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The map label for this gene is pyrD

Identifier: 41407981

GI number: 41407981

Start: 2079791

End: 2080903

Strand: Direct

Name: pyrD

Synonym: MAP1883

Alternate gene names: 41407981

Gene position: 2079791-2080903 (Clockwise)

Preceding gene: 41407980

Following gene: 41407985

Centisome position: 43.06

GC content: 73.05

Gene sequence:

>1113_bases
GTGAGCGGGGCGCCCCCGGCACCACGCGGCGGCGGCCATCGCTGGTATGGCGTGGCGCGGCAACTGTTTTTCCTGGTACC
CGCCGAGCGGATTCACACGCTGGTGTTCGCCCTGCTGCGCGGCGTCACGGCCGTCGGCTGGCCCCGGCGACTGCTGCGCC
GACTGCTGGCTCCGACGGATCCCGTGCTGGCCAGCACGGTGTTCGGGGTGCGCTTCCCGGGGCCGCTGGGGCTGGCGGCC
GGCTTCGACAAGGACGGGCTGGGGCTGCACGCCTGGGGCGCGCTGGGTTTCGGATATGCCGAGATCGGCACCGTCACCGC
CGGCCCGCAGCCCGGCAATCCGGCGCCGCGGCTGTTCCGGCTGCCCGCCGACCGGGCGCTGCTGAACCGGATGGGCTTCA
ACAATCTCGGCGCCGGCGCGCTGGCGGTGCGGCTCGCCCGCCGACAGCCCGACATCCCGATCGGGGTCAACATCGGCAAG
ACCAAAGCGACGCCGCCGGATCAGGCGGTCGATGACTACCGGGCCAGCGCGCGGCTGCTCGGCCCGCTGGCGTCGTATCT
GGTGGTCAACGTCAGCTCGCCGAACACGCCCGGGCTGCGCGATCTGCAGGCGGTGGGGTCGCTGCGGCCGATCCTGTCGG
CCGTTCTCGCCGAGACGTCCACCCCGGTGCTGGTGAAGATCGCGCCGGATCTGTCCGACTCCGACGTCGACGACATCGCG
GACCTGGCCGTCGAACTCGGCCTGGCCGGCATCGTCGCCACCAACACCACGGTGTCGCGGGACGGCCTGCGCACCGCGGG
GGTCGACCAGCTGGGTGCCGGCGGCATCTCCGGGCCGCCGGTGGCCCGCCGCGCGGTCGAGGTGTTGCGCCGGCTCTACG
GCCGGGTCGGCGATCGCCTGGTGCTGATCAGTGTCGGCGGCATCGAGACCGCCGACCACGCCTGGGAGCGGATCACCGCG
GGCGCCTCCCTGCTGCAGGGCTACACGGGCTTCGTGTACGGAGGAGGCTTGTGGGCCAAGCAGATTCACGACGGCATCGC
GCAGCGGCTGCGCGATGGCGGGTTCGCCTCGCTGCGCGATGCCGTCGGGTCGTCGGCGCGCGAATCGGGTTGA

Upstream 100 bases:

>100_bases
GGCTGTACACCGACGGCAGCAGGCGAGTGTTGTTGCGCCGCAAGAAATCTCGCGTCGATGCTGGCGGCTTCGAGGGGCGG
CGGCCCGACCAGCCGCAACT

Downstream 100 bases:

>100_bases
CTCACGCGGCGCCGTCCTCCTCGTCGGCTCCGTCTTGTTGGTCAGCCTGATCTTGCTGGTCTTCGGTGTCGCACAGCATG
TCCTCGGGGTGGTGAAACGA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSGAPPAPRGGGHRWYGVARQLFFLVPAERIHTLVFALLRGVTAVGWPRRLLRRLLAPTDPVLASTVFGVRFPGPLGLAA
GFDKDGLGLHAWGALGFGYAEIGTVTAGPQPGNPAPRLFRLPADRALLNRMGFNNLGAGALAVRLARRQPDIPIGVNIGK
TKATPPDQAVDDYRASARLLGPLASYLVVNVSSPNTPGLRDLQAVGSLRPILSAVLAETSTPVLVKIAPDLSDSDVDDIA
DLAVELGLAGIVATNTTVSRDGLRTAGVDQLGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIETADHAWERITA
GASLLQGYTGFVYGGGLWAKQIHDGIAQRLRDGGFASLRDAVGSSARESG

Sequences:

>Translated_370_residues
MSGAPPAPRGGGHRWYGVARQLFFLVPAERIHTLVFALLRGVTAVGWPRRLLRRLLAPTDPVLASTVFGVRFPGPLGLAA
GFDKDGLGLHAWGALGFGYAEIGTVTAGPQPGNPAPRLFRLPADRALLNRMGFNNLGAGALAVRLARRQPDIPIGVNIGK
TKATPPDQAVDDYRASARLLGPLASYLVVNVSSPNTPGLRDLQAVGSLRPILSAVLAETSTPVLVKIAPDLSDSDVDDIA
DLAVELGLAGIVATNTTVSRDGLRTAGVDQLGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIETADHAWERITA
GASLLQGYTGFVYGGGLWAKQIHDGIAQRLRDGGFASLRDAVGSSARESG
>Mature_369_residues
SGAPPAPRGGGHRWYGVARQLFFLVPAERIHTLVFALLRGVTAVGWPRRLLRRLLAPTDPVLASTVFGVRFPGPLGLAAG
FDKDGLGLHAWGALGFGYAEIGTVTAGPQPGNPAPRLFRLPADRALLNRMGFNNLGAGALAVRLARRQPDIPIGVNIGKT
KATPPDQAVDDYRASARLLGPLASYLVVNVSSPNTPGLRDLQAVGSLRPILSAVLAETSTPVLVKIAPDLSDSDVDDIAD
LAVELGLAGIVATNTTVSRDGLRTAGVDQLGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIETADHAWERITAG
ASLLQGYTGFVYGGGLWAKQIHDGIAQRLRDGGFASLRDAVGSSARESG

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=322, Percent_Identity=43.4782608695652, Blast_Score=239, Evalue=3e-63,
Organism=Escherichia coli, GI1787177, Length=338, Percent_Identity=43.1952662721894, Blast_Score=254, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17509475, Length=341, Percent_Identity=39.0029325513196, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI281361352, Length=367, Percent_Identity=36.5122615803815, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17137316, Length=367, Percent_Identity=36.5122615803815, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_MYCPA (Q73YS2)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_960817.1
- ProteinModelPortal:   Q73YS2
- SMR:   Q73YS2
- EnsemblBacteria:   EBMYCT00000037202
- GeneID:   2718468
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP1883
- NMPDR:   fig|262316.1.peg.1883
- GeneTree:   EBGT00050000017343
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- ProtClustDB:   PRK05286
- BRENDA:   1.3.3.1
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 38622; Mature: 38491

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 193-193

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAPPAPRGGGHRWYGVARQLFFLVPAERIHTLVFALLRGVTAVGWPRRLLRRLLAPTD
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
PVLASTVFGVRFPGPLGLAAGFDKDGLGLHAWGALGFGYAEIGTVTAGPQPGNPAPRLFR
HHHHHHHHCEECCCCCCCCCCCCCCCCCEEEHHHHHCCHHHHCEEECCCCCCCCCCCEEE
LPADRALLNRMGFNNLGAGALAVRLARRQPDIPIGVNIGKTKATPPDQAVDDYRASARLL
CCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHH
GPLASYLVVNVSSPNTPGLRDLQAVGSLRPILSAVLAETSTPVLVKIAPDLSDSDVDDIA
HHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHH
DLAVELGLAGIVATNTTVSRDGLRTAGVDQLGAGGISGPPVARRAVEVLRRLYGRVGDRL
HHHHHHHHHHEEECCCEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
VLISVGGIETADHAWERITAGASLLQGYTGFVYGGGLWAKQIHDGIAQRLRDGGFASLRD
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCHHHHHH
AVGSSARESG
HHCCCCCCCC
>Mature Secondary Structure 
SGAPPAPRGGGHRWYGVARQLFFLVPAERIHTLVFALLRGVTAVGWPRRLLRRLLAPTD
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
PVLASTVFGVRFPGPLGLAAGFDKDGLGLHAWGALGFGYAEIGTVTAGPQPGNPAPRLFR
HHHHHHHHCEECCCCCCCCCCCCCCCCCEEEHHHHHCCHHHHCEEECCCCCCCCCCCEEE
LPADRALLNRMGFNNLGAGALAVRLARRQPDIPIGVNIGKTKATPPDQAVDDYRASARLL
CCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHH
GPLASYLVVNVSSPNTPGLRDLQAVGSLRPILSAVLAETSTPVLVKIAPDLSDSDVDDIA
HHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHH
DLAVELGLAGIVATNTTVSRDGLRTAGVDQLGAGGISGPPVARRAVEVLRRLYGRVGDRL
HHHHHHHHHHEEECCCEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
VLISVGGIETADHAWERITAGASLLQGYTGFVYGGGLWAKQIHDGIAQRLRDGGFASLRD
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCHHHHHH
AVGSSARESG
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA