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The map label for this gene is idsA2_1

Identifier: 41408009

GI number: 41408009

Start: 2111266

End: 2112312

Strand: Direct

Name: idsA2_1

Synonym: MAP1911

Alternate gene names: 41408009

Gene position: 2111266-2112312 (Clockwise)

Preceding gene: 41408007

Following gene: 41408010

Centisome position: 43.71

GC content: 70.77

Gene sequence:

>1047_bases
TTGACCGGCGCCATCACCGAGCAATTGCGGCGGTATCTGCATGACCGGCGCGCCGAGACCGCCTACATCGGTGACGACTA
CAGCGGCCTGATCGCCGCGCTGGAAGAGTTCGTGCTGAACGGCGGCAAGCGGCTGCGGCCCGCCTTCGCCTACTGGGGCT
GGCGCGCGGTGGCCACCGAGGCGCCCGATGACCAAGCGCTGCTGCTGTTTTCCGCACTCGAGCTGCTGCACGCGTGCGCC
CTGGTGCACGACGACGTGATCGACGACTCGGCCACCCGCCGGGGCCGGCCCACCACGCACGTGCGGTTCGCGTCGTTGCA
CCGAGACCGGCAGTGGCAGGGCTCGCCGGAGCGGTTCGGGATGTCGGCGGCGATCCTGCTCGGCGATCTCGCCCTGGCCT
GGGCTGACGACATCGTCCTCGGTGTCGACCTGACACCGCAGGCGGCGCGCCGGGTGCGGCGGGTGTGGGCCAACATCCGC
ACCGAGGTGCTCGGCGGGCAGTACCTCGACATCGTCGCCGAGGCCAGCGCCGCCGCCTCGATCGCCTCGGCGATGAACGT
CGACACCTTCAAGACCGCCTGCTACACCGTGTCGCGCCCGTTGCAGCTCGGCGCGGCCGCCGCCGACCGGCCGGACGTGC
ACGACCTGTTCAGCCAGTTCGGGACCGACCTCGGGGTGGCGTTTCAGCTGCGCGACGACGTGCTGGGCGTGTTCGGCGAC
CCCGCGGTGACCGGCAAACCGTCTGGCGACGACCTGCGATCCGGTAAGCGCACCGTGCTGTTGGCCGAGGCGGTGGAGTT
GGCGGAGAAGTCGGATCCGTTGGCCGCCAAGCTGTTACGAGACTCCATCGGCGCACAGCTGAGCGACGCCGAAGTGGATC
GGCTGCGCGACGTGATCGAGTCGGTGGGTGCGCTGGCCGCCGCCGAGCAGCGCATCGCCACGCTGACCCAGCGGGCCCTG
GCCACCCTGGCGGCCGCACCCATCAACACCGCCGCCAAGGCGGGGTTGTCCGAATTGGCCAAGCTGGCCACCAACCGGTC
GGCCTGA

Upstream 100 bases:

>100_bases
GCGGCGAATACACTGGTCGGGCCTGCAACACCCAGCCAGCCGAGCAGAAAGGGGCGCCGCGCTGAGCCTACGAGCTTCAG
AAGCGGCGGCAACCGTCGAG

Downstream 100 bases:

>100_bases
ACCGATGGCCACCGGAACCGACACCCCGGCCGCCGACCCACCGGCGGCCAAACCCTCTCGCGGACAATGGTTTTCGCGGC
TGAAGGCGTTCGCCGGTAGC

Product: IdsA2_1

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTGAITEQLRRYLHDRRAETAYIGDDYSGLIAALEEFVLNGGKRLRPAFAYWGWRAVATEAPDDQALLLFSALELLHACA
LVHDDVIDDSATRRGRPTTHVRFASLHRDRQWQGSPERFGMSAAILLGDLALAWADDIVLGVDLTPQAARRVRRVWANIR
TEVLGGQYLDIVAEASAAASIASAMNVDTFKTACYTVSRPLQLGAAAADRPDVHDLFSQFGTDLGVAFQLRDDVLGVFGD
PAVTGKPSGDDLRSGKRTVLLAEAVELAEKSDPLAAKLLRDSIGAQLSDAEVDRLRDVIESVGALAAAEQRIATLTQRAL
ATLAAAPINTAAKAGLSELAKLATNRSA

Sequences:

>Translated_348_residues
MTGAITEQLRRYLHDRRAETAYIGDDYSGLIAALEEFVLNGGKRLRPAFAYWGWRAVATEAPDDQALLLFSALELLHACA
LVHDDVIDDSATRRGRPTTHVRFASLHRDRQWQGSPERFGMSAAILLGDLALAWADDIVLGVDLTPQAARRVRRVWANIR
TEVLGGQYLDIVAEASAAASIASAMNVDTFKTACYTVSRPLQLGAAAADRPDVHDLFSQFGTDLGVAFQLRDDVLGVFGD
PAVTGKPSGDDLRSGKRTVLLAEAVELAEKSDPLAAKLLRDSIGAQLSDAEVDRLRDVIESVGALAAAEQRIATLTQRAL
ATLAAAPINTAAKAGLSELAKLATNRSA
>Mature_347_residues
TGAITEQLRRYLHDRRAETAYIGDDYSGLIAALEEFVLNGGKRLRPAFAYWGWRAVATEAPDDQALLLFSALELLHACAL
VHDDVIDDSATRRGRPTTHVRFASLHRDRQWQGSPERFGMSAAILLGDLALAWADDIVLGVDLTPQAARRVRRVWANIRT
EVLGGQYLDIVAEASAAASIASAMNVDTFKTACYTVSRPLQLGAAAADRPDVHDLFSQFGTDLGVAFQLRDDVLGVFGDP
AVTGKPSGDDLRSGKRTVLLAEAVELAEKSDPLAAKLLRDSIGAQLSDAEVDRLRDVIESVGALAAAEQRIATLTQRALA
TLAAAPINTAAKAGLSELAKLATNRSA

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=233, Percent_Identity=26.6094420600858, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1789578, Length=318, Percent_Identity=27.3584905660377, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786623, Length=254, Percent_Identity=30.3149606299213, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17508563, Length=227, Percent_Identity=28.1938325991189, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17505681, Length=277, Percent_Identity=24.5487364620939, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24651612, Length=314, Percent_Identity=23.8853503184713, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 37341; Mature: 37209

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGAITEQLRRYLHDRRAETAYIGDDYSGLIAALEEFVLNGGKRLRPAFAYWGWRAVATE
CCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEECC
APDDQALLLFSALELLHACALVHDDVIDDSATRRGRPTTHVRFASLHRDRQWQGSPERFG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHCCCCCCCCHHHHC
MSAAILLGDLALAWADDIVLGVDLTPQAARRVRRVWANIRTEVLGGQYLDIVAEASAAAS
HHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
IASAMNVDTFKTACYTVSRPLQLGAAAADRPDVHDLFSQFGTDLGVAFQLRDDVLGVFGD
HHHHHCCHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEHHHHHHHCCC
PAVTGKPSGDDLRSGKRTVLLAEAVELAEKSDPLAAKLLRDSIGAQLSDAEVDRLRDVIE
CCCCCCCCCCHHHCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SVGALAAAEQRIATLTQRALATLAAAPINTAAKAGLSELAKLATNRSA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGAITEQLRRYLHDRRAETAYIGDDYSGLIAALEEFVLNGGKRLRPAFAYWGWRAVATE
CCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEECC
APDDQALLLFSALELLHACALVHDDVIDDSATRRGRPTTHVRFASLHRDRQWQGSPERFG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHCCCCCCCCHHHHC
MSAAILLGDLALAWADDIVLGVDLTPQAARRVRRVWANIRTEVLGGQYLDIVAEASAAAS
HHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
IASAMNVDTFKTACYTVSRPLQLGAAAADRPDVHDLFSQFGTDLGVAFQLRDDVLGVFGD
HHHHHCCHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEHHHHHHHCCC
PAVTGKPSGDDLRSGKRTVLLAEAVELAEKSDPLAAKLLRDSIGAQLSDAEVDRLRDVIE
CCCCCCCCCCHHHCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SVGALAAAEQRIATLTQRALATLAAAPINTAAKAGLSELAKLATNRSA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8182085 [H]