAGLRTCTNRLGRAALHGPLCPE
AEVAPCPAARGVTATQYAAAVARVAALIDGADNSALAAAVDQVAALAERRHFESAARLRDRTATAVETLWRGQRLRALAS
LPELVAAAPDGQGGYQLAVVRYGRLAAAGNARRGVPPMPVVDAITAAAQAIWPEPGPLGGALVEETALIARWLEAPGVRI
VRVKGTPDAAGWASPLRSAGAWAAWAAAARSARLASEQALRASELLTEPHPTREQLFGRAGVDGGAGAGQPVLPGRQPFG
AAG
>Mature_642_residues
SVVLPTVTTVASDGATQLSFADVGPAFGPDEVALRDTTFVVVDLETTGGRSTSTEETAPDAITEIGAVKVRGGVVLGEFA
TLVDPQRSIPPQIMRLTGITTAMVSDAPAIDAVLPMFLEFAGLDRGAVLVAHNAGFDVGFLRAAAQQCDIAWPRPRVLCT
VRLARRVLSREEAPSVRLASLARLFAVTTQPTHRALDDARATVDVLHALIERVGNQGVHTYADLRGYLPDVTPTQRRKRV
LAEGLPRRPGVYLFRGPSGEVLYIGTAVDLRRRVAQYFTGADPRGRMKEMVALAGAVDHVECAHALEAGVRELRLLAAHA
PPYNRRSRFPQRWWWVALTDEAYPRLAVVRAPRHDRAVGPFRARADAADTAELLARFAGLRTCTNRLGRAALHGPLCPEA
EVAPCPAARGVTATQYAAAVARVAALIDGADNSALAAAVDQVAALAERRHFESAARLRDRTATAVETLWRGQRLRALASL
PELVAAAPDGQGGYQLAVVRYGRLAAAGNARRGVPPMPVVDAITAAAQAIWPEPGPLGGALVEETALIARWLEAPGVRIV
RVKGTPDAAGWASPLRSAGAWAAWAAAARSARLASEQALRASELLTEPHPTREQLFGRAGVDGGAGAGQPVLPGRQPFGA
AG

Specific function: The Uvrabc Repair System Catalyzes The Recognition And Processing Of DNA Lesions. Uvrc Both Incises The 5' And 3' Sides Of The Lesion. The N-Terminal Half Is Responsible For The 3' Incision And The C-Terminal Half Is Responsible For The 5' Incision. [C]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87081999, Length=277, Percent_Identity=25.6317689530686, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788149, Length=228, Percent_Identity=29.3859649122807, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012337
- InterPro:   IPR000305 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF01541 GIY-YIG [H]

EC number: 2.7.7.7

Molecular weight: Translated: 68152; Mature: 68020

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVLPTVTTVASDGATQLSFADVGPAFGPDEVALRDTTFVVVDLETTGGRSTSTEETAP
CCEECCCHHHHCCCCCCEEEEHHCCCCCCCCCEEEECEEEEEEEEECCCCCCCCCCCCCC
DAITEIGAVKVRGGVVLGEFATLVDPQRSIPPQIMRLTGITTAMVSDAPAIDAVLPMFLE
HHHHHHCCEEEECCEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FAGLDRGAVLVAHNAGFDVGFLRAAAQQCDIAWPRPRVLCTVRLARRVLSREEAPSVRLA
HHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHH
SLARLFAVTTQPTHRALDDARATVDVLHALIERVGNQGVHTYADLRGYLPDVTPTQRRKR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHH
VLAEGLPRRPGVYLFRGPSGEVLYIGTAVDLRRRVAQYFTGADPRGRMKEMVALAGAVDH
HHHHCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VECAHALEAGVRELRLLAAHAPPYNRRSRFPQRWWWVALTDEAYPRLAVVRAPRHDRAVG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEEEECCCCCCCEEEEECCCCCCCCC
PFRARADAADTAELLARFAGLRTCTNRLGRAALHGPLCPEAEVAPCPAARGVTATQYAAA
CCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
VARVAALIDGADNSALAAAVDQVAALAERRHFESAARLRDRTATAVETLWRGQRLRALAS
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LPELVAAAPDGQGGYQLAVVRYGRLAAAGNARRGVPPMPVVDAITAAAQAIWPEPGPLGG
HHHHHHCCCCCCCCEEEEEEEECHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
ALVEETALIARWLEAPGVRIVRVKGTPDAAGWASPLRSAGAWAAWAAAARSARLASEQAL
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RASELLTEPHPTREQLFGRAGVDGGAGAGQPVLPGRQPFGAAG
HHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVVLPTVTTVASDGATQLSFADVGPAFGPDEVALRDTTFVVVDLETTGGRSTSTEETAP
CEECCCHHHHCCCCCCEEEEHHCCCCCCCCCEEEECEEEEEEEEECCCCCCCCCCCCCC
DAITEIGAVKVRGGVVLGEFATLVDPQRSIPPQIMRLTGITTAMVSDAPAIDAVLPMFLE
HHHHHHCCEEEECCEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FAGLDRGAVLVAHNAGFDVGFLRAAAQQCDIAWPRPRVLCTVRLARRVLSREEAPSVRLA
HHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHH
SLARLFAVTTQPTHRALDDARATVDVLHALIERVGNQGVHTYADLRGYLPDVTPTQRRKR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHH
VLAEGLPRRPGVYLFRGPSGEVLYIGTAVDLRRRVAQYFTGADPRGRMKEMVALAGAVDH
HHHHCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VECAHALEAGVRELRLLAAHAPPYNRRSRFPQRWWWVALTDEAYPRLAVVRAPRHDRAVG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEEEECCCCCCCEEEEECCCCCCCCC
PFRARADAADTAELLARFAGLRTCTNRLGRAALHGPLCPEAEVAPCPAARGVTATQYAAA
CCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
VARVAALIDGADNSALAAAVDQVAALAERRHFESAARLRDRTATAVETLWRGQRLRALAS
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LPELVAAAPDGQGGYQLAVVRYGRLAAAGNARRGVPPMPVVDAITAAAQAIWPEPGPLGG
HHHHHHCCCCCCCCEEEEEEEECHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
ALVEETALIARWLEAPGVRIVRVKGTPDAAGWASPLRSAGAWAAWAAAARSARLASEQAL
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RASELLTEPHPTREQLFGRAGVDGGAGAGQPVLPGRQPFGAAG
HHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxynucleoside triphosphate; DNAn

Specific reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]